Annals of lung cancer最新文献

{"title":"The Risk of Developing Coal Workers' Pneumoconiosis in a German Inception Cohort of Coal Miners of Ruhr Area - Results after 30 Years of Follow-up","authors":"Y. M, Anderle L, L. H, Derwall R, Brand D, Morfeld P","doi":"10.36959/825/577","DOIUrl":"https://doi.org/10.36959/825/577","url":null,"abstract":"","PeriodicalId":92751,"journal":{"name":"Annals of lung cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48486777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and Grades vs. Costs and Values of Nivolumab in Cancer; The Impact of PD-L1 Positivity","authors":"Guirgis Helmy M","doi":"10.36959/825/576","DOIUrl":"https://doi.org/10.36959/825/576","url":null,"abstract":"","PeriodicalId":92751,"journal":{"name":"Annals of lung cancer","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44182788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There an Increased Risk of Lung Cancer among the Chinese Silica Cohort? - The Influence of Occupational Confounders","authors":"S. Yi, B. Frank","doi":"10.36959/571/714","DOIUrl":"https://doi.org/10.36959/571/714","url":null,"abstract":"To evaluate a possible influence of confounding in risk estimation for lung cancer in relation to silica dust exposure, we re-analyze a recently published exposure-response relationship using a sub-cohort of Chinese tungsten miners which has no relevant occupational confounders. The cohort of tungsten miners consisted of 19,007 workers in six tungsten mines with a follow-up period from January 1, 1960 to December 31, 2003. Cumulative silica dust exposure was estimated by linking the work history to the job-exposure matrix. The time-dependent Cox proportional hazards model was used for exposure-response analysis. Analysis of the cohort of tungsten miners does not deliver a clear exposure-response relationship between silica dust exposure and lung cancer deaths. The Chinese silica cohort fails as yet to provide clear evidence of a dose-response relationship between silica dust exposure and lung cancer risk in the absence of occupational confounding factors.","PeriodicalId":92751,"journal":{"name":"Annals of lung cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69788507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Quantitative Assessment of Lung Tumor Motion under Abdominal Compression using 4D-CT Imaging","authors":"M. Dennis, G. Jorge, Malhotra Harish K","doi":"10.36959/571/713","DOIUrl":"https://doi.org/10.36959/571/713","url":null,"abstract":"Stereotactic Body Radiation Therapy (SBRT) has rapidly emerged as a curative procedure for early stage non-small cell lung cancer (NSCLC). The ablative hypo-fractionated radiation doses used with SBRT requires very small tumor margins, making tumor motion management very important to reduce the risk of long term morbidity. However, in conventional free-breathing situations, lung tumors can reportedly move up to 2.5 cm requiring a large treatment margin. In this clinical study, we analyzed the efficacy of using simple abdominal compression to dampen and suppress tumor motion. Sixty-five patients treated with SBRT between 2009 and 2013 were investigated. Patients were anatomically categorized based on lung lobe location as follows: 17 had lesions appearing in the right upper lobe (RUL), 7 in right middle lobe (RML), and 18 in right lower lobe (RLL), 14 in left upper lobe (LUL) and 9 in left lower lobe (LLL). 4D-CT data sets were acquired using a GE RT16 CT scanner with a 1.25 mm slice width in conjunction with a Varian’s Real-time Position Management (RPM) system. On the GE Advantage 4D workstation, images were binned in 10 phases, T00 being the maximum inspiration phase & T50, the maximum expiration phase. The tumor volume was segmented at its centroid position using the CT-lung window. Tumor displacement was then measured from phase to phase in all three directions superior-inferior, anteriorposterior & medial-lateral. The mean tumor movement in each lobe was as follows: RUL = 3.8 ± 2.0 mm (mean ITV: 9.1 cm3), RML = 4.7 ± 2.8 mm (mean ITV: 9.2 cm3), RLL = 6.6 ± 2.6 mm (mean ITV: 12.2 cm3), LUL = 3.8 ± 2.4 mm (mean ITV: 18.5 cm3), & LLL = 4.7 ± 2.5 mm (mean ITV: 11.9 cm3). These results show tumor motion is anatomic (lobe) location dependent, specifically the magnitude of motion increases as the target nears the diaphragm. Furthermore, we found tumor amplitude to be respiratory cycle dependent as well, generally decreasing for shorter cycle duration. For RUL lesions, a strong correlation between the ranges of tumor movement with respect to respiratory cycle was noticed. Besides, for RML & RLL tumors, a linear correlation between the ratio of GTV50 volume with ipsilateral lung volume vs. tumor motion has been found [R2 > 0.9]. No tumor motion dependence on the tumor size was seen. The present study has demonstrated the usefulness of a simple abdominal compression in the management of NSCLC using radiotherapy.","PeriodicalId":92751,"journal":{"name":"Annals of lung cancer","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47482950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}