HSOA journal of gastroenterology & hepatology research最新文献

{"title":"Progress of research on tetrahydrocurcumin against liver injury","authors":"Ke-Yu Chen, Shuang Luo, Yun-Teng Liu, Xue Wang, Jian-Bo Wang","doi":"10.53388/ghr2023-03-078","DOIUrl":"https://doi.org/10.53388/ghr2023-03-078","url":null,"abstract":"Liver injury has become a serious liver disease worldwide, and its incidence is increasing year by year, bringing a serious health burden to people in all countries. Tetrahydrocurcumin is an active metabolite of curcumin, which has pharmacological effects such as antioxidant, anti-inflammatory, inhibition of apoptosis, anti-tumor, and anti-aging, and it can inhibit apoptosis in liver cells under the state of hepatic injury and reduce the level of oxidative stress and inflammation in liver tissues through the signaling pathways such as MAPK, PI3K/Akt, PPAR, AMPK, and Nrf2 to prevent and control liver injury. The purpose of preventing and controlling liver injury can be achieved. The active structure, pharmacological effects and application of tetrahydrocurcumin in liver injury were summarized by reviewing domestic and international literature, with a view to providing reference for further research on tetrahydrocurcumin in the field of liver injury.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135601047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of alarm features in diagnosing upper gastrointestinal malignancies among dyspeptic patients: A cross-sectional study in Ethiopia","authors":"Wudassie Melak, Wassihun Asmare, Abate Bane, Mengistu Erkie","doi":"10.53388/ghr2023-03-077","DOIUrl":"https://doi.org/10.53388/ghr2023-03-077","url":null,"abstract":"Author contributions Wudassie, M., Wassihun, A., Abate, B.: writing the original draft; resources; methodology; project administration; supervision. Wassihun, A., Abate, B., Mengistu, E: methodology, project administration Wassihun, A., Abate, B.: software, resources, data curation, and visualisation. Wassihun, A., Abate, B., Mengistu, E: supervision, project administration, writing review, and editing; All authors read and approved the manuscript. Competing interests The authors declare no conflicts of interest. Acknowledgments This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Peer review information Gastroenterology & Hepatology Research thanks all anonymous reviewers for their contribution to the peer review of this paper. Abbreviations GI, Gastrointestinal; UGI, upper gastrointestinal; AMC, Adera Medical Centre; CT, Computed topography; CI, Confidence Interval; ENT, Ear-Nose-Throat; EGD, Esophagogastroduodenoscopy; NPV, Negative Predictive Value; PUD, Peptic Ulcer Disease; PPV, Positive Predictive Value; SEF, Significant Endoscopic Findings; TASH, Tikur Anbessa Special Hospital; UGI,Upper Gastrointestinal. Citation Melak W, Asmare W, Bane A, Erkie M. Predictive value of alarm features in diagnosing upper gastrointestinal malignancies among dyspeptic patients: A cross-sectional study in Ethiopia. Gastroenterol Hepatol Res. 2023;5(3):13. doi: 10.53388/ghr2023-03-077.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135549382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the mechanism of action of Xiayuxue Tang against hepatic fibrosis based on GEO data mining, network pharmacology and molecular docking technology","authors":"Rui-Zhu Jiang, Yu-Hong Ling, Xin-Rui Xian, Xian-Ling Yuan, Yang Zheng, Jia-Hui Wang, Tie-Jian Zhao","doi":"10.53388/ghr2023-03-079","DOIUrl":"https://doi.org/10.53388/ghr2023-03-079","url":null,"abstract":"Objective: To study the mechanism of action of Xiayuxue Tang in treating hepatic fibrosis by combining GEO data mining, network pharmacology, and molecular docking technology, and provide new research directions for the treatment of hepatic fibrosis. Method: Utilizing multiple databases, we aim to identify the relevant targets of various components in Xiayuxue Tang and their associations with hepatic fibrosis. After pinpointing the key targets through interaction analysis, we will construct both the compound-target network and the protein interaction network for Xiayuxue Tang. Conclusively, we will conduct GO and KEGG enrichment analyses on these key targets, followed by molecular docking verification. Result: Through mining the GEO database, 171 related targets were identified. When combined with other databases, a total of 2,343 hepatic fibrosis-related targets were obtained. Xiayuxue Tang comprises 82 related components, which include 26 active components from rhubarb, 1 from ground beetle worm, 46 from peach kernels, with a total of 314 predicted targets. The GO enrichment analysis revealed 748 biological processes, 32 cellular components, and 73 molecular functions, while the KEGG enrichment analysis identified 222 pathways. Molecular docking verification confirmed that effective compounds can bind stably to key proteins, exhibiting strong binding activity. This underscores the potential efficacy of Xiayuxue Tang in addressing hepatic fibrosis. Conclusion: Xiayuxue Tang exerts regulatory effects on hepatic fibrosis through different targets and pathways, suggesting that the herbal compound has the characteristics of multiple pathways and targets.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135699576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying medication regularity of traditional Chinese medicine and potential pharmacological mechanism of Jiedu Sangen decoction in colorectal cancer treatment by data mining and network pharmacology","authors":"Xin-Ru Jia, Xiang-Chang Ying, Yu-Wei Xia, Li-Hui Qian, Lei-Tao Sun, Pei-Pei Wang","doi":"10.53388/ghr2023-03-076","DOIUrl":"https://doi.org/10.53388/ghr2023-03-076","url":null,"abstract":"Objective: Colorectal cancer (CRC) is one of the most common malignancies in the world, and traditional Chinese medicine (TCM) is widely used in its treatment in China. However, the medication rules of TCM for CRC treatment remain unclear. Therefore, data mining combined with network pharmacology was utilized to establish treatment principles and rules. Methods: The CRC cases treated at Zhejiang Provincial Hospital of Chinese Medicine from January 1, 2016 to October 31, 2021 were analyzed using data mining methods. UPLC-Q/TOF-MS analysis was performed to identify the chemical composition of Jiedu Sangen decoction (JSD). Network pharmacology was used to reveal the therapeutic mechanism of JSD. Results: A total of 312 cases 2,998 prescriptions that met the inclusion criteria used 343 kinds of traditional Chinese medicines. The nature of the herbs used in treatment was mainly warm and mild. The taste was mainly sweet, bitter, and pungent. The meridian tropisms were mainly the spleen meridian, followed by lung and stomach meridians. Tonifying and replenishing herbs were the most frequently used in treatment. High-frequency herbs were classified into 11 categories by cluster analysis, and 42 association rules were obtained by association rule analysis. Combined with complex network analysis, 3 core prescriptions for clinical CRC treatment were obtained. Jiedu Sangen decoction contains 64 chemical ingredients, out of which 31 active ingredients were identified, including polydatin, caffeic acid, and glutamic acid, along with 130 potential targets such as AKT1, SRC, and MAPK1. Jiedu Sangen decoction may play a role in regulating inflammation, immunity, metabolism, and hormones in the development of CRC via pathways such as the relaxin signaling pathway, IL-17 signaling pathway, prolactin signaling pathway, and T cell receptor signaling pathway. Conclusions: This study summarizes the treatment and medication principles for clinical CRC treatment, promoting the inheritance and development of the traditional Chinese medical experience.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135401819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explore potential biomarkers to provide a theoretical basis for the treatment of liver fibrosis with pirfenidone","authors":"Hao Li, Xi-Yang Dong, Qin Zhou, Zhi-Xiang Ding, Qing-Hai Wang, De-Hui Li","doi":"10.53388/ghr2023-03-075","DOIUrl":"https://doi.org/10.53388/ghr2023-03-075","url":null,"abstract":"Background: Hepatic fibrosis is a common chronic liver disease in clinic, the purpose of our study is to explore potential biomarkers to provide a theoretical basis for the treatment of liver fibrosis with pirfenidone. Methods: We downloaded a gene-sequencing dataset and a single-cell dataset from the GEO database and pirfenidone target genes from three different databases. First, we performed GO, KEGG, and DO analysis on pirfenidone target genes. Then, we grouped the liver tissue sequencing data (GSE162694) in the sequencing data set (N-F0 group and F1-F4 group) and performed gene expression differential analysis on these two groups, weighted gene co-expression network analysis and gene Enrichment analysis. Finally, we intersected the significantly upregulated genes in the F1-F4 group with the pirfenidone target genes and performed PPI network analysis. In order to further explore the expression of both pirfenidone drug target genes and liver fibrosis disease genes (PDLFG) in different immune cells of liver tissue, we used the CD45+ cell data in the GSE136103 data set for further analysis. Results: A subnetwork consisting of CDC42, HNF4A, BHLHE40, CCDC71L, NR1H3, TNF, MGLL, GPT, SCD and PLIN1 was screened out, and by analysis, we finally identified the SCD as PDLFG. In single-cell sequencing analysis, we found that SCD was highly expressed in M2-polarized macrophages. Conclusion : SCD may be an important target protein to inhibit the progression of liver fibrosis.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135556199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post Hepatitis B Vaccination Sero-Conversion among Health Care Workers in a Referral Hospital Tanzania: A Cross Sectional Study","authors":"A. Gembe, E. Bilaro, L. Mrosso, S. Mhina, P. Komba, J. Jumanne, L. Nzota, A. Mwelela, J. Joseph, L. Mashiku, B. Sikira","doi":"10.36959/621/634","DOIUrl":"https://doi.org/10.36959/621/634","url":null,"abstract":"","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76668830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpolypectomy Syndrome Presenting with Small Bowel Obstruction","authors":"Huckabee Casey, Yglesias Benjamin, Mashburn Penelope","doi":"10.36959/621/635","DOIUrl":"https://doi.org/10.36959/621/635","url":null,"abstract":"","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75615600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Single Bite and Double Bite Biopsy Techniques in Gastrointestinal Endoscopy: A Scoping Review","authors":"M. Humayun, Umar Seemeen, A. Saqib, Mayberry John F","doi":"10.36959/621/627","DOIUrl":"https://doi.org/10.36959/621/627","url":null,"abstract":"Endoscopic biopsies may be taken as single or double bite. In the former method intubation time may be proportionately prolonged depending upon the number of biopsies. In contrast to this, in the latter approach, although, a greater number of biopsies may be taken per unit time, equally, it may have effect on the quality of the biopsy specimen. This is because there is a perception that taking biopsies in such a manner may lead to crush artifacts and difficulty with orientation of the specimens. This, as a result, may pose diagnostic challenge to the histopathologist. A literature search was performed, and 11 studies, examining the histological quality of biopsies taken by these techniques, were identified. There were conflicting results. This is because there are considerable differences in the methodology, study power and interpretation of these studies. A holistic study is needed, which is clinically relevant, minimises selection bias and has sufficient power to clarify conflicting issues.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79038941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Differences in Incidence and Mortality from Non-Variceal Upper Gastrointestinal Hemorrhage: A Nationwide Time Trend Analysis, 2008-2018","authors":"Farooq Umer, Tarar Zahid Ijaz, Ashraf Muddasir, Tahan Veysel, Daglilar Ebubekir","doi":"10.36959/621/632","DOIUrl":"https://doi.org/10.36959/621/632","url":null,"abstract":"Non-variceal upper gastrointestinal hemorrhage (NVUGIH) is a common reason for hospital admissions and carries 2-10% mortality. Mortality trends from NVUGIB over the last two decades were shown to be decreasing previously (1989-2009) [1]. However, there is limited literature addressing racial differences in longitudinal incidence and related mortality trends from NVUGIH [2]. We studied racial differences in incidence and mortality from NVUGIH in the USA between 2008-2018.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83114789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary and Secondary Factors in Hypertriglyceridemia Induced Acute Pancreatitis: A Case-Based Focus Review","authors":"Agrawal Pankaj","doi":"10.36959/621/629","DOIUrl":"https://doi.org/10.36959/621/629","url":null,"abstract":"Hypertriglyceridemia (HTG) is a known cause of pancreatitis. We described a case of severe hypertriglyceridemia (likely familial) causing the first episode of pancreatitis in this patient. A 21-year-old female known for hypertriglyceridemia and DM type 2 came to the emergency room with severe epigastric pain along with nausea and vomiting. Physical exam revealed epigastric tenderness, diminished bowel sounds, and signs of dehydration. Initial blood work was mostly unremarkable mildly elevated lipase 83. CT scan abdomen pelvis showing signs of peripancreatic inflammation. Additional workup revealed triglycerides > 5000 mg/dl. Diagnosis of hypertriglyceridemia-induced pancreatitis (HTGP) was made. The patient was treated with aggressive isotonic fluids, analgesics, and intravenous insulin therapy. This case highlights the presence of multiple secondary risk factors leading to severe HTG and HTGP in patients with the primary (genetic) predisposition. Incidence, pathophysiology, and management of HTGP will also be reviewed.","PeriodicalId":92206,"journal":{"name":"HSOA journal of gastroenterology & hepatology research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83094934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}