International journal of cerebrovascular disease and stroke最新文献

{"title":"Creation of a Merged Harmonized Large Database of Subject-Level Data from Acute Secondary Prevention Studies in Minor Non-Cardioembolic Stroke or TIA.","authors":"James R Brorson, Simmer Beniwal, Mihai Giurcanu, Danielle Landron, Stacie Landron, James E Siegler, Shyam Prabhakaran, Julie A Johnson","doi":"10.29011/2688-8734.100205","DOIUrl":"10.29011/2688-8734.100205","url":null,"abstract":"<p><strong>Introduction: </strong>Prevention of early recurrence of ischemic stroke after an initial event is a clinically important problem that has been the subject of a number of large clinical trials testing acute treatment interventions. Datasets of clinical trials provide a rich source of information beyond the primary research questions addressed. Merging of datasets, providing greater statistical power and wider applicability for novel exploratory analyses, requires careful harmonization of similar data elements.</p><p><strong>Methods: </strong>The Acute Stroke or Transient Ischaemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes (SOCRATES), Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial (POINT), and Acute STroke or Transient IscHaemic Attack Treated with TicAgreLor and ASA for PrEvention of Stroke and Death (THALES) trials each examined the effects of early administration of enhanced antiplatelet therapy versus aspirin alone within 12-24 hours following minor ischemic stroke or transient ischemic attack.</p><p><strong>Results: </strong>The datasets of these 3 trials have been harmonized and merged into a single large data table comprising 26319 subjects with 75 clinical and demographic variables, 196 concomitant medication descriptors, and event flags and event timing variables for 20 clinical outcome events. A high degree of data completeness was attained for most variables.</p><p><strong>Conclusion: </strong>This merged data table provides a powerful resource of pooled clinical trial data to enable future large-scaled analyses for the study of stroke recurrence risks, and is now curated and available for other investigators.</p>","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"9 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13215695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148058641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Subdural Hematoma Treatment with Embolization Versus Surgery Study (CHESS): Trial Rationale and Protocol.","authors":"Manisha Koneru, Ajith J Thomas, Farhan Siddiq, Magdy H Selim, Adnan I Qureshi, Jeremy Brown, Renee L Martin, Jessica Spahn, Peter T Kan, Christy Cassarly","doi":"10.29011/2688-8734.100199","DOIUrl":"10.29011/2688-8734.100199","url":null,"abstract":"<p><strong>Background: </strong>Current treatment paradigms for Chronic Subdural Hematoma (CSDH) include either medical management for mildly symptomatic patients or surgical evacuation for severely symptomatic patients. Middle Meningeal Artery Embolization (MMAE) has demonstrated potential to reduce rate of recurrence and rescue surgery as an adjunctive or standalone treatment for CSDH. However, there currently lacks randomized trial data to support the safety and efficacy of standalone MMAE in CSDH patients.</p><p><strong>Objective: </strong>The objective of Chronic Subdural Hematoma Treatment with Embolization versus Surgery Study (CHESS) is to compare standalone MMAE to conventional surgery for treatment of moderately symptomatic CSDH.</p><p><strong>Methods: </strong>CHESS is a prospective, multi-center, open-label randomized controlled trial. Eligible CSDH patients will be randomized 1:1 to either conventional surgery (burr holes or craniotomy) or standalone MMAE with either polyvinyl alcohol particles or microspheres. The follow-up duration will be for 180 days following randomization.</p><p><strong>Results: </strong>The primary endpoint is a composite measure, comprising of the centrally-adjudicated need of rescue surgery and/or mortality, assessed from randomization through 180 days. Safety outcomes include symptomatic ischemic stroke, serious/life threatening adverse events, worsening neurological status, seizures, and cranial neuropathy. Exploratory endpoints include hematoma volume reduction (at least 50%), functional outcome, as well as changes in quality of life, cognition, and headache severity.</p><p><strong>Conclusions: </strong>CHESS is the first randomized controlled trial to characterize the safety and efficacy of standalone MMAE compared to conventional surgery in a moderately-symptomatic CSDH patient population. Results of this trial will further advance the role of endovascular approaches to CSDH treatment.</p>","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of High-Intensity Interval Training with Short Bursts of Work (≤30s) on Body Composition and Exercise Capacity in Overweight or Obese Adults: A Systematic Review","authors":"","doi":"10.29011/2688-8734.100177","DOIUrl":"https://doi.org/10.29011/2688-8734.100177","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"23 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of High Intensity Interval Training in Atrial Fibrillation: A Literature Review","authors":"","doi":"10.29011/2688-8734.100175","DOIUrl":"https://doi.org/10.29011/2688-8734.100175","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"13 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of High Intensity Interval Training in Atrial Fibrillation: A Literature Review","authors":"","doi":"10.29011/2688-8734.100175","DOIUrl":"https://doi.org/10.29011/2688-8734.100175","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"74 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility of Lateral Externally-Induced Perturbation Training in Fall Prevention after Stroke","authors":"","doi":"10.29011/2688-8734.100174","DOIUrl":"https://doi.org/10.29011/2688-8734.100174","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140492085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-hospitalar Factors Associated with Delayed Arrival of Stroke Patients in Emergency Room in Brazil","authors":"","doi":"10.29011/2688-8734.100173","DOIUrl":"https://doi.org/10.29011/2688-8734.100173","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"100 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Intravenous Thrombolysis for Acute Ischemic Stroke of the Anterior Circulation in a Patient Taking Ticagrelor: A Case Report and Literature Review","authors":"","doi":"10.29011/2688-8734.100172","DOIUrl":"https://doi.org/10.29011/2688-8734.100172","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"45 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140504392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Cerebral Microinfarcts and Dementia by Sex: Findings from a community-based Autopsy Study","authors":"","doi":"10.29011/2688-8734.100171","DOIUrl":"https://doi.org/10.29011/2688-8734.100171","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treadmill Integrated Robot-assisted Ankle Dorsiflexion Training for Stroke Rehabilitation: A Pilot Randomized Controlled Trial","authors":"","doi":"10.29011/2688-8734.100170","DOIUrl":"https://doi.org/10.29011/2688-8734.100170","url":null,"abstract":"","PeriodicalId":92795,"journal":{"name":"International journal of cerebrovascular disease and stroke","volume":"62 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}