Journal of pancreatology最新文献_第4页

Genetic alterations and tumor mutation burden predict chemosensitivity of pancreatic cancer: a retrospective study 遗传改变和肿瘤突变负荷预测胰腺癌的化疗敏感性:一项回顾性研究

Journal of pancreatology Pub Date : 2023-10-27 DOI: 10.1097/jp9.0000000000000147

Manyi Hu, Yiting Xu, Yangyang Wang, Cao Chen, Junjun He, Ke Sun, Qi Zhang, Tingbo Liang

{"title":"Genetic alterations and tumor mutation burden predict chemosensitivity of pancreatic cancer: a retrospective study","authors":"Manyi Hu, Yiting Xu, Yangyang Wang, Cao Chen, Junjun He, Ke Sun, Qi Zhang, Tingbo Liang","doi":"10.1097/jp9.0000000000000147","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000147","url":null,"abstract":"Background: Chemotherapy stands as a recommended approach for all stages of pancreatic cancer. However, its efficacy stratification remains obscure. Genomic sequencing is extensively applied across diverse diseases. This study aims to explore the potential genomic markers in relation to the decision-making of chemotherapy. Methods: A total of 140 patients with pancreatic cancer were categorized into chemotherapy-first group and adjuvant chemotherapy group. The genomic alterations were detected from the next-generation sequencing using surgical or fine-needle-biopsy specimens. Chemotherapy response was defined according to objective response based on the RECIST criteria (version 1.1). Results: In the chemotherapy-first group, the patients who harbored higher TMB levels had significant shorter PFS than that with low TMB levels (Hazard ratio [HR] = 30.362, P = 0.002). No independent risk factors were found to be correlated with chemoresistance in patients receiving chemotherapy at first (all P > 0.05). In the adjuvant chemotherapy group, the increased CA125 level of more than 35 U/mL potentially elucidated a shorter period of DFS (HR = 3.695, P = 0.020). Conclusion: Our study indicated that a high level of TMB may predict earlier tumor progression in pancreatic cancer patients received chemotherapy at first. The elevation of CA125 presents itself as a predictive indicator for postoperative chemotherapy patients' tumor recurrence, whereas gene mutations remain unrelated to this phenomenon.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136234223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Signatures in Pancreatic Ductal Adenocarcinoma: Diagnostic and Therapeutic Implications 胰腺导管腺癌的代谢特征:诊断和治疗意义

Journal of pancreatology Pub Date : 2023-10-21 DOI: 10.1097/jp9.0000000000000146

Ruining Gong, Yonglu Hu, Qian Yu, Lin Fang, He Ren

引用次数: 0

Initial chemotherapy option for Pancreatic ductal adenocarcinoma in patients with adequate performance status 表现良好的胰腺导管腺癌患者的初始化疗选择

Journal of pancreatology Pub Date : 2023-09-27 DOI: 10.1097/jp9.0000000000000144

Jiazhang Xing, Yuping Ge, Xiaolei Gong, Yuan Liu, Yuejuan Cheng

{"title":"Initial chemotherapy option for Pancreatic ductal adenocarcinoma in patients with adequate performance status","authors":"Jiazhang Xing, Yuping Ge, Xiaolei Gong, Yuan Liu, Yuejuan Cheng","doi":"10.1097/jp9.0000000000000144","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000144","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is a highly progressive lethal malignancy, with chemotherapy being the primary treatment modality. This article provides a review of the initial chemotherapy options for PDAC patients with adequate performance status, comparing FOLFIRINOX (oxaliplatin, irinotecan, 5-fluorouracil, and leucovorin) or modified FOLFIRINOX and gemcitabine plus nab-paclitaxel (GEM-NabP) regimens. The availability of limited evidence from randomized trials restricts a direct comparison between the two regimens. Based on our review, (m)FOLFIRINOX yields superior survival outcomes compared to GEM-NabP in metastatic PDAC. For locally advanced PDAC, either (m)FOLFIRINOX or GEM-NabP can be considered initial chemotherapy. In the neoadjuvant setting for borderline resectable PDAC, both regimens have demonstrated promising results in achieving feasible resection rates. However, mFOLFIRINOX remains the preferred choice for adjuvant chemotherapy. The selection of initial chemotherapy for PDAC depends on the disease stage, patients' performance status, and tumor molecular alterations. Further research and clinical trials are necessary to optimize treatment approaches for PDAC patients.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135477065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE ROLE OF PREDICTIVE AND PROGNOSTIC VALUES OF INFLAMMATORY MARKERS IN ACUTE PANCREATITIS: A NARRATIVE REVIEW 急性胰腺炎炎症标志物的预测和预后价值的作用:一个叙述性的回顾

Journal of pancreatology Pub Date : 2023-09-27 DOI: 10.1097/jp9.0000000000000145

Saira Rafaqat, Aqsa Sattar, Farhan Anjum, Mahrukh Gilani, Sana Rafaqat

{"title":"THE ROLE OF PREDICTIVE AND PROGNOSTIC VALUES OF INFLAMMATORY MARKERS IN ACUTE PANCREATITIS: A NARRATIVE REVIEW","authors":"Saira Rafaqat, Aqsa Sattar, Farhan Anjum, Mahrukh Gilani, Sana Rafaqat","doi":"10.1097/jp9.0000000000000145","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000145","url":null,"abstract":"Pancreatitis is an inflammatory condition affecting the pancreas and is classified into two types, acute and chronic, which can manifest in various forms. This review article summarizes the role of predictive and prognostic values of inflammatory markers in the pathogenesis of acute pancreatitis, mainly focused on preclinical and clinical studies. It includes serum amyloid A, monocyte chemotactic protein-1, erythrocyte sedimentation rate, interleukin-6(IL-6), C-reactive protein, interleukin 10(IL-10), myeloperoxidase, pentraxin 3 and plasminogen activator inhibitor 1. SAA3 plays a crucial role in developing acute pancreatitis by triggering a receptor-interacting protein 3-dependent necroptosis pathway in acinar cells. Targeting SAA3 could be a potential strategy for treating acute pancreatitis. The recruitment of monocytes/macrophages and the activation of the systemic monocyte chemotactic protein-1 (MCP-1) signaling pathway play a role in the progression of pancreatitis, and blocking MCP-1 may have a suppressive effect on the development of pancreatic fibrosis. The erythrocyte sedimentation rate (ESR) can predict severe acute pancreatitis with slightly lower accuracy than C-reactive protein (CRP). When ESR and CRP levels are combined at 24 hours, they predict severe acute pancreatitis accurately. IL-6 plays a crucial role in activating the Janus kinase/signal transducers and activators of the transcription pathway, exacerbating pancreatitis and contributing to the initiation and progression of pancreatic cancer. Endogenous interleukin-10 plays a crucial role in controlling the regenerative phase and limiting the severity of fibrosis and glandular atrophy induced by repeated episodes of acute pancreatitis in mice. The predictive and diagnostic roles of these inflammatory factors in pancreatitis were introduced in detail in this review.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135477063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platinum-based chemotherapy for metastatic insulinoma harboring germline mutation in DNA damage repair pathway: A case report 铂基化疗治疗DNA损伤修复途径中携带种系突变的转移性胰岛素瘤:1例报告

Journal of pancreatology Pub Date : 2023-09-20 DOI: 10.1097/jp9.0000000000000143

Kaili Yang, Hongyan Ying, Mei Guan, Lina Wang, Jia Xu, Yuejuan Cheng

引用次数: 0

Pancreatic tuberculosis misdiagnosed for surgical treatment: Clinical analysis 胰腺结核误诊手术治疗:临床分析

Journal of pancreatology Pub Date : 2023-08-29 DOI: 10.1097/jp9.0000000000000142

Bin Zhou, Zusen Wang, Caiyan Yu, Shuxiang Jin, Tengfei Qu

引用次数: 0

Chinese Expert Consensus on Multidisciplinary Diagnosis and Treatment of Pancreatic Neuroendocrine Liver Metastases 胰腺神经内分泌肝转移多学科诊治中国专家共识

Journal of pancreatology Pub Date : 2023-08-24 DOI: 10.1097/jp9.0000000000000141

Y. Chi, Liming Jiang, S. Shi, S. He, C. Bai, D. Cao, Qichen Chen, Xiao Chen, Yiqiao Deng, S. Du, Zhen Huang, Li Huo, Yuan Ji, Jie Li, W. Lou, Jie Luo, Xueying Shi, Lijie Song, Bei Sun, H. Tan, Feng Wang, Xuan Wang, Zhewen Wei, Wenming Wu, D. Xiu, Jianming Xu, Huadan Xue, Yi Yang, Fei Yin, Jiangyuan Yu, C. Yuan, Ye‐fan Zhang, Weixun Zhou, Dongbing Zhao, Hong Zhao

{"title":"Chinese Expert Consensus on Multidisciplinary Diagnosis and Treatment of Pancreatic Neuroendocrine Liver Metastases","authors":"Y. Chi, Liming Jiang, S. Shi, S. He, C. Bai, D. Cao, Qichen Chen, Xiao Chen, Yiqiao Deng, S. Du, Zhen Huang, Li Huo, Yuan Ji, Jie Li, W. Lou, Jie Luo, Xueying Shi, Lijie Song, Bei Sun, H. Tan, Feng Wang, Xuan Wang, Zhewen Wei, Wenming Wu, D. Xiu, Jianming Xu, Huadan Xue, Yi Yang, Fei Yin, Jiangyuan Yu, C. Yuan, Ye‐fan Zhang, Weixun Zhou, Dongbing Zhao, Hong Zhao","doi":"10.1097/jp9.0000000000000141","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000141","url":null,"abstract":"Many management strategies are available for pancreatic neuroendocrine neoplasms with liver metastases. However, a lack of biological, molecular, and genomic information and an absence of data from rigorous trials limit the validity of these strategies. This review presents the viewpoints from an international conference consisting of several expert working groups. The working groups reviewed a series of questions of particular interest to clinicians taking care of patients with pancreatic neuroendocrine neoplasms with liver metastases by reviewing the existing management strategies and literature, evaluating the evidence on which management decisions were based, developing internationally acceptable recommendations for clinical practice, and making recommendations for clinical and research endeavors. The review for each question will be followed by recommendations from the panel.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41507031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Cancer Related Pain: Mechanism and Management 胰腺癌相关疼痛:机制和管理

Journal of pancreatology Pub Date : 2023-08-17 DOI: 10.1097/jp9.0000000000000140

Meijing Wu, A-Fang Zhu, Le Shen

引用次数: 0

Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter less than 2cm 直径小于2cm的非功能性胰腺神经内分泌肿瘤的临床诊治共识

Journal of pancreatology Pub Date : 2023-08-10 DOI: 10.1097/jp9.0000000000000139

Wenming Wu, S. Cai, Rufu Chen, D. Fu, C. Ge, C. Hao, J. Hao, Heguang Huang, Z. Jian, G. Jin, Fei Li, Hai-ming Li, Sheng-ping Li, Weiqin Li, Yixiong Li, T. Liang, Xu-Bao Liu, W. Lou, Y. Miao, Yiping Mou, C. Peng, R. Qin, C. Shao, B. Sun, Guang-xi Tan, Huaizhi Wang, Lei Wang, Wei Wang, Weilin Wang, Junmin Wei, Heshui Wu, Zheng-Ren Wu, Chang-qing Yan, Yinmo Yang, Xiaoyu Yin, Xianjun Yu, C. Yuan, Yupei Zhao

引用次数: 0

Comparison of Outcomes with Stapler Versus Hand-Sewn Closure of the Pancreatic Stump following Minimally Invasive Distal Pancreatectomy: A Retrospective Cohort Study 微创远端胰腺切除术后吻合吻合钉与手缝合胰腺残端的疗效比较：一项回顾性队列研究

Journal of pancreatology Pub Date : 2023-08-10 DOI: 10.1097/jp9.0000000000000138

Tao Qian, Kaiquan Huang, Wenqing Chen, X. Bai, Shunliang Gao, Yan Shen, M. Zhang, Jian Wu, Jun Yu, T. Ma, T. Liang

{"title":"Comparison of Outcomes with Stapler Versus Hand-Sewn Closure of the Pancreatic Stump following Minimally Invasive Distal Pancreatectomy: A Retrospective Cohort Study","authors":"Tao Qian, Kaiquan Huang, Wenqing Chen, X. Bai, Shunliang Gao, Yan Shen, M. Zhang, Jian Wu, Jun Yu, T. Ma, T. Liang","doi":"10.1097/jp9.0000000000000138","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000138","url":null,"abstract":"\u0000 \u0000 Pancreatic fistula after distal pancreatectomy is a common and potentially lethal complication. The optimal closure method for the pancreatic remnant during minimally invasive distal pancreatectomy (MDP) remains unclear.\u0000 \u0000 \u0000 \u0000 Data of consecutive patients who underwent MDP in our institution between July 2018 and June 2021 were collected. The outcomes of MDP with stapler and hand-sewn closure were compared. The primary outcome was clinically relevant postoperative pancreatic fistula (CR-POPF) per the International Study Group of Pancreatic Surgery definition.\u0000 \u0000 \u0000 \u0000 Of the 384 patients (stapler closure, 339; hand-sewn closure, 45) enrolled, 249 developed CR-POPF (grades B and C: 242 and 7 patients, respectively). The rates of grade B and grade C POPF in the stapler group were similar to the corresponding rates in the hand-sewn group (64.6% and 1.5% vs. 51.1% and 4.4%, P = 0.078 and P = 0.223, respectively). No differences between the stapler and hand-sewn groups were observed regarding the median operation time (207 min vs. 222 min, P = 0.139), incidence of major complications (16.5% vs. 20.0%, P = 0.559), and mortality (0.2% vs. 0%, P = 1.000). The independent risk factors of CR-POPF were abdominal abscess, prolonged operation time, and transection site (P = 0.004, 0.006, and 0.001, respectively).\u0000 \u0000 \u0000 \u0000 The incidence and severity of CR-POPF by stapler closure of the pancreatic stump were comparable to those associated with hand-sewn closure in MDP in this retrospective cohort. Randomized controlled trials are needed to verify this finding.\u0000","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47631886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0