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HSOA journal of stem cells research, development & therapy最新文献

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Wharton´S Jelly Mesenchymal Stem Cell Therapy For Skin Wound Healing 华顿果冻间充质干细胞治疗皮肤伤口愈合
HSOA journal of stem cells research, development & therapy Pub Date : 2020-06-23 DOI: 10.24966/srdt-2060/100037
Ana I. García-Guillén
{"title":"Wharton´S Jelly Mesenchymal Stem Cell Therapy For Skin Wound Healing","authors":"Ana I. García-Guillén","doi":"10.24966/srdt-2060/100037","DOIUrl":"https://doi.org/10.24966/srdt-2060/100037","url":null,"abstract":"The management of chronic wounds still remains an important unsolved problem in clinical practice. Different therapeutic approach-es, including regenerative medicine or tissue engineering strategies, have been used to ameliorate this pathology to achieve skin regeneration. Mesenchymal stem cells represent a potential therapeutic option for chronic wounds due to their differentiation, proliferation, and immunomodulatory properties. Among them, Wharton’s jelly mesenchymal stem cells from the umbilical cord are a type of ex- traembryonic stem cells that have been proven to be very effective for treating chronic wounds. These cells possess some advantages when compared to adult mesenchymal stem cells such as higher proliferation rate, multipotency, and low immunogenicity. They act as potent immunomodulators during the inflammation phase of wound healing and are also involved in replacing the damaged skin tissue. In this review we will discuss the findings obtained in different preclin ical and clinical studies performed with Wharton´s jelly mesenchymal stem cells systemically administered, implanted on a biocompatible scaffold, or using mesenchymal stem cell-derived extracellular ves- icles or their conditioned medium as possible treatments for chronic wounds","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"266 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75066160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
PKM2-Mediated Glycolysis And Redox Equilibrium In Cancer Stem Cells: The Metabostemness Phenomenon 肿瘤干细胞中pkm2介导的糖酵解和氧化还原平衡:代谢现象
HSOA journal of stem cells research, development & therapy Pub Date : 2020-06-23 DOI: 10.24966/srdt-2060/100040
S. Manolakou
{"title":"PKM2-Mediated Glycolysis And Redox Equilibrium In Cancer Stem Cells: The Metabostemness Phenomenon","authors":"S. Manolakou","doi":"10.24966/srdt-2060/100040","DOIUrl":"https://doi.org/10.24966/srdt-2060/100040","url":null,"abstract":"Glycolysis and Redox Equilibrium in Cancer Stem Cells: The Metabostemness Phenomenon. J Stem Cell Res Dev Ther 6: 040. Abstract The discovery of novel targets in cancer cells along with the rapid development of innovative therapeutic agents against them and especially in last decade has led to better cancer survival rate. However, the existence of Cancer Stem Cells (CSCs) into the tumor col-onies has been suggested as a crucial impediment in cancer fight. Not only the self-renewal and high proliferative ability of CSCs but also the diversity of their metabolic signatures amplifies the tumor heterogeneity and treatment-resistance, defining a new hallmark of oncogenesis called metabostemness phenomenon. This phenomenon concludes several patterns of metabolic behaviour which rely on three basic phenotypes; (i) Aerobic glycolysis or Warburg effect; (ii) Reverse Warburg effect and (iii) Oxidative Phosphorylation (OX- PHOS) phenotype. Pyruvate Kinase M2 (PKM2) has been considered as the key regulator enzyme of metabolic reprogramming of CSCs as alternates itself between a dimer state, responsible for aerobic glycolysis and a tetramer state, responsible for OXPHOS pro- cedure. Several PKM2 interactions which perceive the changes of a usually oxidative microenvironment of CSCs attribute to a metabolic plasticity and as a result to survival, proliferation, metastasis and drug-resistance. Henceforth, this review highlights the evidence regarding CSCs about these PKM2-mediated interactions describing the outcome of them in terms of metabolic reprogramming and of maintenance of redox equilibrium. Thereafter, a recapitulation of molecular targeting of PKM2 and metabostemness will be attempt-ed so as to be given prominence to the development of innovative metabolic targets and therapies against the triangle “PKM2 - metabolic plasticity - oxidative scale” in CSCs.","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81489575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing the Therapeutic Potential of Stem Cell Therapies for Critical Limb Ischemia. 提高干细胞疗法对严重肢体缺血的治疗潜力。
HSOA journal of stem cells research, development & therapy Pub Date : 2020-01-01 Epub Date: 2020-01-20 DOI: 10.24966/srdt-2060/100024
Hallie J Quiroz, Samantha F Valencia, Zhao-Jun Liu, Omaida C Velazquez
{"title":"Increasing the Therapeutic Potential of Stem Cell Therapies for Critical Limb Ischemia.","authors":"Hallie J Quiroz, Samantha F Valencia, Zhao-Jun Liu, Omaida C Velazquez","doi":"10.24966/srdt-2060/100024","DOIUrl":"10.24966/srdt-2060/100024","url":null,"abstract":"<p><p>Peripheral Arterial Disease (PAD) is a progressive, atherosclerotic disease that at its end stage, Critical Limb Ischemia (CLI), results in severely diminished limb perfusion and causes leg pain at rest, non-healing ulcers, and tissue gangrene. Many patients with CLI fail current medical and surgical therapies and thus are deemed \"no option\" and require limb amputation. Novel therapies to attempt limb salvage in these \"no option\" patients are needed. Stem cell therapy is one therapeutic angiogenic avenue that has been tested over the last 20 years. To date, clinical trials have shown promise but with only modest improvement and none demonstrated a significant decrease in amputation rates in those treated with stem cell therapy. Thus, recent investigations into improving stem cell therapy have been the focus of our laboratory and many others. This review aims to describe recent advances in increasing the therapeutic potential of stem cell therapies for CLI.</p>","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39916158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human Prostate Stem Cells and Their Niche - A Comprehensive Review 人类前列腺干细胞及其生态位综述
HSOA journal of stem cells research, development & therapy Pub Date : 2019-11-12 DOI: 10.24966/srdt-2060/100020
R. Heer
{"title":"Human Prostate Stem Cells and Their Niche - A Comprehensive Review","authors":"R. Heer","doi":"10.24966/srdt-2060/100020","DOIUrl":"https://doi.org/10.24966/srdt-2060/100020","url":null,"abstract":"","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"61 3A 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89356749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LncRNAs Regulate the PDLSCs Osteogenic Differentiation in Periodontitis lncrna调控牙周炎患者PDLSCs成骨分化
HSOA journal of stem cells research, development & therapy Pub Date : 2019-11-12 DOI: 10.24966/srdt-2060/100021
Zuolin Jin
{"title":"LncRNAs Regulate the PDLSCs Osteogenic Differentiation in Periodontitis","authors":"Zuolin Jin","doi":"10.24966/srdt-2060/100021","DOIUrl":"https://doi.org/10.24966/srdt-2060/100021","url":null,"abstract":"","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"191 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79596296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Stromal Cells and Micro Fragmented Adipose Tissue: New Horizons of Effectiveness of Lipogems 间充质间质细胞和微碎片化脂肪组织:脂质体有效性的新视野
HSOA journal of stem cells research, development & therapy Pub Date : 2019-09-25 DOI: 10.24966/srdt-2060/100017
C. Tremolada, Image Regenerative Clinic
{"title":"Mesenchymal Stromal Cells and Micro Fragmented Adipose Tissue: New Horizons of Effectiveness of Lipogems","authors":"C. Tremolada, Image Regenerative Clinic","doi":"10.24966/srdt-2060/100017","DOIUrl":"https://doi.org/10.24966/srdt-2060/100017","url":null,"abstract":"In the last three years there has been an explosion of published in vivo and clinical data discussing micro fragmented adipose tissue and its regenerative properties. In fact, the paracrine activity of micro fragmented adipose tissue has been well described, showing the importance of the maintenance of an intact microvascular environment of fat tissue during the processing in order to guarantee cellular activation and long-term viability there by maintaining their signaling capacity in order to effectively modulate inflammation and immune response. Lipogems®, patented in 2010 and clinically available since 2013, is a novel technology that reproducibly and simply obtains, micro fragmented adipose tissue with enhanced regenerative properties with somewhat astonishing results that are now confirmed from recent clinical trials. In this review we have summarized all the new evidence published, focusing on possible new clinical indications from intriguing new in vivo studies.","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86380466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Using Transcriptome Analysis for Redefining the in vivo Relevance of in vitro Cultured Circulating Angiogenic Cells (CACiv) 利用转录组分析重新定义体外培养循环血管生成细胞(CACiv)的体内相关性
HSOA journal of stem cells research, development & therapy Pub Date : 2019-09-25 DOI: 10.24966/srdt-2060/100015
B. Everaert
{"title":"Using Transcriptome Analysis for Redefining the in vivo Relevance of in vitro Cultured Circulating Angiogenic Cells (CACiv)","authors":"B. Everaert","doi":"10.24966/srdt-2060/100015","DOIUrl":"https://doi.org/10.24966/srdt-2060/100015","url":null,"abstract":"","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83321894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Tgf-β1 Over Expression has Major Impact on Multilineage Differentiation of Mesenchymal Stromal Cells Tgf-β1过表达对间充质间质细胞多系分化有重要影响
HSOA journal of stem cells research, development & therapy Pub Date : 2019-09-25 DOI: 10.24966/srdt-2060/100013
H. Salkın
{"title":"The Tgf-β1 Over Expression has Major Impact on Multilineage Differentiation of Mesenchymal Stromal Cells","authors":"H. Salkın","doi":"10.24966/srdt-2060/100013","DOIUrl":"https://doi.org/10.24966/srdt-2060/100013","url":null,"abstract":"with a superior capacity for self-renewal, and are capable of differentiating into adipocytes, osteoblasts, chondrocytes [1,2]. In these days, MSCs have been broadly used in regenerative medicine [3]. Dental Pulp-derived Mesenchymal Stem Cells (DPSCs) have become a popular research topic in that they are similar too the rmesenchymal stem cells, easy to obtain and are used in regenerative medicine and tissue engineering [4]. In vitro and in vivo studies have been previously performed to understand the biology of DPSCs. The differentiation of mesenchymal stem cells usually involves the use of signaling factors as recombinant proteins or gene therapy that an functionally activate genes [5]. Transforming Growth Factor Beta 1 (TGF-β1) activates mainly SMAD transcription factors with complex cellular responses [6]. The superior proliferative ability and regenerative potential are primary phenotypes of MSCs [7].","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73612655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem/Progenitor Cells in Skin 皮肤中的干细胞/祖细胞
HSOA journal of stem cells research, development & therapy Pub Date : 2019-09-25 DOI: 10.24966/srdt-2060/100016
Xusehng Wang
{"title":"Stem/Progenitor Cells in Skin","authors":"Xusehng Wang","doi":"10.24966/srdt-2060/100016","DOIUrl":"https://doi.org/10.24966/srdt-2060/100016","url":null,"abstract":"","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79014753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recellularization Of Canine Placental Extracellular Matrix: Mesenchymal Stem Cells Applied To Tissue Bioengineering 犬胎盘细胞外基质的再细胞化:间充质干细胞在组织生物工程中的应用
HSOA journal of stem cells research, development & therapy Pub Date : 2019-08-01 DOI: 10.1016/j.placenta.2019.06.347
G. Matias, A. C. Carreira, M. Miglino, P. Fratini, R. Barreto
{"title":"Recellularization Of Canine Placental Extracellular Matrix: Mesenchymal Stem Cells Applied To Tissue Bioengineering","authors":"G. Matias, A. C. Carreira, M. Miglino, P. Fratini, R. Barreto","doi":"10.1016/j.placenta.2019.06.347","DOIUrl":"https://doi.org/10.1016/j.placenta.2019.06.347","url":null,"abstract":"","PeriodicalId":93004,"journal":{"name":"HSOA journal of stem cells research, development & therapy","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82654458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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