Archives of basic and applied medicine最新文献

{"title":"Prevalence and Genotypes of Parvovirus B19 Among HIV Positive Children in Ibadan, Oyo State, Nigeria.","authors":"B O Aleru,&nbsp;B A Olusola,&nbsp;A O Faneye,&nbsp;G N Odaibo,&nbsp;D O Olaleye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human Parvovirus B19 (B19V) is a global infection with over 50% of infected children residing in sub-Saharan Africa. It causes persistent anaemia under immuno-compromised states such as HIV infection, thereby complicating the course of HIV infection. This study was therefore designed to determine the prevalence and genotypes of B19V among HIV positive children. Blood specimens were collected from HIV positive children and genomic DNA extracted and assayed for the presence of Parvovirus B19 DNA using polymerase chain reaction and the product detected by gel electrophoresis. Amplicons for positive PCR were purified and sequenced for genotype analysis. For the purpose of comparison (differences in the sequences of the NS1/VP1u region), nine HIV negative children were enrolled in this study. Two (1.3%) of the 158 HIV infected children were positive for Parvovirus B19 DNA. Analysis of the results showed a low prevalence of Parvovirus B19 among HIV positive children but a significant relationship was established between Parvovirus B19 infection and the severity of anaemia (p=0.015). Phylogenetic analysis of the sequence data showed that all the B19 virus isolates detected in this study were genotype 1. This study therefore has been able to give an insight to the prevalence and circulating genotypes of Parvovirus B19 among HIV infected children and also establishing a relationship between anaemia and parvovirus B19 infection.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"113-117"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039191/pdf/nihms968423.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36308159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teachers' Training and Involvement in School Health Programme in Oyo State, Southwest Nigeria.","authors":"A M Adebayo,&nbsp;G I Makinde,&nbsp;P K Omode","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>School Health Programme (SHP) currently lacks effective implementation in Nigeria. Lack of training/orientation of teachers in the programme may have contributed to this. Developing an appropriate training intervention may require prior situation analysis to know teachers' current level of training and involvement in the programme, as there is paucity of information on such study in Oyo State. Thus, this study was carried out to assess primary school teachers' training and involvement in the SHP in Oyo state, Nigeria. A descriptive cross-sectional study was conducted using a 2-stage cluster sampling method to select 2 out of the 33 Local Government Areas (LGAs) in Oyo State. A semi-structured self-administered questionnaire was used to obtain information on respondents' characteristics and previous training and involvement in the SHP. The major variable for assessing teachers' involvement in the SHP was \"ever been involved in health inspection of pupils\". Level of involvement was categorized into \"never, \"once\", \"occasionally\", \"frequently\", and \"very regularly\". These options were further re-categorized into \"never\", \"infrequently\" (once and occasionally) and \"frequently\" (frequently and very regularly) for the purpose of inferential statistics. Data were analyzed using descriptive statistics and Chi-square test at p=0.05. A total of 811 respondents participated in the study. Twenty-eight percent of the respondents reported previous training in the SHP out of whom 44.7% received the training on-the-job. Forty-seven percent were regularly involved in health inspection of pupils. Teachers who taught health education (92.3%) were involved in health inspection of pupils compared with counterparts who did not (74.4%) (p<0.001). Similarly, 85.3% of teachers trained on-the-job were frequently involved in the SHP compared with 73.6% of those trained during undergraduate years (p=0.026). Training and involvement of public primary school teachers in the SHP in Oyo State were suboptimal. Efforts at building the capacity of teachers through on-the-job training in SHP may be necessary to improving the current level of implementation in the State.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002249/pdf/nihms967701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, Characterisation and Identification of Plant Growth Promoting Rhizobacteria from Cauliflower (<i>Brassica oleracea</i>).","authors":"Khan F M,&nbsp;Inamul H,&nbsp;Nimatullah,&nbsp;Tariq S,&nbsp;Muhammad F,&nbsp;Ohia C,&nbsp;Tauseef A","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bio-fertilizers are currently being considered as effective and environmentally-safe alternatives to synthetic fertilizers. In recent years, the use of many Rhizobia in the growth of many plants has found commercial utilization in developing countries especially as growth promoters. This study was conducted to isolate Rhizobacteria from the rhizosphere, rhizoplane and endorhizosphere of cauliflower (<i>Brasicca oleracea</i>) collected from ChattaBakhtawar, Islamabad, Pakistan. Extraction of rhizobacteria was done and the composition was maintained accordingly as for biofertilizers. Luria-Bertini (LB) media was used to isolate rhizobacterial strains and the identification of rhizobacteria was done by studying many morphological characteristics of colonies growing on the media. These characteristics include Form, Elevation, Margin, Opacity and Colour; these were recorded periodically. For the confirmation of rhizobacteria; biochemical tests were performed. Gram staining was done for 14 strains CF-ES-4, CF-ES-5A, CF-ES-5B, CF-ES-5C, CF-ES-6A, CF-ES-6B, CF-RP-4C, CF-RP-4B, CF-RP-6, CF-RP-5A, CF-RP-4, CF-RS -4, CF-RS-5, and CF-RS-6: Among these, 11 strains were Gram negative while the 3 strains CF-RP-5A, CF-ES-5A and CF-RP-4 were Gram positive. The strains which were phosphate negative were: CF-RP-4C, CF-RS-8, CF-RP-4A, CF-ES-4, CF-RS-7, CF-ES-5C, CF-RP-6 while the CF-RP-5A CF-RP-5B, CF-ES-5B, CF-ES-5A, CF-RP-4B, CF-ES-6B, CF-RS-4 and CF-RS-6 strains were phosphate positive; these confirmed qualities of rhizobacteria. Taken together, the present investigation adds more information to current understanding of Nitrogen-fixing by rhizobacteria; and will be useful for the commercialization of these strains to improve the yield of economic plants like cauliflower. Thus, identification of strains to species level and field studies are recommended before adoption by farmers in agricultural field practices.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126378/pdf/nihms-985850.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36477098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of Mothers and Selected Informal Maternity Caregivers Regarding Maternal Depression in Two Communities of Ibadan In Nigeria.","authors":"A O Adefolarin, O S Arulogun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article described the perception of young mothers and selected informal maternity caregivers with no known antecedents of depression residing in two communities in Ibadan, Nigeria about maternal depression. This study is qualitative in design. We purposively selected fifty-one pregnant women and nursing mothers (young mothers) within the communities and the clinics. Thirty-three informal caregivers (Community Birth attendants (CBAs), elderly mothers and men of reproductive age) were also selected. We utilized Focus Group Discussions (FGD), Key Informant Interviews (KIIs), open-ended interviews and document consultation to obtain information about maternal depression. Discussions and interviews were digitally recorded, transcribed verbatim and analyzed using thematic analysis with Nvivo version 15. Common phrases used to describe maternal depression were \"severe worrying\" and \"chronic unhappiness\". Young mothers opined that maternal depression was caused by lack of partner support while more of the men and elderly mothers felt spiritual causes were responsible. Symptoms of maternal depression described by the participants included prolonged loss of interest in pleasurable activities and being moody. Common consequences of maternal depression mentioned were premature onset of labour and low birth weight babies. The perceived help-seeking behaviour included special rituals and deliverance. CBAs mentioned referral to a psychiatrist as a last resort. Participants were aware of maternal depression and its symptoms, however, there were misconceptions about the causes which influenced the perceived help-seeking of elderly mothers and men. Health education interventions to dispel these misconceptions should therefore target the mothers and informal caregivers in the study area.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152900/pdf/nihms967716.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36524135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papilloma Virus Vaccine Awareness and Vaccination History in Patients Attending STI Clinics in Lagos and Ibadan, Nigeria.","authors":"A O Faneye,&nbsp;A A Adeiga,&nbsp;O B Awoderu,&nbsp;A S Fayemiwo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>HPV is one of the most common causes of sexually transmitted disease in both men and women worldwide. It is transmitted through vaginal, anal, and oral sex. This study provided information on the Human Papilloma Virus (HPV) vaccine awareness and vaccination history in relation to the level of antibodies to (HPV) in the population at risk in Nigeria. Patients attending STI clinics at Lagos and Ibadan were recruited and informed consent was obtained from all the participants. Using semi structured questionnaire, vaccination history, demography and past experiences of the patients were obtained. Whole blood samples were obtained and the sera screened for specific antibodies to HPV using ELISA test kits for determination of IgG to HPV by DIA PRO Diagnostic Bioprobes Milano-Italy according to the manufacturer's instruction. Of the170 samples analysed 50 (29.4%) samples were positive for HPV. Thirty (17.6%) were from females and 20 (11.7%) of them were males. Thirty-five (35%) of the 100 women participants were aware of HPV vaccine. 15(15%) women did not take the vaccine because they did not know where to get it while 20 (20%) of them could not afford it. It was also noted that there is higher prevalence among the middle-aged women. A high prevalence of HPV antibodies was observed in the study yet none of the participants had received the HPV vaccine thus the antibodies may be from infection. Implication is that the 30 women who tested positive for the HPV antibodies may be at risk of cervical cancer.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"95-98"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169802/pdf/nihms968428.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Respiratory Syncytial Virus Subtypes A and B Infection Among Children Attending Primary and Secondary Health Care Facilities in Ibadan, Nigeria.","authors":"O Ogunsemowo,&nbsp;D O Olaleye,&nbsp;G N Odaibo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human respiratory syncytial virus (HRSV) causes high morbidity and mortality in infants and young children. Although a high prevalence of HRSV has been reported in Nigeria, the subtype of the virus circulating in the country is not known. This crosssectional study was therefore designed to determine the subtypes of HRSV circulating among children in Ibadan. Two hundred and thirty-one nasopharyngeal and oropharyngeal swabs were collected from children presenting with respiratory infections in Secondary Health Facility (SHF) as well as those attending immunization centers in Primary Health Centers (PHCs) in Ibadan, Nigeria. Viral RNA was extracted directly from the clinical specimen and used for HRSV detection with a pair of primers that targets the conserved region of the viral matrix gene. HRSV-positive samples were subtyped using subtype-specific primers targeting the second hypervariable region of the G gene. The prevalence of HRSV infection was 8.7% and 34.6% among children attending the PHCs and SHF respectively. Both subtypes of HRSV were detected (co-circulating) among the study population. None of children was co-infected with of HRSV A and B. Overall, HRSV-A was the predominant subtype detected among children presenting with respiratory infection at the SHF while subtype B was predominant among participants attending PHCs for routine immunization. Higher disease severity scores were associated with HRSV-A infection than infection with HRSV-B. Only HRSV subtype A was detected from those diagnosed of bronchopneumonia and bronchiolitis. In conclusion, subtypes A and B co-circulating among children in Ibadan, with HRSV-A being the predominant subtype. Additional study including samples collected from other parts of the country over a longer period that will cover both wet and dry season will be done to determine the pattern of HRSV circulation in Nigeria.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997266/pdf/nihms968418.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36225365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Risk Factors for Genital Human Papillomavirus Infections Among Women in Southwest Nigeria.","authors":"Y T Nejo,&nbsp;D O Olaleye,&nbsp;G N Odaibo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is a great variation in the prevalence of cervical HPV infection worldwide with some of the highest rates being found in African women. Early onset of sexual activity (≤ 15 age), multiparity and sexual promiscuity have been recognized as some of the significant risk factors for HPV infection. In Nigeria, there is scarcity of data on the degree of relationship between these factors and the prevalence of HPV infection. Thus, this study was designed to determine the prevalence of genital HPV infection with its potential risk factors among women in Southwest Nigeria. Cervical swab specimen was collected from 295 consenting women including those presenting for routine cervical cancer screening, STI clinic attendees and women who attended community based outreach programmes. Viral DNA was extracted from the swab samples using commercially available DNA extraction Kit and amplified by PCR using two set of consensus primers (PGMY09/11 and degenerate GP-E6/E7). Fifty-five samples were positive to HPV DNA giving a prevalence of 18.6%. Risk factors such as lack of formal education (P-value: 0.003), divorcee (P-value: 0.019), polygamy (P-value: 0.027), unemployment (P-value: 0.023), low income earnings (P-value: 0.018), younger age (<18years) at sexual debut (P-value: 0.039) and passive smoking (P-value: 0.017) were significantly associated with HPV infection. High HPV prevalence and associated risk factors observed in this study shows the continuous transmission of the virus in Southwest Nigeria. Hence, enlarged monitoring including intense public awareness and cervical cancer screening is urgently needed for prevention and control strategies.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"105-112"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997288/pdf/nihms968798.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36225885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occult HBV Infection in Nigeria.","authors":"O A Akintule,&nbsp;B A Olusola,&nbsp;G N Odaibo,&nbsp;D O Olaleye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Occult hepatitis B virus infection (OBI) is manifested by presence of HBV-DNA in the absence of detectable Hepatitis B surface antigen (HBsAg) with or without anti-HBV antibodies. Hence it is a potential threat in blood transfusion medicine. This study was carried out to determine the prevalence of OBI as well as evaluate the effectiveness of using Hepatitis B surface antigen (HBsAg) marker alone in the diagnosis of HBV infection among HBsAg negative blood donors in Ilorin, Nigeria. A purposive sampling, including samples from 206 already donated and prescreened blood units from HBsAg negative from apparently healthy volunteer blood donors at the General Hospital Blood Transfusion Centre, Ilorin, Nigeria, were collected for further laboratory analysis for this study. Five millilitres of blood was collected and plasma sample tested for the presence of HBsAg using a commercially available ELISA kit. In addition, Polymerase Chain Reaction (PCR) was used for molecular detection of HBV DNA in each of the samples. Data was analyzed using descriptive statistics, Chi square at p = 0.05. Of the 206 HBsAg Micropoint® rapid kits pre-screened seronegative samples collected from the blood transfusion centre, 8 (3.9%) samples were positive for the presence of HBsAg when retested using ELISA in the laboratory. Eighteen of the 206 samples (8.7%) were HBV-DNA positive by a semi-nested PCR technique giving an OBI rate of 8.7%. Out of the 18 HBV-DNA positive samples, 17 (4.4%) were from males and only one (5.6%) was from a female donor. Analysis of the 18 HBV DNA positive samples using genotype specific primers into genotype A and Non-A showed that 15 (83.3%) were HBV genotype A, while 2 (11.1%) were genotypes other than A (Non-A), one (5.6%) sample had mixed genotypes (A & non-A). A prevalence of 8.7% OBI found in this study indicates substantial risk of post transfusion HBV infection in the study area in Nigeria. Hence, the need to include HBV DNA detection in the routine blood screening that is, using Nucleic Acid Testing (NAT) technique for transfusion safety in the country.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022766/pdf/nihms968422.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Diversity of Hepatitis C Virus Among Blood Donors and Patients with Clinical Hepatitis in Ibadan, Nigeria.","authors":"J A Shenge,&nbsp;G N Odaibo,&nbsp;D O Olaleye","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatitis C virus (HCV) infection is responsible for liver diseases and hepatocellular carcinoma in chronically-infected patients. Owing to high sequence variability in HCV genome, numerous subtypes have emerged. This study determined HCV strains among patients with clinical hepatitis and blood donors in Ibadan. Blood samples were collected from consented 176 subjects who tested positive to HCV IgM antibodies, including 99 patients with clinical hepatitis and 77 apparently healthy blood donors. Viral RNA was extracted from blood samples, while presence of HCV was tested by amplifying the NS5B gene using polymerase chain reaction (PCR). The amplified NS5B gene was sequenced and sequences were aligned on MEGA 7.0. Phylogenetic tree was constructed with Neighbor-Joining method. Data were analyzed using descriptive statistics at P<0 .05. The NS5B gene was amplified in 38 samples, of which 29 were successfully sequenced. Phylogenetic analysis revealed three of seven known genotypes of HCV including genotypes / subtypes 1a (34.5%), 1b (17.2%), 2b (13.8%), 2c (3.6%) and 5a (31.3%). Subtypes 1b and 2b were found among patients with clinical hepatitis, while the single 2c was found among donors. Although subtype 1a was detected among both populations, its rate was higher among blood donors (P = 0 .003). Subtype 5a was found among the two groups (P= 1. 00). HCV subtypes 1a and 5a are the predominant strains in Ibadan. The diversity of HCV observed has implications for treatment of patients and design of a broadly protective vaccine against the virus.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988250/pdf/nihms968419.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36205574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Satisfaction and Medication Adherence Among Hypertensive Patients Seeking Care in Selected Hospitals in Ibadan, Nigeria.","authors":"D T Ajayi,&nbsp;B O Adedokun,&nbsp;D O Owoeye,&nbsp;O M Akpa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Poor adherence to hypertension treatment is a major health-related problem, and a significant risk factor for complications, disability and hypertension associated mortality. There is a paucity of evidence on the impact of treatment satisfaction on medication adherence among hypertensive patients in Nigeria. This study aimed to determine the association between treatment satisfaction and medication adherence among hypertensive patients in Ibadan, Nigeria. A descriptive cross-sectional study was conducted, wherein hypertensive patients were consecutively recruited from 5 hospitals in Ibadan, Nigeria. A pre-tested, interviewer-administered questionnaire was used to collect data. Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8), and treatment satisfaction using the 9-item Treatment Satisfaction Questionnaire for Medication (TSQM). Descriptive statistics were computed for all variables. Bivariate analysis was carried out using chi-square test, and multivariate analysis using binary logistic regression. Sensitivity analysis was conducted to adjust for unmeasured binary confounders. Statistical significance was set at p < 0.05 for a 2-tailed. A total of 342 respondents with the mean age of 59.6 ± 12.6 years participated in the study. The overall prevalence of medication adherence was 35.1% (MMAS-8 scores = 8). Treatment satisfaction (AOR=2.03, 95% CI: 1.21-3.43) was independently associated with medication adherence. Sensitivity analysis revealed that the observed association between treatment satisfaction and medication adherence was unlikely to be due to unmeasured confounding variables. Medication adherence was low, and treatment satisfaction independently increases medication adherence. Treatment satisfaction strategies should be part of any treatment intervention packages in this population.</p>","PeriodicalId":92330,"journal":{"name":"Archives of basic and applied medicine","volume":"6 1","pages":"67-72"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007840/pdf/nihms968414.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36246595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}