Brain Pathology最新文献

{"title":"Society News","authors":"Audrey Rousseau","doi":"10.1111/bpa.13333","DOIUrl":"https://doi.org/10.1111/bpa.13333","url":null,"abstract":"<p><b>The ISN is looking for a group of young motivated neuropathologists</b> to promote the specialty via the ISN website. If you are interested in participating, please contact Audrey Rousseau (<span>[email protected]</span>) or Monika Hofer (<span>[email protected]</span>).</p><p><b>The International Congress of Neuropathology (ICN)</b> will be held in Edinburgh, Scotland, in 2027 (ICN27). The Congress President will be Prof Colin Smith, and the ICN27 will be hosted by the British Neuropathological Society (BNS).</p><p>“On behalf of the British Neuropathological Society, I am delighted to extend a warm invitation to all our colleagues across the world to join us in Edinburgh for the International Congress of Neuropathology 2027. Edinburgh is an easily accessible center, surrounded by 1000 years of living history. We will develop a strong academic programme covering all aspects of neuropathology with world leading plenary speakers, supported by a social programme highlighting some of Edinburgh's historic charms. For those wishing to explore further, Edinburgh offers access to many of Scotland's highlights, be it touring the Highlands, sampling our famous whisky, or golfing on some of our picturesque courses. I do hope you will be able to join us for what I am sure will be a memorable meeting showcasing the best in international neuropathology.</p><p>Colin Smith.</p><p>Congress President ISN 2027”</p><p>Summary report for ICN23 Berlin (our most recent International Congress of Neuropathology, September 2023) now available in the Society's journal <i>Brain Pathology</i> (see link: https://doi.org/10.1111/bpa.13249).</p><p>We are delighted to start the bidding process for holding the <b>2031 XXII International Congress of Neuropathology (ICN)</b>. As you know, the 2027 XXI ICN Congress will be in Edinburgh and we now need to think ahead to 2031 and find a new home for our much-loved congress.</p><p>The Invitation Letter calling for bids and outlining the process can be found on the ISN website (www.intsocneuropathol.com). Please note that the deadline is the <b>March 1, 2025</b>.</p><p><b><i>Brain Pathology has joined Wiley's Open Access</i></b> portfolio as of January 2021. As a result, all submissions are subject to an Article Publication Charge (APC) if accepted and published in the journal. ISN members are eligible for a 10% discount of the Open Access APC. For more information on the fees, please click https://onlinelibrary.wiley.com/page/journal/17503639/article_publication_charges#:~:text=Brain%20Pathology%20is%20an%20Open,of%20CC%20license%20be%20used.</p><p><b>Free resource: digital microscopy platform for neurodegenerative diseases curated in Munich</b>. Prof Jochen Herms and his team have been setting up a digital microscopy platform for neurodegenerative diseases in their department in Munich. Registration is free. ISN members and interested colleagues are invited to use this resource, which will be particularly useful for teaching and","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":"35 2","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bpa.13333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An 11-year-old boy with a posterior fossa tumor","authors":"Gina Del Vecchio, Sabina Barresi, Sara Patrizi, Claudia D'Orazio, Silvia Genovese, Isabella Giovannoni, Chantal Tancredi, Anne Falcou, Angela Mastronuzzi, Giovanna Stefania Colafati, Andrea Carai, Viola Alesi, Evelina Miele, Rita Alaggio, Sabrina Rossi","doi":"10.1111/bpa.13332","DOIUrl":"https://doi.org/10.1111/bpa.13332","url":null,"abstract":"<p>An 11-year-old boy was referred to our institution from a resource-limited country with a history of hydrocephalus secondary to a posterior fossa tumor. Magnetic resonance imaging (MRI) revealed a large extra-axial neoplasm located at the tentorium, measuring 5.1 × 4.2 × 4.0 cm (Figure 1), causing marked distortion of the adjacent structures and transtentorial herniation. The lesion was strongly enhancing, associated with massive vasogenic edema. Microsurgical excision of the lesion was performed by a supracerebellar infratentorial approach, obtaining a gross total resection. After recovery, the boy returned to his country, where he has been followed with periodical computed tomography scans. He remains free of disease 58 months from surgery (Box 1).</p><p>The lesion consisted of epithelioid and rhabdoid cells arranged in a chordoid pattern within a myxoid stroma (Figure 2A) with foci of collagen deposition sometimes featuring amianthoid fibers (Figure 2B). Solid sheets of rhabdoid and epithelioid cells with focal clear cell changes were also present. Mitotic figures were infrequent (1/1.96 mm<sup>2</sup>). There was a sparse lymphoplasmocytic inflammatory infiltrate at the periphery. The possibility of a chordoid meningioma was first considered, and the expression of epithelial membrane antigen (EMA) seemed to support this hypothesis. However, given the rarity of this meningioma subtype and the lack of a specific marker, an extensive immunohistochemical panel was performed: the diffuse desmin expression, combined with focal CD99 and D2-40, prompted us to consider an intracranial mesenchymal tumor (IMT) with FET::CREB fusion (Figure 2C–E). RNA sequencing (Agilent) demonstrated the presence of a <i>SMARCA2::CREM</i> transcript (Figure 2F). No pathogenic/likely pathogenic variants were identified (TSO500). CGH/SNP array revealed only a mosaic 12p trisomy. Genome-wide DNA methylation profiling classified the lesion as meningioma (score 0.98), subclass 3 (score 0.93) according to the Heidelberg Brain Tumor Classifier v12.5. t-distributed stochastic neighbor embedding (t-SNE) analysis was performed using selected Deutsches Krebsforschungszentrum (German Cancer Research Center) (DFKZ) reference classes and two previously characterized IMT cases, both harboring an <i>EWSR1::CREM</i> fusion. The current case clustered with one of the IMT and was close to meningiomas, whereas the other IMT was near angiomatoid fibrous histiocytomas (Figure 2G).</p><p>IMT harboring a <i>SMARCA2::CREM</i> fusion.</p><p>We describe a rare example of a pediatric posterior fossa IMT with a <i>SMARCA2::CREM</i> fusion. A case with an identical fusion transcript has been reported in the parietal lobe of a 40-year-old man with a 15-year history of multiple recurrences of a “chordoid meningioma” [<span>1</span>]. These cases share a striking chordoid morphology. IMT generally shows two main patterns: (i) stellate/spindle cells and abundant myxoid stroma preferentially character","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":"35 2","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bpa.13332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral blood-derived immune cell counts as prognostic indicators and their relationship with DNA methylation subclasses in glioblastoma patients.","authors":"Benedikt Asey, Tobias F Pantel, Malte Mohme, Yahya Zghaibeh, Lasse Dührsen, Dana Silverbush, Ulrich Schüller, Richard Drexler, Franz L Ricklefs","doi":"10.1111/bpa.13334","DOIUrl":"https://doi.org/10.1111/bpa.13334","url":null,"abstract":"<p><p>Glioblastomas are known for their immunosuppressive tumor microenvironment, which may explain the failure of most clinical trials in the past decade. Recent studies have emphasized the significance of stratifying glioblastoma patients to predict better therapeutic responses and survival outcomes. This study aims to investigate the prognostic relevance of peripheral immune cell counts sampled prior to surgery, with a special focus on methylation-based subclassification. Peripheral blood was sampled in patients with newly diagnosed (n = 176) and recurrent (n = 41) glioblastoma at the time of surgery and analyzed for neutrophils, monocytes, leukocytes, platelets, neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and platelet-lymphocyte ratio. Peripheral immune cell counts were correlated with patients' survival after combined radiochemotherapy. In addition, 850 k genome-wide DNA methylation was assessed on tissue for defining tumor subclasses and performing cell-type deconvolution. In newly diagnosed glioblastoma, patients with higher peripheral neutrophil counts had an unfavorable overall survival (OS) (p = 0.01, median overall-survival (mOS) 17.0 vs. 10.0 months). At the time of first recurrence, a significant decrease of peripheral immune cell counts was observed, and elevated monocyte (p = 0.03), neutrophil (p = 0.04), and platelet (p = 0.01) counts were associated with poorer survival outcomes. DNA methylation subclass-stratified analysis revealed a significant survival influence of neutrophils (p = 0.007) and lymphocytes (p = 0.04) in the mesenchymal (MES) subclass. Integrating deconvolution of matched tumor tissue showed that platelets and monocytes were correlated with a more differentiated, tumor-progressive cell state, and peripheral immune cell counts were most accurately reflected in tissue of the MES subclass. This study illustrates a restricted prognostic significance of peripheral immune cell counts in newly diagnosed glioblastoma and a constrained representation in matched tumor tissue, but it demonstrates a more pertinent situation at the time of recurrence and after DNA methylation-based stratification.</p>","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":" ","pages":"e13334"},"PeriodicalIF":5.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-derived textiloma post glioblastoma resection and application of oxidized regenerated cellulose: A pilot, bedside-to-bench, translational study.","authors":"Joshua A Kra, Christopher Markosian, Fenny H F Tang, Ada Baisre de León, Anupama Chundury, Pankaj K Agarwalla, Daniela I Staquicini, Renata Pasqualini, Wadih Arap","doi":"10.1111/bpa.13331","DOIUrl":"https://doi.org/10.1111/bpa.13331","url":null,"abstract":"<p><p>Oxidized regenerated cellulose (ORC; marketed as Surgicel® and Tabotamp®) is routinely used as an intraoperative hemostatic agent. Rarely, residual ORC has been associated with a foreign body reaction generating cystic or granulomatous lesions (i.e., textilomas) at the surgical site. Here, we report a bedside-to-bench, translational report of an intracranial mass after neurosurgical resection of glioblastoma with ORC application. As part of patient care, we performed magnetic resonance imaging and histopathological analysis of the mass. We then performed in vitro studies to evaluate the effect of ORC on cytokine production and viability of BV-2 murine microglial cells by using quantitative PCR along with live cell microscopy and crystal violet staining, respectively. Magnetic resonance imaging demonstrated a recurrent mass pressing on the adjacent right ventricle, which was removed in a second surgery for diagnostic and therapeutic purposes. Unexpectedly, histopathological examination of the resected mass revealed abundant ORC arising from the site with inflammation, microglial activation, and collagenization. Mechanistically, we show an ORC-induced modest increase in inflammatory cytokines with a subsequent decrease in microglial cell viability. These findings suggest that ORC may mediate microglial immune response and viability, and serve to raise awareness and guide interpretation of post-treatment surveillance imaging findings in the instance of foreign body reaction.</p>","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":" ","pages":"e13331"},"PeriodicalIF":5.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resource availability for CNS tumor diagnostics in the Asian Oceanian region: A survey by the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR).","authors":"Chitra Sarkar, Shilpa Rao, Vani Santosh, Maysa Al-Hussaini, Sung Hye Park, Tarik Tihan, Michael E Buckland, Ho-Keung Ng, Takashi Komori","doi":"10.1111/bpa.13329","DOIUrl":"https://doi.org/10.1111/bpa.13329","url":null,"abstract":"<p><p>The shift toward a histo-molecular approach in World Health Organization classification of central nervous system tumors (WHO CNS5) emphasizes the critical role of molecular testing, such as next-generation sequencing (NGS) and DNA methylation profiling, for accurate diagnosis. However, implementing these advanced techniques is particularly challenging in resource-constrained countries. To address this, the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR) was initiated to help pathologists in resource-limited regions to implement WHO CNS5 diagnoses using simpler diagnostic tools, mainly immunohistochemistry. An online survey by this group assessed the in-house/local availability of diagnostic resources and outsourcing capabilities across the Asian Oceanian region, covering 19 countries. Of 318 responding centers, the availability of molecular techniques in-house/locally was limited in lower middle-income countries (LMICs), with 29% having fluorescence in situ hybridization, 10.7% Sanger sequencing, and only 9.4% NGS. DNA methylation was largely unavailable in-house/locally in of LMICs, while in the whole region, its availability stood at a meager 4.4%. Though outsourcing for all diagnostic tests was an easily accessible alternative, outsourcing for NGS and DNA methylation was uncommon because of the financial burden on patients being a significant obstacle. The survey categorized centers into five resource levels (RLs) based on the in-house/local access to diagnostic techniques, which highlighted the variability and disparity in diagnostic capabilities across the region. High-income countries had 80% of centers with advanced RL IV, V resources, in contrast to LMICs, where 70.5% of centers fell into RL I-III. This comprehensive evaluation emphasizes the need for tailored resource level guidelines, with the aim of improving diagnostic accuracy and treatment as well as advocating better healthcare infrastructure in resource-constrained areas. However, the survey's reliance on responses from better-resourced centers may underestimate challenges in lower-resource settings, stressing the need for broader outreach and support.</p>","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":" ","pages":"e13329"},"PeriodicalIF":5.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function.","authors":"Ingrid Dudink, Amy E Sutherland, Margie Castillo-Melendez, Elham Ahmadzadeh, Tegan A White, Atul Malhotra, Harold A Coleman, Helena C Parkington, Justin M Dean, Yen Pham, Tamara Yawno, Tara Sepehrizadeh, Graham Jenkin, Emily J Camm, Beth J Allison, Suzanne L Miller","doi":"10.1111/bpa.13330","DOIUrl":"https://doi.org/10.1111/bpa.13330","url":null,"abstract":"<p><p>The last pregnancy trimester is critical for fetal brain development but is a vulnerable period if the pregnancy is compromised by fetal growth restriction (FGR). The impact of FGR on the maturational development of neuronal morphology is not known, however, studies in fetal sheep allow longitudinal analysis in a long gestation species. Here we compared hippocampal neuron dendritogenesis in FGR and control fetal sheep at three timepoints equivalent to the third trimester of pregnancy, complemented by magnetic resonance image for brain volume, and electrophysiology for synaptic function. We hypothesized that the trajectory of hippocampal neuronal dendrite outgrowth would be decreased in the growth-restricted fetus, with implications for hippocampal volume, connectivity, and function. In control animals, total dendrite length increased with advancing gestation, but not in FGR, resulting in a significantly reduced trajectory of dendrite outgrowth in FGR fetuses for total length, branching, and complexity. Ex vivo electrophysiology analysis shows that paired-pulse facilitation was reduced in FGR compared to controls for cornu ammonis 1 hippocampal outputs, reflecting synaptic dysfunction. Hippocampal brain-derived neurotrophic factor density decreased over late gestation in FGR fetuses but not in controls. This study reveals that FGR is associated with a significant deviation in the trajectory of dendrite outgrowth of hippocampal neurons. Where dendrite length significantly increased over the third trimester of pregnancy in control brains, there was no corresponding increase over time in FGR brains, and the trajectory of dendrite outgrowth in FGR offspring was significantly reduced compared to controls. Reduced hippocampal dendritogenesis in FGR offspring has severe implications for the development of hippocampal connectivity and long-term function.</p>","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":" ","pages":"e13330"},"PeriodicalIF":5.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications.","authors":"Paola Fabbrizio, Sharada Baindoor, Cassandra Margotta, Junyi Su, Elena P Morrissey, Ina Woods, Marion C Hogg, Sara Vianello, Morten T Venø, Jørgen Kjems, Gianni Sorarù, Caterina Bendotti, Jochen H M Prehn, Giovanni Nardo","doi":"10.1111/bpa.13328","DOIUrl":"https://doi.org/10.1111/bpa.13328","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease with no effective treatments, in part caused by variations in progression and the absence of biomarkers. Mice carrying the SOD1G93A transgene with different genetic backgrounds show variable disease rates, reflecting the diversity of patients. While extensive research has been done on the involvement of the central nervous system, the role of skeletal muscle remains underexplored. We examined the impact of angiogenin, including its RNase activity, in skeletal muscles of ALS mouse models and in biopsies from ALS patients. Elevated levels of angiogenin were found in slowly progressing mice but not in rapidly progressing mice, correlating with increased muscle regeneration and vascularisation. In patients, higher levels of angiogenin in skeletal muscles correlated with milder disease. Mechanistically, angiogenin promotes muscle regeneration and vascularisation through satellite cell-endothelial interactions during myogenesis and angiogenesis. Furthermore, specific angiogenin-derived tiRNAs were upregulated in slowly progressing mice, suggesting their role in mediating the effects of angiogenin. These findings highlight angiogenin and its tiRNAs as potential prognostic markers and therapeutic targets for ALS, offering avenues for patient stratification and interventions to mitigate disease progression by promoting muscle regeneration.</p>","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":" ","pages":"e13328"},"PeriodicalIF":5.8,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society News","authors":"","doi":"10.1111/bpa.13320","DOIUrl":"https://doi.org/10.1111/bpa.13320","url":null,"abstract":"","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":"35 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bpa.13320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentiating microglial efferocytosis by MFG-E8 improves survival and neurological outcome after successful cardiopulmonary resuscitation in mice.","authors":"Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Jiancong Chen, Yuan Chang, Yongchuan Li, Shuxin Zeng, Sifan Pan, Suyue Pan, Kaibin Huang","doi":"10.1111/bpa.13327","DOIUrl":"https://doi.org/10.1111/bpa.13327","url":null,"abstract":"<p><p>Brain injury represents the leading cause of mortality and disability after cardiopulmonary resuscitation (CPR) from cardiac arrest (CA), in which the accumulation of dying cells aggravate tissue injury by releasing proinflammatory intracellular components. Microglia play an essential role in maintaining brain homeostasis via milk fat globule epidermal growth factor 8 (MFG-E8)-opsonized efferocytosis, the engulfment of dying cells and debris. This study investigates whether potentiating microglia efferocytosis by MFG-E8 provides neuroprotection after CA/CPR. After 8-minute asphyxial CA/CPR, male adult C57BL/6J mice were randomly assigned to receive recombinant mouse MFG-E8 (rmMFG-E8) or vehicle. We evaluated the survival and neurological deficits of mice, along with histological damages, phagocytosis index of dying cells, and microglia polarization. A transcriptome analysis was conducted to explore the downstream molecules modulated by MFG-E8. In mice resuscitated from CA, rmMFG-E8 administration significantly enhanced the efferocytosis of apoptotic cells by microglia, improved the survival and neurological function of mice, and attenuated neuropathological injuries. Additionally, rmMFG-E8 induced a prominent alteration in microglial gene expression and promoted a shift from a proinflammatory phenotype to an anti-inflammatory phenotype. Moreover, rmMFG-E8 treatment induced up-regulation of interferon regulatory factor 7 (IRF7), and IRF7 gene silencing largely reversed the neuroprotective effects of rmMFG-E8. This study demonstrates that rmMFG-E8 improves survival and neurological outcomes after CA/CPR by enhancing microglial efferocytosis and reshaping the inflammatory microenvironment in brain tissue. Potentiating MFG-E8 is a promising strategy to combat post-CA brain injury.</p>","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":" ","pages":"e13327"},"PeriodicalIF":5.8,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extra-axial mass in a 72-year-old woman","authors":"S. Rima,&nbsp;B. N. Nandeesh,&nbsp;Mangalkumar Rachatte,&nbsp;Anil Pande","doi":"10.1111/bpa.13325","DOIUrl":"10.1111/bpa.13325","url":null,"abstract":"&lt;p&gt;A 72-year-old lady presented with complaints of slurring of speech, loss of appetite, sleep disturbance for the past 1 month. Magnetic resonance imaging brain showed a large extra-axial space occupying lesion noted along left frontal convexity, measuring 47 × 70 × 36 mm. The lesion was hyperintense on T2 and hypointense on T1 and showed diffusion restriction and contrast enhancement (Figure 1). Cerebrospinal fluid (CSF) cleft sign and buckling of adjacent white matter (anterior) and pial vessels were noted around the lesion. The lesion showed few prominent intralesional flow voids. The overall imaging features favored a meningioma. She underwent left frontoparietal craniotomy and Simpson's Grade II excision of lesion (Box 1).&lt;/p&gt;&lt;p&gt;Histopathological examination showed a meningothelial tumor composed of neoplastic meningothelial cells with mild nuclear anisonucleosis, arranged as whorls and syncytium. Embedded and admixed within this meningothelial neoplasm were deposits from an epithelial neoplasm comprising of tumor cells arranged in acini of varying sizes and papillae (Figure 2A,B and Box 1). These cells were polygonal with vesicular nuclei, visible nucleoli and moderate amounts of eosinophilic cytoplasm. Mitoses were noted within both the components, and atypical mitotic figures were seen in the epithelial component (Figure 2C). The mitotic activity in the meningothelial component was 1–2/10 high power fields. On immunohistochemistry, the meningioma component was positive for Vimentin, EMA (epithelial membrane antigen), and SSTR2A (somatostatin receptor 2A) (Figure 2D). The epithelial component was positive for EMA, CK (cytokeratin; Figure 2E) and CK7. TTF-1 (thyroid transcription factor) showed diffuse moderate to strong positivity in the epithelial component, indicating a primary carcinoma from lung or thyroid origin (Figure 2F). The tumor cells were negative for CK20. MIB1 labeling index was 5%–6% in the meningothelial component and 20%–25% in the epithelial component.&lt;/p&gt;&lt;p&gt;Metastatic adenocarcinoma, consistent with lung primary to transitional meningioma (CNS WHO grade 1).&lt;/p&gt;&lt;p&gt;This case is an example of tumor-to-tumor metastasis (TTM). Tumor-to-meningioma metastasis (TTMM) refers to a phenomenon where a tumor metastasizes to a meningioma, also known as intrameningioma metastasis. It is important to distinguish TTM from collision tumors. Collision tumors are tumors that grow adjacent to each other and infiltrates into one another. The first tumor-to-tumor phenomenon was reported in 1902 by Berent. The criteria for TTM proposed by L.V. Campbell are: at least two primary tumors must exist; the host tumor must be a true neoplasm; the metastatic focus must show established growth inside the host tumor, and not be of contiguous growth; the host tumor cannot be a lymph node involved in leukemia or lymphoma [&lt;span&gt;1&lt;/span&gt;]. The most common tumors associated with TTMM are breast carcinoma and lung carcinoma. Other tumors associated with TTMM","PeriodicalId":9290,"journal":{"name":"Brain Pathology","volume":"35 2","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bpa.13325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}