{"title":"Is it now time to prepare psychiatry for a psychedelic future?: commentary, Breen et al.","authors":"Eugene G Breen, Faisal Al-Harbi","doi":"10.1192/bjp.2024.260","DOIUrl":"https://doi.org/10.1192/bjp.2024.260","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"1-2"},"PeriodicalIF":8.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alois Alzheimer and some of his lesser-known scientific contributions - Psychiatry in history.","authors":"Madhusudan Dalvi","doi":"10.1192/bjp.2024.158","DOIUrl":"https://doi.org/10.1192/bjp.2024.158","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"226 1","pages":"60"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clozapine monitoring requirements: is it time for an update?","authors":"Emilio Fernandez-Egea, Robert A McCutcheon","doi":"10.1192/bjp.2024.150","DOIUrl":"10.1192/bjp.2024.150","url":null,"abstract":"<p><p>Oloyede and colleagues advocate for updating haematological monitoring requirements for clozapine, arguing that current protocols overestimate the risk of clozapine-induced agranulocytosis. Their research suggests that stringent monitoring may unnecessarily limit access to clozapine, a crucial treatment for resistant schizophrenia. The editorial supports calls for international consensus to carefully weigh the pros and cons of relaxing monitoring guidelines while ensuring comprehensive care for patients.</p>","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"1-3"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunqing Zhu, Yongbing Lan, Jun Lv, Dianjianyi Sun, Liming Li, Dai Zhang, Canqing Yu, Weihua Yue
{"title":"Association between dietary fat intake and the risk of Alzheimer's disease: Mendelian randomisation study.","authors":"Yunqing Zhu, Yongbing Lan, Jun Lv, Dianjianyi Sun, Liming Li, Dai Zhang, Canqing Yu, Weihua Yue","doi":"10.1192/bjp.2024.163","DOIUrl":"10.1192/bjp.2024.163","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have shown a controversial relationship between dietary fat intake and Alzheimer's disease, and the causal effects are unclear.</p><p><strong>Aims: </strong>To assess the causal effects of total fat, saturated fat and polyunsaturated fat (PUF) intakes on the risk of Alzheimer's disease.</p><p><strong>Method: </strong>A two-sample Mendelian randomisation analysis was performed using genome-wide association study summary statistics on different types of fat intake from UK Biobank (<i>n</i> = 51 413) and on late-onset Alzheimer's disease (LOAD; 4282 cases, <i>n</i> = 307 112) and all forms of Alzheimer's disease (6281 cases, <i>n</i> = 309 154) from the FinnGen consortium. In addition, a multivariable Mendelian randomisation (MVMR) analysis was conducted to estimate the effects independent of carbohydrate and protein intakes.</p><p><strong>Results: </strong>Genetically predicted per standard deviation increase in the total fat and saturated fat intakes were associated with 44 and 38% higher risks of LOAD (total fat: odds ratio = 1.44, 95% CI 1.03-2.02; saturated fat: odds ratio = 1.38, 95% CI 1.002-1.90; <i>P</i> = 0.049). The associations remained significant in the MVMR analysis (total fat: odds ratio = 3.31, 95% CI 1.74-6.29; saturated fat: odds ratio = 2.04, 95% CI 1.16-3.59). Total fat and saturated fat intakes were associated with a higher risk of all forms of Alzheimer's disease in the MVMR analysis (total fat: odds ratio = 2.09, 95% CI 1.22-3.57; saturated fat: odds ratio = 1.60, 95% CI 1.01-2.52). The PUF intake was not associated with LOAD or all forms of Alzheimer's disease.</p><p><strong>Conclusions: </strong>This study indicated that total dietary fat intake, especially saturated fat, contributed to the risk of Alzheimer's disease, and the effects were independent of other nutrients. These findings informed prevention strategies and management for Alzheimer's disease directly towards reducing dietary saturated fat intake.</p>","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"24-30"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John H Ward, Brendan Sargent, Rob Bale, Johannes C Klein, Paul J Harrison, Belinda Lennox, Adam Al-Diwani, Adam E Handel
{"title":"Can liaison neurology add value to patient care within a mental health setting?","authors":"John H Ward, Brendan Sargent, Rob Bale, Johannes C Klein, Paul J Harrison, Belinda Lennox, Adam Al-Diwani, Adam E Handel","doi":"10.1192/bjp.2024.149","DOIUrl":"https://doi.org/10.1192/bjp.2024.149","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"226 1","pages":"47-48"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamaldeep Bhui, Aileen O'Brien, Rachel Upthegrove, Alexander C Tsai, Mustafa Soomro, Giles Newton-Howes, Matthew R Broome, Andrew Forrester, Patricia Casey, Anne M Doherty, William Lee, Kenneth R Kaufman
{"title":"Protecting and promoting editorial independence.","authors":"Kamaldeep Bhui, Aileen O'Brien, Rachel Upthegrove, Alexander C Tsai, Mustafa Soomro, Giles Newton-Howes, Matthew R Broome, Andrew Forrester, Patricia Casey, Anne M Doherty, William Lee, Kenneth R Kaufman","doi":"10.1192/bjp.2024.6","DOIUrl":"10.1192/bjp.2024.6","url":null,"abstract":"<p><p>We argue that editorial independence, through robust practice of publication ethics and research integrity, promotes good science and prevents bad science. We elucidate the concept of research integrity, and then discuss the dimensions of editorial independence. Best practice guidelines exist, but compliance with these guidelines varies. Therefore, we make recommendations for protecting and strengthening editorial independence.</p>","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"4-6"},"PeriodicalIF":8.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The phenomenology within Cézanne's work: a reflection - Psychiatry in art.","authors":"João Martins-Correia","doi":"10.1192/bjp.2024.192","DOIUrl":"https://doi.org/10.1192/bjp.2024.192","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":"225 6","pages":"592"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dosage effects of psychodynamic and schema therapy in people with comorbid depression and personality disorder: four-arm pragmatic randomised controlled trial: commentary, Mulder.","authors":"Roger T Mulder","doi":"10.1192/bjp.2024.105","DOIUrl":"10.1192/bjp.2024.105","url":null,"abstract":"","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"583-584"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jialin Li, Ding Xia, Mei Cui, Yingzhe Wang, Jincheng Li, Li Jin, Xingdong Chen, Chen Suo, Yanfeng Jiang
{"title":"Disease trajectories before dementia: evidence from a large-scale community-based prospective study.","authors":"Jialin Li, Ding Xia, Mei Cui, Yingzhe Wang, Jincheng Li, Li Jin, Xingdong Chen, Chen Suo, Yanfeng Jiang","doi":"10.1192/bjp.2024.122","DOIUrl":"10.1192/bjp.2024.122","url":null,"abstract":"<p><strong>Background: </strong>Systemic changes in multiple diseases may influence the onset of dementia. However, the specific temporality between exposure diseases and dementia remains uncertain.</p><p><strong>Aims: </strong>By characterising the full spectrum of temporal disease trajectories before dementia, this study aims to yield a global picture of precursor diseases to dementia and to provide detailed instructions for risk management and primary prevention of dementia.</p><p><strong>Method: </strong>Using the multicentre, community-based prospective UK Biobank, we constructed disease trajectories before dementia utilising the phenome-wide association analysis, paired directional test and association quantification. Stratified disease trajectories were constructed by dementia subtypes, gender, age of diagnosis and Apolipoprotein E (<i>ApoE</i>) status, respectively.</p><p><strong>Results: </strong>Our study population comprised 434 266 participants without baseline dementia and 4638 individuals with all-cause dementia. In total, 1253 diseases were extracted as potential components of the disease trajectory before dementia. We identified three clusters of disease trajectories preceding all-cause dementia, initiated by circulatory, metabolic and respiratory diseases occurring approximately 5-15 years before dementia. Cerebral infarction or chronic renal failure following chronic ischaemic heart disease was the specific trajectory before vascular dementia. Apolipoprotein E (<i>ApoE</i>) ε4 non-carriers exhibited more complex trajectories compared with carriers. Lipid metabolism disorders remained in the trajectories regardless of dementia subtypes, gender, age of diagnosis and <i>ApoE</i> status.</p><p><strong>Conclusions: </strong>This study provides a comprehensive view of the longitudinal disease trajectories before dementia and highlights the potential targets of midlife cardiometabolic dysfunction for dementia screening and prevention.</p>","PeriodicalId":9259,"journal":{"name":"British Journal of Psychiatry","volume":" ","pages":"538-546"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}