利用基因修饰t细胞治疗滑膜细胞肉瘤?

Shravana kumar Chinnikatti, Soumya Shravan, H.N Asikur Rahaman, Shraavya Shraavya
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引用次数: 0

摘要

滑膜细胞肉瘤是一种罕见的肿瘤,但如果不及早治疗,则具有很强的侵袭性,由于这种肿瘤的无痛性,患者通常出现在晚期和晚期,可发生在骨骼、肌肉细胞、软骨、韧带和来自身体任何部位的多能干细胞的新生细胞中,但最常见的是手臂、腿或脚,以及关节附近,如手腕或脚踝,也可能来自身体的任何关节,甚至来自肺和腹部的软组织。这种肿瘤的另一个名字叫恶性滑膜瘤。有效的初次治疗后的5年生存率为30-75%如果肿瘤在初次治疗后1年内复发,生存率低于5%这就是为什么不断探索新的治疗方法。由于对这种罕见肿瘤的认识和诊断较晚,在治疗和病程中存在许多问题。这种肿瘤可以发生在任何年龄,但最常见于生长时期,如青少年。这种肿瘤可以扩散到身体的任何器官,但最常见的是远处转移发生在肺部。滑膜肉瘤实际上是之前认为的用词不当,现在随着细胞结构的进步,这些肿瘤不仅可以发生在滑膜细胞上也可以发生在任何骨细胞,肌肉,肌腱,韧带和软骨形成细胞和支持细胞上。这些肿瘤在较年轻的男性和女性中发生的倾向相同。如果早期诊断和早期手术治疗,患者可以完全治愈,没有任何发病率和死亡率
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New Treatments for Synovial Cell Sarcoma with Genetically Modified T-Cell?
Synovial cell sarcoma is rare but very aggressive tumour if not treated early, due to the painless nature of this tumour patients normally come in late and advances stage, can occur in bones, muscle cells, cartilages, ligaments and de-novo from pleuripotent stem cells from asnywhere in the body but most commonly arm, leg, or foot, and near joints such as the wrist or ankle and possibly from any joints in the body, even from soft tissues of lung and abdomen, the other name for this tumour is called malignant synovioma.The 5 year survival after the effective primary treatment is 30-75% and the survival rate is less than 5% if the tumour recurred within 1 year of primary treatment and that’s why new treatments are explored continuously. Due to late recognition and diagnosis of this rare tumour leads to many problems in treatment and in disease course. This tumour can occur at any age but is most common in growing periods like teen agers and adolescents. This tumour can spread to any organ in the body but most commonly distant metastases occur in lungs. Synovial sarcomas actually a misnomer as previously thought, now with advances in cell structure advances, These tumours can occur not only from synovial cells but from any cell of bone, muscle, tendon, ligaments and cartilage forming cells and supporting cells. These tumours occur with equal propensity in both men and women of younger age. If diagnosed early and treated early with surgery alone patients can be cured completely without any morbidity and mortality
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