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UPLC-MS/MS法同时测定小鼠血浆中的15种胆汁酸 UPLC-MS/MS法同时测定小鼠血浆中的15种胆汁酸
IF 0.6 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2024-07-31 DOI: 10.13375/j.cnki.wcjps.2024.04.011
冯闫茹玉 | 杨倩 | 张萌琳 | 付春梅 | 李大鹏
{"title":"UPLC-MS/MS法同时测定小鼠血浆中的15种胆汁酸","authors":"冯闫茹玉 | 杨倩 | 张萌琳 | 付春梅 | 李大鹏","doi":"10.13375/j.cnki.wcjps.2024.04.011","DOIUrl":"https://doi.org/10.13375/j.cnki.wcjps.2024.04.011","url":null,"abstract":"","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142033254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HPLC同时测定小儿氨酚黄那敏制剂中的4种甜味剂 HPLC同时测定小儿氨酚黄那敏制剂中的4种甜味剂
IF 0.6 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2024-06-15 DOI: 10.13375/j.cnki.wcjps.2024.03.019
阿玉梅 | 魏文芝 | 陈学艳 | 彭双
{"title":"HPLC同时测定小儿氨酚黄那敏制剂中的4种甜味剂","authors":"阿玉梅 | 魏文芝 | 陈学艳 | 彭双","doi":"10.13375/j.cnki.wcjps.2024.03.019","DOIUrl":"https://doi.org/10.13375/j.cnki.wcjps.2024.03.019","url":null,"abstract":"","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142033528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HPLC同时测定沙棘中的6种色胺类生物碱 HPLC同时测定沙棘中的6种色胺类生物碱
IF 0.6 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2024-06-15 DOI: 10.13375/j.cnki.wcjps.2024.03.016
刘振华 | 任李成城 | 王月 | 董琦 | 王洪伦 | 胡娜
{"title":"HPLC同时测定沙棘中的6种色胺类生物碱","authors":"刘振华 | 任李成城 | 王月 | 董琦 | 王洪伦 | 胡娜","doi":"10.13375/j.cnki.wcjps.2024.03.016","DOIUrl":"https://doi.org/10.13375/j.cnki.wcjps.2024.03.016","url":null,"abstract":"","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142033530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
多指标综合评价法优选衢产陈皮的干燥方法 多指标综合评价法优选衢产陈皮的干燥方法
IF 0.6 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2024-04-15 DOI: 10.13375/j.cnki.wcjps.2024.02.009
胡晨霞 | 金国明 | 盛孝孝 | 应佳璐 | 朱灵昊 | 刘梦 | 梁泽华
{"title":"多指标综合评价法优选衢产陈皮的干燥方法","authors":"胡晨霞 | 金国明 | 盛孝孝 | 应佳璐 | 朱灵昊 | 刘梦 | 梁泽华","doi":"10.13375/j.cnki.wcjps.2024.02.009","DOIUrl":"https://doi.org/10.13375/j.cnki.wcjps.2024.02.009","url":null,"abstract":"","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142033305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
三七总皂苷对调节性T细胞再分化为辅助性T细胞的影响 三七总皂苷对调节性T细胞再分化为辅助性T细胞的影响
IF 0.6 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2024-02-06 DOI: 10.13375/j.cnki.wcjps.2024.01.007
田锋祥 | 张明菲 | 申美玉 | 狄昱希 | 周玲玲
{"title":"三七总皂苷对调节性T细胞再分化为辅助性T细胞的影响","authors":"田锋祥 | 张明菲 | 申美玉 | 狄昱希 | 周玲玲","doi":"10.13375/j.cnki.wcjps.2024.01.007","DOIUrl":"https://doi.org/10.13375/j.cnki.wcjps.2024.01.007","url":null,"abstract":"","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142032827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
网络药理学研究升白方治疗免疫力低下的作用机制 网络药理学研究升白方治疗免疫力低下的作用机制
IF 0.6 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2023-12-15 DOI: 10.13375/j.cnki.wcjps.2023.06.009
王月 | 张孟东 | 赵岩 | 何忠梅 | 宗颖 | 陈维佳 | 杜锐
{"title":"网络药理学研究升白方治疗免疫力低下的作用机制","authors":"王月 | 张孟东 | 赵岩 | 何忠梅 | 宗颖 | 陈维佳 | 杜锐","doi":"10.13375/j.cnki.wcjps.2023.06.009","DOIUrl":"https://doi.org/10.13375/j.cnki.wcjps.2023.06.009","url":null,"abstract":"","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142026772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
黄精芡实改良方对脾虚小鼠消化酶及氧化应激指标的影响 黄精芡实改良方对脾虚小鼠消化酶及氧化应激指标的影响
IF 0.6 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2023-10-15 DOI: 10.13375/j.cnki.wcjps.2023.05.005
代建刚 | 汪程远 | 谭婷婷 | 傅勇围
{"title":"黄精芡实改良方对脾虚小鼠消化酶及氧化应激指标的影响","authors":"代建刚 | 汪程远 | 谭婷婷 | 傅勇围","doi":"10.13375/j.cnki.wcjps.2023.05.005","DOIUrl":"https://doi.org/10.13375/j.cnki.wcjps.2023.05.005","url":null,"abstract":"","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142027766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compound Danshen Dripping Pills pretreatment protects the heart from ischemia/reperfusion injury by enhancing autophagic flux 复方丹参滴丸预处理通过增强自噬通量对心脏缺血再灌注损伤有保护作用
IF 1.3 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2023-09-08 DOI: 10.1590/s2175-97902023e211035
Haiqiong Liu, Qian Liang, Xiheng Mei, Hekai Li, Jing Yan, Man Long, Xili Yang, Wei Wang, Weijie Li, Aihua Chen, Yuanna Ling
{"title":"Compound Danshen Dripping Pills pretreatment protects the heart from ischemia/reperfusion injury by enhancing autophagic flux","authors":"Haiqiong Liu, Qian Liang, Xiheng Mei, Hekai Li, Jing Yan, Man Long, Xili Yang, Wei Wang, Weijie Li, Aihua Chen, Yuanna Ling","doi":"10.1590/s2175-97902023e211035","DOIUrl":"https://doi.org/10.1590/s2175-97902023e211035","url":null,"abstract":"Compound Danshen Dripping Pills (CDDPs) have been used in clinical treatment to protect the heart from ischemia/reperfusion (IR) injury for many years. However, the underlying mechanism implicated in the protective effects remains to be explored. Here, we determined the effects of CDDPs in Sprague–Dawley rats with the IR model. Cardiac function in vivo was assessed by echocardiography. Transmission electron microscopy, histological and immunohistochemical techniques, Western blotting and recombinant adeno-associated virus 9 transfection were used to illustrate the effects of CDDPs on IR and autophagy. Our results showed that pretreatment with CDDPs decreased the level of serum myocardial enzymes and infarct size in rats after IR. Apoptosis evaluation showed that CDDPs significantly ameliorated the cardiac apoptosis level after IR. Meanwhile, CDDPs pretreatment increased myocardial autophagic flux, with upregulation of LC3B, downregulation of p62, and increased autophagosomes and autolysosomes. Moreover, the autophagic flux inhibitor chloroquine could increase IR injury, while CDDPs could partially reverse the effects. Furthermore, our results showed that the activation of AMPK/mTOR was involved in the cardioprotective effect exerted by CDDPs. Herein, we suggest that CDDPs partially protect the heart from IR injury by enhancing autophagic flux through the activation of AMPK/mTOR.","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67738109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Brain Angiotensin-II in Development of Experimental Diabetic Nephropathy in Wistar Rats 脑血管紧张素- ii在Wistar大鼠实验性糖尿病肾病发生中的作用
IF 1.3 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2023-09-04 DOI: 10.1590/s2175-97902023e20200
Anubhav Kumar Singh, Niraj Kumar Singh, Ahsas Goyal, B. Semwal, H. Yadav
{"title":"Role of Brain Angiotensin-II in Development of Experimental Diabetic Nephropathy in Wistar Rats","authors":"Anubhav Kumar Singh, Niraj Kumar Singh, Ahsas Goyal, B. Semwal, H. Yadav","doi":"10.1590/s2175-97902023e20200","DOIUrl":"https://doi.org/10.1590/s2175-97902023e20200","url":null,"abstract":"The renin-angiotensin-aldosterone system (RAAS) plays a key role in diabetic nephropathy (DN). Angiotensin-II secreted during the RAAS pathway increases nephropathy. It stimulates oxidative stress which can quench nitric oxide. Reduced nitric oxide level aggravates Ang-II-induced vasoconstriction. Ang-II has also emerged as a central mediator of the glomerular hemodynamic changes that are associated with renal injury. Deletion of ACE2 is also noted due to increased Ang-II level which leads to the development of DN. We hypothesize that nephropathy caused by Ang-II in the periphery may be controlled by brain RAAS. ACE inhibitors and ARBs may show the renoprotective effect when administered through ICV without crossing the blood-brain barrier. DN was observed after 8 weeks of diabetes induction through alloxan. Administration of captopril and valsartan once and in combined therapy for 2 weeks, significantly reduced urine output, blood urea nitrogen, total protein in the urine, serum cholesterol, serum creatinine, serum triglycerides, and kidney/body weight ratio as compared to diabetic control rats. Further, combination therapy significantly increased the body weight and serum nitrate level as compared to diabetic control animals. However, increased ACE2 levels in the brain may reduce the sympathetic outflow and might have decreased the peripheral activity of Ang-II which shows beneficial effects in DN.","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67737103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focal adhesion kinase inhibition decreases cell viability and induces apoptosis of JAK2 V617F positive cells 粘着斑激酶抑制降低JAK2 V617F阳性细胞的细胞活力并诱导细胞凋亡
IF 1.3 4区 医学
Brazilian Journal of Pharmaceutical Sciences Pub Date : 2023-08-28 DOI: 10.1590/s2175-97902023e23075
Ana Carolina Menezes Mendonça Valente, Gustavo Henrique Lima de Farias, Ana Cristina Ribeiro Bernardo, C. Alves, Michelle Bueno de Moura Pereira, Raquel Tognon-Ribeiro
{"title":"Focal adhesion kinase inhibition decreases cell viability and induces apoptosis of JAK2 V617F positive cells","authors":"Ana Carolina Menezes Mendonça Valente, Gustavo Henrique Lima de Farias, Ana Cristina Ribeiro Bernardo, C. Alves, Michelle Bueno de Moura Pereira, Raquel Tognon-Ribeiro","doi":"10.1590/s2175-97902023e23075","DOIUrl":"https://doi.org/10.1590/s2175-97902023e23075","url":null,"abstract":"Focal Adhesion Kinase (FAK) protein participates in proliferation, migration, cell survival, and apoptosis process. It has been described as overexpressed in several neoplasms being a promising target for therapy. BCR-ABL negative chronic Myeloproliferative Neoplasms (MPN) are clonal disorders characterized by the excess of proliferation and apoptosis resistance. The identification of the acquired JAK2 V617F mutation in MPN patients allowed a better understanding of pathogenesis. However, there is still no pharmacological treatment that leads all patients to molecular remission, justifying new studies. The present study aimed to evaluate FAK involvement in the viability and apoptosis of HEL and SET-2 cells, both JAK2 V617F positive cell lines. The FAK inhibitor PF 562,271 was used. Cell viability was determined using MTT assay and apoptosis verified by cleaved PARP, cleaved Caspase 3 and Annexin-V/PI staining detection. FAK inhibition significantly reduced HEL and SET-2 cells viability and induced apoptosis. Considering the role of JAK/STAT pathway in MPN, further investigation of FAK participation in the MPN cells proliferation and apoptosis resistance, as well as possible crosstalk between JAK and FAK and downstream pathways may contribute to the knowledge of MPN pathophysiology, the discovery of new molecular targets, and JAK inhibitors resistance mechanisms.","PeriodicalId":9218,"journal":{"name":"Brazilian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67743347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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