Journal of pancreatology最新文献_第6页

The role of gut microbiota in acute pancreatitis: new perspectives in pathogenesis and therapeutic approaches 肠道微生物群在急性胰腺炎中的作用：发病机制和治疗方法的新视角

Journal of pancreatology Pub Date : 2023-06-16 DOI: 10.1097/jp9.0000000000000131

Zu-Chao Du, Guanqun Li, Yongde Luo, X. Bai, Bei Sun

引用次数: 0

Artificial intelligence in pancreatic surgery: current applications 人工智能在胰腺手术中的应用现状

Journal of pancreatology Pub Date : 2023-04-26 DOI: 10.1097/JP9.0000000000000129

C. Kuemmerli, F. Rössler, Caroline Berchtold, Michael C. Frey, A. Studier-Fischer, Amila Cizmic, J. P. Jonas, T. Hackert, F. Nickel, P. Müller

引用次数: 0

A case of abdominal abscess after simultaneous omentum intraomental bio-scaffold islet-kidney transplantation 大网膜内生物支架胰岛肾移植并发腹腔脓肿1例

Journal of pancreatology Pub Date : 2023-04-13 DOI: 10.1097/jp9.0000000000000128

Zewen Liu, Boya Zhang, Guang-hui Pei, Xiangheng Cai, Jiaqi Zou, Xuejie Ding, Peng Sun, Rui Liang, Shusen Wang

引用次数: 0

Pancreatic head cancer with gastrointestinal bleeding as the initial manifestation：A case report and literature review 以消化道出血为首发表现的胰头癌1例报告并文献复习

Journal of pancreatology Pub Date : 2023-04-06 DOI: 10.1097/jp9.0000000000000127

Minghui Zheng, Z. Fu, Ting Niu, A. Liu, Danlei Chen, J. Peng, Judong Li, Zhiyuan Hao, Qin-mei Yu, Zechao Lyu, C. Shao

引用次数: 0

Expression, clinicopathologic, and prognostic significance of MMP15 in operable pancreatic ductal adenocarcinoma MMP15在可手术胰腺导管腺癌中的表达、临床病理及预后意义

Journal of pancreatology Pub Date : 2023-03-28 DOI: 10.1097/JP9.0000000000000126

Wen-Jing Liu, Jian-Zhou Liu, W. Zhou, Li Zhou, Junchao Guo

{"title":"Expression, clinicopathologic, and prognostic significance of MMP15 in operable pancreatic ductal adenocarcinoma","authors":"Wen-Jing Liu, Jian-Zhou Liu, W. Zhou, Li Zhou, Junchao Guo","doi":"10.1097/JP9.0000000000000126","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000126","url":null,"abstract":"Objective: Matrix metalloproteinase 15 (MMP15) has been previously reported to be involved in many cancers. However, its expression pattern in pancreatic ductal adenocarcinoma (PDAC) remains contradictory. In addition, its clinicopathologic and prognostic significance in this malignancy has not been elucidated. Methods: Expression of MMP15 was immunohistochemically detected in a tissue microarray of formalin-fixed paraffin-embedded samples from 95 patients of PDAC after surgery. Its expression pattern and relations with clinicopathologic factors and disease-specific survival (DSS) were then evaluated. Finally, its expression and prognostic value were measured in the on-line publically available database, GEPIA, using TCGA data. Results: In comparison of all samples and 75 paired ones, MMP15 expression in tumor tissues was all significantly higher than that in para-tumor ones (P = .037 and .016). Furthermore, tumoral MMP15 expression was associated with peri-neural invasion. Survival analysis showed that patients with high tumoral MMP15 expression had significantly poorer DSS than those with low MMP15 expression (P = .0059). In univariate and multivariate Cox regression tests, tumoral MMP15 expression was all significantly predictive for DSS. In the on-line publically available GEPIA database, MMP15 was also overexpressed in PDAC, but was not found to be prognostic. Conclusion: Our results indicated that MMP15 expression was elevated in operable PDAC and might have a prognostic impact.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"6 1","pages":"96 - 100"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45630344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular alterations and therapeutic targets in pancreatic neuroendocrine tumors 胰腺神经内分泌肿瘤的分子改变和治疗靶点

Journal of pancreatology Pub Date : 2023-03-24 DOI: 10.1097/JP9.0000000000000125

Yarui Ma, Xiaoyue Wang, Hong Zhao, Y. Jiao

引用次数: 0

Autoimmune Pancreatitis with Different Clinical Manifestations and Imaging Findings: A Series of Three Cases 不同临床表现及影像学表现的自身免疫性胰腺炎:附3例报告

Journal of pancreatology Pub Date : 2023-03-22 DOI: 10.1097/jp9.0000000000000124

Changhao Gao, Z. Fan, H. Zhan

引用次数: 0

KCNH2 regulates the growth and metastasis of pancreatic cancer KCNH2调控胰腺癌的生长和转移

Journal of pancreatology Pub Date : 2023-03-13 DOI: 10.1097/jp9.0000000000000123

Jinghao Lei, Qiang Wang, Tengfei Qu, Lichao Cha, Hanxiang Zhan, Jianwei Xu, Shanglong Liu, Lantian Tian, Chuandong Sun, Jingyu Cao, Fabo Qiu, Weidong Guo, Bin Zhou

{"title":"KCNH2 regulates the growth and metastasis of pancreatic cancer","authors":"Jinghao Lei, Qiang Wang, Tengfei Qu, Lichao Cha, Hanxiang Zhan, Jianwei Xu, Shanglong Liu, Lantian Tian, Chuandong Sun, Jingyu Cao, Fabo Qiu, Weidong Guo, Bin Zhou","doi":"10.1097/jp9.0000000000000123","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000123","url":null,"abstract":"Objective: Due to the characteristics of insidious onset and early metastasis of pancreatic cancer (PC), patients are often diagnosed at an advanced stage and often delayed in completing surgical resection timely, resulting in poor prognosis. Therefore, this study aims to explore the expression of potassium voltage-gated channel subfamily H member 2 (KCNH2) in PC and its relationship with clinicopathological parameters and the related mechanisms. Methods: GEPIA database and immunohistochemical staining were used to analyze the difference in KCNH2 expression between PC and adjacent tissue in RNA and protein levels. Chi-squared test was used to evaluate the relationship between KCNH2 expression and clinicopathological features. The Cox regression model was used for multivariate analysis and univariate analysis. Histological diagnosis was performed according to World Health Organization (WHO) criteria to evaluate the relationship between KCNH2 expression and clinicopathological features. Results: KCNH2 expression was upregulated in PC compared with normal pancreatic tissue. In addition, the knockdown of KCNH2 inhibits PC cell proliferation, migration, invasion, and epithelial-mesenchymal transformation and promotes their apoptosis. In addition, clinical data showed that the abnormal expression of KCNH2 in PC was related to the tumor stage. Patients with high expression of KCNH2 had a poor prognosis. Conclusions: KCNH2 is expected to be a novel targeted molecule in treating PC.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"159 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135904906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspective of molecular imaging and peptide receptor radionuclide therapy in pancreatic neuroendocrine tumors: where do we stand? 分子成像和肽受体核素治疗胰腺神经内分泌肿瘤的前景:我们站在哪里?

Journal of pancreatology Pub Date : 2023-03-06 DOI: 10.1097/jp9.0000000000000122

Wenjia Zhu, Meixi Liu, Li Huo

引用次数: 0

Characteristics and outcomes of patients with autoimmune pancreatitis after pancreatectomy: a retrospective study 胰腺切除术后自身免疫性胰腺炎患者的特点和预后:一项回顾性研究

Journal of pancreatology Pub Date : 2023-02-08 DOI: 10.1097/JP9.0000000000000119

Bangbo Zhao, Cheng Qin, Tianyu Li, Zeru Li, Yuanyang Wang, Weibin Wang

{"title":"Characteristics and outcomes of patients with autoimmune pancreatitis after pancreatectomy: a retrospective study","authors":"Bangbo Zhao, Cheng Qin, Tianyu Li, Zeru Li, Yuanyang Wang, Weibin Wang","doi":"10.1097/JP9.0000000000000119","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000119","url":null,"abstract":"Objective: Autoimmune pancreatitis (AIP) is a rare and special type of pancreatitis, which is often difficult to distinguish from pancreatic cancer. We aimed to discuss the clinical characteristics, operation characteristics, and therapeutic effects of AIP patients who received surgical treatment based on retrospective analysis. Methods: The medical records of patients who underwent surgery at Peking Union Medical College Hospital from January 2012 to July 2021 and whose postoperative pathology was AIP were collected. Clinical symptoms, laboratory examinations, imaging features, surgical information, and prognostic data were analyzed. Results: Nineteen patients with AIP (median age 60 years old, 14 males) underwent surgery, whose main indication for surgery was suspected of a malignant lesion (n = 18, 94.7%). Ten patients underwent pancreaticoduodenectomy, 8 underwent distal pancreatectomy, and 1 underwent total pancreatectomy, the pathological result of whom were all AIP. The main postoperative complication was pancreatic fistula (n = 11, 57.9%), and one patient (5.3%) underwent a second operation due to gastrointestinal anastomotic bleeding. One patient (5.6%) had a recurrence of AIP, 3 patients (16.7%) were treated with glucocorticoid after surgery, and one patient (5.6%) was treated with immunosuppressors. Conclusions: Differential diagnosis of AIP from pancreatic cancer is complex. Operation difficulty and complication incidence for patients with AIP were similar to pancreatic cancer patients. Although glucocorticoid is the first-line treatment for AIP, surgery may still be necessary for patients who are strongly suspected of a malignant lesion.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"6 1","pages":"43 - 47"},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48070769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0