International journal of biosensors & bioelectronics最新文献

{"title":"Fabrication of dissolvable, polymer microneedles by through-hole mold filling","authors":"Yi-Je Juang","doi":"10.15406/IJBSBE.2020.06.00191","DOIUrl":"https://doi.org/10.15406/IJBSBE.2020.06.00191","url":null,"abstract":"Transdermal drug delivery (TDD) has become an attractive approach for drug administration owing to its characteristic advantages such as prevention of the drug from degradation in the gastrointestinal tract and the first pass metabolism, sustaining the therapeutic drug level, non-invasive drug application, lower risk of infection, self-administration and improved patient compliance.1–3 TDD is a self-contained, discrete dosage form, which delivers the drug through the skin at controlled rate to the systemic circulation. Because of the Stratum corneum layer (about 20μm) and viable epidermis layer (about 300μm) of human skin, penetrating these barriers is the first step for successful TDD. There are primarily two strategies applied to overcome the skin barrier.4 One is the chemical treatment where the chemical compounds like sulphoxides, azones, pyrrolidones, alcohols, alkanols, etc. are used to reversibly change the physical properties of lipid bilayer. The other is the physical treatment where the methods like iontophoresis, electroporation, ultrasound technique, photoacoustic approaches and microneedles are applied to create the reversible pinholes to allow the molecular drug to penetrate skin barrier. Among these techniques, application of microneedles (MNs) permits easy and painless administration without the need of expensive equipment and system integration. There are a variety of materials used to fabricate MNs such as silicon,5,6,metal,7,8 photoresist9 and polymers.10 However, concerns are raised due to risk of residual fragment caused by the broken MNs, biohazardous sharps waste and insufficient mechanical strength. To resolve these issues, the dissolvable and biodegradable polymers were adopted and many fabrication techniques have been proposed and demonstrated.11–19 For example, the droplet-born air blowing is a method that droplets of polymer solution are first dispensed on a substrate. Next, another substrate is brought into contact with the droplets and then slowly moved apart. Meanwhile, the air is blown to dry the solution. Once the solution is dried, the polymer forms hourglass like structures, which subsequently break into cone-like MNs. With this method, an array of MNs can be fabricated within 10 mins.13 The drawing method is another additive technique to produce MNs from 2D planar substrate.14 The MNs are formed by well-controlled, set temperatures at each individual steps starting from pillar contact with polymer substrate, followed by drawing of viscous polymer and solidification of polymer to separation. For the membrane filtration technique, a PDMS through-hole mold was used and formation of MNs followed the principle of cake formation during filtration and the MNs can be made within 1 hr.18 Fabrication of MNs by 3D printing, scanning-based stereolithography (SLA) was proposed in recent years.19 The MN mold was first constructed by printing out the UVcurable resin and using a laser to track and “draw” each layer where the r","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnologies in the health care system","authors":"Petrov Sergey, V. Alexandr","doi":"10.15406/IJBSBE.2020.06.00181","DOIUrl":"https://doi.org/10.15406/IJBSBE.2020.06.00181","url":null,"abstract":"Commercialization of nanotechnologies in Russian Health Care System (RHCS) requires detailed analysis of existing obstacles to technology translation. Here we will discuss three key innovations (i) Prof. Ilizarov’s apparatus, (ii) ‘Perftorun’, known as ‘blue blood’ therapy of Russian prof. Beloyartsev, (iii) ‘Litar’ and artificial bone technology invented by Prof. Krasnov which is used to replace bones defects. We will consider challenges of Russian bionanotechnology clusters and education of scientists concerning the principles of technology transfer. Prof. Petrov, a coauthor of this paper, has extensive experience in implementation of novel technologies for health protection and safety. Historic data and case studies suggest that Russia’s technology innovations require 30 - 40 years before it is successfully commercialization compared to 5 to 10 years in the United States. Substantial investment capital significant and high probability of technology failure in preclinical or clinical trials hinder commercialization of biomedical and health technologies in developed countries. Stringent regulatory approval process further increases the time and cost of moving the technology from laboratory into commercialization. Patent protection of new inventions is a key strategy for attracting substantial investment required for early stage transition of biomedical technologies into commercial products. Following the discussion of the three innovations mentioned above, our paper will suggest approaches of how to enhance commercial translation. oncological diseases. The main purpose was to study the serum osteoprotegerin and s-rank levels in dental patients with different results of bone implant integration using bone grafts of xenogenic origin. 63 patients were examined: 41 women and 22 men aged 40 to 67 years. The general condition of the body was assessed on the basis of the collection of anamnesis of life, the conclusion of the therapist and blood test data. Osteoprotegerin and s rank - l osteoclastogenesis markers were studied in all patients, who were selected for the study with their voluntary consent. It is necessary to note the presence of common diseases, such as osteoporosis, diabetes mellitus, impaired immune system, in some patients. All of above are are absolute Thus, thanks of absolute contraindications to dental implantation.","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the significance and application sphere of SPR based fiber–optic sensors","authors":"R. Tabassum","doi":"10.15406/ijbsbe.2020.06.00187","DOIUrl":"https://doi.org/10.15406/ijbsbe.2020.06.00187","url":null,"abstract":"This opinion pertains to the significance of surface plasmon resonance based fiber–optic sensors for sensing applications in contemporary research and industrial avenues. The advantages of these sensors have been highlighted along with a few important examples.","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable bio-sensors: a gigantic leap in health care system","authors":"Biswas R","doi":"10.15406/ijbsbe.2020.06.00196","DOIUrl":"https://doi.org/10.15406/ijbsbe.2020.06.00196","url":null,"abstract":"This concise communication overviews the development of wearable bio-sensors. It outlines the basics as well as emerging development of wearable bio-sensors. Apart from this, the recent development in this filed comprehensively analyzed along with future recommendations.","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant tissue differentiation using electrical impedance spectroscopy with deep neural networks","authors":"P. Bertemes-Filho, R. Cavalieri","doi":"10.15406/ijbsbe.2020.06.00182","DOIUrl":"https://doi.org/10.15406/ijbsbe.2020.06.00182","url":null,"abstract":"Electrical Impedance Spectroscopy (EIS) is a powerful tool for characterization of electrical properties of a wide range of materials.1 It has been demonstrated to reliably represent both organic and inorganic structures through the extraction of electrical parameters that serve as descriptors of the physiological state of biological tissues.2 Viable applications of EIS can be found in many different fields, ranging from the assessment of aging effects in lithium ion batteries3 to characterization of biological tissue, both from animal4 and plant5 origins. EIS in medicine have recently gained many different applications in the field since the minimally invasive characteristic of the procedure is very appealing for both patients and doctors. EIS has been used for the detection of malignant tumors in different organs such as the breasts,6 prostate7 and skin.8 In the application of characterization of biological tissue, excitation is usually provided by a current source with variable frequency between 10 Hz and 10 MHz. Analysis of impedance measurements in this range of frequency allows modelling of complex tissues as the association of passive electrical components.9 The most popular method for fitting EIS data into a mathematical equation is the Cole function,10 represented by","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of zinc oxide nanostructures in biosensor application","authors":"Zainiharyati Mohd Zain, Iman Nurelissa Mohd Ramzuz, Norazreen Zakaria","doi":"10.15406/ijbsbe.2020.06.00188","DOIUrl":"https://doi.org/10.15406/ijbsbe.2020.06.00188","url":null,"abstract":"Nanostructures are defined as any structures or materials with one or more dimension which in the nanometer scale range which is under 100 nanometers. Zinc oxide is a one of many nanomaterials with considerable interest because zinc oxide provides striking advantages in biomedical and clinical sites, thanks to its excellent actions in photonics, electronics, and optics. On account of their large volume surface area ratio, special chemical and physical characteristics, nanosize inorganic compounds showed impressive antibacterial activity at very low concentrations. In order to its outstanding properties, zinc oxide is broadly utilize for varied potential operation for example sun powered cells, optical, bright (UV) lasers, photo-detectors, light-emitting diodes, and electrical instruments. Nonetheless, some few reviews shows that structure, size and uniformity of particles have had a profound impact on zinc oxide nanoparticles, properties and resulted in biosensor application. Homogeneous particle morphology, size and consistency are therefore commonly fundamental necessity for its biomedical appliance. However, zinc oxide nanoparticles morphology is highly depend on their synthesis process and is a multifunctional substance with its own features and versatility. The successful application of zinc oxide in nanodevices and nanobiotechnology are represented by one dimensional (1-D) nanostructures, for example like nanotubes, nanowires, nanorings, nanotetrapods and nanoribbons, tetrapods, nanorods, nanorings, nanoplates, hexagonal, nanospheres, nanoflowers, nanoboxes, tripods, nanotubes, and nanocapses with enhanced biosensor analytical performances.","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of sulfur dioxide and particulate matter (PM2.5 and PM10) in greater Cairo, Egypt","authors":"Atef M. F. Mohammed, Inas A. Saleh","doi":"10.15406/ijbsbe.2020.06.00189","DOIUrl":"https://doi.org/10.15406/ijbsbe.2020.06.00189","url":null,"abstract":"Greater Cairo is the largest metropolitan area in Egypt, with an estimated population density of 13107 people/km 2 . The increased population and, thus, rapid urban growth in Greater Cairo has created a problem of overcrowded streets filled with cars and trucks which plays a big role in increased air pollution. This review aimed to showing concentrations of PM (PM 10 , PM 2.5 ) and SO 2 in Greater Cairo during last years. Also, showing Sources of Air Pollutants, efforts of the Government of Egypt to Improve Air Quality, Egyptian Laws and guidelines, Regulations and Policies. In addition, showing role of the Egyptian Environmental Affairs Agency (EEAA) and national network to monitoring air pollutants. Finally, compare levels monitored in Greater Cairo with other cities at different countries around the world.","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintenance effects on life cycle of large above storage tanks","authors":"M. Yousaf, Ali Mustafa","doi":"10.15406/ijbsbe.2020.06.00201","DOIUrl":"https://doi.org/10.15406/ijbsbe.2020.06.00201","url":null,"abstract":"","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67072021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ripening classification of bananas (Musa acuminate) using electrical impedance spectroscopy and support vector machine","authors":"P. Bertemes-Filho, William Laus Bertemes, R. Cavalieri, Aline Torres Paré, Julia Spessatto, D. Savi","doi":"10.15406/ijbsbe.2020.06.00195","DOIUrl":"https://doi.org/10.15406/ijbsbe.2020.06.00195","url":null,"abstract":"Bananas are one of the most nutritious and widely available food products in the world. An important step of the mass production of bananas ( Musa acuminate ) is determining it’s ripening stages, indicating that it is ready for consumption, and with the most concentration of important nutrients, what will not be achieved in under-ripening or over-ripening. The use of faster and easier assays to determinate the optimum ripening stage will allow the production of fruits with quality and consistence, increasing also the producer income. The industry standard for this process relies on the use of the Von Loesecke scale through visual analysis of the fruits which can result in significant discrepancies and commercial losses. Biochemical analyses can also be used but are time-consuming. The objective here is to investigate and develop a ripening classification test for bananas by using electrical impedance spectroscopy together with a support vector machine algorithm. 100 samples of bananas at 3 ripening stages were used for measuring both impedance modulus and phase of the impedance in the frequency range from 50 Hz to 1MHz. Results showed that this process is able to identify ripeness stages with 100% accuracy with low requirements for processing time. The techniques presented here might be applied in large scale production in order to make the automation process of the harvest time more reliable and profitable.","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Singular oscillators’ amplitude-period aproximation","authors":"Andrés García, A. Lannes","doi":"10.15406/IJBSBE.2020.06.00183","DOIUrl":"https://doi.org/10.15406/IJBSBE.2020.06.00183","url":null,"abstract":"Second order singular oscillators are considered and approximated. The amplitude- period relationship is determined and compared with the formulas in (10) and (11). The approximations show a great exactness and open a wide range of applications based upon singular nonlinear oscillators.","PeriodicalId":92654,"journal":{"name":"International journal of biosensors & bioelectronics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67071384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}