New frontiers in ophthalmology (London)最新文献

Interactive test to categorize metamorphopsia 变态视障碍分类的互动测试

New frontiers in ophthalmology (London) Pub Date : 2021-01-01 DOI: 10.15761/nfo.1000256

D. Claessens, Ronald V Krueger

引用次数: 1

Regulation of time-dependent lens opacification by hydrogen sulfide-releasing compounds 硫化氢释放化合物对时间依赖性晶状体混浊的调节

New frontiers in ophthalmology (London) Pub Date : 2021-01-01 DOI: 10.15761/nfo.1000258

Segewkal H Heruye, Ya Fatou Njie Mbye, Sunny E Ohia, Catherine A Opere

引用次数: 0

Ocular immunity and peculiarities around COVID-19: Can universal protective eye wear be a game changer? 眼部免疫和COVID-19的特殊性:通用护目镜能改变游戏规则吗?

New frontiers in ophthalmology (London) Pub Date : 2021-01-01 DOI: 10.15761/nfo.1000255

Mohamed A. Hussein, E. Hussein

引用次数: 0

Intra- and early postoperative complications after standard cataract surgery or femtosecond laser-assisted cataract surgery combined with pars plana vitrectomy in cases of retinal diseases 标准白内障手术或飞秒激光辅助白内障手术联合玻璃体切割视网膜疾病后的术后早期并发症

New frontiers in ophthalmology (London) Pub Date : 2021-01-01 DOI: 10.15761/nfo.1000257

F. Hengerer, G. Auffarth, I. Conrad‐Hengerer

引用次数: 0

Head to head comparison of the clinical and cost effectiveness of Observe and Plan versus PRN for the treatment of wet macular degeneration 观察和计划与PRN治疗湿性黄斑变性的临床和成本效益的正面比较

New frontiers in ophthalmology (London) Pub Date : 2020-01-01 DOI: 10.15761/NFO.1000243

J. Wawrzynski, Ramiro Salom, A. Pouncey, M. Martin, M. Ozturk

{"title":"Head to head comparison of the clinical and cost effectiveness of Observe and Plan versus PRN for the treatment of wet macular degeneration","authors":"J. Wawrzynski, Ramiro Salom, A. Pouncey, M. Martin, M. Ozturk","doi":"10.15761/NFO.1000243","DOIUrl":"https://doi.org/10.15761/NFO.1000243","url":null,"abstract":"Purpose: “Observe and Plan” (O&P) is a novel treatment regimen for neovascular AMD (nAMD). It aims to optimise the intravitreal anti-VEGF injection frequency whilst dramatically reducing the number of clinical reviews (compared to PRN/ treat and extend). However, there has been no head-to-head comparison of O&P versus the other regimens: We aim to establish whether O&P is non-inferior to PRN and whether there is an economic advantage. Methods: Prospective interventional cohort study: Patients undergoing treatment with PRN aflibercept for nAMD were enrolled. All were switched to O&P aflibercept for one year. Best corrected visual acuity (BCVA) and central macular thickness (CMT) were recorded in addition to the number of clinic visits and intravitreal injections. Their results were compared in a paired analysis to their own data whilst on PRN treatment the preceding year. Results: 25 patients were enrolled. 17 completed one year of treatment, one of whom was subsequently excluded (confounding pathology). Analysis of area under the curve for BCVA and CMT found O&P to be non-inferior to PRN p=0.03, p<0.01. The mean number of clinical reviews was significantly reduced under O&P (1.80 (SD 0.68) vs. 8.66 (SD 0.72) visits per year; P=<0.01) with an improvement in injection to visit ratio (1.01 vs. 1.67 vists/injection), equating to an estimated saving of £1,228 per patient per year. Conclusion: The O&P regimen for treatment of nAMD was clinically non-inferior to PRN. The O&P regimen was superior to PRN in terms of reducing the health economic burden and treatment burden of nAMD.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated cotton-wool spot during pregnancy: A case report 妊娠期孤立性棉絮斑1例

New frontiers in ophthalmology (London) Pub Date : 2020-01-01 DOI: 10.15761/NFO.1000244

Praveena K. Gupta, G. Taibbi

{"title":"Isolated cotton-wool spot during pregnancy: A case report","authors":"Praveena K. Gupta, G. Taibbi","doi":"10.15761/NFO.1000244","DOIUrl":"https://doi.org/10.15761/NFO.1000244","url":null,"abstract":"Introduction: The presence of cotton-wool spots warrants a full systemic workup. We present a case of an isolated cotton-wool spot in a pregnant woman with visual changes after a recent flu-like illness. Case Report: A 25 year-old Middle Eastern female at the 20 th gestational age with a past medical history of Lyme disease, presented with a 24-hour history of a sudden onset of a dark, horizontal line in the center of her right eye vision. She experienced a flu-like illness while on a recent trip to Puerto Rico. Dilated fundus exam revealed an isolated cotton-wool spot along the superior temporal arcade of the right eye, producing focal Retinal Nerve Fiber Layer thickness. Buried optic disc drusen were detected by ocular ultrasound bilaterally. Inflammatory/infectious blood workup, including antibody against Zika virus, was negative except for a mild increase of ANA titer (1:40) in the absence of rheumatologic disease. The patient was managed conservatively and no treatment was initiated. At 4-month follow-up, there was a nearly complete resolution of the cotton-wool spot in the absence of any visual symptoms. The patient had a full-term uncomplicated vaginal delivery. Discussion: The presence of cotton-wool spots, alone or in combination with other clinical findings, warrants further investigation. Although most cotton-wool spots resolve without long-term visual sequelae and could be managed with close observation only, they have been associated with life- or sight-threatening conditions. Therefore, any underlying causes should be identified and treated appropriately. Given the absence of a pre-specified workup for cotton-wool spots, the extent and type of workup should be dictated by the appropriate clinical context.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccination of corneal herpes (HSK) 角膜疱疹疫苗(HSK)

New frontiers in ophthalmology (London) Pub Date : 2020-01-01 DOI: 10.15761/NFO.1000253

Kozaburo Hayashi

引用次数: 0

Toxic epidermal necrolysis associated with meibomian gland dysfunction: Report of a case managed by thermal pulsation treatment 中毒性表皮坏死松解与睑板腺功能障碍相关:一例热搏动治疗

New frontiers in ophthalmology (London) Pub Date : 2020-01-01 DOI: 10.15761/NFO.1000246

J. Greiner, Michael E. Lindsay, K. Kenyon, Paula J Oliver, H. El-Rayess

{"title":"Toxic epidermal necrolysis associated with meibomian gland dysfunction: Report of a case managed by thermal pulsation treatment","authors":"J. Greiner, Michael E. Lindsay, K. Kenyon, Paula J Oliver, H. El-Rayess","doi":"10.15761/NFO.1000246","DOIUrl":"https://doi.org/10.15761/NFO.1000246","url":null,"abstract":"Purpose: To report a case of toxic epidermal necrolysis (TEN) with meibomian gland dysfunction demonstrating improvement in signs and symptoms after a single thermal pulsation system treatment (TPST). Methods: Baseline signs (meibomian gland assessment [MGA] scores and lipid layer thickness [LLT]) and symptoms (SPEED and OSDI scores) were evaluated in a 41 year old Caucasian female with a 16 years history of dry eye diseases secondary to a TEN episode. The patient was treated with a single 12-min TPST and re-evaluated at 3, 9, and 36 months post-treatment. Results: At 3 months post-TPST, both signs and symptoms scores improved relative to baseline and when re-measured at 9 months and 3 years. Conclusion: This report is the first to suggest the benefit of TPST on improving dry eye signs and symptoms in TEN. Interestingly, the improvement in symptoms as measured by SPEED and OSDI, was paralleled by the improvement in signs (MGA and LLT). Improvements in signs and symptoms were sustained over baseline including the relative decline at 3 years from the optimum improvements post-TPST.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological significance of recombination-activating gene 1, RAG1 in optic nerve neuropathy 重组激活基因1 RAG1在视神经病变中的生物学意义

New frontiers in ophthalmology (London) Pub Date : 2020-01-01 DOI: 10.15761/NFO.1000245

Takao Hirano, Tomoko Nakamura-Yanagidaira, Takuma Hayashi

{"title":"Biological significance of recombination-activating gene 1, RAG1 in optic nerve neuropathy","authors":"Takao Hirano, Tomoko Nakamura-Yanagidaira, Takuma Hayashi","doi":"10.15761/NFO.1000245","DOIUrl":"https://doi.org/10.15761/NFO.1000245","url":null,"abstract":"Although the transcription factor, nuclear factor-kappa-B (NF- κ B) is known to regulate programed-cell death and survival, its precise role in cell death within the central nervous system (CNS) remains unknown. We previously reported that mice with a homozygous deficiency for Nf- κ b1p50 spontaneously developed optic neuropathy. We investigated the expression and activation of pro-apoptotic factor(s), which mediate optic nerve neuropathy in Nf- κ b1p50- deficient mice. Recombination activating gene 1 (RAG1) is known to control the recombination of immunoglobulin V(D)J. Experiments with genetically engineered mice revealed the involvement of RAG1 expression in the programmed-cell death of POU domain protein (POU4f2)/brain-specific homeobox 3A (BRN3a)-positive retinal ganglion cells (RGCs), and also showed the specific effects of a Nf- κ b1p50 - deficient on the activation of Rag1 gene transcription. Furthermore, a genetic analysis of murine neuronal stem-like cells clarified the biological significance of RAG1 in N-methyl-D-aspartate (NMDA)-induced neuronal cell death. The apoptotic inducing factors were detected in human cell line expressing the external molecule of RAG1, and human histopathological examinations with retina tissues revealed the expression of RAG1 in RGCs. Recent studies indicated that RAG1 played a key role in optic nerve neuropathy as a pro-apoptotic candidate in Nf- κ b1p50- deficient mice. These results may lead to new therapeutic targets in optic nerve neuropathy.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser-intraocular lenses interaction: Aspects to consider for in situ vision correction 激光-人工晶状体相互作用:原位视力矫正需要考虑的方面

New frontiers in ophthalmology (London) Pub Date : 2020-01-01 DOI: 10.15761/NFO.1000250

G. Kareliotis, E. Drakaki, C. Bacharis, M. Makropoulou, A. Serafetinides

{"title":"Laser-intraocular lenses interaction: Aspects to consider for in situ vision correction","authors":"G. Kareliotis, E. Drakaki, C. Bacharis, M. Makropoulou, A. Serafetinides","doi":"10.15761/NFO.1000250","DOIUrl":"https://doi.org/10.15761/NFO.1000250","url":null,"abstract":"Today, 60 years after the laser discovery, the long experience in refractive surgery, the evaluation of the accumulated clinical outcomes and the limitations of kerato- refractive surgery generated the demand to develop alternative methods for treating vision defects. In the frame of this new philosophy for vision correction, the use of polymeric intraocular lenses (IOLs) provides sufficient predictability and optical quality. The new Ophthalmology era takes their use one step further, through the IOLs’ customization, aiming at the long desired personalized treatment. Inspired by the need to correct some post-operative complications in cataract surgery and IOLs implantation, the laser use is proposed, for in situ refractive modification of the implanted polymeric material, without any alteration in IOL’s light transmittance behavior. In this work we present a brief literature overview of new perspectives in this field, enriched with some of our experimental studies. Through discussion of the laser-material interactions we intend to present the prospects, the limitations and the aspects that have to be considered in the route for in situ laser-based IOL- surgery and finally, vision correction.","PeriodicalId":91933,"journal":{"name":"New frontiers in ophthalmology (London)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0