发布求助
文献互助 智能选刊 最新文献

Biotechnology (Faisalabad, Pakistan)最新文献

筛选
英文 中文
Knowledge Management in Biotechnology Drugs in Brazil as a Case Study of the National Pharmaceuticals Laboratories 巴西生物技术药物的知识管理——以国家药物实验室为例
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-3012-1.CH033
J. Magalhães, M. D. Carmo, Z. Hartz
{"title":"Knowledge Management in Biotechnology Drugs in Brazil as a Case Study of the National Pharmaceuticals Laboratories","authors":"J. Magalhães, M. D. Carmo, Z. Hartz","doi":"10.4018/978-1-5225-3012-1.CH033","DOIUrl":"https://doi.org/10.4018/978-1-5225-3012-1.CH033","url":null,"abstract":"The informational age in the twenty-first century is also known as the age of knowledge. The great differential of organizations has been the strategic innovation through the best way to manage the existing knowledge. The pharmaceutical area is one of the most intensive areas in research, development, and innovation. In this century, the discovery of new drugs and biotechnology drugs has revolutionized several treatments for human health. It is estimated that in 2017 the medical prescriptions of biotech drugs will exceed US $220 billion. It was identified that by the year 2019, several biotechnological patents will be expired in the world. New structures and strategic innovations in the scientific and technological environment of the Brazilian pharmaceutical area have occurred. There is a boom in investment opportunities in the industry through strategic innovation fostered by the updating of Brazilian legislation and investments by private companies. Knowledge management in biotechnological drugs has favored scientific, technological, and market growth in Brazilian organizations.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70433060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intelligent Techniques Inspired by Nature and Used in Biomedical Engineering 受自然启发并应用于生物医学工程的智能技术
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-4769-3.CH003
Omer Deperlioglu
{"title":"Intelligent Techniques Inspired by Nature and Used in Biomedical Engineering","authors":"Omer Deperlioglu","doi":"10.4018/978-1-5225-4769-3.CH003","DOIUrl":"https://doi.org/10.4018/978-1-5225-4769-3.CH003","url":null,"abstract":"Managing medical information and knowledge is becoming an increasing problem for healthcare professionals. Medical science that contains ever-increasing amounts of knowledge, such as the medical history of a patient, medical data about diseases, diagnosis and treatment methods, should be necessarily a science of information. The real problem faced by patients and healthcare providers is finding and using relevant knowledge at the right time. In this context, in the middle of 1950s, intelligent computer systems, called clinical decision support systems (CDSS), were introduced as a new concept. CDSS is defined as an active intelligent system that can help medical experts to make decisions by taking specific recommendations. Also, it provides decisions based on resolving patient-specific information and related medical truths. The objective of this chapter is to focus on these systems and explain relations with the field of artificial intelligence methods, approaches, or techniques in this manner.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70434027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
The Turkish Biotechnology System 土耳其生物技术体系
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8903-7.ch049
D. Cetindamar
{"title":"The Turkish Biotechnology System","authors":"D. Cetindamar","doi":"10.4018/978-1-5225-8903-7.ch049","DOIUrl":"https://doi.org/10.4018/978-1-5225-8903-7.ch049","url":null,"abstract":"This chapter empirically examines biotechnology innovation system in order to present the concerns of developing countries. Even though it is not possible to create standard prescriptions across countries, this paper aims to develop a solid understanding of how biotechnology and institutions co-evolve that might shed light to innovation policy issues for biotechnology across developing countries. The immediate goal is the Turkish policy makers but it will surely have policy implications for developing countries in general. Through mapping innovation processes/functions over time, it is possible to develop insights of the dynamics of innovation systems. This mapping is carried out for the Turkish biotechnology system, and the findings are summarized.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70434918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the Reduction of the Costs Inherent to Fossil Fuel Biodesulfurization Towards Its Potential Industrial Applications 降低化石燃料生物脱硫成本及其潜在工业应用的研究进展
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8903-7.ch081
S. Paixão, Tiago P. Silva, B. F. Arez, L. Alves
{"title":"Advances in the Reduction of the Costs Inherent to Fossil Fuel Biodesulfurization Towards Its Potential Industrial Applications","authors":"S. Paixão, Tiago P. Silva, B. F. Arez, L. Alves","doi":"10.4018/978-1-5225-8903-7.ch081","DOIUrl":"https://doi.org/10.4018/978-1-5225-8903-7.ch081","url":null,"abstract":"The biodesulfurization (BDS) process consists of the use of microorganisms for the removal of sulfur from fossil fuels. Through BDS it is possible to treat most of the organosulfur compounds recalcitrant to the conventional hydrodesulfurization (HDS), the petroleum industry's solution, at mild operating conditions, without the need for molecular hydrogen or metal catalysts. This technique results in lower emissions, smaller residue production, and less energy consumption, which makes BDS an eco-friendly process that can complement HDS making it more efficient. BDS has been extensively studied and much is already known about the process. Clearly, BDS presents advantages as a complementary technique to HDS; however, its commercial use has been delayed by several limitations both upstream and downstream the process. This study will comprehensively review and discuss key issues, like reduction of the BDS costs, advances, and/or challenges for a competitive BDS towards its potential industrial application aiming ultra-low sulfur fuels.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70435345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Microbial Degradation of Azo Dyes 偶氮染料的微生物降解
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-8903-7.ch076
D. Tischler, Jingxian Qi, A. C. R. Ngo, M. Schlömann
{"title":"Microbial Degradation of Azo Dyes","authors":"D. Tischler, Jingxian Qi, A. C. R. Ngo, M. Schlömann","doi":"10.4018/978-1-5225-8903-7.ch076","DOIUrl":"https://doi.org/10.4018/978-1-5225-8903-7.ch076","url":null,"abstract":"Azo dyes are considered as xenobiotic compounds, which are often recalcitrant to be biodegraded. Many dyes are relevant for staining in industries, especially textile and food related. Among other environmental problems, one obvious issue is the coloring effect on effluents from industrial sites and thus the release of xenobiotics into nature. Microorganisms (algae, fungi, yeast, and bacteria) have been found to decolorize a number of azo dyes. Decolorization of azo dyes by microbial cultures is summarized and this is mostly linked to initial activation or even cleavage of the azo bond (e.g., by azoreductases). However, it does not necessarily mean that the compound is degraded to non-toxic products. Various mechanisms of microbial decolorization processes were discovered, including adsorption, enzymatic degradation, or a combination of both. Oxidases and reductases were found to be involved, which contain azoreductase, lignin peroxidase, Mn peroxidase, laccase, tyrosinase, and so on. A focus is on the azoreductases including classification, activity, and applicability.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70435484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inference of Gene Regulatory Networks by Topological Prior Information and Data Integration 基于拓扑先验信息和数据集成的基因调控网络推断
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-0353-8.CH001
D. Martins, Fabricio M. Lopes, S. S. Ray
{"title":"Inference of Gene Regulatory Networks by Topological Prior Information and Data Integration","authors":"D. Martins, Fabricio M. Lopes, S. S. Ray","doi":"10.4018/978-1-5225-0353-8.CH001","DOIUrl":"https://doi.org/10.4018/978-1-5225-0353-8.CH001","url":null,"abstract":"The inference of Gene Regulatory Networks (GRNs) is a very challenging problem which has attracted increasing attention since the development of high-throughput sequencing and gene expression measurement technologies. Many models and algorithms have been developed to identify GRNs using mainly gene expression profile as data source. As the gene expression data usually has limited number of samples and inherent noise, the integration of gene expression with several other sources of information can be vital for accurately inferring GRNs. For instance, some prior information about the overall topological structure of the GRN can guide inference techniques toward better results. In addition to gene expression data, recently biological information from heterogeneous data sources have been integrated by GRN inference methods as well. The objective of this chapter is to present an overview of GRN inference models and techniques with focus on incorporation of prior information such as, global and local topological features and integration of several heterogeneous data sources.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70431077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Structural Intervention and External Control for Markovian Regulatory Network Models 马尔可夫调节网络模型的结构干预与外部控制
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-0353-8.CH004
Xiaoning Qian, R. Pal
{"title":"Structural Intervention and External Control for Markovian Regulatory Network Models","authors":"Xiaoning Qian, R. Pal","doi":"10.4018/978-1-5225-0353-8.CH004","DOIUrl":"https://doi.org/10.4018/978-1-5225-0353-8.CH004","url":null,"abstract":"In order to derive system-based methods to control dynamic behavior of biological systems of interest for future gene-based intervention therapeutics, two basic categories of intervention strategies have been studied based on the Markov chain theory and Markov decision processes: Structural intervention by function perturbation and external control based on state perturbation. The chapter reviews the existing network analysis and control methods in these two categories and discusses their extensions for more robust and clinically relevant intervention strategies considering collateral damages from intervention.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70431116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Prospective Study on Emerging Role of Phytoremediation by Endophytic Microorganisms 植物内生微生物修复新作用的前瞻性研究
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-4666-9734-8.CH012
A. Verma, P. Shukla
{"title":"A Prospective Study on Emerging Role of Phytoremediation by Endophytic Microorganisms","authors":"A. Verma, P. Shukla","doi":"10.4018/978-1-4666-9734-8.CH012","DOIUrl":"https://doi.org/10.4018/978-1-4666-9734-8.CH012","url":null,"abstract":"Colonies of endophytes are excellent example of beneficial association with most plants in their natural state. Endophytic colonies and plant associations are beneficial in many ways such as supplying biologically fixed nitrogen, regulation of phytohormone production thus enhancing the plant growth, resistance to environmental stress etc. these associations are also important for the agriculture and industries because they produce important medicinal, agriculture and industrial compounds as endophytic metabolites. When we concern about the waste management, degradation and biotransformation of several toxins, the phytoremediation by using endophytes has been developed as important tool. Current chapter reviles, study and collect most of important knowledge, recent ongoing research, technologies, roles and advancements in biodegradation and biotransformation of different types of toxic wastes and their effects on environment with phytoremediation by endophytes.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70431283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Collaboration, Innovation, and Funding as Survival Factors for Canadian Biotechnology SMEs 合作、创新与资金:加拿大生物科技中小企业的生存要素
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-1040-6.CH013
C. Beaudry
{"title":"Collaboration, Innovation, and Funding as Survival Factors for Canadian Biotechnology SMEs","authors":"C. Beaudry","doi":"10.4018/978-1-5225-1040-6.CH013","DOIUrl":"https://doi.org/10.4018/978-1-5225-1040-6.CH013","url":null,"abstract":"This chapter aims to determine the factors, such as collaboration, research and development, intellectual property, product management and financing, that influence the survival of biotechnology firms in Canada. The research uses data from four biannual surveys on the use and development of biotechnology collected by Statistics Canada between 1999 and 2005, and follows these firms in the official business register of the organisation up to 2009, to build a Cox proportional hazard model of firm survival. The research finds that firms that collaborate for exploration purposes have better chances of survival than others. Results also suggest that a larger number of patents decreases the probability of survival. Investigation of the product development process shows that because of the vast resources necessary for clinical research, firms enter the production and commercialisation stage in a weak position, which may then result in firm exit.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70432137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Protein Docking and Drug Design 蛋白质对接和药物设计
Biotechnology (Faisalabad, Pakistan) Pub Date : 2019-01-01 DOI: 10.4018/978-1-5225-2607-0.CH009
Aditi Gangopadhyay, H. Chakraborty, A. Datta
{"title":"Protein Docking and Drug Design","authors":"Aditi Gangopadhyay, H. Chakraborty, A. Datta","doi":"10.4018/978-1-5225-2607-0.CH009","DOIUrl":"https://doi.org/10.4018/978-1-5225-2607-0.CH009","url":null,"abstract":"Protein docking is integral to structure-based drug design and molecular biology. The recent surge of big data in biology, the demand for personalised medicines, evolving pathogens and increasing lifestyle-associated risks, asks for smart, robust, low-cost and high-throughput drug design. Computer-aided drug design techniques allow rapid screening of ultra-large chemical libraries within minutes. This is immensely necessary to the drug discovery pipeline, which is presently burdened with high attrition rates, failures, huge capital and time investment. With increasing drug resistance and difficult druggable targets, there is a growing need for novel drug scaffolds which is partly satisfied by fragment based drug design and de novo methods. The chapter discusses various aspects of protein docking and emphasises on its application in drug design.","PeriodicalId":93084,"journal":{"name":"Biotechnology (Faisalabad, Pakistan)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70432684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信