Journal of glycobiology最新文献_第7页

Molecular Dynamics and Monte–Carlo Simulations for Replacement Sugars in Insulin Resistance, Obesity, LDL Cholesterol, Triglycerides, Metabolic Syndrome, Type 2 Diabetes and Cardiovascular Disease: A Glycobiological Study 胰岛素抵抗、肥胖、低密度脂蛋白胆固醇、甘油三酯、代谢综合征、2型糖尿病和心血管疾病中替代糖的分子动力学和蒙特卡罗模拟:糖生物学研究

Journal of glycobiology Pub Date : 2016-06-13 DOI: 10.4172/2168-958X.1000E111

A. Heidari

{"title":"Molecular Dynamics and Monte–Carlo Simulations for Replacement Sugars in Insulin Resistance, Obesity, LDL Cholesterol, Triglycerides, Metabolic Syndrome, Type 2 Diabetes and Cardiovascular Disease: A Glycobiological Study","authors":"A. Heidari","doi":"10.4172/2168-958X.1000E111","DOIUrl":"https://doi.org/10.4172/2168-958X.1000E111","url":null,"abstract":"Ketonic monosaccharide and disaccharide sucrose have long been added to Fructose, Glucose and Galactose to improve their biochemical, glycobiological and biological properties [1–11]. Ketonic monosaccharide and disaccharide have begun to replace larger sugars in insulin resistance, obesity, LDL cholesterol, triglycerides, metabolic syndrome, type 2 diabetes and cardiovascular disease because they can impart different properties such as biochemical, glycobiological and biological properties, at the same time, provide property enhancements at lower loadings sugars form a variety of ordered structures on nanometer length scales, allowing them to severe as a ordered matrix for Fructose, Glucose and Galactose which add functionality to the sugars [11–21]. Discontinuous molecular dynamics simulation is used to study the phase behavior of Fructose, Glucose and Galactose [22– 25]. Considerable effort has been devoted to theoretical and computational simulation studies of sugars phase behavior [26–31]. This editorial describes the models used for phase diagrams of self– assembled mono–tethered nanospheres (TNS) from molecular simulation and comparison to larger sugars. An impressive variety of Fructose, Glucose and Galactose of different sugars and geometries has been synthesized. Also, in this editorial, we aim to predict the assembled structures formed from Fructose, Glucose and Galactose as well as to compare with larger sugars. Moreover, we have developed a model for self–assembled mono–tethered nanospheres (TNS) and perform Brownian Dynamics (BD) simulations to investigate the tendency for these model self–assemble.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70860456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 132

Characterization of Two Non-Fetuin-Binding Lectins from Tepary Bean ( Phaseolus acutifolius ) Seeds with Differential Cytotoxicity on Colon Cancer Cells 两种非胎儿素结合凝集素对结肠癌细胞毒性差异的研究

Journal of glycobiology Pub Date : 2016-05-30 DOI: 10.4172/2168-958X.1000117

Iovanna Torres Arteaga, J. L. Guillén, E. M. Olaya, T. G. Gasca, Marco Vinicio Ángeles Zaragoza, Violeta García-Santoyo, J. A. T. Castillo, C. Aguirre, B. Phinney, Alej, ro Blanco-Labra

{"title":"Characterization of Two Non-Fetuin-Binding Lectins from Tepary Bean ( Phaseolus acutifolius ) Seeds with Differential Cytotoxicity on Colon Cancer Cells","authors":"Iovanna Torres Arteaga, J. L. Guillén, E. M. Olaya, T. G. Gasca, Marco Vinicio Ángeles Zaragoza, Violeta García-Santoyo, J. A. T. Castillo, C. Aguirre, B. Phinney, Alej, ro Blanco-Labra","doi":"10.4172/2168-958X.1000117","DOIUrl":"https://doi.org/10.4172/2168-958X.1000117","url":null,"abstract":"Two non-fetuin-binding lectins from tepary bean (Phaseolus acutifolius) seeds were purified and characterized. Both lectins LA and LB showed by two dimensional gel electrophoresis very similar apparent molecular mass, and their isoelectric point for both lectins were also very close. Mass spectrometry analysis confirmed these similarities showing high sequence homology among them, and when these sequences were compared to the Mirkov´s deduced sequence of the phyto-hemagglutinin from Phaseolus acutifolius, LA showed higher homology than LB. On the other hand, when their biological activity was determined, only LA possessed affinity to type A erythrocytes, and when these lectins using a semi pure fraction were measured for their cytotoxic effect on colon cancer cells, they showed a differential effect. In the semi pure protein fraction tested, the rest of no-lectin proteins separated by electrophoresis presented no activity. Our results indicate that despite the high homology in their sequence, isoelectric point, and apparent molecular mass, these two structurally closely related lectins, showed differences in their biological behaviour, represented by their agglutinatination activity, as well as, in their cytotoxic effect on human colon cancer cells.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"5 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70859561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Association between Pulse Wave Velocity and the Framingham Risk Score in Patients with different Glucose Metabolism Status 不同糖代谢状态患者脉搏波速度与Framingham风险评分的关系

Journal of glycobiology Pub Date : 2016-04-08 DOI: 10.4172/2168-958X.1000116

Qian Zhang, Q. Fu, Chongrong Qiu, K. Zhu, P. Wei

{"title":"Association between Pulse Wave Velocity and the Framingham Risk Score in Patients with different Glucose Metabolism Status","authors":"Qian Zhang, Q. Fu, Chongrong Qiu, K. Zhu, P. Wei","doi":"10.4172/2168-958X.1000116","DOIUrl":"https://doi.org/10.4172/2168-958X.1000116","url":null,"abstract":"Objective: To investigate the relationship between different glucose metabolism status and Pulse Wave Velocity (PWV)and further explore the relationship between PWV, HOMA-IR and the Framingham risk score of 10-year (FRS). \u0000Methods: 105 subjects were divided into three groups: normal glucose tolerance group (G1, n=47); pre-diabetes group (G2, n=32)and type 2 diabetes mellitus (DM) group (G3, n=26)General clinical data and biochemical parameters of each subject were collected. PWV was measured using the Complior SP. FRS was calculated with the lipids excel spreadsheets from Framingham Heart Study homepage. The correlation of different glucose metabolism status, PWV and FRS were analyzed and compared. \u0000Results: A positive correlation was found between carotid-to-femoral PWV (cf-PWV) and age, (Systolic Blood Pressure) SBP, 2-hr plasma glucose (2h PG). There is a direct connection between homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-IR (CP). FRS was difference among three groups. A correlation was found between FRS and cf-PWV, 2h PG, HOMA-IR (CP). \u0000Conclusion: HOMA-IR (CP) and cf-PWV are positive correlation with FRS, which is a predictor of cardiovascular disease (CVD). Hence HOMA-IR (CP) and cf-PWV may have a good clinical value for indicating vascular structure and function and further evaluating the 10-year risk of CVD.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2168-958X.1000116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70859853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glycosylation Change in Cancer as Therapeutic Target: Opportunities and Challenges 肿瘤糖基化变化作为治疗靶点:机遇与挑战

Journal of glycobiology Pub Date : 2016-01-01 DOI: 10.4172/2168-958X.S1-E001

Lu-Gang Yu

引用次数: 1

Chemical assembly of N-glycans by use of modular building blocks n -聚糖的化学组装使用模块化的建筑块

Journal of glycobiology Pub Date : 2015-08-29 DOI: 10.4172/2168-958X.S1.003

Yunpeng Liu

{"title":"Chemical assembly of N-glycans by use of modular building blocks","authors":"Yunpeng Liu","doi":"10.4172/2168-958X.S1.003","DOIUrl":"https://doi.org/10.4172/2168-958X.S1.003","url":null,"abstract":"G and free fatty acids (FFA) are the predominant metabolic substrates in heart. Their relative uptake in normal hearts varies with the metabolic milieu (fed/fasting state), plasma levels and insulin levels. Myocardial ischemia results in a profound up-regulation of glucose and down regulation of FFA metabolism. Fluorine-18 labeled deoxyglucose (FDG); a glucose analogue is used extensively in clinical practice for imaging glucose metabolism in heart, tumors and other organs. Alternations in glucose metabolism accompanying several disease conditions can be used to diagnose these conditions. Exercise results in ischemia and up-regulates glucose uptake in regions perfused by diseased coronary arteries. This can be used for developing a non-invasive diagnostic imaging test for coronary artery disease (CAD). We evaluated the diagnostic potential of exercise FDG imaging for CAD and compared it with exercise-rest myocardial perfusion imaging (MPI), an established and routinely used test. FDG imaging had higher diagnostic sensitivity compared to MPI. Furthermore, increased regional FDG uptake is observed only on exercise images. Persistence of FDG uptake 24 hours later is seen in less than one third of cases and is indicative of more severe CAD. Cardiac imaging using radiolabeled sugars is a highly promising new diagnostic test for CAD and may also provide a powerful tool for studying the pathophysiology of myocardial ischemia.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70861475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Membrane lipids regulate glyco sphingolipid catabolism, their enzymes and lipid binding proteins 膜脂调节糖鞘脂分解代谢及其酶和脂质结合蛋白

Journal of glycobiology Pub Date : 2015-08-29 DOI: 10.4172/2168-958X.S1.001

S. Konrad, Hoff

引用次数: 5

Direct Immunological Detection of Wood Cell Wall Polysaccharides after Microwave-Assisted Ionic Liquid Disruption 微波辅助离子液体破坏后木材细胞壁多糖的直接免疫检测

Journal of glycobiology Pub Date : 2015-04-05 DOI: 10.4172/2168-958X.1000115

I. Plazanet, R. Zerrouki, S. Lhernould, C. Breton, G. Costa

引用次数: 4

Role of HSGAGs in Regulation of FGF Signaling Pathway: Insights from Mathematical Modeling HSGAGs在FGF信号通路调控中的作用:来自数学模型的见解

Journal of glycobiology Pub Date : 2014-12-19 DOI: 10.4172/2168-958X.1000113

J. Kanodia, G. Finn

{"title":"Role of HSGAGs in Regulation of FGF Signaling Pathway: Insights from Mathematical Modeling","authors":"J. Kanodia, G. Finn","doi":"10.4172/2168-958X.1000113","DOIUrl":"https://doi.org/10.4172/2168-958X.1000113","url":null,"abstract":"Signaling pathways act as relay systems that drive how biological systems respond to specific environmental cues. These cues act as regulators of how cells undergo biological processes like development and normal tissue homeostasis among others. Errors in environmental cues or the ability of cells to respond to such cues leads to erroneous cellular behavior and potentially disease states like cancer. Accordingly, insghts into cell-signaling and processing can be instrumental in design of effective therapies against malignancies. A central paradigm of signaling pathways is that ligands bind to and activate cell-membrane bound receptors, which in turn leads to activation of intracellular cascades. However, to target receptor mediated signaling effectively, it may not be enough to understand the biology of the target receptor in isolation. Interactions with other receptors of the same receptor tyrosine kinase (RTK) family or other families might be critical for understanding the signaling diversity of a particular pathway from the systems perspective. For instance, the role of kinase-dead ErbB3 receptor in the regulation of EGFR and ErbB2 has been critical for a deeper understanding of the ErbB-pathway Along similar lines, heparan sulfate glycosaminoglycans (HSGAGs) have been shown to serve as co-receptors essential for signaling through cell-surface interactions on multiple receptors such as MET and FGFRs. We have recently investigated signaling responses in the FGFR system and found a thus far unappreciated signaling mechanism. We have leveraged a data-driven mechanistic modeling approach to examine the role of FGF2-dependent FGFR signaling driven by FGF2-HSGAG-FGFR1 trimeric complexes. The insights gained from this work can be useful for targeting the FGFR pathway but also to reveal greater insights into the fundamental principles of signaling pathway regulation by HSGAGs in general.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2014-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2168-958X.1000113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70859352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Evolutionary Emmergence Of N-Acetylneuraminic Acid (Sialic Acid)-Containing Glycosphingolipids From Deuterosome Echinodermata Starfish 后前体棘皮海星含n -乙酰神经氨酸(唾液酸)鞘脂的进化出现

Journal of glycobiology Pub Date : 2014-12-12 DOI: 10.4172/2168-958X.1000E109

Cheorl-Ho Kim

引用次数: 3

Targeting Protein Kinase Substrate Docking in Cancers 靶向蛋白激酶底物在癌症中的对接

Journal of glycobiology Pub Date : 2014-12-12 DOI: 10.4172/2168-958X.1000E110

A. Padmanabhan

{"title":"Targeting Protein Kinase Substrate Docking in Cancers","authors":"A. Padmanabhan","doi":"10.4172/2168-958X.1000E110","DOIUrl":"https://doi.org/10.4172/2168-958X.1000E110","url":null,"abstract":"Copyright: © 2014 Padmanabhan A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Cancers are characterized by uncontrolled cell growth, increased cell survival, remodeling of tumor microenvironment, neovascularization, invasion and metastasis. Each of these processes involves perturbation of key regulatory pathways. Disruption of these pathways is often caused by mutations and modifications in proteins that occupy hub positions, resulting in either disruption of their function or aberrant activation. Protein kinases are an excellent example of a class of enzymes whose activity if often found to be deregulated in diseases including cancers [1,2]. Protein kinases mediate the covalent addition of phosphate group to amino acid side chains in proteins thereby modifying them post-translationally. The hydroxyl groups of serine, threonine, tyrosine or histidine amino acid side chains are the most common phosphoacceptor sites on proteins. Reversible protein phosphorylation plays an important role in essentially every aspect of life including cellular processes that mediate metabolism, cell cycle progression, proliferation, apoptosis, differentiation, cytoskeletal dynamics, cell migration, immune response, and intracellular transport.","PeriodicalId":92404,"journal":{"name":"Journal of glycobiology","volume":"274 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2014-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70860871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3