Cancer reports and reviews最新文献

{"title":"Do we need cost-effectiveness analysis of brachytherapy for cervical cancer in the 3D image-guided era?","authors":"E. Suzumura, Gama Lm, Desiree Ha, de Soárez Pc","doi":"10.15761/crr.1000202","DOIUrl":"https://doi.org/10.15761/crr.1000202","url":null,"abstract":"Cervical cancer is the second most prevalent cancer in the female population. Intracavitary brachytherapy is considered an essential component of the disease management. In conventional brachytherapy, treatment planning is performed using X-ray imaging to visualize the pelvic bones structures and applicators, considering point A as the reference for dose delivery. For the last years, three-dimensional (3D) image-guided brachytherapy, with the use of computed tomography or magnetic resonance imaging, has been used to determine tumor volume and shape, as well as the healthy organs at risk, and prescribed dose is delivered to an ‘at-risk’ volume. Although 3D brachytherapy shows technical advantage and potentially superior clinical outcomes over conventional, 3D planning does carry added costs. The decision about incorporating new health technologies in health care systems should be based in multiple aspects, including financial issues. Economic evaluation studies have been adopted as a method for supporting efficient resource allocation. Cost-effectiveness analysis, in particular assessing consequences as quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs), that is cost-utility analysis, are the preferred type of economic evaluation study for decision-making on technology incorporation. Evidence from economic evaluation studies are not transferrable to other health care systems with distinct health policies, resources and priorities, therefore, whether the benefits afforded by 3D brachytherapy are cost-effective is to be determined withing each health care system considering local context.","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67452834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial melanoma syndrome - phenotypic characterization and comparison with sporadic melanoma and healthy individuals – A Brazilian study","authors":"Moredo Lf, Soares de Sá Bc, de Ávila Alr, G. Landman, Duprat Jp","doi":"10.15761/crr.1000219","DOIUrl":"https://doi.org/10.15761/crr.1000219","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition and evaluation of cytotoxic activity of Achillea falcata essential oil on HeLa and Caco-2 human cancer cell lines","authors":"Banan Younos, Chadi Soukkarieh, Hossam Murad","doi":"10.15761/crr.1000215","DOIUrl":"https://doi.org/10.15761/crr.1000215","url":null,"abstract":"Plants and their products, e.g. essential oils are mostly considered as safe medicine products. In recent years, medicinal plants have used as natural products that contribute to the prevention and treatment of disease. Medicinal plants play a crucial role in traditional medicine and in the maintenance of human health worldwide. The majority of Achillea species include highly bioactive compounds, so they have therapeutic applications. In the present study, the aim was to investigate in vitro anti-oxidant and cytotoxic effects of Achillea falcata essential oil. The essential oil was extracted from aerial parts using Clevenger method and its components were determined using GC-MS analysis. The anti-oxidant potential of the essential oil was analyzed by DPPH and total phenolic content methods. MTT assay was used to detect cytotoxicity of the essential oil on human cervical cancer cells HeLa and colon cancer cells Caco-2. The results showed that essential oil exhibited a low DPPH scavenging activity, and 32.467 Gallic acid equivalents/g plant oil of total phenolic content. As concentration was increased, the essential oil exhibited a more powerful cytotoxic effect on HeLa and Caco-2 cancer cell lines indicating that Achillea falcate essential oil might include anti-cancer compounds triggering the cytotoxicity on HeLa and Caco-2 cancer cells. *Correspondence to: Hossam Murad, Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria (AECS), Syria, E-mail: hmurad@aec.org.sy Received: August 20, 2020; Accepted: August 30, 2020; Published: September 06, 2020 Introduction In the past few years, interest in the antioxidant and radical scavenging properties of medicinal herbs and their extracts has risen enormously. In fact, antioxidants contained in plants seem to be involved in the preservation of human health, e.g. by preventing cancer, slowing down the aging process and reducing the risk of cardiovascular and neurodegenerative diseases. Oxidative damage is a hallmark of all these physio pathological conditions and plants, providing an exogenous source of antioxidants, may aid the natural defence systems of cells [1-3]. Therefore, the assessment of antioxidant and radical scavenging properties of traditionally widely used plants and plant extracts is an important issue in the quest both of new sources of natural antioxidants for functional foods, nutraceuticals [4,5] and of feasible and ‘natural’ alternatives to synthetic antioxidants in the food industry, since foodpreserving compounds are being restricted due to their inherent risk of carcinogenicity [6]. Achillea, one of the most important genera of the Compositae (Asteraceae) family, comprises more than 100 species around the world, mainly distributed in Europe, Asia and North Africa [7], In particular, Achillea falcata has been reported to have beneficial effects on internal hemorrhage, uterine hemorrhoid, stomach ailment, gastritis, and bladder stones [8]. In recent year","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation pneumonitis and Covid-19 pneumonia: are there overlapping features? Letter to editor","authors":"Lazzari G, Silvano G","doi":"10.15761/crr.1000210","DOIUrl":"https://doi.org/10.15761/crr.1000210","url":null,"abstract":"Respiratory involvement of Covid-19 infection, presenting as a mild flu-like illness to potentially lethal acute respiratory distress syndrome is the main clinical manifestation in adults. As well assessed by many reports, CT scan of the chest show a pictorial fashion of images due to the severity and stage of the disease, starting from focal nodular or mass-like opacities with air bronchogram to areas of ground glass consolidation or whited out lung. However, these findings have been defined not specific to this disease. At the Covid-19 pandemic time, they could yield confounding reporting in case of cancer patients treated with thoracic radiotherapy (RT) developing features of atypical radiation pneumonitis. Hypersensitivity pneumonitis and radiation induced Bronchiolitis Obliterans Organizing Pneumonitis (RT- BOOP) should be accounted in the differential diagnosis.","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous regression of a big BCC. Is there a role for aloe verra?","authors":"C. Stefanaki, M. Plaka, M. Skylakaki, B. Theologi, D. Rigopoulos, A. Stratigos","doi":"10.15761/crr.1000213","DOIUrl":"https://doi.org/10.15761/crr.1000213","url":null,"abstract":"A 95-year-old man presented with a 10cm mass on the forehead with a central ulceration and a rolled edge, hard and fixed with underlying tissues present for 9 months. Histopathological examination revealed a typical basal cell carcinoma with metatypic features. Computed tomography of the head excluded infiltration of the bone and underlying tissues. We also detected two pearly nodular lesions on the left cheek and a similar on the nose suggestive of bccs. The patient was advised to start vismodegib but he refused and decided to start a herbal medicine based on aloe verra (one leaf per day) mixed with the juice of one pomegranate and one orange daily. After 3 months on the herbal juice the big lesion and all other tumors on the patient’s face regressed totally. Interestingly, he reported that regression of the big lesion halted when he stopped the medication for 10 days. *Correspondence to: Christina Stefanaki, 13 Pontou street, Ilisia 11527, Athens, Greece, Tel: +30210-7487822, Fax: +30210-7487822, Email: cstefana@otenet.gr","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer stem cells and breast cancer","authors":"Hyder Sm, Slight Sh","doi":"10.15761/crr.1000199","DOIUrl":"https://doi.org/10.15761/crr.1000199","url":null,"abstract":"Received: February 29, 2020; Accepted: : March 11, 2020 Published: March 16, 2020 Breast cancer is one of the leading causes of death in women, both globally and in the United States. In the US over 40,000 women die from the disease annually [1]. Although breast cancer is an extremely heterogeneous disease that may be characterized by the presence or absence of various phenotypic markers, the initiation, proliferation and ultimate metastasis of breast tumors is dependent on pluripotent cancer stem cells (CSCs); undifferentiated CSCs can self-renew and become differentiated into a variety of specialized cell types [2]. Compared with the majority of cells within a tumor, CSCs are more resistant to established methods of chemotherapy, including radio-, chemoand hormone treatments. When transplanted into an animal model, CSCs have the capacity to seed new tumors. CSCs typically exhibit a specific phenotypic signature of CD24low/-, CD44high, ALDH (aldehyde dehydrogenase) [3]. The cell surface glycoprotein, CD44 plays a role in cell/cell communication, cell adhesion and migration. Since CSCs resist conventional breast cancer therapies, there is an urgent need to develop specialized treatments to decrease their population and thereby reduce metastasis.","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a management guideline wheel for uterine neoplasms based on different guidelines for management of uterine neoplasms","authors":"Mahmoud Samy Ismail, F. Ismail, Julia Ismail, Ashish Rustogi, U. Torsten, Stephanie Hsu, Muneera Ahmed Alkhalifa, Alaa Zeineldine, E. Fadel","doi":"10.15761/crr.1000220","DOIUrl":"https://doi.org/10.15761/crr.1000220","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful use of Eltrombopag in a patient with refractory HIV-associated Immune Thrombocytopenic Purpura","authors":"Juárez Lm, D. Condé, S. Dalia","doi":"10.15761/crr.1000207","DOIUrl":"https://doi.org/10.15761/crr.1000207","url":null,"abstract":"Immune Thrombocytopenic Purpura (ITP) is not uncommon in patients with Human Immunodeficiency Virus (HIV) infection. This entity can be recurrent to standard therapy, which includes corticosteroids, intravenous immunoglobulins (IVIG) and highly active antiretroviral therapy (HAART). In immunocompetent patients with ITP, Eltrombopag, a thrombopoetin receptor agonist (TRA), has proven to be save and useful for increasing platelet counts and for treating patients with Hepatitis C virus (HCV) associated thrombocytopenia that need an interferon-based therapy. Safety and efficacy data with the use of TRAs in HIV-associated ITP are scarce, being a non-authorized indication. We report our one-year experience with Eltrombopag for treating a severe and refractory HIV-associated ITP.","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic engineering of a probiotic-based drug delivery system for colorectal cancer therapy","authors":"B. C. An, Yongku Ryu, Oksik Choi, Sunwoong Hong, Jinseok Heo, M. Chung","doi":"10.15761/crr.1000208","DOIUrl":"https://doi.org/10.15761/crr.1000208","url":null,"abstract":"Food-grade bacteria, including lactic acid bacteria (LAB), are safe to ingest and are not associated with development of disease. The impact of LAB on health has been studied in depth from a clinical perspective. Evidence suggests that LAB benefit health in several ways, including improving the balance between probiotic and harmful bacteria in the intestine, protecting against pathogen infections, and modulating host immunity in the gut. Recent publications show that LAB are safe biotherapeutics that exert positive effects against various cancer types, including colorectal cancer (CRC). CRC develops in intestine and, unless treated early, will invade the surrounding tissue and spread to other parts of the body. One intrinsic advantage of food-grade LAB is that they can be applied easily as oral medications and act as vehicles for bio-therapeutics, which can be delivered directly to the mucosal surface of the intestine. Consequently, a LAB-based drug delivery system (DDS) can have synergistic effects: the patient derives benefit from both the LAB and the therapeutic cargo. Furthermore, the localized effect of LAB-based DDS in the intestine would ensure targeted treatment at the site of disease; this has the benefits of requiring a lower dose of a drug, with fewer systemic side effects. In this review, we discuss the evidence supporting the beneficial effects of LAB-based DDS and its application to CRC. *Correspondence to: Myung Jun Chung, Ph.D., R&D Center, Cell Biotech, Co., Ltd., 50, Aegibong-ro 409 beon-gil, Gaegok-ri, Wolgot-myeon, Gimpo-si, Gyeonggi-do, Korea, E-mail: ceo@cellbiotech.com","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol biosynthesis inhibitor RO 48-8071 inhibits viability of aggressive cancer cells","authors":"Yayun Liang, X. Zou, S. Hyder","doi":"10.15761/crr.1000216","DOIUrl":"https://doi.org/10.15761/crr.1000216","url":null,"abstract":"","PeriodicalId":91850,"journal":{"name":"Cancer reports and reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67453671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}