Modern clinical medicine research最新文献

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Determination of the Dose of Erythrosine B as a Preparation for Inducing the Experimental Rats to Be Spastic 红素B作为实验性大鼠痉挛制剂的剂量测定
Modern clinical medicine research Pub Date : 2019-07-20 DOI: 10.22606/MCMR.2019.32001
Marina Indriasari, Hardinsyah, L. Kustiyah, B. Priosoeryanto, F. H. Idris
{"title":"Determination of the Dose of Erythrosine B as a Preparation for Inducing the Experimental Rats to Be Spastic","authors":"Marina Indriasari, Hardinsyah, L. Kustiyah, B. Priosoeryanto, F. H. Idris","doi":"10.22606/MCMR.2019.32001","DOIUrl":"https://doi.org/10.22606/MCMR.2019.32001","url":null,"abstract":"This study aimed to make the experimental rats spastic using Erythrosine B (ErB) in the correct dose. Five male Sprague-Dawley rats (T) aged 10-12 weeks with a weight of 200-250 mg were injected with ErB and doses as follows: 20 mg/kg bw for T1, 80 mg/kg bw for T2, 160 mg/kg bw for T3, 320 mg/kg bw for T4, and 400 mg/kg bw for T5. The results of 4-wk observation indicated that T1 had a rapid decrease in spasticity. T2 still experienced spasticity on day 3 with 100% muscle resistance. Its spasticity reduced by 25% within 14 days, and it still experienced spasticity with 50% muscle resistance within 28 days. T3 experienced spasticity with 100% muscle resistance until day 7. T4 and T5 died after induction. It could be concluded that the ErB dose of 80 mg/kg bw was used as a preparation for the induction of experimental rats.","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89936628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Relation of Food Consumption and Nutritional Adequacy to Nutritional Status of Children with Cerebral Palsy 脑性麻痹儿童营养状况与食物摄取量及营养充足程度的关系
Modern clinical medicine research Pub Date : 2019-04-30 DOI: 10.22606/MCMR.2019.31001
Marina Indriasari, Hardinsyah, L. Kustiyah, Ferial Hadipoetro
{"title":"Relation of Food Consumption and Nutritional Adequacy to Nutritional Status of Children with Cerebral Palsy","authors":"Marina Indriasari, Hardinsyah, L. Kustiyah, Ferial Hadipoetro","doi":"10.22606/MCMR.2019.31001","DOIUrl":"https://doi.org/10.22606/MCMR.2019.31001","url":null,"abstract":"Nutritional problems in children with cerebral palsy (CP) may occur due to inadequate dietary intake. This study aimed to identify food consumption and nutritional adequacy in relation to the nutritional status. This study used a cross-sectional design which was conducted in Special Schools at Jakarta, Depok and Bogor.The subjects were selected by purposive sampling, i.e., CP children aged 5-18 years. The data collected included the subjects’ characteristics through questionnaires, food consumption by 1x24-hour food record method, and nutritional status assessed from body mass index (BMI)-for-age. The results of this study showed that about 45% of CP children were 6-12 years old and there were more boys than girls. Approximately 65% of CP children had eating frequency of three times a day with a protein adequacy level of 81,1%. There were 64,4% of CP children with thin nutritional status. Zinc and vitamin C adequacy levels had significant associations with nutritional status.","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88694473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myringoplasty in Children: When and How. Retrospective Analysis of 15 Years Experience and Prospective Considerations 儿童鼓膜成形术:何时及如何。15年经验的回顾性分析及前瞻性考虑
Modern clinical medicine research Pub Date : 2018-10-01 DOI: 10.22606/mcmr.2018.24001
Enrico Maria Amadei M.D, B. M.D., C. M.D.
{"title":"Myringoplasty in Children: When and How. Retrospective Analysis of 15 Years Experience and Prospective Considerations","authors":"Enrico Maria Amadei M.D, B. M.D., C. M.D.","doi":"10.22606/mcmr.2018.24001","DOIUrl":"https://doi.org/10.22606/mcmr.2018.24001","url":null,"abstract":"","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91437110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Stent Implantation Combined with Balloon Dilatation in the Treatment of Severe Peripheral Arterial Occlusive Disease of Lower Extremity in Macao—A Single Center Experience 澳门地区支架植入联合球囊扩张治疗下肢严重外周动脉闭塞性疾病的疗效——单中心经验
Modern clinical medicine research Pub Date : 2018-10-01 DOI: 10.22606/MCMR.2018.24002
Ieong Chon Man, Liang Zhu, Tam Man Pan, K. Chau, Kuok Cheong U
{"title":"Efficacy of Stent Implantation Combined with Balloon Dilatation in the Treatment of Severe Peripheral Arterial Occlusive Disease of Lower Extremity in Macao—A Single Center Experience","authors":"Ieong Chon Man, Liang Zhu, Tam Man Pan, K. Chau, Kuok Cheong U","doi":"10.22606/MCMR.2018.24002","DOIUrl":"https://doi.org/10.22606/MCMR.2018.24002","url":null,"abstract":"Objective: To investigate the feasibility and clinical efficacy of stent implantation and balloon angioplasty in the treatment of severe lower extremity arterial ischemia. Methods: Twentytwo patients with severe lower extremity ischemia were enrolled from January 2016 to December 2016. According to the scope of the patient's lesions, we choose the appropriate length of the balloon, according to different degrees of balloon dilation lesion stenosis or occlusion of the adjacent multiple short part of the lesion, as far as possible the formation of long balloon. Metallic stents were implanted in the dilated vessels to prevent restenosis. The incidence of postoperative complications, the rate of technical success and the clinical efficacy were observed, and the primary patency rate was evaluated through follow-up. Results: The total of 22 patients had 42 vessels with varying degrees of stenosis and occlusion, with an operative success rate of 100%. The primary patency rate was 90.9% and 81.8% at 6 and 12 months respectively. The ankle brachial index was significantly higher than that before the operation, and the Rutherford classification of most patients was significantly improved after the operation (P<0.05). No serious complications or death cases were found in this study. The average postoperative hospital stay was 4.3 days. Conclusion: For the severe ischemic disease of the lower extremities, interventional therapy is more effective than surgical treatment, with fewer complications and faster recovery. Stent implantation combined with balloon therapy does not affect the postoperative blood supply of the affected limb. The initial technical and clinical success rate is very high. It is a safe and effective method for the treatment of severe arterial ischemia disease of the lower extremities.","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88765370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Research Progress of Chinese Medicine in Treating Recurrent Respiratory Tract Infections in Children 中医药治疗儿童反复呼吸道感染的临床研究进展
Modern clinical medicine research Pub Date : 2018-07-01 DOI: 10.22606/mcmr.2018.23002
Shufeng Li, Jihua Liu, Guoliang Zhou, Ya-Chun Han, Wei Zhang
{"title":"Clinical Research Progress of Chinese Medicine in Treating Recurrent Respiratory Tract Infections in Children","authors":"Shufeng Li, Jihua Liu, Guoliang Zhou, Ya-Chun Han, Wei Zhang","doi":"10.22606/mcmr.2018.23002","DOIUrl":"https://doi.org/10.22606/mcmr.2018.23002","url":null,"abstract":"Objective: To study the effect of traditional Chinese medicine ointment on recurrent respiratory infection in children in cold area, and the effect on the changes of trace elements and serum immune indexes. Methods: 100 cases of children with recurrent respiratory infection were selected from 06 months from 2016 to 06 months in 2017 in our hospital. All the children were divided into the observation group and the control group according to the random digital table method, with 50 cases in each group[3]. The children in the control group were treated with the standard treatment of anti inflammation of Western medicine[7], improving immunity and so on. The observation group was added with Jianpi moistening ointment on the basis of the standard treatment of Western medicine. After 2 weeks of continuous treatment[9], the clinical and laboratory indexes were compared between the 2 groups. Results: the total effective rate of treatment in the observation group was 90%, which was significantly higher than that of the control group (72%), and the difference between the 2 groups was statistically significant (P < 0.05). The serum immunologic level of the observation group and the control group were significantly improved after the treatment (P < 0.05), but the observation group was better than the control group (P < 0.05). Conclusion: traditional Chinese medicine ointment is effective in the treatment of recurrent respiratory infection in children, and it can significantly improve the serum immune level of children. It is worthy of clinical application[5].","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87266379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antibacterial Activity of Medicinal Plants Used in the Management of HIV/AIDs Opportunistic Infections in Njeru Sub County, Buikwe District Buikwe区Njeru县用于治疗HIV/AIDs机会性感染的药用植物抑菌活性
Modern clinical medicine research Pub Date : 2018-07-01 DOI: 10.22606/mcmr.2018.23001
Mustapha W. Shehu, N. Abdulkadir, I. Bello, A. Shehu, S. Waziri
{"title":"Antibacterial Activity of Medicinal Plants Used in the Management of HIV/AIDs Opportunistic Infections in Njeru Sub County, Buikwe District","authors":"Mustapha W. Shehu, N. Abdulkadir, I. Bello, A. Shehu, S. Waziri","doi":"10.22606/mcmr.2018.23001","DOIUrl":"https://doi.org/10.22606/mcmr.2018.23001","url":null,"abstract":"Infectious diseases such as skin infection, chronic cough, stomach infection, tuberculosis, diarrhoea, warts, herpes zoster and others were claimed to be treated using medicinal plants. The study was aimed at determining the antibacterial activity and determination of bioactive compound of some medicinal plants used in management of HIV/AIDS opportunistic infections. A total of six plants were subjected to phytochemical and three out of six were tested against bacterial pathogens. The aqueous extracts of plants leaves of Pseudospondias microcarpa (PM), Callistemon citrinus (CC) and Spathodea campanulata (SC) were tested against two bacterial pathogens namely: Staphylococcus aureus and Pseudomonas aeruginosa. The result revealed the presence of Saponins, Tannins, Anthracenosides and Steroid glycosides. Alkaloids, flavonoids and reducing sugars had narrow distribution among the species. The highest clear zones were found in PM against Staphylococcus aureus (21.18mm) followed by 20.07mm for CC and 19.03mm for PM against the same bacterium. For Pseudomonas aeruginosa 20.36mm, was recorded for PM, 21.3mm for CC and 20.16mm for Sc at different concentration. The antibiotic used as control revealed highest against all the tested bacteria. There was no significant difference between the bacterial activities of the extracts of the three plant species but it varied significantly across the different serial dilutions. Further studies should be conducted on phytochemical analysis to establish more active ingredients that may be used in the development of drugs by pharmaceutical companies.","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85918634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Survey of Physician Perspective towards Management of Pain for Chronic Conditions in the Emergency Department. 急诊科医师对慢性疼痛管理的观点调查。
Modern clinical medicine research Pub Date : 2017-10-01 DOI: 10.22606/mcmr.2017.13002
Daniel Sop, Wally Smith, Abdulkhaliq Alsalman, Jennifer Li Wong, Ding-Yu Fei, Donna McClish, Azhar Rafiq, Patrick Coyne, Shirley Johnson, Thokozeni Lipato
{"title":"Survey of Physician Perspective towards Management of Pain for Chronic Conditions in the Emergency Department.","authors":"Daniel Sop,&nbsp;Wally Smith,&nbsp;Abdulkhaliq Alsalman,&nbsp;Jennifer Li Wong,&nbsp;Ding-Yu Fei,&nbsp;Donna McClish,&nbsp;Azhar Rafiq,&nbsp;Patrick Coyne,&nbsp;Shirley Johnson,&nbsp;Thokozeni Lipato","doi":"10.22606/mcmr.2017.13002","DOIUrl":"https://doi.org/10.22606/mcmr.2017.13002","url":null,"abstract":"<p><p>Sickle cell disease (SCD) pain is often acute-on-chronic, likening it to other chronic acute-on-chronic pain conditions. Pain treatment of SCD was already reported as inadequate prior to the current opioid epidemic, but attitudes underlying treatment were understudied. Understanding these attitudes prior to the current epidemic would be revealing. Therefore in 1997, before the current opioid epidemic, we surveyed physicians' attitudes toward pain management and treatment preferences for acute pain exacerbations in the Emergency Department in SCD versus those of chronic pancreatitis and chronic low back pain, two other acute-on-chronic pain diseases. Thirty-nine residency trainees were surveyed in a level one triage hospital. Resident estimates of the rate of opioid addiction in SCD were higher than estimates in both chronic pancreatitis and chronic low back pain. Most residents relied on their personal clinical experience rather than external sources of data or knowledge as the most important driver when they managed chronic pain. This survey research shows that, predating the current opioid epidemic, there was both a backdrop of opioid-phobia and a bias against treating SCD pain compared to other chronic pain conditions among our sample. Repeating this survey research among current training physicians, along with surveys of other attitudes, would provide useful comparisons.</p>","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439417/pdf/nihms-1563293.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39423197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Access to Medical Care for Individuals with Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: A Call for Centers of Excellence. 肌痛性脑脊髓炎和慢性疲劳综合征患者的就医途径:呼吁建立卓越中心。
Modern clinical medicine research Pub Date : 2017-04-01 Epub Date: 2017-04-13 DOI: 10.22606/mcmr.2017.11005
Madison Sunnquist, Laura Nicholson, Leonard A Jason, Kenneth J Friedman
{"title":"Access to Medical Care for Individuals with Myalgic Encephalomyelitis and Chronic Fatigue Syndrome: A Call for Centers of Excellence.","authors":"Madison Sunnquist, Laura Nicholson, Leonard A Jason, Kenneth J Friedman","doi":"10.22606/mcmr.2017.11005","DOIUrl":"10.22606/mcmr.2017.11005","url":null,"abstract":"<p><p>The current study sought to better understand the experience of individuals with myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) in accessing care for their debilitating illness. Of 898 participants, less than half had ever seen an ME or CFS specialist, though 99% of participants were interested in specialist care. Participants cited geographic and financial barriers as most frequently precluding access to specialists. Furthermore, satisfaction with specialist care greatly exceeded satisfaction with non-specialist care. These findings suggested that individuals with ME and CFS represent a medically-underserved population, due to lack of available care. The CFS Advisory Committee and NIH Pathways to Prevention Working Group recommended the creation of ME and CFS Centers of Excellence to improve the healthcare access of patients with ME and CFS. The current study documents the need for these centers, as they would ameliorate geographic and financial barriers to quality care.</p>","PeriodicalId":91930,"journal":{"name":"Modern clinical medicine research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510655/pdf/nihms873010.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35175987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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