Biomedical research and reviews最新文献

SARS-CoV-2 infection and electrocorticographic changes SARS-CoV-2感染与皮质电图变化

Biomedical research and reviews Pub Date : 2022-01-01 DOI: 10.15761/brr.1000149

Joel M Oster, Andy Wang, M. Tucker, M. Sukiennik, Emma Jost Price, Neelima Thakur, James T Kryzanski

引用次数: 0

Is there a relationship between pregnancy and the levels of long-chain polyunsaturated fatty acids? Role of placental fatty acid binding/transporter proteins and nuclear transcription factors in this relationship: A review 妊娠与长链多不饱和脂肪酸水平之间是否存在关系?胎盘脂肪酸结合/转运蛋白和核转录因子在这一关系中的作用:综述

Biomedical research and reviews Pub Date : 2022-01-01 DOI: 10.15761/brr.1000147

M. Biendo, G. Kongolo, Elion Dzon Bertin, A. Léké

引用次数: 0

Electrocorticography in patients who received vaccines available in the United States providing immunity to SARS-CoV-2 (“Covid-19”) 在美国接种可提供对SARS-CoV-2(“Covid-19”)免疫的疫苗的患者的皮质电图

Biomedical research and reviews Pub Date : 2022-01-01 DOI: 10.15761/brr.1000148

Joel M Oster, Andy Wang, Matthew C Tucker, M. Sukiennik, Emma Jost Price, Neelima Thakur, James T Kryzanski

引用次数: 0

The neuropsychological impact of the CoVID-19 pandemic on the mental wellbeing of individuals – what have we learnt thus far CoVID-19大流行对个人心理健康的神经心理学影响——迄今为止我们了解到什么

Biomedical research and reviews Pub Date : 2021-01-01 DOI: 10.15761/brr.1000142

R. Harricharan, William Mark Uren Daniels

{"title":"The neuropsychological impact of the CoVID-19 pandemic on the mental wellbeing of individuals – what have we learnt thus far","authors":"R. Harricharan, William Mark Uren Daniels","doi":"10.15761/brr.1000142","DOIUrl":"https://doi.org/10.15761/brr.1000142","url":null,"abstract":"The novel Corona virus disease (COVID-19) has escalated drastically to become a global pandemic. Here we review the impact of COVID-19 on the brain. The search string “coronavirus and brain” was typed in Google Scholar and PubMed to yield 31500 and 2044 results respectively. Based on these results the effects of COVID-19 on the brain are two-fold, both neuropathological and psychological in nature. SARS CoV-2 produces a range of non-specific neurological symptoms (headaches, nausea, vomiting, altered mental status, anosmia, neuropathy, delirium, cerebrovascular incidents, seizures, Guillain-Barré Syndrome, cranial nerve dysfunctions, viral and autoimmune encephalitis). Indirect effects of SARS CoV-2 on the brain reside in the practices imposed by lockdown regulations including quarantine and self-isolation. These practices have resulted in psychological manifestations including stress, anxiety and post-traumatic stress disorder-related symptoms in infected and uninfected individuals. While online counselling platforms, resilience-building programmes and cognitive behavioural therapy strategies have been established, more need to be implemented to reduce the impact of these practices. *Correspondence to: Rivona Harricharan, Department of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa; E-mail: rivonah3@gmail.com","PeriodicalId":92337,"journal":{"name":"Biomedical research and reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67432797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of IgG antibodies against arenavirus, hepatitis E and HTLV in a municipality in the northeast of Colombia 在哥伦比亚东北部的一个城市中检测到沙粒病毒、戊型肝炎和HTLV的IgG抗体

Biomedical research and reviews Pub Date : 2021-01-01 DOI: 10.15761/brr.1000144

Carolina Montoya-Ruiz, Ileana M Salguedo, Valentina Martinez, M. Parra, M. P. Pilar Delgado

{"title":"Identification of IgG antibodies against arenavirus, hepatitis E and HTLV in a municipality in the northeast of Colombia","authors":"Carolina Montoya-Ruiz, Ileana M Salguedo, Valentina Martinez, M. Parra, M. P. Pilar Delgado","doi":"10.15761/brr.1000144","DOIUrl":"https://doi.org/10.15761/brr.1000144","url":null,"abstract":"Migration and urbanization processes contribute to the dispersion of pathogens, especially those with possible epizootic cycles, gaining importance in new populated areas. This panorama gets worst in developing countries like Colombia that still has limited capacity in strong epidemiological surveillance for noncommon microbial agents. Aim: This study evaluated the presence of IgG antibodies against Mammarenavirus from Tacaribe complex, Hepatitis E virus and HTLV type I or II in patients who visited the health center of a Montelibano (Cordoba), a rural-urban municipality of Colombia. Methods: ELISA's test carried out on 182 patients from Montelibano, Colombia in order to detect IgG antibodies. The sero-epidemiological study for IgG detection was conducted using Junin virus antigen, a HEV and an indirect HTLV-I/II Enzime-Linked Immunosorbent Assay, respectively. Results: Serological analysis allowed the detection of IgG antibodies for all the agents evaluated. Seroprevalence of IgG was 1.64% for the Mammarenavirus, 0,61% for the Hepatitis E and 0.61% for HTLV type 1 or 2. Conclusions: The results indicate the circulation of Mammarenavirus, Hepatitis E and HTLV in Montelibano, a municipality in the northeast of Colombia. Current seropositive percentage is similar or lower in comparison to other studies nevertheless epidemiological conditions like the presence of rodents at home and poor garbage collection services underline the necessity of better surveillance of these neglected viruses of which sporadic outbreaks have been reported. *Correspondence to: María del Pilar Delgado, Department of Biological Sciences, University of the Andes, Carrera 1 #18A-12, Bogotá D.C, Colombia, Tel: +571 3394949; E-mail: mdelgado@uniandes.edu.co","PeriodicalId":92337,"journal":{"name":"Biomedical research and reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67433153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human papilloma virus genotypes associated with cervical cancer in Senegal 与塞内加尔宫颈癌相关的人乳头瘤病毒基因型

Biomedical research and reviews Pub Date : 2021-01-01 DOI: 10.15761/brr.1000145

Niane Khadidiatou, Diagne Cheikh Tidiane, D. Gora, Dia Ndongo, T. Cheikh, Loucoubar Cheikh, N. Moussa, N. Mbayame, D. Aissatou, Sembene Pape Mbacke, Ka Sidy, D. Alioune, S. Alpha, D. Ahmadou

引用次数: 0

The interrelation between aerobic exercise, mental well-being, stress response and epigenetics 有氧运动、心理健康、应激反应和表观遗传学之间的相互关系

Biomedical research and reviews Pub Date : 2021-01-01 DOI: 10.15761/brr.1000143

Feller L, Nemutandani Ms, Feller G, Jose Rj, L. J., Khammissa Rag

引用次数: 2

Evaluation of 20 toxic metals and essential elements in the blood of metal recycling tinsmiths of Cotonou (Benin) 贝宁科托努金属回收铁匠血液中20种有毒金属和必需元素的评价

Biomedical research and reviews Pub Date : 2020-01-01 DOI: 10.15761/BRR.1000139

B. Yedomon, A. Menudier, Katia Dugleux, B. Fayomi, M. Druet‐Cabanac, C. Moesch

{"title":"Evaluation of 20 toxic metals and essential elements in the blood of metal recycling tinsmiths of Cotonou (Benin)","authors":"B. Yedomon, A. Menudier, Katia Dugleux, B. Fayomi, M. Druet‐Cabanac, C. Moesch","doi":"10.15761/BRR.1000139","DOIUrl":"https://doi.org/10.15761/BRR.1000139","url":null,"abstract":"It is common for trainees and craftsmen in the informal economy to not use protective equipment. With tinsmiths, exposure to toxic emissions such as fumes of molten metal that may contain metallic particles is likely to lead to uptake of toxic metals. Aims: The principal aim of this study was to evaluate the biological concentrations of toxic metals and essential trace elements in tinsmiths, craftsmen, and trainees working in the informal sector of Cotonou in Benin. Materials and Methods: Twenty metallic trace elements were measured in whole blood from 111 adult male tinsmith craftsmen, while only the blood lead level was measured in twenty-four trainees of less than 18 years of age. The blood samples were collected at the ERASME health center of Cotonou, using 6 ml EDTA-K2 trace element tubes. The analyses were performed by ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) with a NexION 350 D (PerkinElmer) spectrometer. The results obtained were then compared to those obtained with a reference population that was not subject to professional exposure. Results: For three trace elements, more than 25% of the adult tinsmiths exhibited blood concentrations above the biological reference values. By increasing order of uptake, these were antimony (28.8%), tin (31.5%), and lead (71.2%). For trainees under 18year of age, the prevalence of workers with a blood lead level ≥ 100 µg/L was 83%. Conclusions : Exposure to lead was the greatest concern, and protection and awareness measures should be implemented so as to decrease the health risks linked to lead exposure, particularly among young workers.","PeriodicalId":92337,"journal":{"name":"Biomedical research and reviews","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67432513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of poor road network and maintenance on safety and security in Delta State Nigeria: Mixed perceptions in industrialized oil-producing community 尼日利亚三角洲州糟糕的道路网络和维护对安全和治安的影响:工业化石油生产社区的不同看法

Biomedical research and reviews Pub Date : 2020-01-01 DOI: 10.15761/BRR.1000140

Akuirene Oa, Atie Mo, Ishiekwene Cm, Nwose Eu

{"title":"Effect of poor road network and maintenance on safety and security in Delta State Nigeria: Mixed perceptions in industrialized oil-producing community","authors":"Akuirene Oa, Atie Mo, Ishiekwene Cm, Nwose Eu","doi":"10.15761/BRR.1000140","DOIUrl":"https://doi.org/10.15761/BRR.1000140","url":null,"abstract":"Background: Factors influencing road transport accidents include human and non-human. The extent that non-human factors increases accidents has yet to exhaustively evaluated, especially in Delta State Nigeria. Objective: To access the perception about road networks. Also, to model the effects of poor road network (PRN) on vehicle repairs; and road maintenance on occupational health and safety (OHS) issues in Delta state, Nigeria. Method: This study adopted a survey approach. Likert scaled questionnaire was used to survey the perception of different stakeholders. The responses were used to model the effects of environmental and mechanical factors of road traffic accidents. ANOVA and regression modelling techniques were performed. Results: This study shows mixed perceptions from respondents. 64% of responses agreed on state of the roads being poor while a lower (49%) indicate insecurity on the roads. Modelling shows over 32% increases in vehicle repairs and OHS concerns attributable to PRN and road maintenance respectively. Conclusion: This report highlights gap in knowledge about road traffic, which calls for OHS education. This educational promotion need is adoptable particularly in low-mid income countries where PRN remains an OHS issue, but also relevant in developed countries as unhealthy driving behaviour is still a factor of drivers’ perceptions.","PeriodicalId":92337,"journal":{"name":"Biomedical research and reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67432713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of necroptosis in immune responses 坏死下垂在免疫应答中的作用

Biomedical research and reviews Pub Date : 2020-01-01 DOI: 10.15761/brr.1000137

Young Sik Cho

{"title":"Roles of necroptosis in immune responses","authors":"Young Sik Cho","doi":"10.15761/brr.1000137","DOIUrl":"https://doi.org/10.15761/brr.1000137","url":null,"abstract":"Cell survival and cell death should be well regulated in an orchestrated way for cell proliferation, differentiation, and development in multicellular organism. A variety of physiological outcomes in vertebrate is dependent on cell death modality in response to infectious pathogens and functionally damaged cells. Physiological and pathological roles of cell death are often addressed to describe normal and disease state. Particularly, immune responses can be affected from cell death modes of host cells and various immune-associated cells. Immunogenic cell death occurs in either an accidental or a regulated way could elicit the immune responses. Representatively, apoptosis and necroptosis are involved in homeostasis of immune reaction. So far, apoptosis in immune system has been well defined, acting as deletion of self-recognizing immune cells and cytotoxic killing. However, it has been a growing body of evidence that alternative programmed cell death necroptosis could be involved in immune surveillance, although its underlying mechanism remains elusive. Therefore, necroptosis or programmed necrosis will be emphasized as a regulator of immunity. With immunological role of necroptosis, unmasking of necroptosis and its associated signaling pathway are also dealt in this review. complex II consisting of RIP1, RIP3, FADD, pro-caspase-8. Then, activated RIP3 recruits MLKL to induce the necrotic process. Based on necroptotic signaling pathway, some chemicals have been identified as pharmacological inhibitors of the necroptotic proteins. RIP1, RIP3 or MLKL can be specifically modulated by chemical inhibitors indicated.","PeriodicalId":92337,"journal":{"name":"Biomedical research and reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67432449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2