Precision nanomedicine最新文献_第2页

Comment on article "Development of copper nanoparticles and their prospective use in the pharmaceutical sector” Vol. 6, Issue 2, 2023 by Tyagi et al. 评论 Tyagi 等人撰写的文章 "纳米铜粒子的开发及其在制药领域的应用前景"（第 6 卷第 2 期，2023 年）。

Precision nanomedicine Pub Date : 2023-11-15 DOI: 10.33218/001c.90170

Dipanjan Pan

引用次数: 0

Green Synthesized Nanoparticle Based Drug Delivery: Recent Trends and Future Prospects 基于绿色合成纳米颗粒的给药:最新趋势和未来展望

Precision nanomedicine Pub Date : 2023-10-19 DOI: 10.33218/001c.89165

Aparna Kaushik, Ravi Kant Singh, Pankaj K. Tyagi

{"title":"Green Synthesized Nanoparticle Based Drug Delivery: Recent Trends and Future Prospects","authors":"Aparna Kaushik, Ravi Kant Singh, Pankaj K. Tyagi","doi":"10.33218/001c.89165","DOIUrl":"https://doi.org/10.33218/001c.89165","url":null,"abstract":"This review highlights the scope for integrating green nanoparticle-based drug-delivery systems with Ayurveda and presents a compelling opportunity to bridge ancient healing wisdom with modern scientific advancements by bringing forward the recent advancements in the field of Ayurveda and nanomedicine. Combining the principles of Ayurveda with green nanoparticles offers an eco-friendly approach to drug delivery, aligning with Ayurvedic emphasis on natural remedies and sustainable practices. This convergence could lead to the development of envi-ronmentally conscious therapeutic solutions. The potential for enhanced therapeutic efficacy through targeted delivery of Ayurvedic bioactive compounds using green nanoparticles holds promise. This could potentially optimize treatment outcomes and reduce side effects, aligning with Ayurveda’s holistic approach to healing. By encapsulating Ayurvedic ingredients within green nanoparticles, the bioavailability and stability of herbal compounds can be addressed, po-tentially unlocking their full therapeutic potential. This aligns with Ayurvedic teachings on opti-mal absorption and assimilation of remedies. The personalized and targeted approach of Ayur-veda, combined with the precision of green nanoparticle-based drug delivery, could usher in a new era of individualized medicine. This convergence represents a powerful example of how the synergy between traditional knowledge and scientific progress can drive transformative ad-vancements in medicine.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135778467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Sublingual Tablet Quality through QbD: Current Trends and Insights" 通过QbD提高舌下片剂质量:当前趋势和见解

Precision nanomedicine Pub Date : 2023-09-24 DOI: 10.33218/001c.88223

Deepak Joshi, Naveen K Choudhary

引用次数: 0

Injectable nanogel systems for brain drug delivery 用于脑部药物输送的可注射纳米凝胶系统

Precision nanomedicine Pub Date : 2023-09-23 DOI: 10.33218/001c.88217

MANZOOR KOYAKUTTY, Greeshma Devassy, Devika Das, Shantikumar V Nair

{"title":"Injectable nanogel systems for brain drug delivery","authors":"MANZOOR KOYAKUTTY, Greeshma Devassy, Devika Das, Shantikumar V Nair","doi":"10.33218/001c.88217","DOIUrl":"https://doi.org/10.33218/001c.88217","url":null,"abstract":"<img src=” https://s3.amazonaws.com/production.scholastica/article/88217/large/prnano_912023ga.jpg?1695507286”> The central nervous system (CNS) controls many critical functions, such as intelligence, emotion, sense, and memory, and modulates many other functions of the entire human body. Diseases affecting the CNS are challenging to treat because of the CNS’s sensitive functional and structural features and limited accessibility. The brain is secured from the systemic circulation by a unique biological fence, the blood-brain barrier (BBB), that limits molecular exchange between the peripheral and CNS systems. Most drugs used for treating CNS diseases fail to reach the brain in effective therapeutic concentrations due to the presence of BBB. During the last decade, specifically engineered drug delivery systems (DDS) have offered the opportunity to overcome systemic barriers in brain drug delivery. However, even with the best-engineered nano-carriers, delivering sufficient drug doses into the brain through systemic circulation remains challenging. Here, we review various systems for ‘direct’ drug delivery to the brain using im-plantable or injectable intracranial nano-drug delivery systems (nDDS), which can ensure 100% release of drug to the brain in a sustained or controlled fashion for prolonged periods, bypassing the BBB, thereby radically improving the therapeutic efficacy while minimizing systemic toxicity. Brain injectable nanogels or nanoparticle systems can be considered superior compared to other local drug-delivery systems because they possess better diffusivity of drugs. The nanogels can be injected through minimally invasive procedures, precisely delivering drugs to specific target sites. This review covers a detailed discussion about locally injectable DDS and various nanogel-based drugs, oligonucleotide, and theragnostic delivery systems used for treating brain malignancies, infections, and neurodegenerative diseases.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135959271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyanine lipids promote shedding of extracellular vesicles from cell membranes 花青素脂质促进细胞外囊泡从细胞膜脱落

Precision nanomedicine Pub Date : 2023-09-15 DOI: 10.33218/001c.88009

Dmitri Simberg, Hanmant Gaikwad, David Siegel, Ashlynn Barnes, Masamitsu Kanada, Chun Wan, Jingshi Shen, Irina Balyasnikova

{"title":"Cyanine lipids promote shedding of extracellular vesicles from cell membranes","authors":"Dmitri Simberg, Hanmant Gaikwad, David Siegel, Ashlynn Barnes, Masamitsu Kanada, Chun Wan, Jingshi Shen, Irina Balyasnikova","doi":"10.33218/001c.88009","DOIUrl":"https://doi.org/10.33218/001c.88009","url":null,"abstract":"<img src=” https://s3.amazonaws.com/production.scholastica/article/88009/medium/prnano_1052023ga.jpg?1694809016”> Extracellular vesicles (EV) have garnered significant attention in the fields of drug delivery, imaging, and immunotherapy. There is a need in methods to enhance release of EVs from cells. We found that at high labeling concentrations (100µM), indocarbocyanine lipids DiD and DiR that are commonly used for labeling cells, nanoparticles and EVs, promoted shedding of cell membrane tetraspanins with concomitant release of EVs in the medium. To further investigate this phenomenon, we screened a library of lipids and liposomal formulations for the release of membrane marker CD63 from THP-1 cells, and membrane red nanolantern (RNL) from 4T1 cells. We found a strong dependency of the EV release on lipid structure. In general, lipids that had a cyanine headgroup were more efficient than PEGylated phospholipids, neutral and cationic liposomes, with some lipids enhancing the release of CD63 up to 4-fold, and of RNL up to 8-fold, over vehicle treated control. A side-by-side comparison of cyanine lipid derivatives and corresponding precursor lipids confirmed that the cyanine headgroup significantly promoted shedding of RNL. Mutation of an exosome biogenesis regulator UNC13D did not hinder the release. Lipid-released EV could be modified with anti-interleukin 13 receptor alpha 2 antibody and targeted to glioma cells, suggesting potential utility in drug delivery. Furthermore, the impact of extraneously added lipids on cell membrane integrity should be carefully considered in cell labeling and drug delivery applications.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector 铜纳米颗粒的开发及其在制药行业中作为抗氧化剂、抗菌剂和抗癌剂的潜在用途

Precision nanomedicine Pub Date : 2023-07-07 DOI: 10.33218/001c.83932

P. Tyagi, A. Arya, Avijit Mazumder, Shruti Tyagi

{"title":"Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector","authors":"P. Tyagi, A. Arya, Avijit Mazumder, Shruti Tyagi","doi":"10.33218/001c.83932","DOIUrl":"https://doi.org/10.33218/001c.83932","url":null,"abstract":"In this study, we review the synthesis of copper nanoparticles (CuNPs) and their prospective uses as antioxidants, antimicrobials, and anticancer agents in the pharmaceutical sector. Copper nanoparticles could be created through a variety of methods, including chemical reduction, green synthesis, physical methods, electrochemical deposition, and the microemulsion method. These methods make it possible to precisely create nanoparticles with the necessary shapes, sizes, and surface properties, which in turn affect how well they perform biologically. CuNPs have strong antioxidant properties because they can scavenge reactive oxygen species (ROS) and prevent oxidative damage. In addition to their antioxidant properties, CuNPs show antibacterial activity against a number of microbes, including bacteria, fungi, and viruses. The potential of CuNPs as an anticancer agent has also been extensively investigated. These nanoparticles have toxic effects on a variety of cancer cell lines by inducing apoptosis, inhibiting cell proliferation, and preventing tumour angiogenesis. Because of their specific toxicity towards cancer cells while protecting normal cells, they provide the fascinating potential for tailored therapy to overcome multidrug resistance. CuNPs have also been studied in relation to their usage in medications. They may be utilised to improve drug delivery systems, wound healing, diagnostic imaging, immunotherapy, and anti-inflammatory and antioxidant effects. They can also be used to improve pharmaceutical stability, bioavailability, and provide controlled release. More research is needed to ensure their safety, enhance their synthesis processes, and explore their full potential in therapeutic situations","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49496762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Application of Nanotechnology and Nanomaterials in Depression: An Updated Review 纳米技术和纳米材料在抑郁症中的应用进展

Precision nanomedicine Pub Date : 2023-06-28 DOI: 10.33218/001c.82215

K. Yadav, A. Rani, P. Tyagi, M. Babu

{"title":"The Application of Nanotechnology and Nanomaterials in Depression: An Updated Review","authors":"K. Yadav, A. Rani, P. Tyagi, M. Babu","doi":"10.33218/001c.82215","DOIUrl":"https://doi.org/10.33218/001c.82215","url":null,"abstract":"Depression is the most common stress-related mental illness. It has an impact on millions of individuals globally. Genetic, biochemical, environmental, and psychological elements can all play a role in its development. Medications, psychotherapy, and lifestyle changes are frequently used to treat depression. Antidepressant medications work by altering the levels of certain chem-icals in the brain. At the same time, psychotherapy aims to help individuals better understand and manage their emotions and thoughts, which otherwise may lead to depression. The current treatment strategy for the illness has several drawbacks, such as adverse effects, ineffectiveness, long-term use, stigma, and cost-related issues of the medication used. These negative effects un-derscore the need for more successful and novel methods of treating depression, such as the investigation of medication delivery techniques based on nanotechnology. Increased medication effectiveness, fewer side effects, long-lasting medication effects, a good understanding of the neural underpinnings of depression, and the potential for the creation of personalized medicines are some of the potential benefits of using nanotechnology in depressive disorder treatment. In several scientific domains, nanotechnology has many benefits. Nanoparticles are the fundamen-tal building blocks of nanotechnology in this regard. Nanoparticles hold great promise for use in medical applications, as recently developed nanotechnology has shown. This review focuses on the most popular nanomaterials that are used to treat depression, in addition to how well these nanomaterials are at managing depression based on their physical, chemical, and biological properties. We have also talked about the difficulties that the various nanomaterials face, which limit their uses and prevent the development of effective clinical therapies.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42702711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Amyloid cascade hypothesis for Alzheimer’s disease. Does it work under physiological conditions? 阿尔茨海默病的淀粉样蛋白级联假说。它在生理条件下起作用吗?

Precision nanomedicine Pub Date : 2023-06-07 DOI: 10.33218/001c.77826

Y. Lyubchenko

{"title":"Amyloid cascade hypothesis for Alzheimer’s disease. Does it work under physiological conditions?","authors":"Y. Lyubchenko","doi":"10.33218/001c.77826","DOIUrl":"https://doi.org/10.33218/001c.77826","url":null,"abstract":"Plaques in the brain consisting of proteins are a hallmark of diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD). Such aggregates can be assembled spontaneously by specialized proteins such as amyloid beta (A β) proteins in the case of AD. Numerous in vitro studies made a foundation for the Amyloid Cascade Hypothesis (ACH), according to which the misfolding of proteins leads to their self-assembly into toxic oligomers along with the formation of amyloid fibrils assembled as plaques in the brain. Notably physiological concentration of A β proteins in the brain is in the low nanomolar concentration, so no spontaneous aggregation of A β protein occurs at such conditions, questioning the validity of the ACH model. However, recent studies revealed that surfaces could play a role as a catalyst of the aggregation process, so self-assembly of A β can be observed at physiologically low concentrations of A β proteins, although no spontaneous aggregation occurs in the bulk solution. The catalytic property of membrane surfaces towards A β aggregation depends on the membrane composition. This finding suggests a number of novel ideas on molecular mechanisms of amyloid self-assembly, which lay a foundation for the development of treatments and preventions for AD, as discussed in this article.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46663141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are we there yet? 我们到了吗?

Precision nanomedicine Pub Date : 2023-03-28 DOI: 10.33218/001c.74009

Lajos P Balogh

引用次数: 0

Polymeric nanocarriers co-encapsulating PET probes and protein therapeutics 高分子纳米载体共包封PET探针与蛋白质治疗

Precision nanomedicine Pub Date : 2022-12-13 DOI: 10.33218/001c.57619

Chester E Markwalter, Leon Z. Wang, O. Sharaf, Prashanth K. Padakanti, M. Esposito, Brian K. Wilson, E. Blankemeyer, S. Carlin, A. Alavi, R. Prud’homme

{"title":"Polymeric nanocarriers co-encapsulating PET probes and protein therapeutics","authors":"Chester E Markwalter, Leon Z. Wang, O. Sharaf, Prashanth K. Padakanti, M. Esposito, Brian K. Wilson, E. Blankemeyer, S. Carlin, A. Alavi, R. Prud’homme","doi":"10.33218/001c.57619","DOIUrl":"https://doi.org/10.33218/001c.57619","url":null,"abstract":"Nanocarriers encapsulating nucleic acids or protein therapeutics are important tools for modulating biodistribution and enhancing intracellular delivery of biologics. We have recently developed inverse Flash NanoPrecipitation (iFNP), demonstrating its effectiveness in encapsulating biologics at high loadings and encapsulation efficiency. Here, we present the biodistribution of two iFNP nanocarriers using 64Cu positron emission tomography imaging in a murine adenocarcinoma xenograft model characterized by elevated macrophage content. Two nanocarriers with similar sizes and surfaces were prepared. iFNP produces core-shell-corona nanocarriers where the hydrophobic shell layer in one case was poly(lactic acid) (PLA), and the other nanocarrier shell was poly(styrene) (PS). While the expectation was that the biodistribution and clearance of both nanocarriers would be similar, it was found that the clearance of the PS nanocarrier oc-curred in less than 3 hours while the PLA nanocarrier exhibited sustained circulation times. The mechanism of nanocarrier instability for the PS shell nanocarrier manifests as the development of a negative surface charge due to the exposure of the anionic nanocarrier inner core. The stable PLA-based formulation exhibited circulation times greater than 24 hours and enhanced accumu-lation in the lymphatics and the tumor relative to the unstable formulation. The novel mecha-nism of encapsulation by iFNP motivates the fundamental studies on nanoparticle biodistribu-tion reported here.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44982488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0