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Abstract PO-097: Addition of losartan to FOLFIRINOX and chemoradiation reduces the expression of pro-invasive and immunosuppressive genes in locally-advanced pancreatic cancer PO-097:在FOLFIRINOX和放化疗中添加氯沙坦可降低局部晚期胰腺癌中促侵袭性和免疫抑制基因的表达
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-097
Y. Boucher, Jessica M Posada, S. Subudhi, A. Kumar, Ivy X. Chen, M. Ng, M. Mino‐Kenudson, Nilesh P. Talele, D. Duda, D. Fukumura, Janet E. Murphy, Jeffrey W. Clark, D. Ryan, C. F. Fernandez-Del Castillo, T. Hong, R. Jain
{"title":"Abstract PO-097: Addition of losartan to FOLFIRINOX and chemoradiation reduces the expression of pro-invasive and immunosuppressive genes in locally-advanced pancreatic cancer","authors":"Y. Boucher, Jessica M Posada, S. Subudhi, A. Kumar, Ivy X. Chen, M. Ng, M. Mino‐Kenudson, Nilesh P. Talele, D. Duda, D. Fukumura, Janet E. Murphy, Jeffrey W. Clark, D. Ryan, C. F. Fernandez-Del Castillo, T. Hong, R. Jain","doi":"10.1158/1538-7445.panca21-po-097","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-097","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"157 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77618727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-110: Targeting cathepsin B in the pancreatic stellate cells stimulates CD8+ T cell dependent anti-tumor immune response PO-110:靶向胰腺星状细胞组织蛋白酶B刺激CD8+ T细胞依赖的抗肿瘤免疫反应
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-110
B. Garg, T. Jain, U. Vaish, V. Dudeja
{"title":"Abstract PO-110: Targeting cathepsin B in the pancreatic stellate cells stimulates CD8+ T cell dependent anti-tumor immune response","authors":"B. Garg, T. Jain, U. Vaish, V. Dudeja","doi":"10.1158/1538-7445.panca21-po-110","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-110","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85514334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-126: Loss of HIF1A decreases resistance to radiation and invasiveness in pancreatic ductal adenocarcinoma PO-126: HIF1A的缺失降低了胰腺导管腺癌对辐射的抵抗力和侵袭性
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-126
Kevin J Tu, S. Roy, B. Bhandary, Amit K. Sawant, H. Shukla
{"title":"Abstract PO-126: Loss of HIF1A decreases resistance to radiation and invasiveness in pancreatic ductal adenocarcinoma","authors":"Kevin J Tu, S. Roy, B. Bhandary, Amit K. Sawant, H. Shukla","doi":"10.1158/1538-7445.panca21-po-126","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-126","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76103071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-131: The role of liver endothelium on pancreatic cancer growth 肝内皮细胞PO-131在胰腺癌生长中的作用
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-131
Wei Zhang, Michel’le Wright, Moeez Rathore, Ali Vaziri-Gohar, J. Winter, Rui Wang
{"title":"Abstract PO-131: The role of liver endothelium on pancreatic cancer growth","authors":"Wei Zhang, Michel’le Wright, Moeez Rathore, Ali Vaziri-Gohar, J. Winter, Rui Wang","doi":"10.1158/1538-7445.panca21-po-131","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-131","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"14 39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86468217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-114: STAT3 in cancer-associated fibroblasts promotes an immunosuppressive tumor microenvironment PO-114: STAT3在癌症相关成纤维细胞中促进免疫抑制肿瘤微环境
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-114
Julia E. Lefler, Michael C Ostrowski, Catherine B MarElia-Bennett
{"title":"Abstract PO-114: STAT3 in cancer-associated fibroblasts promotes an immunosuppressive tumor microenvironment","authors":"Julia E. Lefler, Michael C Ostrowski, Catherine B MarElia-Bennett","doi":"10.1158/1538-7445.panca21-po-114","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-114","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75326975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-120: Differential expression of polyamine pathways in human pancreatic tumor progression and effects of polyamine blockade therapy on the in vivo pancreatic tumor microenvironment PO-120:多胺通路在人胰腺肿瘤进展中的差异表达及多胺阻断治疗对体内胰腺肿瘤微环境的影响
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-120
Sai Preethi Nakkina, Sarah B Gitto, Veethika Pandey, J. Parikh, D. Geerts, K. Olive, O. Phanstiel, D. Altomare, Carlo Maurer
{"title":"Abstract PO-120: Differential expression of polyamine pathways in human pancreatic tumor progression and effects of polyamine blockade therapy on the in vivo pancreatic tumor microenvironment","authors":"Sai Preethi Nakkina, Sarah B Gitto, Veethika Pandey, J. Parikh, D. Geerts, K. Olive, O. Phanstiel, D. Altomare, Carlo Maurer","doi":"10.1158/1538-7445.panca21-po-120","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-120","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74493664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-124: EZH2 blockade overcomes suppression of the proinflammatory senescence-associated secretory phenotype in the pancreas and drives NK cell-mediated pancreatic tumor responses PO-124: EZH2阻断克服了胰腺促炎衰老相关分泌表型的抑制，并驱动NK细胞介导的胰腺肿瘤反应
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-124
Loretah Chibaya, Y. Lopez-Diaz, Haibo Liu, K. C. Murphy, John P. Morris, Yu-jui Ho, Janelle M Simon, W. Luan, Amanda Kulick, L. Leang, E. de Stanchina, Lihua Zhu, S. Lowe, M. Ruscetti
{"title":"Abstract PO-124: EZH2 blockade overcomes suppression of the proinflammatory senescence-associated secretory phenotype in the pancreas and drives NK cell-mediated pancreatic tumor responses","authors":"Loretah Chibaya, Y. Lopez-Diaz, Haibo Liu, K. C. Murphy, John P. Morris, Yu-jui Ho, Janelle M Simon, W. Luan, Amanda Kulick, L. Leang, E. de Stanchina, Lihua Zhu, S. Lowe, M. Ruscetti","doi":"10.1158/1538-7445.panca21-po-124","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-124","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72818580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-113: The prolyl isomerase PIN1 plays a critical role in fibroblast differentiation states to support pancreatic cancer PO-113:脯氨酸异构酶PIN1在成纤维细胞分化状态中起关键作用，支持胰腺癌
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-113
Ellen M. Langer, I. English, V. Shah, Kevin A. MacPherson, K. Kresse, B. Allen-Petersen, Colin J. Daniel, M. Sherman, Andrew C. Adey, R. Sears
{"title":"Abstract PO-113: The prolyl isomerase PIN1 plays a critical role in fibroblast differentiation states to support pancreatic cancer","authors":"Ellen M. Langer, I. English, V. Shah, Kevin A. MacPherson, K. Kresse, B. Allen-Petersen, Colin J. Daniel, M. Sherman, Andrew C. Adey, R. Sears","doi":"10.1158/1538-7445.panca21-po-113","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-113","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74036718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-122: Combined CDK and BET inhibition reprograms the tumor and stromal compartments to enhance anti-tumor immunity in immunologically-cold CDKN2A-deficient pancreatic cancer PO-122: CDK和BET联合抑制可重编程肿瘤和间质室，增强免疫冷cdkn2a缺陷胰腺癌的抗肿瘤免疫
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-122
Brian M Olson, Alison J. Thomas, M. Ware, G. Lesinski
{"title":"Abstract PO-122: Combined CDK and BET inhibition reprograms the tumor and stromal compartments to enhance anti-tumor immunity in immunologically-cold CDKN2A-deficient pancreatic cancer","authors":"Brian M Olson, Alison J. Thomas, M. Ware, G. Lesinski","doi":"10.1158/1538-7445.panca21-po-122","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-122","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90719858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PR-015: Cancer-associated fibroblasts sustain critical dependency of pancreatic cancer cells on exogenous lipids PR-015:癌症相关成纤维细胞维持胰腺癌细胞对外源性脂质的关键依赖性
Tumor & microenvironment Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-pr-015
Charline Ogier, A. Klochkova, L. Gabitova, Battuya Bayarmagnai, D. Restifo, A. Surumbayeva, J. Franco-Barraza, R. Francescone, D. Vendramini-Costa, Jaye C. Gardiner, E. Nicolas, E. Handorf, K. Cai, E. Cukierman, I. Astsaturov
{"title":"Abstract PR-015: Cancer-associated fibroblasts sustain critical dependency of pancreatic cancer cells on exogenous lipids","authors":"Charline Ogier, A. Klochkova, L. Gabitova, Battuya Bayarmagnai, D. Restifo, A. Surumbayeva, J. Franco-Barraza, R. Francescone, D. Vendramini-Costa, Jaye C. Gardiner, E. Nicolas, E. Handorf, K. Cai, E. Cukierman, I. Astsaturov","doi":"10.1158/1538-7445.panca21-pr-015","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-pr-015","url":null,"abstract":"","PeriodicalId":92311,"journal":{"name":"Tumor & microenvironment","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75162698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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