Precision nanomedicine最新文献

Advancements in Lipid Nanoparticle Technologies for Precision Targeting in Therapeutic Delivery 用于精准靶向治疗的脂质纳米粒子技术进展

Precision nanomedicine Pub Date : 2024-07-22 DOI: 10.33218/001c.121633

Peiyang Gao

{"title":"Advancements in Lipid Nanoparticle Technologies for Precision Targeting in Therapeutic Delivery","authors":"Peiyang Gao","doi":"10.33218/001c.121633","DOIUrl":"https://doi.org/10.33218/001c.121633","url":null,"abstract":"Lipid nanoparticles (LNPs) are at the forefront of targeted therapeutic delivery, serving as an innovative platform for precisely delivering therapeutic agents directly to specific cells or tissues. Therapeutic delivery seeks to enhance drug efficacy and safety by controlling the distribution of drugs within the body, thereby minimizing off-target effects while maximizing therapeutic impact. This review delves into advancements and innovations in LNP design to achieve unprecedented targeting precision, surmount biological barriers, and diminish off-target interactions. It encom-passes exploring targeting strategies, including passive targeting that leverages the enhanced permeability and retention effect, active targeting via receptor-ligand interactions, and stimuli-responsive methodologies for the controlled release of therapeutics. With a focus on novel tar-geting techniques, including endogenous targeting and strategic de-targeting, to enhance LNP de-livery specificity and therapeutic efficacy. This review articulates the critical role of lipid com-position, nanoparticle characterization, and surface engineering in tailoring LNPs for therapeutic applications. Through evaluating the forefront of LNP technology in drug delivery and gene therapy, this review forecasts the trajectory of nanoparticle-based therapeutics, envisioning their pivotal role in the advent of personalized medicine, thereby providing a foundation for future explorations aimed at refining and optimizing LNP systems for clinical applications.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"14 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the influence of microgravity and space radiation on astronauts’ gene expression: An approach using quantum simulations and fuzzy logic 分析微重力和太空辐射对宇航员基因表达的影响：利用量子模拟和模糊逻辑的方法

Precision nanomedicine Pub Date : 2024-05-08 DOI: 10.33218/001c.117460

Miguel Angel Vargas Cruz

引用次数: 0

Magnetic resonance imaging of mesenchymal stem cell – migration towards glioblastoma using a nano-calcium phosphate contrast agent 使用纳米磷酸钙造影剂对间充质干细胞--向胶质母细胞瘤迁移进行磁共振成像

Precision nanomedicine Pub Date : 2024-02-20 DOI: 10.33218/001c.94159

Ida M. Anna, G. S. Gowd, A. Ashokan, Maneesh Manohar, Shanti Nair, Kishore Bhakoo, Manzoor Koyakutty

引用次数: 0

Plant-Polyphenol-Mediated Synthesis of Magnetic Biocompatible Iron Oxide Nanoparticles for Diagnostic Imaging and Management of Neurodegenerative Diseases 植物多酚介导的磁性生物相容性氧化铁纳米粒子的合成，用于神经退行性疾病的诊断成像和治疗

Precision nanomedicine Pub Date : 2024-01-20 DOI: 10.33218/001c.92424

Mohamed Abdelmonem, Emmellie Laura Albert, Maha A. Alhadad, Che A. Abdullah

{"title":"Plant-Polyphenol-Mediated Synthesis of Magnetic Biocompatible Iron Oxide Nanoparticles for Diagnostic Imaging and Management of Neurodegenerative Diseases","authors":"Mohamed Abdelmonem, Emmellie Laura Albert, Maha A. Alhadad, Che A. Abdullah","doi":"10.33218/001c.92424","DOIUrl":"https://doi.org/10.33218/001c.92424","url":null,"abstract":"Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), and glioblastoma tumors (GB), represent a spectrum of disorders characterized by progressive neuronal degeneration. This gradual deterioration presents significant challenges in early diagnosis and treatment. As a solution, iron oxide nanoparticles (IONPs) have emerged as promising materials due to their diminutive size and inherent biocompatibility, which facilitates bypassing the blood-brain barrier (BBB), thereby serving as effective targeted nanocarriers for neuroprotective therapeutics, offering efficient delivery to the brain. Furthermore, IONPs demonstrate efficacy as T1/T2 contrast agents (CAs), offering a novel diagnostic tool for various NDDs, emphasizing GB. Despite the expanding potential of IONPs in the management of NDDs, a clear gap exists in developing environmentally sustainable synthesis methods. Such methods must adhere to ecological standards and enable the production of nanoparticles capable of efficiently crossing the BBB. This is essential for precisely delivering and monitoring therapeutic interventions in diseases such as AD, PD, and GB. This review systematically explores the potential of green-synthesized IONPs in the context of NDD treatment. In this review, we emphasize different functionalization techniques for IONPs, tackling how these functionalized IONPs can be effective therapeutic approaches for NDDs. Moreover, we discuss biosafety and biocompatibility by covering a range of in vitro biocompatibility studies to analyze the safety of green-synthesized IONPs for the human body. Furthermore, our thorough analysis discussed the current state of green-synthesized IONPs using plant extracts polyphenols, which also act as neuroprotective agents, as proved by studies mentioned in the review.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"25 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139610713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Effectiveness of Lecanemab on Alzheimer’s Disease 来卡尼单抗对阿尔茨海默病的疗效

Precision nanomedicine Pub Date : 2024-01-08 DOI: 10.33218/001c.92098

Flen John Thomas, Mohammad Aamir Qayyum Sarguroh Khan, Ramlah Atif Khan, Sarthak Vasantkumar Patel

{"title":"Effectiveness of Lecanemab on Alzheimer’s Disease","authors":"Flen John Thomas, Mohammad Aamir Qayyum Sarguroh Khan, Ramlah Atif Khan, Sarthak Vasantkumar Patel","doi":"10.33218/001c.92098","DOIUrl":"https://doi.org/10.33218/001c.92098","url":null,"abstract":"Alzheimer’s disease (AD) is a global public health crisis with a significant impact on individuals, families, and societies. Monoclonal antibodies have emerged as a potential disease-modifying therapy targeting amyloid-β (Aβ), a hallmark of AD pathology. This study offers a comprehensive overview of the efficacy and safety of lecanemab, a monoclonal antibody, focusing on its binding properties and clinical trial results. Lecanemab’s unique binding profile, with a strong affinity for toxic Aβ protofibrils, sets it apart from other monoclonal antibodies. Clinical trials have shown promising results, including reductions in amyloid burden, improvements in cognitive measures, and a reduction in the rate of cognitive decline. However, limitations such as small sample sizes, short-term follow-up, and the exclusion of certain patient groups must be considered. While lecanemab shows potential in slowing the progression of AD, a more extensive study is required to provide robust evidence of its efficacy, especially in diverse patient populations. Adverse effects and long-term safety also warrant further investigation. The results of this study have the potential to inform clinical guidelines and benefit healthcare professionals, caregivers, and researchers in their efforts to improve the treatment of AD. This review is a crucial step in addressing the growing challenge of AD and enhancing the well-being of affected individuals and their families.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solid Lipid Nanoparticles Encapsulating Naturally Derived Boschniakine Mitigates Induced Diabetic Nephropathy 固态脂质纳米颗粒包裹天然来源的波什尼亚克碱，可缓解诱发的糖尿病肾病

Precision nanomedicine Pub Date : 2023-12-28 DOI: 10.33218/001c.91544

Adriel Ekozin, Michele Senrubolo, Christopher Pam, Ishola Bamiji

{"title":"Solid Lipid Nanoparticles Encapsulating Naturally Derived Boschniakine Mitigates Induced Diabetic Nephropathy","authors":"Adriel Ekozin, Michele Senrubolo, Christopher Pam, Ishola Bamiji","doi":"10.33218/001c.91544","DOIUrl":"https://doi.org/10.33218/001c.91544","url":null,"abstract":"Boschniakine, a bioalkaloid isolated from the Tecoma stans plant, has been reported to be traditionally utilized for the management of diabetes in model systems through multiple biochemical mechanisms. Studies on Boschniakine are sparse, also, taking into consideration that poor absorption, a rapid metabolic rate, and rapid systemic elimination could limit bioalkaloids’ pharmacological efficacy. To recognize such limitations, we propose the use of highly bioavailable Boschniakine-Solid Lipid Nanoparticles (Bos-SLNPs). This study examined the potential molecular mechanisms underlying the anti-diabetic effects of Bos-SLNP. Bos-SLNP (25 and 50 mg/kg) was evaluated for 30 days for its antidiabetic activity in streptozotocin-induced Type 1 and Type 2 diabetic rats. In addition, the RT-PCR technique was used to determine messenger-RNA expression of Interleukin-1, Interleukin-6, and Tumor Necrosis Factor-alpha in renal tissue. haematoxylin and eosin staining and Western blotting were used to find differences in the nuclear factor erythroid 2-related factor 2/heme oxygenase/Nuclear Factor-κB signaling pathway and how its proteins were expressed. Bos-SLNPs treatment resulted in an increase in the expression of nuclear factors erythroid 2-related factor 2 and heme oxygenase-1 and a decrease in the expression of Nuclear factor-B. This was because Bos-SLNPs have a protective mechanism, which comes from their anti-inflammatory and anti-oxidant properties. Bos-SLNPs exhibited a protective effect against diabetic nephropathy in rats induced with streptozocin, possibly via the nuclear factor erythroid 2-related factor pathway 2 / heme oxygenase 1/ nuclear factor B.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"21 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mushroom-Derived Nanoparticles in Drug Delivery Systems – Therapeutic Roles and Biological Functions 药物输送系统中的蘑菇衍生纳米粒子--治疗作用和生物功能

Precision nanomedicine Pub Date : 2023-12-11 DOI: 10.33218/001c.91083

Niharika Pandey, Firoz Ahmad, Kratika Singh, Shad Ahmad, Dr. Rolee Sharma

{"title":"Mushroom-Derived Nanoparticles in Drug Delivery Systems – Therapeutic Roles and Biological Functions","authors":"Niharika Pandey, Firoz Ahmad, Kratika Singh, Shad Ahmad, Dr. Rolee Sharma","doi":"10.33218/001c.91083","DOIUrl":"https://doi.org/10.33218/001c.91083","url":null,"abstract":"In this era of globalization, there is an urgent demand for green synthesis of nanoparticles (NPs), which should decrease the tremendous energy consumption and the utilization of toxic compounds, and can help save the environment from hazardous effects. Green synthesis attempts to utilize products from natural agents like plants and fungi because of their profound availability of bio compounds. The NPs derived from them may exhibit anticancer, antibacterial, antimicrobial, antioxidant, anti-diabetic, and immunomodulatory properties because of their unique physical and chemical properties. These extraordinary properties make them promising agents in medicine and agriculture areas. The review summarizes mushroom-derived NPs and bioactive compounds, including the nutritional content of mushrooms with their multipurpose properties, followed by encapsulation and delivery of the biotherapeutics. These NPs have found significant applications in advancing industrial and biomedical ventures. A complete understanding of the synthesis mechanism will help optimize the synthesis protocols and control the shape and size of NPs.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138978812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of American Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B 一例通过米替福新外用药和两性霉素 B 注射剂联合治疗治愈的美洲皮肤利什曼病病例

Precision nanomedicine Pub Date : 2023-12-08 DOI: 10.33218/001c.90983

D. Carrer, Ma. Laura Guzman, M. Peralta, M. Quipildor, Francesca Papera, Elvia Mejía, J. Lauthier, Manuela Bono, Paola A. Barroso, M. Olivera

{"title":"A Case of American Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B","authors":"D. Carrer, Ma. Laura Guzman, M. Peralta, M. Quipildor, Francesca Papera, Elvia Mejía, J. Lauthier, Manuela Bono, Paola A. Barroso, M. Olivera","doi":"10.33218/001c.90983","DOIUrl":"https://doi.org/10.33218/001c.90983","url":null,"abstract":"A male rural worker with cutaneous leishmaniasis (CL) was initially treated with repeated cy-cles of Meglumine Antimoniate (Glucantime®) and two cycles of Amphotericin B deoxycholate during a three-year period. However, the patient remained with two active lesions. An experi-mental topical treatment with liposomal Miltefosine was tested. The efficacy was determined from the MD’s inspection of the patient and analysis of the lesions’ photographic images, le-sions samples culture, and anti-Leishmania antibodies quantification. The parasites from the patient were isolated. The parasites were typified as Leishmania (Viannia) braziliensis, and their susceptibility to Miltefosine, Meglumine Antimoniate, and Amphotericin B was measured. The wound healing was initially good with the topical treat-meant, but the clinical cure was achieved only with a combination of the topical liposomal Miltefosine and intravenous Amphotericin B. Of note, the treatment efficacy was strongly corre-lated with the degree of stress suffered by the patient. To our knowledge, this is the first report on using a topical Miltefosine formulation on a CL patient.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"8 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138589702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in Nano-carrier based therapeutic and diagnostic approaches in mycobacterium Tuberculosis 基于纳米载体的结核分枝杆菌治疗和诊断方法的最新进展

Precision nanomedicine Pub Date : 2023-11-29 DOI: 10.33218/001c.90699

Firoz Ahmad, Niharika Pandey, Kratika Singh, Shad Ahmad, Mohd Khubaib, Rolee Sharma

{"title":"Recent advances in Nano-carrier based therapeutic and diagnostic approaches in mycobacterium Tuberculosis","authors":"Firoz Ahmad, Niharika Pandey, Kratika Singh, Shad Ahmad, Mohd Khubaib, Rolee Sharma","doi":"10.33218/001c.90699","DOIUrl":"https://doi.org/10.33218/001c.90699","url":null,"abstract":"Tuberculosis is one of the most contagious and lethal infectious diseases, leading to high worldwide morbidity. While several anti-TB drugs are currently commercially available, the main problem with these drugs is the requirement of prolonged treatment duration and frequent dosing. They are non-specifically distributed in the whole body through the blood circulation system, resulting in lower therapeutic efficacy and also causing other severe complications with-in the body. This review article focuses on the currently available various nanotechnolo-gy-based therapeutic approaches, including lipid nanoparticles, polymeric particles, carbon nanotubes, glucan, and alginate-based anti-TB drug-delivery systems, that allow the delivery and targeting of anti-TB drugs to host macrophage. Finally, we also present some promising recent nanotechnology-based mycobacterial detection systems using silver nanoparticles, silica nano-particles, magnetic nanoparticles, quantum dots, and biosensors that have recently emerged as the latest diagnostic tools against TB. Functionalized nanomaterials for emerging aggregation-induced photodynamic therapy as next-generation theranostics have also been discussed as a novel option for TB diagnosis and therapy.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139214398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Synergetic Approach Utilizing Nanotechnology, Chemotherapy, and Radiotherapy for Pancreatic Cancer Treatment 利用纳米技术、化疗和放疗治疗胰腺癌的协同方法

Precision nanomedicine Pub Date : 2023-11-22 DOI: 10.33218/001c.90447

Abdulaziz Alhussan, Reinali Calisin, Nolan Jackson, Jessica Morgan, Sam Chen, Yuen Yi C. Tam, Wayne Beckham, Sunil Krishnan, D. Chithrani

{"title":"A Synergetic Approach Utilizing Nanotechnology, Chemotherapy, and Radiotherapy for Pancreatic Cancer Treatment","authors":"Abdulaziz Alhussan, Reinali Calisin, Nolan Jackson, Jessica Morgan, Sam Chen, Yuen Yi C. Tam, Wayne Beckham, Sunil Krishnan, D. Chithrani","doi":"10.33218/001c.90447","DOIUrl":"https://doi.org/10.33218/001c.90447","url":null,"abstract":"The objective of this study was to assess the anticancer effectiveness of gold nanoparticles (GNPs) and lipid-encapsulated docetaxel prodrug (LNPDTX-P) with radiotherapy (RT). The study utilized a co-culture spheroid model comprising MIA PaCa-2 cancer cells and patient-derived cancer-associated fibroblasts (CAF-98) to mimic pancreatic cancer conditions. The spheroids underwent treatment with GNPs (7.5 μg/mL), LNPDTX-P (99 nM of DTX pro-drug), and 2 Gy of RT. Cell viability of the spheroids was evaluated using the CellTiter-Glo 3D assay. At the same time, DNA double-strand breaks (DSBs) were assessed by examining the expression of the DNA damage marker 53BP1 through an immunofluorescence assay. Alt-hough GNPs/RT and RT/LNPDTX-P showed a reduction in spheroid size and an apparent in-crease in DNA DSB damage, the combination of the two nanoparticles, GNPs, and LNPDTX-P, with RT, significantly enhanced the anticancer efficacy, resulting in a 28% decrease in spheroid size and an estimated 39% increase in DNA DSB. The combination of GNPs and LNPDTX-P with RT showed a synergetic effect due to their radiosensitizing properties, improving the ther-apeutic efficacy of each treatment modality alone. This triple modality offers a hopeful strategy to enhance cancer treatment efficacy while reducing adverse effects.","PeriodicalId":92706,"journal":{"name":"Precision nanomedicine","volume":"45 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0