International journal of cerebrovascular disease and stroke最新文献_第3页

Histopathological Profile of Thrombi Differs Depending on Pathogenesis of Embolic Cerebral Infarction and Evidence of Intracardiac Thrombus 血栓的组织病理学特征取决于栓塞性脑梗死的发病机制和心内血栓的证据

International journal of cerebrovascular disease and stroke Pub Date : 2023-04-28 DOI: 10.29011/2688-8734.100047

V. Meļņikova, K. Jurjāns, Katrīna Kupča, J. Vētra, Daira Lapse, A. Veiss, Jurijs Nazarovs, E. Miglāne, V. Meļņikova

引用次数: 0

Delayed Activation of Sirt1 Induced Autophagy Signaling Promotes Astrogliosis, Infarct in Experimental Stroke 延迟激活Sirt1诱导的自噬信号促进实验性脑卒中的星形胶质细胞形成和梗死

International journal of cerebrovascular disease and stroke Pub Date : 2023-04-27 DOI: 10.29011/2688-8734.100048

S. Teertam, Varalakshmi Manchana, P. Phanithi, P. Babu, Phanithi

引用次数: 0

AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum. 妊娠期输注AT1-AA会影响产后CBF的自我调节。

International journal of cerebrovascular disease and stroke Pub Date : 2023-01-01 Epub Date: 2023-07-17 DOI: 10.29011/2688-8734.100154

Nathan Campbell, Luke Strong, Xing Fang, Jane J Border, Owen Herrock, Ty Turner, Evangeline Deer, Lorena Amaral, Ralf Dechend, Richard J Roman, Babbette LaMarca

{"title":"AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum.","authors":"Nathan Campbell, Luke Strong, Xing Fang, Jane J Border, Owen Herrock, Ty Turner, Evangeline Deer, Lorena Amaral, Ralf Dechend, Richard J Roman, Babbette LaMarca","doi":"10.29011/2688-8734.100154","DOIUrl":"10.29011/2688-8734.100154","url":null,"abstract":"<p><p>Preeclampsia (PE), new-onset hypertension during pregnancy alongside organ dysfunction, is a leading cause of morbidity and mortality for the mother and fetus. PE women have activated B cells that produce agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA). AT1-AA impairs cerebral blood flow (CBF) autoregulation during pregnancy. Although AT1-AA often remains elevated up to 8 years postpartum, AT1-AA's effect on CBF autoregulation postpartum is unknown. This study examined whether elevated AT1-AA during pregnancy impairs CBF autoregulation postpartum and if this was augmented by infusion of AT1-AA postpartum. AT1-AA was infused into 12-week-old timed-pregnant Sprague Dawley rats beginning on gestational day 14. Uterine artery resistance index (UARI) was measured on gestational day 18 as a measure of endothelial dysfunction associated with PE. Dams were allowed to deliver. One group was given a second infusion of AT1-AA (50% perinatal dose mimicking levels observed in postpartum PE women) at 9 weeks postpartum. After postpartum week 10, mean arterial pressure (MAP) was measured in conscious rats and CBF autoregulation was measured by laser Doppler flowmetry. AT1-AA during pregnancy increased UARI (P<0.05). AT1-AA during pregnancy did not affect MAP postpartum but did impair CBF autoregulation postpartum. Infusion of AT1-AA postpartum significantly elevated blood pressure (P<0.01) but did not further impair CBF autoregulation. This study demonstrates that circulating AT1-AA during pregnancy causes impairment of CBF autoregulation well into the postpartum period indicating that elevated AT1-AA leads to long-term cerebrovascular consequences. Targeting AT1-AA may prevent cerebrovascular effects associated with PE during pregnancy and postpartum.</p>","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10610033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71415783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Fatal Outcome after Incident of Stroke among Patients from Three Hospitals in Kinshasa, Democratic Republic of the Congo 来自刚果民主共和国金沙萨三家医院的患者中风事件后致命结果的预测因素

International journal of cerebrovascular disease and stroke Pub Date : 2022-10-26 DOI: 10.29011/2688-8734.000044

Limbole Bakilo, DS NkarnkwinKasanza, Atheno Simele, Panzi Kalunda, Mutombo Beya, Emmanuel Limbole Bakilo

{"title":"Predictors of Fatal Outcome after Incident of Stroke among Patients from Three Hospitals in Kinshasa, Democratic Republic of the Congo","authors":"Limbole Bakilo, DS NkarnkwinKasanza, Atheno Simele, Panzi Kalunda, Mutombo Beya, Emmanuel Limbole Bakilo","doi":"10.29011/2688-8734.000044","DOIUrl":"https://doi.org/10.29011/2688-8734.000044","url":null,"abstract":"Summary Objective: This study investigated the predictors of stroke fatal outcome after a one year follow-up. Methods: This was a historic cohort of 166 stroke patients from three hospitals in Kinshasa, capital of the Democratic Republic of Congo. Data were collected from patients as they were admitted. Vital outcome information was collected throughout the follow-up period. The Cox proportional hazard modeling was used to measure predictors. Results: The patients’ median age was 59 (IQR: 52-68) years. The majority of them were male (65.1%) and known hypertensive (79.5%). Around 31% patients died within the one year period of follow-up; the median duration between the occurrence of stroke and death was 37 (14-155.5) days. The Glasgow Coma Score and day 7 blood glucose showed a significant influence on vital outcome: an early disorder of consciousness (Glasgow score ˂13) multiplies by 2.5 the risk of death (HR: 2.46, 95% CI [1.3-4.6], p = 0.005) and the glycaemia level at day 7 greater than or equal to 180 mg / dl increases the risk of death by 2.4 times (HR: 2.4, 95% CI [1.03 -5.7], p = 0.04). Conclusion: Hyperglycemia in the acute phase of stroke and early consciousness disorder are predictors of fatal prognosis of stroke, easy to detect in routine clinical practice. They should therefore be used to identify patients with potentially poor prognosis in the short and in the long term for appropriate care.","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78824870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Serum BDNF Level and Cognitive-Linguistic Outcomes in Aphasic Stroke 失语症脑卒中患者血清BDNF水平与认知语言预后的关系

International journal of cerebrovascular disease and stroke Pub Date : 2022-01-12 DOI: 10.29011/2688-8734.000042

Lin Zhang, Yaping Huai, Mingzhu Xu, Xin Wang, Xun Luo, Xinjie Zeng, Qing-mei Wang

引用次数: 0

Dysphagia Incidence and Comorbidity in Hospitalized Acute Stroke Patients 住院急性脑卒中患者吞咽困难发生率及合并症

International journal of cerebrovascular disease and stroke Pub Date : 2021-12-06 DOI: 10.29011/2688-8734.000041

Ruiying Ding

{"title":"Dysphagia Incidence and Comorbidity in Hospitalized Acute Stroke Patients","authors":"Ruiying Ding","doi":"10.29011/2688-8734.000041","DOIUrl":"https://doi.org/10.29011/2688-8734.000041","url":null,"abstract":"Introduction: There has been limited literature examined in a general population sample of the incidence of dysphagia in acute stroke patients, stroke patients with pneumonia and gastrostomy comorbidity, and the increased costs associated with the complications. Methods: The current study used Illinois Hospital Discharge data for in-patients admitted during September 2012 to June 2016 to investigate the incidence of dysphagia among patients who had a primary diagnosis of stroke. Sub-analysis of dysphagia incidence among stroke patients with co-morbidity pneumonia and gastrostomy was also performed. Results: The study found a 14.9% incidence of dysphagia in a population of hospitalized acute stroke patients. The rate of dysphagia was greater in the elderly and in blacks and Hispanics than whites. In stroke patients diagnosed with dysphagia, the incidence of pneumonia is 23.1% and the incidence of percutaneous endoscopic gastrostomy (PEG) is 62.1%. Stroke patients with dysphagia had doubled length of hospital stay than those without dysphagia. With the co-morbid conditions of dysphagia and pneumonia or PEG tube placement, the length of hospital stay tripled. Increased length of hospital stay is associated with significantly higher healthcare cost. Conclusions: These findings suggested the importance of early detection and treatment of dysphagia in stroke population. International Journal of Cerebrovascular Disease and Stroke Ding R. Int J Cerebrovasc Dis Stroke 4: 140. www.doi.org/10.29011/2688-8734.000041 www.gavinpublishers.com","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81898630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral Autoregulation and Blood Flow Redistribution in the Precerebral Arteries in Patients with Carotid Artery Occlusion 颈动脉闭塞患者脑自动调节和脑前动脉血流再分布

International journal of cerebrovascular disease and stroke Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000039

引用次数: 0

Inpatient Utility of Pro-BNP in COVID-19: A Single Center Experience 住院患者在COVID-19中使用亲bnp:单中心经验

International journal of cerebrovascular disease and stroke Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000035

引用次数: 0

Imaging of the Intracranial Artery Dissection 颅内动脉夹层的影像学检查

International journal of cerebrovascular disease and stroke Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000027

引用次数: 0

A Case of Caseous Calcification of the Mitral Annulus Leading to Rupture into Pericardium and Cerebral Infarction 二尖瓣环干酪样钙化致心包破裂脑梗死1例

International journal of cerebrovascular disease and stroke Pub Date : 2021-01-01 DOI: 10.29011/2688-8734.000030

引用次数: 0