Sokoto journal of medical laboratory science最新文献

{"title":"Human Papillomavirus Genotype and DNA Methylation of TP53, PIK3CA as Integrated Biomarkers forOropharyngeal Carcinogenesis - AReview","authors":"Garba Yahaya, E. Odigie, I.A. Abubakar, B. Ogeyemhe, N. T. Omorodion, H.A. Halliru","doi":"10.4314/sokjmls.v9i1.1","DOIUrl":"https://doi.org/10.4314/sokjmls.v9i1.1","url":null,"abstract":"No Abstract","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"76 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiogram and Molecular Characterization of Extended Spectrum Beta-Lactamase Producing Escherichia coli Isolates in General Hospital, Ilorin","authors":"Bolarinwa Korede, Toyeeb Olawale Mohammed, AbdulAziz Abubakar","doi":"10.4314/sokjmls.v9i1.12","DOIUrl":"https://doi.org/10.4314/sokjmls.v9i1.12","url":null,"abstract":"No Abstract.","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"19 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140981568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of Bacteria Contamination In Selected Fruits and Vegetables Sold in Uselu Market, Benin City, Edo State","authors":"Z. Omoruyi, E. Nosa-Cole","doi":"10.4314/sokjmls.v9i1.24","DOIUrl":"https://doi.org/10.4314/sokjmls.v9i1.24","url":null,"abstract":"No Abstract","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"85 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Factors Associated with Malaria Infection Among Children Under-5 Years Who Received SMC 1","authors":"Muslim Adamu, Abdullahi Sabo Muhammad, Yahaya Saleh","doi":"10.4314/sokjmls.v9i1.5","DOIUrl":"https://doi.org/10.4314/sokjmls.v9i1.5","url":null,"abstract":"No Abstract","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Antiplasmodial and Antityphoid Activity of Extract from Guava, Paw-Paw and Mango Leaves","authors":"Auwal Shitu, Muhammad Ibrahim Usman","doi":"10.4314/sokjmls.v9i1.6","DOIUrl":"https://doi.org/10.4314/sokjmls.v9i1.6","url":null,"abstract":"No Abstract","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"25 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140981081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory Effects of Vitamin D3 on the Expression of IL-6, IFN-ã and T-BET in Inflammatory Bowel Diseases","authors":"H.M. Alhassan, A.S. Yaraghi","doi":"10.4314/sokjmls.v9i1.16","DOIUrl":"https://doi.org/10.4314/sokjmls.v9i1.16","url":null,"abstract":"No Abstract","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Water Sources from Some Selected Healthcare Facilities in Calabar Metropolis, Cross RiverState, Southern Nigeria","authors":"M. Mbah, S. S. Akpan, N.O. Njok","doi":"10.4314/sokjmls.v9i1.10","DOIUrl":"https://doi.org/10.4314/sokjmls.v9i1.10","url":null,"abstract":"No Abstract","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"98 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of endothelial dysfunction in streptozotocin-induced diabetic Sprague-Dawley rats: Nitric oxide in focus","authors":"M.L. Jidda, J.M. Bunza, M.K. Dallatu, L.S. Bilbis, A.J. Alhassan, Muhammad Yelwa Gwarzo, A.A. Ngaski, A.F. Chiroma, S.L. Kakako, Maryam Kasimu, B.M. Yale, M. Kasimu, S. Haruna, K.A. Ogunwale, A. K. Bello, Ibrahim Kalle Kwaifa","doi":"10.4314/sokjmls.v8i3.11","DOIUrl":"https://doi.org/10.4314/sokjmls.v8i3.11","url":null,"abstract":"Endothelial dysfunction in diabetes manifests in part as reduction of nitric oxide (NO) bioavailability, which leads to inadequate relaxation of the vascular smooth muscle and a disparity between the vasoconstrictive and vasorelaxant intracellular pathways which favours a rise in vasoconstriction. In this current work, we evaluated serum Nitric oxide (NO) concentration and the activity of Nitric oxide synthase (NOS) in streptozotocin-induced diabetic male and female rats' serum. Our results showed initial and final fasting blood glucose concentration 5.30±0.16mmol/l and 5.24±.015mmol/l versus 5.68±0.18mmol/l and 5.43±0.15mmol/l in male and female controls. Among the diabetic rats, the initial and final fasting blood glucose concentration was 17.50±1.91mmol/l and 15.68±2.84mmol/l versus 20.50±4.76mmol/l and 19.40±4.13mmol/l in male and female rats respectively. NO concentration was 106.12±7.23μmol/l and 131.81±12.54 μmol/l in male and female control rats compared to 52.38±3.01μmol/l and 65.29±16.19 μmol/l in male and female diabetic rats respectively. Serum activity of NOS were 133.72±10.92μIU/l and 156.06±18.22 μIU/l in control male and female rats compared to 98.01±1.48 μIU/l, 78.89±8.39μIU/l in diabetic male and female rats respectively. The difference in both NO concentration and NOS activity was significant between diabetics and non-diabetic rats as well as between male and female diabetics rats (p< 0.05). The endothelial dysfunction in diabetic animals regardless of gender may be an initial pointer to upcoming pathogenesis and we recommend routine evaluation of NO concentration and NOS activities among diabetics.","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"3 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135166055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of selected biomarkers of bone healing and inflammation among subjects with fracture on traditional and conventional treatment methods","authors":"Ohiwerei Wisdom Omogbai, Mathew Folaranmi Olaniyan","doi":"10.4314/sokjmls.v8i3.6","DOIUrl":"https://doi.org/10.4314/sokjmls.v8i3.6","url":null,"abstract":"Abstract &#x0D; &#x0D; Fractures have significant implications for health. Treatment approaches vary, including traditional and conventional methods. This study in Ekpoma, Nigeria assessed biomarkers in fracture healing through a cross-sectional random sampling. Blood samples from 60 subjects were analyzed for hydroxyproline, creatinine, calcium, alkaline phosphatase, and C-reactive protein. The aim was to evaluate treatment effectiveness and improvement in patient outcomes by monitoring bone remodeling. Statistical analysis utilized is the SPSS software version 21.0 software (SPSS Inc., Chicago, IL, USA). Biochemical marker analysis revealed that serum alkaline phosphatase activity, calcium, and creatinine did not significantly differ between subjects without fractures and those with fractures (p>0.05). However, hydroxyproline levels exhibited a significant difference (p<0.05), with higher values observed in subjects with fractures. Additionally, C-reactive protein levels showed significant variations (p<0.05), indicating increased inflammation in fracture patients. High-sensitive C-reactive protein levels also displayed significant differences (p<0.05). Further analysis comparing male and female subjects without fractures and those with fractures revealed no significant variations in serum alkaline phosphatase, calcium, and creatinine levels (p>0.05). However, hydroxyproline levels demonstrated significant variations (p<0.05) between males and females in the fracture group, suggesting gender-specific differences in bone metabolism. C-reactive protein and High-sensitive C-reactive protein levels exhibited significant variations (p<0.05) between males and females in the fracture group. Furthermore, a comparison between patients on traditional and conventional treatment methods indicated significant variations in serum alkaline phosphatase activity and calcium levels (p<0.05), suggesting distinct effects of the treatment modalities on these markers. However, no significant differences were observed in creatinine, C-reactive protein, and high-sensitive C-reactive protein levels (p>0.05). Traditional and conventional fracture treatment methods may affect biochemical markers differently, with gender-specific variations in hydroxyproline, C-reactive protein, and high-sensitive C-reactive protein levels. Further research is needed to understand the clinical implications and underlying mechanisms of these findings.","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"22 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135166063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cardiac troponin I levels in adults with sickle cell disease visiting the University College Hospital, Ibadan, Nigeria","authors":"Richard Peter Akpan, Victoria Oluwabunmi Akpan","doi":"10.4314/sokjmls.v8i3.7","DOIUrl":"https://doi.org/10.4314/sokjmls.v8i3.7","url":null,"abstract":"Abstract significant association between troponin I level in&#x0D; &#x0D; Recurrent vaso-occlusive crisis and haemolysis normally affect the lifestyle of patients with sickle cell disease. This may occur for a few hours or some weeks, making many of them to require hospital admission and blood transfusion, with inevitable financial implications on care givers. Due to its tissue specificity, cardiac troponin I and T have been claimed to be important in detecting cardiac damage even in the presence of elevated total creatine kinase (CK) and CK-MB that can likely occur in exercise-induced skeletal muscle damage. The significance of cardiac assessment in sickle cell patients was emphasized in a previous report which showed that evidence of mortality related to cardiovascular causes was often encountered during autopsy. This study aimed at accessing serum cardiac Troponin I (cTnI) in adult patients with sickle cell disease at University College Hospital, Ibadan. After written consents were obtained, 131 individuals above 18 years were recruited, 95 of which were sickle cell disease subjects and 36 were non-sickle cell disease controls. Mean age was 35.4years±SD=7.54years with age range of 19 to 56years for the sickle celled subjects and 36.8years±SD=9.11years with age range of 19 to 58 years for controls. Male to female ratio was approximately 2:1 for control and 2.4 :1 for sickle cell subjects. A total of 4(4.2%) sickle cell patients had abnormal troponin I level. There was a significant difference in mean troponin I level between sickle cell subjects and control, but there was no significant association between troponin I and haematological parameters of the sickle cell patients. The likelihood of the sickle cell subjects developing crisis is low, but there was no significant association significant association between troponin I level in sickle cell subjects and their haematological parameters, while there was a significant difference in mean troponin I between Sickle cell subjects and non-Sickle cell controls.","PeriodicalId":92723,"journal":{"name":"Sokoto journal of medical laboratory science","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135166056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}