Reactive oxygen species (Apex, N.C.)最新文献_第5页

Regulation of Nrf2 Signaling. 调节 Nrf2 信号。

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-11-01

Robert Li, Zhenquan Jia, Hong Zhu

引用次数: 0

Regulation of Nrf2 Signaling. Nrf2信号的调控。

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-11-01 DOI: 10.20455/ROS.2019.865

Robert Li, Z. Jia, Hong Zhu

引用次数: 94

Elimination of Sestrin 2 Compromises Viability in Extracellular Matrix-Detached SKOV3 Ovarian Cancer Cells 消除Sestrin 2对细胞外基质脱离的SKOV3卵巢癌症细胞生存能力的损害

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-09-06 DOI: 10.20455/ROS.2019.861

Y. Gonzalez, Leann Tulisiak, M. Philbin, H. Voss, E. Schramm, Irma Ruelas, Calli A. Davison-Versagli

{"title":"Elimination of Sestrin 2 Compromises Viability in Extracellular Matrix-Detached SKOV3 Ovarian Cancer Cells","authors":"Y. Gonzalez, Leann Tulisiak, M. Philbin, H. Voss, E. Schramm, Irma Ruelas, Calli A. Davison-Versagli","doi":"10.20455/ROS.2019.861","DOIUrl":"https://doi.org/10.20455/ROS.2019.861","url":null,"abstract":"Epithelial ovarian carcinoma (EOC) is considered the deadliest gynecological cancer, largely due to the fact that it is often diagnosed once the cancer has already metastasized, thus making the disease more difficult to treat. Throughout metastasis, ovarian epithelial cancer cells must overcome many feats, including surviving in extracellular matrix (ECM) detachment. ECM-detached cancer cells must evade a number of insults, including increased intracellular reactive oxygen species (ROS). Recent evidence suggests ECM-detached cancer cells rely on antioxidant enzymes to combat these increasing levels of ROS to promote survival; however, the specific antioxidant enzymes involved in this process have yet to be fully elucidated. Sestrin 2 (SESN2) is a multi-functional protein that has been found to be instrumental in many different signaling pathways; notably, it has been recognized to play a critical role in eliminating ROS. Here, we show that SESN2 plays a unique role in maintaining the viability of ECM-detached metastatic ovarian epithelial cancer cells, and elimination of this critical protein results in compromised viability. Thus, these data identify SESN2 as a potentially interesting therapeutic target for treating this deadly metastatic disease.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47566807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hot Pepper Extract Protects against Hypoglycemia-Induced Brain and Liver Injury in Mice 辣椒提取物对小鼠低血糖性脑和肝损伤的保护作用

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-09-01 DOI: 10.20455/ROS.2019.859

O. Abdel-Salam, A. Sleem, E. Youness, F. Morsy, Nermeen M. Shaffie, A. Souleman

{"title":"Hot Pepper Extract Protects against Hypoglycemia-Induced Brain and Liver Injury in Mice","authors":"O. Abdel-Salam, A. Sleem, E. Youness, F. Morsy, Nermeen M. Shaffie, A. Souleman","doi":"10.20455/ROS.2019.859","DOIUrl":"https://doi.org/10.20455/ROS.2019.859","url":null,"abstract":"This study aimed to investigate the potential neuroprotective effect of red hot pepper (Capsicum annuum) extract in hypoglycemic injury in mice. Hypoglycemia was induced by intraperitoneal (ip) injection of insulin (3 IU/kg) followed 30 min later by ip administration of the pepper extract at 0.25 and 0.5 g/kg. Mice were euthanized 3 h after insulin injection and their brains were dissected out for biochemical studies including determination of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide, paraoxonase-1 (PON-1), 5-lipoxygenase, and cholinesterase. Histological investigations for the brain and liver, and brain immunohistochemistry (glial fibrillary acidic protein; GFAP) were carried out. Results indicated that hypoglycemia significantly increased MDA and nitric acid levels and decreased GSH content in the brain. There was also significant inhibition of PON-1 and cholinesterase activities, but increased brain 5-lipoxygenase. Spongiform degeneration, vacuolations, and necrotic and apoptotic neurons were seen in the cerebral cortex. Glial cells were markedly decreased both in number and size with decreased GFAP staining. Additionally, necrosis of hepatocytes, and cytoplasmic vacuoles were observed. The biochemical alterations induced by hypoglycemia in the brain tissue were alleviated by the pepper extract resulting in decreased MDA and nitric oxide levels, restoration of GSH content, increased PON-1 and cholinesterase activities, and inhibition of 5-lipoxygenase. The pepper extract reduced the extent of damage to cortical neurons and increased the number, size, and length of astrocytes processes and GFAP expression. In addition, there was marked improvement in pathological changes induced by hypoglycemia in the liver by administering the pepper extract. The study indicates a protective effect for the hot pepper extract against brain and liver damage induced by hypoglycemia likely via inhibition of oxidative stress and 5-lipoxygenase.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44240819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Elimination of Peroxiredoxin 1 Abrogates Proliferation and Viability in Extracellular Matrix-Detached SKOV3 Ovarian Cancer Cells 细胞外基质分离的SKOV3卵巢癌细胞中过氧化物还氧蛋白1的消除可抑制细胞外基质分离的SKOV3卵巢癌细胞的增殖和活力

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-09-01 DOI: 10.20455/ROS.2019.851

Alyssa Axe, S. Gilligan, Mary Green, Y. Gonzalez, A. Miłoś, Calli A. Davison-Versagli

引用次数: 0

Network Theory and the Resilience of Redox Signaling 网络理论与氧化还原信号的弹性

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-09-01 DOI: 10.20455/ROS.2019.849

J. Hancock, D. Veal, A. Hancock

{"title":"Network Theory and the Resilience of Redox Signaling","authors":"J. Hancock, D. Veal, A. Hancock","doi":"10.20455/ROS.2019.849","DOIUrl":"https://doi.org/10.20455/ROS.2019.849","url":null,"abstract":"The redox status inside and around cells is critically important to control, being used to maintain reduced compounds in the correct state and for cell signaling mechanisms. A myriad of compounds and proteins are involved in a vast network system to regulate the redox state of biological systems. These include reactive molecules such reactive oxygen species (ROS), nitric oxide (NO·) and hydrogen sulfide (H2S) along with systems for their removal, such as antioxidants. Redox buffering involves molecules such as glutathione, low molecular weight thiols and ascorbate. Network Theory attempts to give the mechanisms underlying complex networks a mathematical and model-based underpinning and it has been suggested that metabolic systems can be described as scale-free networks, having a power law degree distribution. Such networks are said to be both robust but vulnerable, suggesting a level of resilience. Redox metabolism also has to be robust, being maintained in what has been described as the Goldilocks Zone, while it is also vulnerable to outside influence, often leading to the phenomenon referred to as oxidative stress. Therefore, it is suggested here that a holistic approach to understand redox networks should embrace Network Theory, which may be able to predict characteristics of the redox network that can be targeted for new therapeutics or agricultural treatments.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43036287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Link between Oxidative Stress and Cancer: Prevention through Yoga 氧化应激和癌症之间的联系:通过瑜伽预防

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-09-01 DOI: 10.20455/ROS.2019.853

S. Gautam, S. Bisht, R. Dada

{"title":"The Link between Oxidative Stress and Cancer: Prevention through Yoga","authors":"S. Gautam, S. Bisht, R. Dada","doi":"10.20455/ROS.2019.853","DOIUrl":"https://doi.org/10.20455/ROS.2019.853","url":null,"abstract":"Sperm DNA damage induced by oxidative stress may lead to accumulation of mutations in sperm genome due to the presence of mutagenic oxidative adducts in DNA. This may contribute to the development of male infertility, recurrent pregnancy loss, congenital malformations, neurodevelopmental disorders, and childhood cancers. This article highlights the impact of lifestyle habits of father preconceptionally, its lifelong impact on offspring’s health and impact of yoga-based lifestyle intervention on sperm genome and epigenome. Sperm is transcriptionally and translationally inert with a very basic repair mechanism and is thus unable to repair DNA damage and this may persist postfertilization and lead to accumulation of damaged DNA in each cell of zygote. This DNA damage with high levels of mutagenic oxidative base adducts may lead to accumulation of mutations in both sperm DNA (germline) and zygote (somatic). Majority of mutations arise during cell replication and as sperm has a limited capacity for DNA damage detection and repair, it is highly susceptible to accumulation of mutations. Paternal unhealthy lifestyle habits like smoking, alcohol, or tobacco consumption are positively associated with the risk of childhood cancers like nonfamilial sporadic heritable retinoblastoma. Lifestyle interventions like yoga improve sperm DNA integrity by reducing levels of oxidative DNA damage, optimizing oxidative stress, and by increasing the expression of genes responsible for DNA repair, cell-cycle control, and anti-inflammatory effects. Thus, social habits affect sperm DNA health and as such, it is recommended that simple lifestyle modifications (diet rich in fruits and vegetables, yoga, meditation) improve DNA health and may thereby decrease the incidence of childhood morbidity and cancer. Hence, biological parenting commences well before birth and even prior to conception, which highlights the need for fathers to adopt a healthy lifestyle.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44812680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative Stress and Diminished Total Antioxidant Capacity in Malaria Patients Correspond to Increased Parasitemia and Severity of the Disease 疟疾患者的氧化应激和总抗氧化能力下降与寄生虫血症的增加和疾病的严重程度相对应

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-09-01 DOI: 10.20455/ROS.2019.855

A. Ebrahim, N. Gnanasekaran, S. Genet

{"title":"Oxidative Stress and Diminished Total Antioxidant Capacity in Malaria Patients Correspond to Increased Parasitemia and Severity of the Disease","authors":"A. Ebrahim, N. Gnanasekaran, S. Genet","doi":"10.20455/ROS.2019.855","DOIUrl":"https://doi.org/10.20455/ROS.2019.855","url":null,"abstract":"Malaria is a leading cause of morbidity and mortality. Of the five Plasmodium species that cause malaria, P. falciparum is the deadliest. Oxidative stress might be increased in malaria patients and contribute to severity and complications. This may originate from intracellular parasitized erythrocytes and extra-erythrocytes as a result of hemolysis and host immune response. Oxidative stress-induced oxidation of hemoglobin to methemoglobin may cause further complications in malaria patients. The aim of this study was to estimate the total oxidative stress and non-enzymatic antioxidant levels in malaria patients. The study was undertaken with 60 malaria patients and 40 healthy controls. Severity of malaria was determined by the density of parasitemia. Out of the 60 malaria patients, 32 had low, 16 moderate, and 12 high parasitemia. Levels of total oxidative stress (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), uric acid, albumin, and total bilirubin and direct bilirubin levels were measured in the serum of malaria patients and healthy controls. Our results showed that TOS, OSI, uric acid, and total bilirubin and direct bilirubin levels were significantly increased in the serum of malaria patients compared to healthy control subjects. On the other hand, TAC and serum albumin levels were significantly reduced in malaria patients compared to control cases. The changes of oxidative stress and antioxidant status also correlated to the severity of parasitemia. Oxidative stress might thus contribute to the pathophysiology of malaria.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43718834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Toxicity of Titanium Dioxide Nanoparticles Induced by Reactive Oxygen Species 活性氧诱导二氧化钛纳米颗粒的毒性研究

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-07-23 DOI: 10.20455/ROS.2019.857

Di Zhou, Shuo Han, T. Yan, C. Long, Jiayu Xu, P. Zheng, Zhangjian Chen, G. Jia

引用次数: 5

Body Mass Index and Age-Related Changes of ROS Production and Oxidative Stress Biomarkers in Healthy Subjects 健康人的体重指数及ROS产生和氧化应激生物标志物的年龄相关变化

Reactive oxygen species (Apex, N.C.) Pub Date : 2019-07-01 DOI: 10.20455/ROS.2019.841

A. Vezzoli, M. Gussoni, M. Montorsi, S. Mrakic-Sposta

{"title":"Body Mass Index and Age-Related Changes of ROS Production and Oxidative Stress Biomarkers in Healthy Subjects","authors":"A. Vezzoli, M. Gussoni, M. Montorsi, S. Mrakic-Sposta","doi":"10.20455/ROS.2019.841","DOIUrl":"https://doi.org/10.20455/ROS.2019.841","url":null,"abstract":"In this study, age-related changes in reactive oxygen species (ROS) production and markers of oxidative stress were investigated specifically addressing the role played by the body mass index (BMI). In two groups of healthy subjects, old (aged 72.6 ± 4.7 years) and young (aged 18.9 ± 1.6 years), ROS production rate, products of lipid peroxidation (as thiobarbituric acid-reactive substances, TBARS), protein oxidation (as total protein carbonyls, PC), and total antioxidant capacity (TAC) were assessed. BMI was also determined, and the subjects were classified into normal weight, overweight, and obese. In both groups (young and old), significant increases in ROS production rate and levels of systemic oxidative damage biomarkers (TBARS and PC) and decreases in TAC levels were shown to correlate with BMI. When comparing data in the same BMI subgroup, significant differences (lower ROS production rate, PC, and TBARS levels, and higher levels of TAC) were observed in the young group versus the old group. In conclusion, the study showed that oxidative stress biomarkers were elevated in obese subjects and old age was associated with increases in oxidative stress markers and decreases in TAC.","PeriodicalId":91793,"journal":{"name":"Reactive oxygen species (Apex, N.C.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43826919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1