{"title":"Management and control of Trichomonas vaginalis infection","authors":"P. Das","doi":"10.21037/aoi.2019.02.01","DOIUrl":"https://doi.org/10.21037/aoi.2019.02.01","url":null,"abstract":"The standard treatment regimen recommended by both World Health Organization (WHO) and Centre for Disease Control (CDC) for Trichomonas vaginalis (TV) infection, is metronidazole or tinidazole, 2 g orally single dose. Alternatively, metronidazole can be administered 500 mg orally twice a day for seven days.","PeriodicalId":92328,"journal":{"name":"Annals of infection","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/aoi.2019.02.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47650708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Xpert Ultra and TB meningitis: advancing towards policy revision?","authors":"M. Caws, S. Dunstan, B. Basnyat","doi":"10.21037/AOI.2018.10.02","DOIUrl":"https://doi.org/10.21037/AOI.2018.10.02","url":null,"abstract":"Tuberculous meningitis (TBM) is a devastating condition with high mortality and survivors are often left with severe neurological sequelae. HIV-associated TBM can have mortality rates exceeding 60% (1). Early diagnosis and initiation of treatment is critical for survival. Unfortunately the diagnosis of TBM can be more of an art than a science, as a recent report in the Lancet by Bahr and colleagues highlights. There is currently no diagnostic test with high sensitivity and specificity.","PeriodicalId":92328,"journal":{"name":"Annals of infection","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/AOI.2018.10.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44409840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of infectionPub Date : 2017-11-01Epub Date: 2017-11-30DOI: 10.21037/aoi.2017.11.01
Cordelia Manickam, R Keith Reeves
{"title":"A mouse model for hepatitis C virus infection: are we there yet?","authors":"Cordelia Manickam, R Keith Reeves","doi":"10.21037/aoi.2017.11.01","DOIUrl":"https://doi.org/10.21037/aoi.2017.11.01","url":null,"abstract":"Collectively, viral hepatitis remains a global epidemic causing an estimated 1.4 million deaths per year, of which hepatitis C virus (HCV) is the leading cause (1). Despite the availability of new antivirals that are capable of effective cure, the number of HCV infections and re-infections continue to rise worldwide. In addition to progressive liver disease and hepatocellular carcinoma (HCC), HCV is associated with metabolic disorders and co-morbidities including obesity, insulin resistance, type 2 diabetes mellitus, cardiovascular disease, mixed cryoglobulinemia among others (2-4)—all adding to the morbidity and mortality associated with this disease. HCV continues to be a challenge to control, due, at least in part, to the lack of a tangible animal model. Chimpanzees are susceptible to HCV and played a major role in understanding the natural history of the disease. But with limitations on the use of chimpanzees in biomedical research and an attenuated disease course, a tangible animal model could provide information on several gaps in HCV knowledge such as viral pathogenesis and persistence, immune correlates of protection, and importantly vaccine development and testing.","PeriodicalId":92328,"journal":{"name":"Annals of infection","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/aoi.2017.11.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36411054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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