British Journal of Cancer最新文献_第2页

Impact of a digital physical activity intervention on reducing sugar-sweetened beverage intake in young childhood cancer survivors.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-28 DOI: 10.1038/s41416-025-02965-y

Lauren Ha, Christina Signorelli, Jennifer Cohen, Kristen A Neville, Claire E Wakefield, Richard J Cohn

引用次数: 0

SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-24 DOI: 10.1038/s41416-025-02963-0

Ellie Sweatman, Rachel Bayley, Richad Selemane, Martin R Higgs

{"title":"SETD1A-dependent EME1 transcription drives PARPi sensitivity in HR deficient tumour cells.","authors":"Ellie Sweatman, Rachel Bayley, Richad Selemane, Martin R Higgs","doi":"10.1038/s41416-025-02963-0","DOIUrl":"https://doi.org/10.1038/s41416-025-02963-0","url":null,"abstract":"Background: Cells deficient in DNA repair factors breast cancer susceptibility 1/2 (BRCA1/2) or ataxia-telangiectasia mutated (ATM) are sensitive to poly-ADP ribose polymerase (PARP) inhibitors. Building on our previous findings, we asked how the lysine methyltransferase SETD1A contributed to PARP inhibitor-mediated cell death in these contexts and determined the mechanisms responsible.Methods: We used cervical, breast, lung and ovarian cancer cells bearing mutations in BRCA1 or ATM and depleted SETD1A using siRNA or CRISPR/Cas9. We assessed the effects of the PARPi Olaparib on cell viability, homologous recombination, and DNA repair. We assessed underlying transcriptional perturbations using RNAseq. We used The Cancer Genomics Atlas (TCGA) and DepMap to investigate patient survival and cancer cell characteristics.Results: Loss of SETD1A from both BRCA1-deficient and ATM-deficient cancer cells was associated with resistance to Olaparib, explained by partial restoration of homologous recombination. Mechanistically, SETD1A-dependent transcription of the crossover junction endonuclease EME1 correlated with sensitivity to Olaparib in these cells. Accordingly, when SETD1A or EME1 was lost, BRCA1 or ATM-mutated cells became resistant to Olaparib, and homologous recombination was partially restored.Conclusions: Loss of SETD1A or EME1 drives cellular resistance to Olaparib in certain genetic contexts and may help explain why patients develop resistance to PARP inhibitors in the clinic.","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potentiation of immune checkpoint blockade with a pH-sensitizer as monitored in two pre-clinical tumor models with acidoCEST MRI.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-24 DOI: 10.1038/s41416-025-02962-1

Renee L Tran, Tianzhe Li, Jorge de la Cerda, F William Schuler, Alia S Khaled, Shivanand Pudakalakatti, Pratip K Bhattacharya, Sanhita Sinharay, Mark D Pagel

{"title":"Potentiation of immune checkpoint blockade with a pH-sensitizer as monitored in two pre-clinical tumor models with acidoCEST MRI.","authors":"Renee L Tran, Tianzhe Li, Jorge de la Cerda, F William Schuler, Alia S Khaled, Shivanand Pudakalakatti, Pratip K Bhattacharya, Sanhita Sinharay, Mark D Pagel","doi":"10.1038/s41416-025-02962-1","DOIUrl":"https://doi.org/10.1038/s41416-025-02962-1","url":null,"abstract":"Background: Tumor acidosis causes resistance to immune checkpoint blockade (ICB). We hypothesized that a \"pH-sensitizer\" can increase tumor extracellular pH (pHe) and improve tumor control following ICB. We also hypothesized that pHe measured with acidoCEST MRI can predict improved tumor control with ICB.Methods: We tested the effects of pH-sensitizers on proton efflux rate (PER), cytotoxicity, T cell activation, tumor immunogenicity, tumor growth and survival using 4T1 and B16-F10 tumor cells. We measured in vivo tumor pHe of 4T1 and B16-F10 models with acidoCEST MRI.Results: Among the pH-sensitizers tested, someprazole caused the greatest reduction in PER without exhibiting cytotoxicity or reducing T cell activation. Esomeprazole improved 4T1 tumor control with ICB administered one day after the pH-sensitizer. Tumor pHe positively correlated with TCF-1 + CD4 effector and CD8 T cell intratumoral frequencies and predicted improved 4T1 tumor control with ICB. For comparison, esomeprazole had a mild effect on B16-F10 tumor pHe, and worsened tumor control with ICB and increased intratumoral myeloid and dendritic cell (DC) frequencies.Conclusions: A pH-sensitizer can improve tumor control with ICB, and acidoCEST MRI can be used to measure pHe and predict tumor control, but only in the 4T1 model and not the B16-F10 model.","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ALLTogether recommendations for biobanking samples from patients with acute lymphoblastic leukaemia: a modified Delphi study.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-22 DOI: 10.1038/s41416-025-02958-x

Amélie Trinquand, James Leveson, Ana Lúcia Barbosa, Paula Gameiro, Tiina Vesterinen, Tim Lammens, Thomas Drost, Anthony V Moorman, Valérie de Haas, Jonathan Bond, Judith M Boer

{"title":"ALLTogether recommendations for biobanking samples from patients with acute lymphoblastic leukaemia: a modified Delphi study.","authors":"Amélie Trinquand, James Leveson, Ana Lúcia Barbosa, Paula Gameiro, Tiina Vesterinen, Tim Lammens, Thomas Drost, Anthony V Moorman, Valérie de Haas, Jonathan Bond, Judith M Boer","doi":"10.1038/s41416-025-02958-x","DOIUrl":"https://doi.org/10.1038/s41416-025-02958-x","url":null,"abstract":"Acute lymphoblastic leukaemia (ALL) is a rare and heterogeneous disease. The ALLTogether consortium has implemented a treatment protocol to improve outcome and reduce treatment-related toxicity across much of Europe. The consortium provides the opportunity to design translational research on patient material stored in national biobanks. However, there are currently no standardized guidelines for the types of material, processing, and storage for leukaemia biobanking. To address this gap, we conducted a modified Delphi survey among 53 experts in different roles related to leukaemia. The first round consisted of 63 statements asking for level of agreement. The second round refined some to reach consensus, using yes-no and multiple-option answers. Key recommendations include cryopreservation of cells from diagnosis, post-induction, post-consolidation, and relapse, with at least two aliquots of plasma and serum, and cerebrospinal fluid from diagnosis, day15, and post-induction. It was advised to distribute cells across multiple vials for various research projects, and to collect data on sample processing, cell viability, and blast percentage. Quality monitoring and user feedback were strongly recommended. The Delphi survey resulted in strong recommendations that can be used by national biobanks to harmonize storage of samples from patients with ALL and ensure high-quality cryopreserved cells for research studies.","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GDP-bound Rab37 modulates M2-like tumor-associated macrophage polarization by attenuating STAT1 translocation to downregulate the type I IFN pathway.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-21 DOI: 10.1038/s41416-025-02955-0

Chen-Tai Hong, You-En Yang, Hsueh-Fen Juan, Chih-Peng Chang, Yi-Ching Wang

{"title":"GDP-bound Rab37 modulates M2-like tumor-associated macrophage polarization by attenuating STAT1 translocation to downregulate the type I IFN pathway.","authors":"Chen-Tai Hong, You-En Yang, Hsueh-Fen Juan, Chih-Peng Chang, Yi-Ching Wang","doi":"10.1038/s41416-025-02955-0","DOIUrl":"https://doi.org/10.1038/s41416-025-02955-0","url":null,"abstract":"Background: Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) primarily polarize into the M2-phenotype. Our previous study showed that the small GTPase Rab37 mediates IL-6 trafficking in macrophages for M2 polarization. Here, we uncover an unconventional role of Rab37, independent of vesicle trafficking, in promoting M2 polarization of TAMs.Methods: The gene profiles in wild-type and Rab37 knockout (KO) bone marrow-derived macrophages (BMDMs) were analyzed using cDNA microarray. The mechanism of Rab37 in regulating the interferon (IFN) pathway was confirmed through in vitro/vivo assays and clinical studies.Results: Type I IFN signaling was highly enriched in BMDMs from Rab37 KO mice. Moreover, Rab37 induction and decreased type I IFN genes were observed in macrophages treated with lung cancer-conditioned medium and epigenetic drugs, indicating an epigenetic regulation of Rab37 in TAMs. Mechanistically, GDP-bound Rab37 interacted with the nuclear localization sequence of STAT1 to sequest it in the cytosol from its transcription activities, thus leading to the downregulation of IFN genes. Clinically, CD163+/Rab37+/STAT1cytosol in TAMs expression signature correlated with advanced tumor stages and poor survival of lung cancer patients.Conclusions: Our findings highlight the cytosolic interaction of Rab37-STAT1 in M2 TAM polarization, with CD163+/Rab37+/STAT1cytosol TAMs as a lung cancer prognosis biomarker.","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced CXCL10 expression in mast cells for cutaneous neurofibroma presenting with pain and itch.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-20 DOI: 10.1038/s41416-025-02956-z

Trang Thao Quoc Pham, Chung-Ping Liao, Yi-Hsien Shih, Woan-Ruoh Lee, Yi-Hua Liao, Chia-Lun Chou, Yun-Wen Chiu, Donald Liu, Hao-Chin Wang, Bo-Jung Chen, Yu-Hsuan Joni Shao, Tian-Shin Yeh, Kuei-Hung Lai, Hao-Jui Weng

{"title":"Enhanced CXCL10 expression in mast cells for cutaneous neurofibroma presenting with pain and itch.","authors":"Trang Thao Quoc Pham, Chung-Ping Liao, Yi-Hsien Shih, Woan-Ruoh Lee, Yi-Hua Liao, Chia-Lun Chou, Yun-Wen Chiu, Donald Liu, Hao-Chin Wang, Bo-Jung Chen, Yu-Hsuan Joni Shao, Tian-Shin Yeh, Kuei-Hung Lai, Hao-Jui Weng","doi":"10.1038/s41416-025-02956-z","DOIUrl":"https://doi.org/10.1038/s41416-025-02956-z","url":null,"abstract":"Background: Cutaneous neurofibroma (cNF) presenting with pain and itch substantially affects the quality of life. The CXCL10/CXCR3 axis, a well-known chemokine signaling pathway involved in pain and itch transmission, has recently been implicated in neurofibroma development. Our study aims to investigate the expression patterns and potential roles of the CXCL10/CXCR3 axis in pain and itch associated with cNFs.Methods: We examined the expression of CXCL10/CXCR3 and immune cell profiles in 53 human solitary cNFs through immunohistochemical staining. The Chinese version of the Short-form McGill Pain Questionnaire and the Chinese Eppendorf Itch Questionnaire were used to assess pain and itch symptoms of cNF tumors, respectively.Results: Elevated expression of CXCL10/CXCR3 was observed in tumoral and dermal parts of symptomatic cNFs. The percentage of mast cells expressing CXCL10, but not CXCR3, was significantly higher in symptomatic cNFs compared to asymptomatic cNFs (51.18% vs. 19.07%, respectively, p < 0.0001). The symptomatic cNFs exhibited significantly higher intraepidermal nerve fiber density compared to asymptomatic cNFs (p = 0.009).Conclusions: Our study suggests that CXCL10, potentially mediated by mast cells, may contribute to sensory dysfunction in cNF and may be a target for treating the pain and itch symptoms associated with cNFs. Our study suggests a model in which the CXCL10/CXCR3 pathway plays a role in inducing pain and itch in cNFs, potentially through mast cell mediation. Mast cells may increase the secretion of CXCL10, thereby contributing to pain and itch in cNF, making them a potential target for treating these symptoms. Created in BioRender. Pham, Q. (2025) https://BioRender.com/i89y356 .","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hot beverage intake and oesophageal cancer in the UK Biobank: prospective cohort study.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-19 DOI: 10.1038/s41416-025-02953-2

Maki Inoue-Choi, Yesenia Ramirez, Caitlin O'Connell, Amy Berrington de Gonzalez, Sanford M Dawsey, Christian C Abnet, Neal D Freedman, Erikka Loftfield

{"title":"Hot beverage intake and oesophageal cancer in the UK Biobank: prospective cohort study.","authors":"Maki Inoue-Choi, Yesenia Ramirez, Caitlin O'Connell, Amy Berrington de Gonzalez, Sanford M Dawsey, Christian C Abnet, Neal D Freedman, Erikka Loftfield","doi":"10.1038/s41416-025-02953-2","DOIUrl":"https://doi.org/10.1038/s41416-025-02953-2","url":null,"abstract":"Background: Drinking maté, a type of tea consumed at a very hot temperature in South America has been considered as a risk factor for oesophageal squamous cell carcinoma (ESCC).Methods: We assessed daily intake and preferred temperature of hot beverages (tea and coffee) in relation to incident ESCC (n = 242) and adenocarcinoma (EAC; n = 710) among 454,796 adults in the UK Biobank. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards regression.Results: Relative to non-drinkers and warm temperature drinkers (referent group), drinking 4-6 cups/d (HR, 1.97; 95% CI, 1.14-3.38) or more of hot temperature beverages was associated with higher risk of ESCC; HRs increased with increasing daily intake of hot temperature beverages (P-trend < 0.01). ESCC risk was still higher for those who drank very hot beverages; drinking ≤ 4 cups/d was associated with a 2.5-fold higher risk (HR, 2.52; 95% CI, 1.27-5.03), and risk increased with increasing daily intake of very hot temperature beverages (P-trend < 0.01). There was no clear association for EAC.Conclusions: Our findings provide new evidence that drinking hot or very hot beverages is a risk factor for ESCC in the UK where drinking hot tea and coffee is common.","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-18 DOI: 10.1038/s41416-025-02960-3

Hanna Elomaa, Vilma Tarkiainen, Ville K Äijälä, Päivi Sirniö, Maarit Ahtiainen, Onni Sirkiä, Henna Karjalainen, Meeri Kastinen, Vilja V Tapiainen, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Anne Tuomisto, Olli Helminen, Erkki-Ville Wirta, Toni T Seppälä, Jan Böhm, Markus J Mäkinen, Jukka-Pekka Mecklin, Juha P Väyrynen

{"title":"Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma.","authors":"Hanna Elomaa, Vilma Tarkiainen, Ville K Äijälä, Päivi Sirniö, Maarit Ahtiainen, Onni Sirkiä, Henna Karjalainen, Meeri Kastinen, Vilja V Tapiainen, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Anne Tuomisto, Olli Helminen, Erkki-Ville Wirta, Toni T Seppälä, Jan Böhm, Markus J Mäkinen, Jukka-Pekka Mecklin, Juha P Väyrynen","doi":"10.1038/s41416-025-02960-3","DOIUrl":"https://doi.org/10.1038/s41416-025-02960-3","url":null,"abstract":"Background: The production of extracellular mucus and expression of mucins are commonly aberrant in colorectal cancer, yet their roles in tumour progression remain unclear.Methods: To investigate the potential influence of mucus on immune response and prognosis, we analysed mucinous differentiation (non-mucinous, 0%; mucinous component, 1-50%; mucinous, >50%) and its associations with immune cell densities (determined with three multiplex immunohistochemistry assays or conventional immunohistochemistry) and survival in 1049 colorectal cancer patients and a validation cohort of 771 patients. We also assessed expression patterns of transmembrane (MUC1, MUC4) and secreted (MUC2, MUC5AC and MUC6) mucins using immunohistochemistry.Results: Mucinous differentiation was associated with higher densities of CD14+HLADR- immature monocytic cells and M2-like macrophages in mismatch repair (MMR) proficient tumours, and lower T-cell densities in MMR-deficient tumours. Mucinous differentiation was not associated with cancer-specific survival in multivariable Cox regression models. Higher cytoplasmic MUC1 expression independently predicted worse cancer-specific survival (multivariable HR for high vs. negative to low expression, 2.14; 95% CI: 1.26-3.64). It was also associated with increased myeloid cell infiltration in MMR-proficient tumours.Conclusions: Although mucinous differentiation did not independently predict survival, extracellular mucus and MUC1 expression could promote tumour progression through immunosuppression.","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apolipoprotein D is crucial for promoting perineural invasion in salivary adenoid cystic carcinoma.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-17 DOI: 10.1038/s41416-025-02946-1

Guangzhao Huang, Su Chen, Bo Han, Gaowei Zhang, Mingzhe Bao, Grace Paka Lubamba, Yufei Hua, Honglin Li, Wenwen Liu, Jiefei Shen, Lei Wang, Jie Lin, Patrick Ming-Kuen Tang, Zhangfan Ding, Chunjie Li

{"title":"Apolipoprotein D is crucial for promoting perineural invasion in salivary adenoid cystic carcinoma.","authors":"Guangzhao Huang, Su Chen, Bo Han, Gaowei Zhang, Mingzhe Bao, Grace Paka Lubamba, Yufei Hua, Honglin Li, Wenwen Liu, Jiefei Shen, Lei Wang, Jie Lin, Patrick Ming-Kuen Tang, Zhangfan Ding, Chunjie Li","doi":"10.1038/s41416-025-02946-1","DOIUrl":"https://doi.org/10.1038/s41416-025-02946-1","url":null,"abstract":"Background: Perineural invasion (PNI) is a prevalent phenomenon in salivary adenoid cystic carcinoma (SACC). Nevertheless, the regulatory mechanism of PNI is largely elusive.Methods: We detected Apolipoprotein D (ApoD) expression and further determined its role in SACC progression. Subsequently, the contributions of SACC-derived ApoD on neurite outgrowth of dorsal root ganglions (DRGs) cells were explored. Moreover, a series of in vivo assays were conducted to elucidate the role of ApoD in the SACC PNI process.Results: We observed a dramatic up-regulation of ApoD in the SACC associated with an enhancement of PNI in patient biopsies. We found that SACC-derived ApoD elevated cancer cell migration and invasion. In addition, ApoD could facilitate the neurite outgrowth of cultured DRG cells in a CXCR4-dependent manner in vitro, as well as innervation, angiogenesis, and invasion along peripheral nerves of SACC in vivo. More importantly, by advanced bioinformatic analysis, we unexpectedly revealed a novel phenomenon 'tumour cell to neuron-like cell transition' in the ApoD-rich microenvironment in vivo, contributing to the neurogenesis in the SACC tumour.Conclusion: we discovered a novel role of cancer-derived ApoD in the pathogenesis of PNI, which may represent an effective therapeutic target for SACC in clinics.","PeriodicalId":9243,"journal":{"name":"British Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Impact of lymph node metastasis on immune microenvironment and prognosis in colorectal cancer liver metastasis: insights from multiomics profiling.

IF 6.4 1区医学

British Journal of Cancer Pub Date : 2025-02-17 DOI: 10.1038/s41416-025-02941-6

Yueyang Zhang, Deng Wu, Zhen Zhang, Jian Ma, Shuai Jiao, Xiaolong Ma, Jiangtao Li, Yongsheng Meng, Zhixun Zhao, Haipeng Chen, Zheng Jiang, Guiyu Wang, Haiyi Liu, Yanfeng Xi, Haitao Zhou, Xishan Wang, Xu Guan

引用次数: 0