Journal of cardiology and cardiovascular sciences最新文献_第3页

Commentary on the "Co-Crystal of Tramadol-Celecoxib in Patients with Moderate to Severe Acute Post-Surgical Oral Pain: A Dose-Finding, Randomised, Double-Blind, Placebo- and Active-Controlled, Multicentre Phase II Trial". Implications for Cardiovascular Safety 关于“曲马多-塞来昔布在中重度术后急性口腔疼痛患者中的共晶体:一项剂量发现、随机、双盲、安慰剂和主动对照、多中心II期试验”的评论。对心血管安全的影响

Journal of cardiology and cardiovascular sciences Pub Date : 2019-01-01 DOI: 10.29245/2578-3025/2018/1.1163

S. Videla, Neus Gascón, C. Plata-Salamán

引用次数: 2

Human Perivascular Adipose Tissue as a Regulator of the Vascular Microenvironment and Diseases of the Coronary Artery and Aorta. 人类血管周围脂肪组织作为血管微环境和冠状动脉和主动脉疾病的调节剂。

Journal of cardiology and cardiovascular sciences Pub Date : 2019-01-01 Epub Date: 2019-08-13 DOI: 10.29245/2578-3025/2019/4.1174

Caitlin Stieber, Kimberly Malka, Joshua M Boucher, Lucy Liaw

{"title":"Human Perivascular Adipose Tissue as a Regulator of the Vascular Microenvironment and Diseases of the Coronary Artery and Aorta.","authors":"Caitlin Stieber, Kimberly Malka, Joshua M Boucher, Lucy Liaw","doi":"10.29245/2578-3025/2019/4.1174","DOIUrl":"https://doi.org/10.29245/2578-3025/2019/4.1174","url":null,"abstract":"<p><p>Perivascular adipose tissue (PVAT) is an adipose depot that surrounds blood vessels in the human body and exerts local paracrine signaling. Under physiologically healthy conditions, PVAT has an anti-contractile effect on vessels, but in obesity this effect is lost. During metabolic disease, adiponectin secretion is dysregulated, influencing nitric oxide bioavailability and macrophage infiltration and inflammation, all of which mediate PVAT signaling. However, based on the location in the body, and the type of adipocyte present, PVAT has different relationships with risk factors for disease. Imaging studies in patients with cardiovascular disease have demonstrated important associations between PVAT structure and pathology, yet insight into molecular pathways regulating human PVAT function are still lacking. This review focuses on our current understanding of human PVAT and its secretory role in the vascular microenvironment. A current area of priority is defining molecular differences in the secretome between PVAT depots, as this could inform the treatment of diseases that occur in anatomically restricted locations. In addition, understanding progressive changes in PVAT structure and function during metabolic disease is required for effective targeted therapies.</p>","PeriodicalId":93019,"journal":{"name":"Journal of cardiology and cardiovascular sciences","volume":"3 4","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37937960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Electron Tomography Contributing to Ultrastructural Research in Vascular Biology and Transfusion Medicine 电子断层扫描对血管生物学和输血医学超微结构研究的贡献

Journal of cardiology and cardiovascular sciences Pub Date : 2019-01-01 DOI: 10.29245/2578-3025/2019/1.1165

J. Neumüller, T. Wagner

引用次数: 0

Commentary: Atherosclerosis, Analysis of the eNOS (T786C) Gene Polymorphism 评论:动脉粥样硬化，eNOS (T786C)基因多态性分析

Journal of cardiology and cardiovascular sciences Pub Date : 2019-01-01 DOI: 10.29245/2578-3025/2019/1.1166

K. Silva

引用次数: 0

Mini Review on: Simple, Practical, and Evidence-Based - an Algorithm for The Diagnosis and Treatment of Iron Deficiency 简单、实用、循证的缺铁诊疗算法综述

Journal of cardiology and cardiovascular sciences Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1162

E. Erdmann

引用次数: 0

Percutaneous Coronary Intervention with Everolimus-Eluting Bioresorbable Vascular Scaffolds in Diffuse Coronary Artery Disease: Current Knowledge and Future Perspectives 依维莫司洗脱生物可吸收血管支架经皮冠状动脉介入治疗弥漫性冠状动脉疾病：当前知识和未来展望

Journal of cardiology and cardiovascular sciences Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1148

G. Masiero, L. N. Fovino, Alessandro Schiavo, D. Ueshima, M. Badawy, G. Tarantini

引用次数: 0

Commentary to an Article: "Molecular Mechanisms Underlying Oxytocin-Induced Cardiomyocyte Protection From Simulated Ischemia-Reperfusion" 一篇文章的评论:“催产素诱导心肌细胞保护模拟缺血-再灌注的分子机制”

Journal of cardiology and cardiovascular sciences Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1158

Marek Jankowski

引用次数: 0

Commentary: Evaluation of the Comorbidity Burden in Patients With Ankylosing Spondylitis Using a Large US Administrative Claims Data Set 评论：使用大型美国行政索赔数据集评估强直性脊柱炎患者的合并症负担

Journal of cardiology and cardiovascular sciences Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1159

J. Walsh, Xue Song, Gilwan Kim, Yujin Park

引用次数: 0

Commentary: Cardiovascular Comorbidities in a United States Patient Population with Hemophilia A: A Comprehensive Chart Review 评论:美国血友病a患者的心血管合并症:综合图表回顾

Journal of cardiology and cardiovascular sciences Pub Date : 2018-11-01 DOI: 10.29245/2578-3025/2018/6.1155

T. Humphries

引用次数: 0

Pathogenesis Of Portal Vein Thrombosis In Liver Cirrhosis: The Role of the ADAMTS13/VWF Unbalance 肝硬化门静脉血栓形成的发病机制：ADAMTS13/VWF失衡的作用

Journal of cardiology and cardiovascular sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3025/2018/5.1150

Stefano lancellotti Monica Sacco, M. Basso, R. Cristofaro

{"title":"Pathogenesis Of Portal Vein Thrombosis In Liver Cirrhosis: The Role of the ADAMTS13/VWF Unbalance","authors":"Stefano lancellotti Monica Sacco, M. Basso, R. Cristofaro","doi":"10.29245/2578-3025/2018/5.1150","DOIUrl":"https://doi.org/10.29245/2578-3025/2018/5.1150","url":null,"abstract":"Increasing evidence shows a potential role of ADAMTS13 deficiency as a risk factor for the high prevalence of portal vein thrombosis (PVT) in cirrhotic patients. This deficiency, due to myofibroblastic transformation of hepatic stellate cells (HSCs), the source of ADAMTS13, is responsible for the prevalence of ultra large molecular weight multimers of von Willebrand factor (UL-VWF) in the hepatic microcirculation. This phenomenon would favor the prohaemostatic function of VWF, which, together with an elevation of coagulation FVIII, which is associated to VWF, could sustain microcirculatory thrombosis in the liver. These phenomena, triggering an increase of the intra-hepatic pressure, would cause a slowdown of the portal flow, favoring the occurrence of PVT. Although this scenario is justified by retrospective observational clinical studies, it will be mandatory to clarify the ADAMTS13 expression in HSCs associated with the activity of plasma ADAMTS13 in different stage of liver diseases. Hence, a prospective clinical trial (ClinicalTrials.gov Identifier: NCT03322696) is ongoing to unravel the linkage between all the actors involved in the complex phenomenon of PVT occurring in cirrhosis.","PeriodicalId":93019,"journal":{"name":"Journal of cardiology and cardiovascular sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43017396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0