Journal of cancer research and cellular therapeutics最新文献

{"title":"Inhibition of Dimethylbenz[a]anthracene-Induced Breast Tumors in Rats by Soy Protein is Mediated by Downregulation of MAPK/AP-1 Signaling","authors":"Salil K. Das","doi":"10.31579/2640-1053/122","DOIUrl":"https://doi.org/10.31579/2640-1053/122","url":null,"abstract":"We reported earlier that replacement of casein by soy protein in the diets of rats exposed to the carcinogen, dimethylbenz[a]anthracene (DMBA), not only delayed the initiation of breast tumor but also had a protective effect against the development of aggressive tumor. The aim of this study was to elucidate the molecular mechanism by which soy protein offers these beneficial effects. Tumor was developed by gavage administration of single dose of 80 mg/kg of DMBA into 50-day old female rats, maintained on a standard AIN-76A diet containing either casein or soy protein. After ~120 days of DMBA administration, we evaluated the role of MAPK phosphorylation and subsequent AP-1 activation on the differential effects of soy protein and casein on the development of aggressiveness and progression of DMBA-induced breast tumor and determined if soy protein controls MMP-9 and uPAR expression by modifying AP-1 activity. The present study demonstrates that the beneficial effect of soy protein in breast tumor development is mediated by control of MAPK/AP-1 signaling. It is concluded that deactivation of MAPK pathway lead to down-regulation of the AP-1 activation which in turn down regulates the target gene and may be responsible for controlling breast tumor aggressiveness. Thus, it is suggested that MAPKs (ERK, p38 and JNK), MMP-9 and uPAR may be a potential target for anticancer therapy inhibiting tumor vasculature and invasion stimulated by tumor-associated stroma, and regulating the target gene and may be responsible for the beneficial effects of soy protein.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48687457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive Digestive Tract Bleeding Caused by EBV-Triggered Hemophagocytic Lymphohistiocytosis and Digestive Tract Vascular Malformation","authors":"Cancan Lu","doi":"10.31579/2640-1053/115","DOIUrl":"https://doi.org/10.31579/2640-1053/115","url":null,"abstract":"We introduced a patient with fetal EBV-triggered who finally developed multidrug-resistant septicemia, perianal abscess, massive alimentary tract bleeding due to gastrointestinal vascular malformation, and acute respiratory distress syndrome. His EB virus maintained chronically active under multiple drug treatments. Interestingly, continuous EB virus infection and a probable idiopathic gastrointestinal vascular malformation might be the cause of the severe digestive tract bleeding.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45927683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of Bacterial Infections in Cancer Patients -Experience from a Tertiary Cancer Center","authors":"Surabhi Gupta","doi":"10.31579/2640-1053/120","DOIUrl":"https://doi.org/10.31579/2640-1053/120","url":null,"abstract":"It is a general belief that cancer patients are more prone to infections, particularly bacterial infections. Firstly, disease itself present an immuno-compromised status, secondarily chemotherapy and radiotherapy further suppress the immunity level which is further overburden by poor nutritional state and poor hygienic conditions in these patients. With the invent of better diagnostic modalities and many technological advancement in treatment delivery, the mortality rates have fallen over the past years, but infection remains a primary or associated cause of death, with bacteria most commonly accounting for infection-associated mortality, followed by fungi. The management of the infections is based on the use of appropriate empirical antimicrobial therapeutic agents with a comprehensive understanding of pathogens which are the commonly encountered in cancer patients in day-to-day practice and also understanding of antibiotic sensitivity patterns. Though the empirical use of antibiotics has reduced the mortality in patients but has also led to the menace of multidrug-resistant bacteria.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42168141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irradiation Consequences from Chromosome Damages to Triggering of Diverse Immunological Responses","authors":"Sherien Abdelwhab Montaser","doi":"10.31579/2640-1053/121","DOIUrl":"https://doi.org/10.31579/2640-1053/121","url":null,"abstract":"Present work was designed to investigate DNA damages post irradiation via cytokinesis-block micronucleus (CBMN) test and its corresponding immunological response. Determination of interferon- α, β for innate, interferon-γ for acquired response, TNF- α and immunoglobulin concentration IgG & IgM. Six human blood samples were divided into 4 groups (control & 3irradiated) which exposed to doses (0.5 - 2 and 4 Gy). Triplet blood samples (control and irradiated groups) were cultured for 72 hours after 1 hour of irradiation. γ - Irradiation induced significant increase of IFN-α (innate immunology hallmark) in all experimental doses (0.5 -2.0 and 4.0 Gy). IFN-β also recorded significant increase with control at dose 4.0 Gy. The results showed significant increase in IFN-γ representing acquired immune response at 2.0 and 4.0 Gy. These results confirmed by exhibits increase in the level of IgG and IgM production. TNF-α late immune response started to give significant increase at 2.0 and 4.0 Gy. TNF-α and IFN-β recorded significant difference when compared with control at 1.0 and 4Gy exposure also 4Gy group recorded significant increase compared with 1.0 Gy exposure. INF-α recorded significant increase at all doses when compared with control and each other. IFN-γ recorded significant increase in 1.0 and 4.0 Gy when compared with control with no significant difference between them. We conclude that immune system can sense when cells damaged. Mni which come from a variety of sources such as irradiation can lead to an immune response similar to that observed during viral infection.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43527820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Cell Neuroendocrine Carcinoma of the Prostate Gland: A Review and Update","authors":"A. Kodzo-Grey Venyo","doi":"10.31579/2640-1053/123","DOIUrl":"https://doi.org/10.31579/2640-1053/123","url":null,"abstract":"It has been documented that the 2016 World Health Organization’s histological classification of prostate cancer has included well-differentiated carcinoid tumours and small- or large-cell poorly differentiated tumours within the category of neuroendocrine tumours. Up to May 2021, only 20 cases of large-cell neuroendocrine tumours of the prostate gland (LCNTPs) had been reported within the literature, among which are nine cases of primary tumours. LCNTPs are a rare histological entity whose evolutive profile and therapeutic potential do differ from those of conventional adenocarcinoma of the prostate gland. Primary neuroendocrine tumours of the prostate gland could be pure or associated with an adenocarcinoma component. Mixed forms of large cell neuroendocrine cancers of the prostate gland (LCNECPs) tend to associated with better prognosis when diagnosed early at a localized stage. Nevertheless, most cases of (LCNTPs) at the time of initial diagnosis could tend to be advanced, locally advanced or metastatic. Even though LCNECPs that are diagnosed initially tend to primary prostate cancers that may be pure primary prostate cancers, few large LCNECPs have been found to be metastatic large cell neuroendocrine carcinomas that had metastasised from other sites of the body for example the lung. Primary LCNECP does tend to manifest similarly to primary adenocarcinoma of prostate gland with lower urinary tract symptoms, haematuria, or signs of obstruction of the upper urinary tract or inability to empty the urinary bladder. Cases of primary LCNECP that manifest tend also to be associated with symptoms related to the sites of the metastases. Serum prostate specific antigen levels tend to be slightly elevated with cases of primary LCNECP, but the levels generally tend not to be as high as most cases of advanced, locally advanced or metastatic primary adenocarcinomas of the prostate gland. Diagnosis of LCNECPs tend to be made pursuant to the undertaking of histopathology and immunohistochemistry staining studies of specimens of the prostate that had been obtained from prostate biopsies, trans-urethral reception of prostate specimens or prostatectomy specimens. The microscopy histopathology examination features of LCNECP the prostate gland have been summarized as follows: (a) Microscopy histopathology examination of LCNECP gland does tend to demonstrate large islands or sheets of tumour cells. (b) Large tumour cells with prominent neuroendocrine features such as salt and pepper chromatin and small nucleoli tend to be visualised upon microscopy examination of specimens of the prostate tumour. (c) High grade features such as lack of glandular formation, frequent mitoses and apoptotic bodies and tumour necrosis tend to be frequent findings upon microscopy examination of specimens of LCNECP. Immunohistochemistry staining features of LCNECP include: (a) At least one of the ensuing neuroendocrine tumour markers should be demonstrated upon immunohistochemistry stain","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41558036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Superoxide Dismutase (SOD) Activity Among Betel Quid Chewers of Indian Population","authors":"Aniket Adhikari, Madhusnata De","doi":"10.31579/2640-1053/117","DOIUrl":"https://doi.org/10.31579/2640-1053/117","url":null,"abstract":"Introduction: Betel quid (BQ) chewing, a habit practiced in Eastern and North Eastern part of India, has known to be associated with cancer of the oral or buccal cavity. BQ is also one of the common mood elevating substances among Indian population. The BQ is a mixture of areca nut (Areca catechu), catechu (Acacia catechu) and slaked lime (calcium oxide and calcium hydroxide) wrapped in a betel leaf (Piper betel). BQ products have been classified by the International Agency for Research on Cancer (IARC) as group I human carcinogens . Superoxide Dismutase (SOD), one of the major enzymatic antioxidant defence system, responsible for scavenging free radicals. Antioxidant enzymes catalyse decomposition of Reactive Oxygen Species (ROS). Overall balance between production and removal of ROS may be more important in various cancers including OSCC (Oral squamous cell carcinoma) or oral cancer. Methods: In this study subjects were screened from Department of Oral and Maxillofacial surgery &E.N.T. of Ramakrishna Mission Seva Pratishthan Hospital (RKMSP), Kolkata and different areas of West Bengal and North Eastern states of India. Quantitative in vitro determination of superoxide dismutase activities in whole blood were estimated manually with 0.05 ml whole blood. The samples were assayed by UV-Visible Spectrophotometer (SPECORD 50 PLUS) at a wavelength of 420 nm. Results: Most of the subjects had betel quid chewing habit. Superoxide dismutase values are lower in healthy control than Cancer cases and Pre cancer with betel quid chewing habit, which is statistically significant. Conclusion: Reactive oxygen species (ROS) are generated due to slaked lime, one of the important constituents of betel quid which can modulate the oral pathology and promote carcinogenesis.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48393018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Treatments for Synovial Cell Sarcoma with Genetically Modified T-Cell?","authors":"Shravana kumar Chinnikatti, Soumya Shravan, H.N Asikur Rahaman, Shraavya Shraavya","doi":"10.31579/2640-1053/113","DOIUrl":"https://doi.org/10.31579/2640-1053/113","url":null,"abstract":"Synovial cell sarcoma is rare but very aggressive tumour if not treated early, due to the painless nature of this tumour patients normally come in late and advances stage, can occur in bones, muscle cells, cartilages, ligaments and de-novo from pleuripotent stem cells from asnywhere in the body but most commonly arm, leg, or foot, and near joints such as the wrist or ankle and possibly from any joints in the body, even from soft tissues of lung and abdomen, the other name for this tumour is called malignant synovioma.The 5 year survival after the effective primary treatment is 30-75% and the survival rate is less than 5% if the tumour recurred within 1 year of primary treatment and that’s why new treatments are explored continuously. Due to late recognition and diagnosis of this rare tumour leads to many problems in treatment and in disease course. This tumour can occur at any age but is most common in growing periods like teen agers and adolescents. This tumour can spread to any organ in the body but most commonly distant metastases occur in lungs. Synovial sarcomas actually a misnomer as previously thought, now with advances in cell structure advances, These tumours can occur not only from synovial cells but from any cell of bone, muscle, tendon, ligaments and cartilage forming cells and supporting cells. These tumours occur with equal propensity in both men and women of younger age. If diagnosed early and treated early with surgery alone patients can be cured completely without any morbidity and mortality","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43959830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papillomavirus and Precancerous Conditions of the Cervix- A Review","authors":"Alemnju Venceslas Tarnju","doi":"10.31579/2640-1053/112","DOIUrl":"https://doi.org/10.31579/2640-1053/112","url":null,"abstract":"Human papillomavirus (HPV) is present in precancerous conditions of the cervix. This review attempts to elucidate our understanding of precancerous cervical cancer, with particular emphasis on the central aetiologic function of persistent human papillomavirus (HPV) infection. The review dwells on recent studies that focused on detecting precancerous cervical lesions using visual inspection with acetic acid (VIA), convection cytology (Pap smear testing), and Schiller test. Anomalies in staining the exocervical epithelium and intraepithelial lesions upon detection with polymerize chain reaction indicated HPV infection. The stages in the evolution of cervical cancer have been widely studied and understood, resulting in successful cancer etiology and prevention.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48062387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial Cancer with Cervical Extension Masquerading as Cervical Cancer","authors":"Sachin S Kadam, Tejaswini Kadam","doi":"10.31579/2640-1053/118","DOIUrl":"https://doi.org/10.31579/2640-1053/118","url":null,"abstract":"The incidence and prevalence of endometrial cancer is less as compared to cervical cancer. Worldwide, in 2018, near about 382000 new cases of endometrial cancer were diagnosed and around 90000 women were died from the disease","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48891894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Adrenal Lymphoma","authors":"Haritha V.S","doi":"10.31579/2640-1053/119","DOIUrl":"https://doi.org/10.31579/2640-1053/119","url":null,"abstract":"Primary adrenal lymphoma is a rare disease entity with only less than 200 cases reported till date. We have seen a single case among the 260 cases reported in our hospital in the last 5 years. Review of the English literature showed 65 such cases reported so far most of them being single case reports. The striking similarity in all of them were – median age of 68 years, bilateral involvement in 60% and predominantly diffuse large cell histology with B cell immunophenotype. adrenal insufficiency was seen in two – thirds of them at diagnosis. About one half respond to treatment with median survival of 4 months. A high index of suspicion is needed for early diagnosis and prompt treatment. We herein report a case of a 65-year-old male who was diagnosed with primary adrenal lymphoma.","PeriodicalId":93018,"journal":{"name":"Journal of cancer research and cellular therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45257236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}