Bioinorganic chemistry最新文献_第8页

Biological function of metallothionein-IV. Biosynthesis and degradation of liver and kidney metallothionein in rats fed diets containing zinc or cadmium 金属硫蛋白iv的生物学功能。含锌或镉大鼠肝脏和肾脏金属硫蛋白的生物合成和降解

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80200-8

S.H. Oh, J.T. Deagen, P.D. Whanger, P.H. Weswig

引用次数: 36

Oxidation of cuprous stellacyanin by aminopolycar☐ylatocobaltate(III) complexes 氨基聚物8.2.2酰钴酸盐(III)配合物氧化星青苷铜

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80272-0

Gerald S. Yoneda, Gary L. Mitchel, Gary L. Blackmer, Robert A. Holwerda

{"title":"Oxidation of cuprous stellacyanin by aminopolycar☐ylatocobaltate(III) complexes","authors":"Gerald S. Yoneda, Gary L. Mitchel, Gary L. Blackmer, Robert A. Holwerda","doi":"10.1016/S0006-3061(00)80272-0","DOIUrl":"10.1016/S0006-3061(00)80272-0","url":null,"abstract":"<div>Rate parameters are reported for the oxidation of cuprous stellacyanin by Co(PDTA)− (k(25.0°) = 17.9 M−1sec−1, Δ H≠ = 8.5 kcal/mol. ΔS≠ = −24 cal/mol-deg; pH 7.0, μ 0.5 M) and Co(CyDTA)− (k(25.1°) = 17.0 M−1 sec−1, ΔH≠ = 8.7 kcal/mol, ΔS≠ = −24 cal/mol-deg; pH 7.0, μ 0.5 M). The first order Co(PDTA)− and Co(CyDTA)− dependences observed over wide concentration ranges contrast with the saturation behavior reported previously for Co(EDTA)− as the oxidant. It is concluded that the -CH3 and -(CH2)4-substituents of PDTA and CyDTA, respectively, prevent the alkylated derivatives of Co(EDTA)− from hydrogen bonding with the reduced blue protein, causing precursor complex formation constants to fall far below that of 149 M−1 (25.1°) observed for the EDTA complex. The similarity between ΔH≠ and ΔS≠ values for the oxidation of stellacyanin by Co(PDTA)− and Co(CyDTA)− indicates that the size of alkyl substituents linked to the carbon atoms of the EDTA ethylenediamine backbone has little influence on activation requirements for Cu(I) to Co(III) electron transfer. The electron transfer reactivity of aminopolycar☐ylatocobalt(III) complexes with cuprous stellacyanin therefore appears to be linked to the accessibility of one or more of the ligated acetate groups to outer-sphere contact with the type 1 Cu(I) center. Saturation in kobsd vs. [oxidant] plots found for the reactions of Co(PDTA)− and Co(CyDTA)− with stellacyanin at pH 6 and at pH 7 in the presence of EDTA is attributed to the formation of “dead-end” oxidant-protein complexes.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"8 5","pages":"Pages 369-386"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80272-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11888913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Effects of glucose and chromium(iii) concentrations in the medium on the uptake of51Cr by brewer's yeast 培养基中葡萄糖和铬(iii)浓度对酿酒酵母吸收51cr的影响

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80277-X

Jorma Kumpulainen, Pekka Koivistoinen

引用次数: 3

Kinetics of the oxidation of rhus vernicifera stellacyanin by the Co(EDTA)-ion Co(EDTA)-离子氧化牛蜡星青苷的动力学研究

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80240-9

Gerald S. Yoneda, Robert A. Holwerda

{"title":"Kinetics of the oxidation of rhus vernicifera stellacyanin by the Co(EDTA)-ion","authors":"Gerald S. Yoneda, Robert A. Holwerda","doi":"10.1016/S0006-3061(00)80240-9","DOIUrl":"10.1016/S0006-3061(00)80240-9","url":null,"abstract":"<div>A kinetic study of the oxidation of the copper(I) form of the blue copper protein stellacyanin (St(I)) by Co(EDTA)- has been performed. Observed rate constants approach a saturation limit with increasing [Co(EDTA)-] at pH 7, consistent with a mechanism involving rapid pre-equilibrium oxidant-protein complex formation followed by rate-limiting intramolecular Cu(I) to Co(III) electron transfer: <figure><img></figure>. Activation parameters based on k2 (ΔH≠ = 1.8 kcal/mol, ΔS≠ = -56 cal/mol-deg) indicate that the electron transfer process is substantially nonadiabatic, in marked contrast with results obtained for Co(phen)33+ as the oxidant. Linear kobsd vs. [Co(EDTA)-] plots are reported for the Co(EDTA)- oxidation of cuprous stellacyanin at pH 10 (k = 8.9 M-1 sec-1; 25.0°, pH 10, μ 0.5 M (carbonate); ΔH≠ = 11.3 kcal/mol, ΔS≠ = -16 cal/mol-deg) and at pH 7 in the presence of excess EDTA (k = 21.2 M-1 sec-1; 25.1°, pH 7.0, μ 0.5M (phosphate), [EDTA]tot = 5 X 10-4 M; ΔH≠ = 5.9 kcal/mol, ΔS≠ = -33 cal/mol-deg). It is concluded that Co(EDTA)- adopts an electron transfer mechanism similar to that preferred by Co(phen)33+ under conditions where the oxidant is prevented from binding strongly to reduced stellacyanin.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"8 2","pages":"Pages 139-159"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80240-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11366414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Reactivity of antiinflammatory and superoxide dismutase active Cu(II)-salicylates 抗炎和超氧化物歧化酶活性Cu(II)-水杨酸酯的反应性

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80196-9

Ulrich Weser, Christoph Richter, Albrecht Wendel, Maged Younes

引用次数: 71

A single-test-tube method for the fluorometric microdetermination of selenium 单试管荧光微量测定硒的方法

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80153-2

Julian E. Spallholz, George F. Collins, Klaus Schwarz

引用次数: 68

Inhibition of Escherichia coli DNA polymerase I by association of the template with an N-methylisatin-β-thiosemicarbazone·copper complex 模板结合n-甲基化atin-β-硫代氨基脲·铜复合物对大肠杆菌DNA聚合酶I的抑制作用

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80131-3

Peter Mikelens, Bruce Woodson, Warren Levinson

{"title":"Inhibition of Escherichia coli DNA polymerase I by association of the template with an N-methylisatin-β-thiosemicarbazone·copper complex","authors":"Peter Mikelens, Bruce Woodson, Warren Levinson","doi":"10.1016/S0006-3061(00)80131-3","DOIUrl":"10.1016/S0006-3061(00)80131-3","url":null,"abstract":"<div>The deoxyribonucleic acid polymerase I (deoxynucleoside triphosphate: DNA deoxynucleotidyl transferase; E.C 2.7.7.7) of Escherichia coli is inhibited more than 99% by 50 μM N-methylisatin-β-thiosemicarbazone (M-IBT) + 50 μM CuSO4. When added alone, 50 μM M-IBT enhanced activity, whereas 50 μM CuSO4 alone inhibits the reaction by 40%. Inhibition is reversed by the competing chelating agent ethylenediamine tetraacetate. A related compound, 1-formylisoquinoline thiosemicarbazone, also inhibits enzyme activity in the presence of cupric ions.Polymerase inhibition by M-IBT + CuSO4 is relieved when increasing amounts of nucleic acid, but not increasing amounts of enzyme, are added. This suggests that the DNA template, not the polymerase, is the target of inhibition by M-IBT + CuSO4.The biological pertinence of nucleic acid as a target for the M-IBT + CuSO4 complex is shown by the binding of Rous sarcoma virus (RSV) 70 S RNA to the complex formed within the intact virus particle. The importance of metal ions for this drug action is supported by the ability of ethylenediamine tetraacetate to reverse the binding.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"9 6","pages":"Pages 469-478"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80131-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87461397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Oscillation reactions in the system: Metabolites of krebs cycle-Mn2+-KBrO3-H2SO4 系统中的振荡反应:krebs循环的代谢物- mn2 +-KBrO3-H2SO4

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80136-2

J.Masełko T. Tłaczala, M. Czerwiński, J. Michałczyk, Z. Sikorski

引用次数: 5

Characterization of gold in the cytosol of rat-kidney cortex cells 大鼠肾皮质细胞胞浆中金的表征

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80147-7

Howard O. Thompson, Judith Blaszak, Connie J. Knudtson , C.Frank Shaw III

{"title":"Characterization of gold in the cytosol of rat-kidney cortex cells","authors":"Howard O. Thompson, Judith Blaszak, Connie J. Knudtson , C.Frank Shaw III","doi":"10.1016/S0006-3061(00)80147-7","DOIUrl":"10.1016/S0006-3061(00)80147-7","url":null,"abstract":"<div>Evidence is presented for a chemical equilibrium of gold(I) among sulfhydryl binding sites in the cytoplasm of renal cortical cells of the rat. The gold distribution among protein and nonprotein species, examined by gel-permeation chromatography following in vivo administration of gold sodium thiomalate, gold sodium thioglucose, NaAuCl4, and (C2H5)3PAuCl, was similar in each case, although the cytoplasmic gold concentrations varied. The pattern of gold elution closely parallels that of the thiol groups in the supernatant. In vitro addition of gold sodium thiomalate to the supernatant fraction produced an identical distribution. Addition of cysteine to cytoplasm following in vivo administration of gold drastically decreased the protein-bound gold and increased the non-protein-bound gold. These data rule out the induced synthesis of a metallothionein-like gold-binding protein. Ultracentrifugation revealed gold to be present in the microsomal fraction as well as the supernatant.</div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"9 5","pages":"Pages 375-388"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80147-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90436869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

The 1H-nmr spectra of mixed valence complexes of copper with derivatives of 1-amino-2,2-dimethyl-2-mercaptoethane 铜与1-氨基-2,2-二甲基-2-巯基乙烷衍生物混合价配合物的1H-nmr谱

Bioinorganic chemistry Pub Date : 1978-01-01 DOI: 10.1016/S0006-3061(00)80242-2

Gordon Leonard Eggleton, Goeh Jung, John Ricken Wright

引用次数: 3