Bukovinian Medical Herald最新文献

{"title":"The state of hormonal balance in puberty girls with menstrual function disorders on the background of obesity","authors":"A. Borshulyak, O. Andriets, Y. Tsysar, A. Andriets","doi":"10.24061/2413-0737.xxv.4.100.2021.2","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.2","url":null,"abstract":"Menstrual disorders in puberty girls against the background of hormonal imbalance occupy a significant place in the structure of gynecological pathology since in the future, they can lead to stable and irreversible changes in the formation of the reproductive system.The purpose of the work - to study the state of hormonal balance in puberty girls against the background of obesity.Material and methods. 79 adolescent girls with impaired menstrual function on the background of obesity were examined and treated. All subjects were also given a comprehensive examination to determine the level of hormones in the blood serum.Results. It was found that obese adolescent girls have a clear difference in the severity of hyperandrogenic disorders of carbohydrate metabolism and insulin resistance.Conclusion. A clear relationship between the formation of menstrual function and the state of gonadotropic function of the pituitary gland is established. Changes in the hormonal profile of puberty girls were found against the background of obesity, namely hyperleptinemia and leptin resistance, which were corrected by non-drug and drug therapy.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87955417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the structural topography of the mandibular canal in case of bone atrophy using computed tomography","authors":"A. Oshurko, I. Oliinyk, N. Kuzniak, K. Yakovets","doi":"10.24061/2413-0737.xxv.4.100.2021.12","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.12","url":null,"abstract":"Objective. The place of CT should be noted in the study of bone tissue, which allows us to establish the features of the structural topography of the left and right mandibular canals in relation to its structures, get information about the structure of the external and internal cortical plates and determine densitometric values that indicate qualitative characteristics that reflect the type of bone density, even in its age dynamics.Aim of the research. The analysis of structural topographic features of the human mandibular canal in case of bone atrophy caused by terminal dentition defects. Material and methods. The paper provides morphometric studies in absolute values, as well as the location of the human mandibular canal with acquired adentia in the form of terminal dentition defects after paraclinical examination of digital records of 243 CT cone-digital images, which were scanned by the Vatech PaX-I 3D Green extra-oral radiography system with a scan size range of 16x9 cm, a focal spot of 0.5 mm (IEC60336) of a 14-bit gray scale with a size of 0.2/0.3 voxel. Results. The obtained average absolute values characterize the existing qualitative morphological transformations, although they require statistical analysis, but can be used in making clinical decisions on the rehabilitation of patients by dental implantation, osteosynthesis, or the use of other maxillofacial reconstructive operations. Conclusions. In case of preserved dental rows (the first group of studies) the topography of the right mandibular canal approaches the lingual surface on the ≈1.5 mm, which is limited only by the cortical layer of bone tissue, in case of acquired terminal dentition defects - ≈3.8 mm. The \"morphological transposition\" for the left mandibular canal in the first comparison group is ≈ 2.1 mm, however, in individuals with acquired terminal defects - ≈ 3.05 mm, with a distance to the middle from the outer cortical layer of the lingual surface of bone tissue.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84861935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial hypertension in rare endocrine pathology: practical observation","authors":"P. Liashuk, R. Liashuk","doi":"10.24061/2413-0737.xxv.4.100.2021.18","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.18","url":null,"abstract":"The article is devoted to the problem of arterial hypertension due to the rare pathology caused by excessive production of adrenal hormones on the example of its own clinical observations: ectopic ACTH-dependent Cushing's syndrome, primary aldosteronism, androsteroma, pheochromocytoma of the bladder. The issue of timely diagnosis and adequate treatment of these diseases remains one of the urgent tasks of clinical medicine.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74313898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Odontogenic stem cells and their prospects in practical use (literature review)","authors":"O. Godovanets, Т. Kitsak, K. Halchuk, E. Sauka","doi":"10.24061/2413-0737.xxv.4.100.2021.20","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.20","url":null,"abstract":"Objective. To analyze the latest literature data on the possibilities of using stem cells of odontogenic origin in the practice of regenerative medicine.Material and methods. The bibliosemantic method was applied, and the structural-logical analysis of the received data was carried out. Electronic databases such as PubMed, MEDLINE, Scopus, Web of Science and EMBASE were used for modern scientific literature searching by keywords «regenerative medicine», «regenerative dentistry», «dental mesenchymal stem cells», «stem cell therapy», «dental pulp stem cells».Results. Stem cells derived from the maxillofacial area differ in origin, differential activity and obtaining source. These cell populations have significant potential for cell line differentiation. It is possible to establish their origin by identifying the expression of stem cell markers during the process of receiving a new pure culture. Scientific research in the field of regenerative medicine has shown that the use of stem cells for therapeutic purposes has a positive therapeutic effect on the illnesses of the gastrointestinal tract, musculoskeletal system, and dental diseases of various etiologies. However, further studies of the possibilities to use these cells during the stages of clinical trials remain relevant.Conclusions. To sum up, based on the literature’s analysis, there is a significant interest in scientific and practical medicine for stem cells of odontogenic origin because there are perspectives for their use both in dentistry and in other branches of medicine.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82548105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of use of bone augmentation materials based on multipotent mesenchymal stromal cells of adipose tissue before dental implantation in patients of study groups","authors":"A. Bambuliak, N. Kuzniak, L. Lopushniak, R. Dmytrenko, O. Boichuk","doi":"10.24061/2413-0737.xxv.4.100.2021.1","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.1","url":null,"abstract":"Objective. To determine the effectiveness of bone augmentation materials based on multipotent mesenchymal stromal cells of adipose tissue, which were used to fill bone defects during dental operations before dental implantation in patients of the study groups.Materials and methods. Examination and treatment with dental implants were performed on 140 patients who had previously undergone surgery to increase the bone volume of the alveolar processes of the jaws with the use of various bone augmentation materials. All patients were divided into three groups: I (main) group – 49 people (35.0%), in whom the material “Colapan–L” was used to restore the bone tissue of the alveolar processes; II (main) group – 62 patients (44.29%), in whom the augmentation of bone defects was performed using our proposed composition: the drug “Colapan–L”, multipotent mesenchymal stromal cells of adipose tissue and platelet-rich plasma; group III (control) – 29 patients (20.71%) in whom wound healing occurred under a blood clot (spontaneous).Results. It was found that in patients in whom a combination based on multipotent mesenchymal stromal cells of adipose tissue, the drug “Colapan–L”and platelet-rich plasma was used to fill bone defects, peri-implant tissues were completely restored after dental implantation.Conclusions. The effectiveness of our proposed osteoplastic combination based on multipotent mesenchymal stromal cells of adipose tissue, the drug “Colapan–L” and platelet-rich plasma in patients was confirmed by the positive dynamics of the periodontal index PMA, Schiller–Pissarev test. The use of bone augmentation materials based on multipotent mesenchymal stromal cells of adipose tissue during dental operations improves the regenerative and reparative properties of the bone tissue of the jaws, facilitates the postoperative course and reduces the duration of inpatient treatment of patients.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91104080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of lipin administration in a comprehensive treatment of community-acquired pneumonia associated with Covid-19","authors":"Yu. Novychenko, O. Khukhlina, S. Kovalenko, I. Dudka","doi":"10.24061/2413-0737.xxv.4.100.2021.11","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.4.100.2021.11","url":null,"abstract":"Objective. Тo investigate the effectiveness of Lipin-Biolik therapy on a clinical course of moderate pneumonia associated with COVID-19 as a supplement to the basic therapy at the Department of Pulmonology. Materials and methods. 94 case histories of institutional patients who were treated at the Department of Pulmonology, Chernivtsi Regional Clinical Hospital during 2020-2021 were examined. The patients were divided into two groups: 66 individuals with viral-bacterial pneumonia of a moderate severity associated with COVID-19 (the main group). Their treatment included antibiotics, anticoagulants and intravenous injection of Lipin solution. The control group included 28 patients suffering from pneumonia who received antibiotics and anticoagulants only.Results. Condition of patients after treatment improved in both groups, but in the main group, it was faster than in control one (4-5 faster): shortness of breath decreased, D-dimer in the blood reduced, high blood pressure and the temperature came to normal values, О2 saturation improved. Moreover, by the chest X-ray findings carried out three weeks after treatment, the patients from the main group presented a faster decrease of infiltration areas in the lungs and formation of stable fibrous changes, respectively.Conclusions. The results presented in the article confirm a high effect of Lipin (liposomal forms of natural phosphatidylcholine) for the treatment of viral pneumonias in practical work of a pulmonologist with the aim to reduce the risk of fibrosis formation in the lung tissue, the risk of clot formation and as surfactant-protective therapy.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88784872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topographic and anatomical characteristics of the bladder neck in early fetuses","authors":"D. Proniaiev, I. Kashperuk-Karpiuk, V. Proniaiev, S. Riabyi","doi":"10.24061/2413-0737.xxv.3.99.2021.14","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.3.99.2021.14","url":null,"abstract":"Aim. To determine macro-and microscopic anatomical characteristics and the dynamics in topographic and anatomical interactions of the bladder neck with adjacent organs and structures at the beginning of the fetal period. Material and methods. The study was carried out on 70 fetal specimens. The age of subjects included in the study was determined according to the tables of B.M. Patten, B.P. Khvatova, Yu.N. Shapovalov based on measurements of the parietal-calcaneal length (PCL), taking into account the Instructions for determining the perinatal period, live birth, and stillbirth criteria, approved by Order of the Ministry of Health of Ukraine No. 179 dated March 29, 2006. To achieve this goal, the following methods of anatomical research were used: anthropometry - to determine the age of the studied subjects; injection of arterial vessels with subsequent dissection under the control of a microscope – to study the peculiarities of the blood supply to the vesicoureteral segment; radiography - to determine the skeletotopy of the vesicoureteral segment; macro-microscopy – to explore the anatomical relationships of the components of the vesicoureteral segment, their structure, shape, position; histological – to study the structure of the wall of the vesicoureteral segment; morphometry – to determine the morphometric parameters of the vesicoureteral segment; 3-D reconstruction method – to study the spatial structure of the vesicoureteral segment; statistical – to analyze and establish the reliability of differences in organometric parameters.Results. Skeletopically, the projection of the vesicoureteral junction of early fetuses is located at the level of the upper third of the pubic symphysis. At the beginning of the perinatal period in female fetuses, the bladder neck (6.9 ± 2.6 mm) is longer than in male fetuses (6.4 ± 2.4 mm). Based on the analysis and generalization of the research results, it is substantiated that at the beginning of the fetal period, the internal urethral sphincter can be formed: a) by two loops of the outer longitudinal layer; b) the ring of the circular layer and the front bundles of the outer longitudinal layer; c) anterior bundles of the outer longitudinal layer and transverse bundles of the inner longitudinal layer within the trigone of urinary bladder; d) a ring of the circular layer, thickened in the anterolateral sections.Conclusions. Considering the topographic and anatomical characteristics of the angio- and myoarchitectonics of the vesicoureteral segment, we believe that its role as a physiological sphincter of the lower urinary tract is provided by the interaction of the vascular and muscle components. The vascular component of the sphincter apparatus of the vesicoureteral segment is provided by veins located in three layers: 1) cavernous-like veins of the submucosa; 2) veins of the muscular membrane; 3) veins of tunica adventitia. The second anatomical component of the sphincter function of the vesicoureteral segment ","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78879926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of deforming osteoarthritis in the family doctor practice","authors":"A. Lehkun, L. Sydorchuk, A. Zaremska","doi":"10.24061/2413-0737.xxv.3.99.2021.8","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.3.99.2021.8","url":null,"abstract":"Osteoarthritis (OA) is the most common bone and joint pathology, affecting, according to the American College of Rheumatology ACR (2019), about 302 million people worldwide and is the leading cause of disability in the elderly.Objective. To investigate the role of additional risk factors in patients with OA in the practice of family physicians for secondary prevention.Material and methods. A retrospective analysis of 50 outpatient records and electronic medical records (EMC) of patients with OA for 2019-2020 was performed: 30 women, 20 men; aged 35-75 years. Concomitant risk factors were studied by epidemiological analysis: obesity / overweight, burdensome family history, traumatic factor, occupational exposure.Results. The respiratory and circulatory systems diseases dominate in the structure of the primary morbidity of the Northern Bukovina inhabitants in 2020. The incidence of bone and joint is 4.04% in the general structure, which does not differ significantly from the European average. The structure of the primary morbidity of the bone and joint sphere is dominated by arthrosis and deforming OA (DOA). The injuries and occupational factors dominated in structure of DOA risk factors at the age under 50, but after 50 years – obesity and burdened heredity prevailed, with a significant impact of the occupational factor. Absence of injuries in the anamnesis and occupational factors reduce the risk of DOA 8 and 3.5 times, respectively (p<0.05). Age over 60 years increases the relative risk of DOA 2.5 times as much (p=0.013), especially in women to almost 4 times.Conclusions. Additional risk factors should be considered in patients with DOA for secondary prevention.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89494974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunosupressive activity of opportunist pathogens of the infectious-inflammatory process in the urinary tract of men with calculous pyelonephritis","authors":"L. Sydorchuk, O. Gavrilyuk, S. Deineka, A. Mikheev, R. Sydorchuk, O. Blinder, I. Sydorchuk","doi":"10.24061/2413-0737.xxv.3.99.2021.16","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.3.99.2021.16","url":null,"abstract":"Objective - identification of pathogens of the infectious-inflammatory process of the urinary tract in men with calculous pyelonephritis, antilysozyme, anticomplementary, anti-immunoglobulin activity and inhibitory effect on the phagocytic activity of peripheral blood neutrophils.Material and methods. 34 strains of opportunistic taxa were isolated and identified by bacteriological method from 30 sick men aged 31 to 65 years (mean age 48.8 ± 4.27 years). These bacteria have antilysozyme, anti-complementary and anti-immunoglobulin activity, as well as the suppressive effect of supernatants of cultures of calculous pyelonephritis pathogens on the phagocytic activity of neutrophils in the peripheral blood of patients. The determination of the anti-complementary activity of bacteria was carried out using the principle, which includes testing the protective action of bacteria and their metabolic products against the growth of an indicator strain in the presence of a bactericidal substance (complement of blood serum). The antilysozyme activity of pathogens was investigated by a photometric method. Anti-immunoglobulin activity was studied by the method described in the work of I.S. Gaidash et al. Results. The majority of 27 (79.41%) isolated strains of Enterobacteriaceae (84%) and facultative anaerobic and aerobic gram-positive cocci (E. faecalis, S.saprophyticus) (66.67%) exhibit antilysozyme activity of varying degrees. The highest antilysozyme activity was found in the isolated strains of K. pneumoniae, 8.14% lower – in E. coli. Most (64.71%) of isolated strains of Enterobacteriaceae (68%) and gram-positive cocci (55.56%) from the urinary tract of men with calculous pyelonephritis exhibit anti-complementary activity. All isolated and identified taxa exhibit inhibitory activity against immunoglobulins of the main classes: Ig M, Ig G, and Ig A. K.pneumoniae inhibits immunoglobulins of all major classes, the concentration of Ig M decreases under the influence of this taxon by 22.36%, Ig G - by 26.88% and Ig A - by 19.61%.Conclusions. Opportunistic pathogens (E. coli, K. pneumoniae, P. mirabilis, E. cloaceae, S. marcescens, E. faecalis, S. saprophyticus) of the infectious-inflammatory process of the urinary tract in men with calculous pyelonephritis exhibit different levels of antilysozyme, anti-complementary activity; reduce the function of immunoglobulins Ig G (by 21.60%), Ig A (by 21.49%) and Ig M (by 14.30%), inhibit the phagocytic activity of neutrophilsby 15.74%, their capturing ability- by 22.59%.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74546571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of pregnancy complications and delivery at low placentation","authors":"S. Pecheriaha, I. Marynchyna","doi":"10.24061/2413-0737.xxv.3.99.2021.13","DOIUrl":"https://doi.org/10.24061/2413-0737.xxv.3.99.2021.13","url":null,"abstract":"Objective is to evaluate the effectiveness of the developed method of preventing pregnancy complications with low placentation from early gestation.Material and methods. We have examined 119 pregnant women with low placentation. This diagnosis was made at 6-7 weeks of gestation on the basis of echographic research. The main group consisted of 64 pregnant women with low chorionic location who underwent prevention from pregnancy complications in early gestation by the complex of medicines developed by us and a control group -55 women with low placentation who had not undergone complications prophylaxis from early gestational periods. The prophylactic complex included Luteina, ginkgo biloba extract, folio and biolectra. To assess the effectiveness of the therapy in the study groups, we analyzed the course of pregnancy in early and late gestation, as well as complications of pregnancy and delivery.Results. The frequency of pregnancy pathologies in the main group, where the prevention of pregnancy complications from early gestation with low placentation, was significantly lower than in the control group. According to the study, the risk of abortion with bleeding and without bleeding in the first and second trimesters significantly decreased in the main group of pregnant women (p<0.05). In the third trimester of gestation in the group where the prevention of pregnancy complications was significantly reduced, the incidence of preterm birth, premature detachment of the low-lying placenta, fetoplacental dysfunction, fetal developmental delay syndrome and fetal distress during pregnancy (p<0.05). Also, in the main group there was a lower percentage of premature births and births that ended by cesarean section.Conclusions. 1. The place of attachment of the placenta in the uterine cavity is closely related to its function, the development of placental dysfunction, pregnancy and delivery. 2. Studies have shown the effectiveness of our proposed comprehensive drug prevention of complications of pregnancy with low placentation, which in turn has led to improved pregnancy and delivery and has become an effective means of preventing placental dysfunction.","PeriodicalId":9270,"journal":{"name":"Bukovinian Medical Herald","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72753145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}