Brain Research Reviews最新文献

{"title":"Molecular and functional heterogeneity of neural circuits: An example from the olfactory bulb","authors":"Marco Sassoè-Pognetto","doi":"10.1016/j.brainresrev.2010.06.003","DOIUrl":"10.1016/j.brainresrev.2010.06.003","url":null,"abstract":"<div><p><span><span><span>In 1875 Camillo Golgi published his classical description of the olfactory bulb, which contained the first images of neurons visualized with the “black reaction”. This new </span>staining method opened the way for structural investigations of the nervous tissue, that culminated in the extraordinary neuroanatomical work of Ramón y Cajal and the formulation of the </span>neuron doctrine<span>. Later developments in neurochemical techniques have revealed an astonishing diversity of neural circuits at the molecular level. This essay reflects on the physiological importance of the molecular heterogeneity of synaptic connections. Dendrodendritic circuits of the olfactory bulb will serve as a case for illustrating the relation between molecular composition and functional properties. Specifically, I will consider how the differential expression of GABA</span></span>_A receptor subtypes shapes dendrodendritic inhibition and influences olfactory bulb network activities. A concept emerging from recent investigations is that the molecular diversity of GABAergic systems supports neural circuit operations under an extensive range of behavior-dependent network states. Considering the great molecular diversity of synaptic connections, it is useful to reflect on the importance of high-resolution immunohistochemical analyses as a tool for investigating the structural and functional architecture of neural circuits.</p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"66 1","pages":"Pages 35-42"},"PeriodicalIF":0.0,"publicationDate":"2011-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29099179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Branched thalamic afferents: What are the messages that they relay to the cortex?","authors":"R.W. Guillery ,&nbsp;S. Murray Sherman","doi":"10.1016/j.brainresrev.2010.08.001","DOIUrl":"10.1016/j.brainresrev.2010.08.001","url":null,"abstract":"<div><p><span><span>Many of the axons that carry messages to the thalamus for relay to the </span>cerebral cortex are branched in a pattern long known from Golgi preparations. They send one branch to the thalamus and the other to motor centers of the </span>brainstem<span><span> or spinal cord. Because the thalamic branches necessarily carry copies of the motor instructions their messages have the properties of efference copies. That is, they can be regarded as providing reliable information about impending instructions contributing to movements that will produce changes in inputs to receptors, thus allowing neural centers to compensate for these changes of input. We consider how a sensory pathway like the medial lemniscus<span>, the spinothalamic tract or the </span></span>optic tract<span><span> can also be seen to act as a pathway for an efference copy. The direct connections that ascending and cortical inputs to the thalamus also establish to motor outputs create sensorimotor relationships that provide cortex with a model of activity in lower circuits and link the sensory and the motor sides of behavior more tightly than can be expected from motor outputs with a single, central origin. These transthalamic connectional patterns differ from classical models of separate </span>neural pathways for carrying efference copies of actions generated at higher levels, and introduce some different functional possibilities.</span></span></p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"66 1","pages":"Pages 205-219"},"PeriodicalIF":0.0,"publicationDate":"2011-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29175896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subverting the hegemony of the synapse: Complicity of neurons, astrocytes, and vasculature in spreading depression and pathology of the cerebral cortex","authors":"Bernice Grafstein","doi":"10.1016/j.brainresrev.2010.09.007","DOIUrl":"10.1016/j.brainresrev.2010.09.007","url":null,"abstract":"<div><p><span>Contrary to Golgi's “reticular” theory of nervous structure, it is clear that the synapse rules over communication among nerve cells. Spreading depression<span>, however, does not follow synaptic pathways. It sweeps across gray matter like a political revolution, ignoring structural boundaries and carefully established regulatory mechanisms. Neurons form alliances with their usually subordinate partners, the astrocytes, to cause a perturbation of function that strains resources necessary for recovery. Innocent bystanders, the blood vessels, are obliged to try to ameliorate the disturbance but may not be able to respond optimally in the chaotic environment. Under extreme circumstances, a purge of some of the instigators may ensue. This anarchic picture of interactions among the elements of nervous tissue does little to rescue the reticular theory that was one of Golgi's most important intellectual offerings. Nevertheless, it reminds us that the behavior of populations of nerve cells need not necessarily be limited by the pathways dictated by synaptic junctions. Spreading depression is a multifactorial phenomenon, in which intense depolarization of neurons and/or astrocytes leads to perturbations that include release of K</span></span>⁺<span>, release of glutamate, increase in intracellular Ca</span>⁺⁺<span>, release of ATP and local anoxia, as well as vascular changes. This process plays a role in migraine and contributes to the damage produced by brain anoxia, trauma, stroke, and subarachnoid hemorrhage. It may provide clues to new treatments for the damaged brain.</span></p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"66 1","pages":"Pages 123-132"},"PeriodicalIF":0.0,"publicationDate":"2011-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.09.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29319721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unipolar brush cell: A remarkable neuron finally receiving deserved attention","authors":"Enrico Mugnaini ,&nbsp;Gabriella Sekerková ,&nbsp;Marco Martina","doi":"10.1016/j.brainresrev.2010.10.001","DOIUrl":"10.1016/j.brainresrev.2010.10.001","url":null,"abstract":"<div><p><span>Unipolar brush cells (UBC) are small, glutamatergic neurons residing in the granular layer of the </span>cerebellar cortex<span> and the granule cell<span><span><span> domain of the cochlear nuclear complex. Recent studies indicate that this neuronal class consists of three or more subsets characterized by distinct chemical phenotypes, as well as by intrinsic properties that may shape their synaptic responses and firing patterns. Yet, all UBCs have a unique morphology, as both the dendritic brush and the large endings of the axonal branches participate in the formation of glomeruli. Although UBCs and granule cells may share the same excitatory and inhibitory inputs, the two cell types are distinctively differentiated. Typically, whereas the granule cell has 4–5 dendrites that are innervated by different mossy fibers, and an axon that divides only once to form parallel fibers after ascending to the molecular layer, the UBC has but one short dendrite whose brush engages in synaptic contact with a single mossy fiber terminal, and an axon that branches locally in the granular layer; branches of UBC axons form a non-canonical, cortex-intrinsic category of mossy fibers synapsing with granule cells and other UBCs. This is thought to generate a feed-forward amplification of single mossy fiber afferent signals that would reach the overlying Purkinje cells via ascending granule cell axons and their parallel fibers. In sharp contrast to other classes of cerebellar neurons, UBCs are not distributed homogeneously across cerebellar lobules, and subsets of UBCs also show different, albeit overlapping, distributions. UBCs are conspicuously rare in the expansive lateral cerebellar areas targeted by the cortico-ponto-cerebellar pathway, while they are a constant component of the vermis and the </span>flocculonodular lobe. The presence of UBCs in cerebellar regions involved in the sensorimotor processes that regulate body, head and eye position, as well as in regions of the </span>cochlear nucleus that process sensorimotor information suggests a key role in these critical functions; it also invites further efforts to clarify the cellular biology of the UBCs and their specific functions in the neuronal microcircuits in which they are embedded. High density of UBCs in specific regions of the cerebellar cortex is a feature largely conserved across mammals and suggests an involvement of these neurons in fundamental aspects of the input/output organization as well as in clinical manifestation of focal cerebellar disease.</span></span></p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"66 1","pages":"Pages 220-245"},"PeriodicalIF":0.0,"publicationDate":"2011-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29343963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Golgi in retrospect: A historiographic examination of contextual influence in tracing the constructs of neuronal organization","authors":"Lawrence Kruger ,&nbsp;Thomas S. Otis ,&nbsp;Matthew Shtrahman","doi":"10.1016/j.brainresrev.2010.07.001","DOIUrl":"10.1016/j.brainresrev.2010.07.001","url":null,"abstract":"<div><p>The concepts underlying the connectivity of neurons and the dynamics of interaction required to explain information processing have undergone significant change over the past century. A re-examination of the evolution of the modern view in historical context reveals that rules for connectivity have changed in a manner that might be expected from critical analysis enabled by technical advance. A retrospective examination of some germane issues that moved Camillo Golgi to question the widely held dogma of his era reveals network principles that could not have been recognized a century ago. The currently evolving rules of cellular discontinuity and interaction have proven sufficiently complex to justify the arguments of critical skepticism that sustain scientific progress.</p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"66 1","pages":"Pages 68-74"},"PeriodicalIF":0.0,"publicationDate":"2011-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29130331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free colour illustrations in the online version of articles","authors":"","doi":"10.1016/S0165-0173(10)00123-2","DOIUrl":"10.1016/S0165-0173(10)00123-2","url":null,"abstract":"","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"65 2","pages":"Page iv"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0165-0173(10)00123-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55963165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal cortex and drug abuse vulnerability: Translation to prevention and treatment interventions","authors":"Jennifer L. Perry ,&nbsp;Jane E. Joseph ,&nbsp;Yang Jiang ,&nbsp;Rick S. Zimmerman ,&nbsp;Thomas H. Kelly ,&nbsp;Mahesh Darna ,&nbsp;Peter Huettl ,&nbsp;Linda P. Dwoskin ,&nbsp;Michael T. Bardo","doi":"10.1016/j.brainresrev.2010.09.001","DOIUrl":"10.1016/j.brainresrev.2010.09.001","url":null,"abstract":"<div><p><span><span>Vulnerability to drug abuse is related to both reward seeking and impulsivity, two constructs thought to have a biological basis in the prefrontal cortex (PFC). This review addresses similarities and differences in neuroanatomy, </span>neurochemistry<span> and behavior associated with PFC function in rodents and humans. Emphasis is placed on </span></span>monoamine<span> and amino acid neurotransmitter systems located in anatomically distinct subregions: medial prefrontal cortex (mPFC); lateral prefrontal cortex (lPFC); anterior cingulate cortex (ACC); and orbitofrontal cortex (OFC). While there are complex interconnections and overlapping functions among these regions, each is thought to be involved in various functions related to health-related risk behaviors and drug abuse vulnerability. Among the various functions implicated, evidence suggests that mPFC is involved in reward processing, attention and drug reinstatement; lPFC is involved in decision-making, behavioral inhibition and attentional gating; ACC is involved in attention, emotional processing and self-monitoring; and OFC is involved in behavioral inhibition, signaling of expected outcomes and reward/punishment sensitivity. Individual differences (e.g., age and sex) influence functioning of these regions, which, in turn, impacts drug abuse vulnerability. Implications for the development of drug abuse prevention and treatment strategies aimed at engaging PFC inhibitory processes that may reduce risk-related behaviors are discussed, including the design of effective public service announcements, cognitive exercises, physical activity, direct current stimulation, feedback control training and pharmacotherapies. A major challenge in drug abuse prevention and treatment rests with improving intervention strategies aimed at strengthening PFC inhibitory systems among at-risk individuals.</span></p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"65 2","pages":"Pages 124-149"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40063528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanol-enhanced GABA release: A focus on G protein-coupled receptors","authors":"M. Katherine Kelm ,&nbsp;Hugh E. Criswell ,&nbsp;George R. Breese","doi":"10.1016/j.brainresrev.2010.09.003","DOIUrl":"10.1016/j.brainresrev.2010.09.003","url":null,"abstract":"<div><p><span><span>While research on the actions of ethanol at the GABAergic synapse has focused on postsynaptic mechanisms, recent data have demonstrated that ethanol also facilitates GABA release from </span>presynaptic terminals in many, but not all, brain regions. The ability of ethanol to increase GABA release can be regulated by different G protein-coupled receptors (GPCRs), such as the cannabinoid-1 receptor, corticotropin-releasing factor 1 receptor, GABA</span>_B receptor, and the 5-hydroxytryptamine 2C receptor. The intracellular messengers linked to these GPCRs, including the calcium that is released from internal stores, also play a role in ethanol-enhanced GABA release. Hypotheses are proposed to explain how ethanol interacts with the GPCR pathways to increase GABA release and how this interaction contributes to the brain region specificity of ethanol-enhanced GABA release. Defining the mechanism of ethanol-facilitated GABA release will further our understanding of the GABAergic profile of ethanol and increase our knowledge of how GABAergic neurotransmission may contribute to the intoxicating effects of alcohol and to alcohol dependence.</p></div><div><h3>Research Highlights</h3><p>► Ethanol facilitates GABA release in some, but not all, brain regions. ► Different GPCRs regulate ethanol-enhanced GABA release. ► Intracellular messengers alter the ability of ethanol to increase GABA release.</p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"65 2","pages":"Pages 113-123"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40064134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent insights into a new hydrodynamics of the cerebrospinal fluid","authors":"Marin Bulat,&nbsp;Marijan Klarica","doi":"10.1016/j.brainresrev.2010.08.002","DOIUrl":"10.1016/j.brainresrev.2010.08.002","url":null,"abstract":"<div><p>According to the traditional hypothesis, the cerebrospinal fluid (CSF) is secreted inside the brain ventricles<span><span><span> and flows unidirectionally along subarachnoid spaces to be absorbed into venous sinuses across arachnoid villi and/or via paraneural sheaths of nerves into lymphatics. However, according to recent investigations, it appears that interstial fluid (ISF) and CSF are formed by water filtration across the walls of arterial capillaries in the </span>central nervous system (CNS), while plasma osmolytes are sieved (retained) so that capillary osmotic counterpressure is generated, which is instrumental in ISF/CSF water absorption into venous capillaries and postcapillary venules. This hypothesis is supported by experiments showing that water, which constitutes 99% of CSF and ISF bulk, does not flow along CSF spaces since it is rapidly absorbed into adjacent CNS </span>microvessels, while distribution of other substances along CSF spaces depends on the rate of their removal into microvessels: faster removal means more limited distribution. Furthermore, the acute occlusion of aqueduct of Sylvius does not change CSF pressure in isolated ventricles, suggesting that the formation and the absorption of CSF are in balance. Multidirectional distribution of substances inside CSF, as well as between CSF and ISF, is caused by to-and-fro pulsations of these fluids and their mixing. Absorption of CSF into venous sinuses and/or lymphatics under the physiological pressure should be of minor importance due to their minute surface area in comparison to the huge absorptive surface area of microvessels.</span></p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"65 2","pages":"Pages 99-112"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.08.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29285557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Retinohypothalamic tract: Comparison of axonal projection patterns from four major targets","authors":"Newton S. Canteras ,&nbsp;Érika Renata Ribeiro-Barbosa ,&nbsp;Marina Goto ,&nbsp;José Cipolla-Neto ,&nbsp;Larry W. Swanson","doi":"10.1016/j.brainresrev.2010.09.006","DOIUrl":"10.1016/j.brainresrev.2010.09.006","url":null,"abstract":"<div><p>The retinohypothalamic tract<span><span> is one component of the optic nerve that transmits information about environmental luminance levels through medial and lateral branches to four major terminal fields in the hypothalamus. The spatial distribution and organization of axonal projections from each of these four terminal fields were analyzed and compared systematically with the anterograde pathway tracer PHAL in rats where the terminal fields had been labeled with intravitreal injections of a different anterograde pathway tracer, CTb.<span> First, the well-known projections of two medial retinohypothalamic tract targets (the ventrolateral suprachiasmatic nucleus and perisuprachiasmatic region) were confirmed and extended. They share qualitatively similar projections to a well-known set of brain regions thought to control circadian rhythms. Second, the projections of a third medial tract target, the ventromedial part of the </span></span>anterior hypothalamic nucleus<span>, were analyzed for the first time and shown to resemble qualitatively those from the suprachiasmatic nucleus and perisuprachiasmatic region. And third, projections from the major lateral retinohypothalamic tract target were analyzed for the first time and shown to be quite different from those associated with medial tract targets. This target is a distinct core part of the ventral zone of the anterior group of the lateral hypothalamic area that lies just dorsal to the caudal two-thirds of the supraoptic nucleus<span><span>. Its axonal projections are to neural networks that control a range of specific goal-oriented </span>behaviors (especially drinking, reproductive, and defensive) along with adaptively appropriate and complementary visceral responses and adjustments to behavioral state.</span></span></span></p></div>","PeriodicalId":9291,"journal":{"name":"Brain Research Reviews","volume":"65 2","pages":"Pages 150-183"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.brainresrev.2010.09.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29300950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}