{"title":"Comparative Study of the Effects of Gabapentin and Esmolol on Hemodynamic Response to Laryngoscopy and Intubation","authors":"Tiwari Ab, Mestha N","doi":"10.19070/2332-2780-18000110","DOIUrl":"https://doi.org/10.19070/2332-2780-18000110","url":null,"abstract":"The suppression of neurovegetative response to laryngoscopy and intubation has been tried out using several pharmacological agents, such as opioids, local anaesthetics, β-blockers and α2 agonists. Gabapentin an anticonvulsant, while esmolol is a cardioselective β1 blocker and a class II antiarrhythmic, they have shown to attenuate pressor response to direct laryngoscopy and tracheal intubation individually. Given these variable characteristics of two drugs, the present study, a prospective randomized double blind aimed to compare their efficacy against haemodynamic response during intubation and laryngoscopy.","PeriodicalId":91883,"journal":{"name":"International journal of anesthesiology & research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45001419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Our Experience of using Caudal Anesthesia in \"Small\" Surgical Interventions in Newborns","authors":"Nasibova Em, I. Ismailov","doi":"10.19070/2332-2780-18000109","DOIUrl":"https://doi.org/10.19070/2332-2780-18000109","url":null,"abstract":"Aim of the Study: To study the effectiveness of anesthesia with caudal administration of ropivacaine in combination with intravenous administration of propofol in new borns with \"small\" surgeries. Material and Methods of the Study: The work was performed in the surgical clinic of the Azerbaijan Medical University. The study included 117 new borns operated on a one-sided or bilateral inguinal hernia, phimosis, paraphimosis and rectal atresia. After the patient completely fell asleep with propofol, a caudal block with ropivacaine was performed. The effectiveness of caudal anesthesia was assessed by hemodynamic indices and by the Robinson index, which was also called the \"double product\" or RPP (rate pressure product). To assess postoperative pain in newborns, we used the CRIES scale. Results of the Study: When the caudal block was performed, no serious complications were noted in the newborn. Throughout the period of the surgical intervention (duration averaged from 30 minutes to 1.5 hours), the central hemodynamics index was stable, while the fluctuations of the studied parameters were insignificant in comparison with the initial data. No patient required intravenous administration of fentanyl. Assessment of pain on the scale CRIES showed that the maximum score was 0-4. And this indicates the absence of pain within 6 hours after the operation. Conclusions: 1. Caudal blockade with ropivacaine provides effective anesthesia in new borns with \"small\" surgical interventions below the navel. 2. In neonates, a single caudal administration of ropivacaine at a dose of 3 mg/kg does not result in significant changes in hemodynamic parameters of the entire period of effective analgesia.","PeriodicalId":91883,"journal":{"name":"International journal of anesthesiology & research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43275217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient Transfer Unit: Clinical Experience On Medical Evacuation In North-East","authors":"Tiwari Ab, M. H N","doi":"10.19070/2332-2780-18000108","DOIUrl":"https://doi.org/10.19070/2332-2780-18000108","url":null,"abstract":"","PeriodicalId":91883,"journal":{"name":"International journal of anesthesiology & research","volume":"69 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41261730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound-Guided Caudal Block for Anal Canal Surgery: A Prospective Cohort Study","authors":"Adriana M Cadavid, William H Joaqui","doi":"10.19070/2332-2780-18000107","DOIUrl":"https://doi.org/10.19070/2332-2780-18000107","url":null,"abstract":"Introduction: Postoperative pain is an important symptom in patients after non-oncological anal canal surgery. A caudal block has shown to be an effective analgesic technique in this type of surgery, and ultrasound facilitates its performance and increases the rate of a successful block. We aimed to determine the effectiveness of ultrasound-guided caudal block (UGCB) in anesthesia and postoperative analgesia in patients scheduled for benign anal surgery. Methods: This was a prospective interventional cohort study in adult patients who underwent benign anal surgery under UGCB. We evaluated the effectiveness of the intervention based on postoperative pain intensity measured with the numeric rating scale (NRS) at the following postoperative time points: 6, 12 and 24 hours. The following outcomes were included in our analysis: lower limbs motor block, urinary retention, rescue analgesia, and patient’s analgesia satisfaction. Results: A total of 23 patients were included for data analysis. At least 65% of the study population reported none to mild pain (NRS ≤ 3) during the first 24 hours after surgery. None of the study patients experienced complete motor block in lower extremities or urinary retention. The mean time for patients to request the first rescue analgesia was 6.4 hours. The survey results indicated that 22 patients (95.7%) out of 23 were satisfied with the postoperative pain control. Conclusions: UGCB is an effective, easy to perform intervention in patients with benign anal canal surgery. This technique offers an alternative multimodal pain control therapy with satisfactory analgesic effect and low rate of adverse events.","PeriodicalId":91883,"journal":{"name":"International journal of anesthesiology & research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41427433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development Process of Sepsis Diagnosis","authors":"Kucuk Ao, E. A.","doi":"10.19070/2332-2780-18000106","DOIUrl":"https://doi.org/10.19070/2332-2780-18000106","url":null,"abstract":"Sepsis is a heterogeneous clinical condition that is most common in intensive care units, which is the cause of morbidity, mortality and increased cost. Diagnosis at the earliest stage in the clinical diversity that can progress from simple infection to sepsis and septic shock is the primary clinical goal. Clinical studies and consensus reports have been published and published over the years so that early diagnosis and resuscitation can be started quickly. In fact, it is easy to use in clinical practice and clinical criteria can be set to facilitate the work of the physician without complicated laboratory procedures. Thus, the treatment stage can be overcome to prevent this severe infectious process leading to organ dysfunction and increased mortality. In this review, consensus definitions used in the definition of sepsis, the latest consensus recommendation, and current developments in sepsis are summarized.","PeriodicalId":91883,"journal":{"name":"International journal of anesthesiology & research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68340910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ossification of the Posterior Longitudinal Ligament: A Case Report of Difficult Intubation in a Resource Limited Setting","authors":"Baral Bk, Jense Rj","doi":"10.19070/2332-2780-18000105","DOIUrl":"https://doi.org/10.19070/2332-2780-18000105","url":null,"abstract":"Ossification of the posterior longitudinal ligament (OPLL) is a rare and often unrecognized cause of difficult intubation that is most commonly found in elderly Asian males. This case report will describe the airway management of such a patient with severely limited neck mobility. A 66-year-old male with diabetes and hypertension presented with ongoing neck pain over three years and new progressive weakness in all extremities over the last two months. Neurological examination revealed mild spastic paresis and hyperreflexia in both upper and lower extremities. Neck movement was severely restricted and radiographic evidence supported the finding of OPLL. A challenging airway was anticipated and management plans were discussed in advance. A difficult intubation set containing a video laryngoscope and a fiberoptic bronchoscope were prepared for the case. Conventional laryngoscopy was avoided due to severely limited neck mobility and the risk of causing trauma to the spine. The trachea was successfully intubated using video laryngoscopy without manipulation of the cervical spine. The patient underwent a successful posterior decompressive laminectomy with posterior lateral mass screw fixations at C2-C6. OPLL is a rare cause of difficult intubation that can pose a challenge to anaesthesia providers, especially in resource limited settings. Preoperative evaluation and appropriate airway preparation is essential. Our case demonstrates that video laryngoscopy can be a great choice for the management of difficult airways in such patients.","PeriodicalId":91883,"journal":{"name":"International journal of anesthesiology & research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44169361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Kline, E Wong, M Haile, S Didehvar, S Farber, A Sacks, E Pirraglia, M J de Leon, A Bekker
{"title":"Peri-Operative Inflammatory Cytokines in Plasma of the Elderly Correlate in Prospective Study with Postoperative Changes in Cognitive Test Scores.","authors":"R Kline, E Wong, M Haile, S Didehvar, S Farber, A Sacks, E Pirraglia, M J de Leon, A Bekker","doi":"10.19070/2332-2780-1600065","DOIUrl":"10.19070/2332-2780-1600065","url":null,"abstract":"<p><p>Increasingly, postoperative cognitive dysfunction (POCD) is recognized as a complication after surgery in the elderly; but it's etiology remains unclear. Here we examine changes in cytokine levels during both the pre-operative and postoperative period, comparing them with long term variation in cognitive test scores. Forty-one patients aged 65 and older undergoing major surgery with general anesthesia were recruited after written consent in this IRB approved study. Thirty went on to complete this prospective, non-interven-tional and non-randomized study. Plasma levels of cytokines Il-6, Il-8, Il-10, and TNF were determined using ELISA with MILLIPLEX Multi-Analyte Profiling (Billerica, MA). All subjects had neurocognitive tests pre-operatively and 6 months post-surgery, including Paragraph Recall Immediate and Delayed, Digit Span Forward (DSF) and Backward (DSB), and Trail Making A and B. Spearman's Rho and repeated measure rank analysis were used to examine the dependence of z score changes in cognitive tests (baseline versus 6 months) as a function of 3 cytokine time points (presurgical, post anesthesia care unit (PACU), and post-operative day one (POD1)). A greater increase in PACU inflammatory burden correlated with a greater decline in performance on the DSB (IL6, IL8; r>-0.560; p<= 0.008). DSF changes correlated slightly better with pre-surgical cytokines, declining more with higher cytokines (IL6, r= -0.551, p=0.002; IL8, -0.468, 0.009). TNF, examining all 3 values, changed only slightly postoperatively, but still correlated with a decline in DSB (p=0.014). Thus, cognitive performance, over 6 months post surgery, declines with elevated perioperative inflammation. Specific cytokines at specific perioperative times may impact specific cognitive functions, serving as diagnostics as well as contributing causation.</p>","PeriodicalId":91883,"journal":{"name":"International journal of anesthesiology & research","volume":"4 8","pages":"313-321"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351884/pdf/nihms-811941.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34833615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}