Myopain最新文献

{"title":"Cost-Utility Analysis of a Six-Weeks Ganoderma Lucidum-Based Treatment for Women with Fibromyalgia: A Randomized Double-Blind, Active Placebo-Controlled Trial","authors":"M. A. García-Gordillo, D. Collado-Mateo, M. Hernández-Mocholí, F. Pazzi, N. Gusi, F. J. Domínguez-Muñoz, J. Adsuar","doi":"10.1080/24708593.2017.1382644","DOIUrl":"https://doi.org/10.1080/24708593.2017.1382644","url":null,"abstract":"Abstract Purpose: To determine the effectiveness of adding Ganoderma lucidum (GL) to standard care for patients with fibromyalgia (FM), and to examine the costs per quality-adjusted life year (QALY) gained from this nutritional supplementation. Materials and methods: This was a randomised controlled trial with a random allocation of participants to two groups; experimental group and active-placebo controlled group. A total of 26 women with FM participated in the experimental group. These participants were instructed to take 3 g of micromilled GL twice a day for six weeks. EQ-5D-5L was used to obtain the utilities and a non-parametric bootstrap was used to plot the acceptability curve. Results: Of the women initially recruited, over 81% completed the experimental treatment. The incremental QALY in the GL group was 0.177, and the incremental QALY in the active placebo group was 0.101. Therefore, the difference in terms of QALYs was 0.076 and the incremental cost-utility ratio was €1348.55/QALYs. The cost-utility acceptability curve showed 90% probability that the addition of GL to the standard care as a nutritional supplement is cost-effective. Conclusions: The GL as nutritional supplementation in patients with FM is cost-effective in women with FM. To authors’ knowledge, the current study reports the first cost-utility analysis of GL as a nutritional supplement.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2017.1382644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60128235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Combining Myofascial Release with Ice Application on a Latent Trigger Point in the Forearm of Young Adults: A Randomized Clinical Trial","authors":"Cristian Gutiérrez-Rojas, Ignacio González, E. Navarrete, Evelyn Olivares, J. Rojas, Diego Tordecilla, C. Bustamante","doi":"10.1080/24708593.2017.1403526","DOIUrl":"https://doi.org/10.1080/24708593.2017.1403526","url":null,"abstract":"Abstract Background: Myofascial trigger points (MTrP) are considered to be a common source of pain in people. Due to their presence in any skeletal muscle in the body, they can be relevant in the genesis of musculoskeletal disorders. Their preventive management could reduce its potential activation and impact over people’s functioning. Objectives: The aim was to determine the immediate effect of combining myofascial release (MFR) with ice on a latent MTrP in the forearm of young adults. Materials and methods: Using a randomized repeated measures design, 30 young adults with one latent MTrP on the extensor muscles of the forearm were allocated into three groups; group I received ice massage, group II received MFR and group III received MFR with ice. The pressure pain threshold (PPT), pressure pain perception (PPP) and strength of the flexor and extensor muscles of the forearm were evaluated at baseline, immediately after treatment and at 30 min. Results: An immediate improvement in PPT (p  < 0.05) and PPP (p  <  0.0005) occurred in group III. Additionally, an increase in flexor muscle strength (p  <  0.05) is observed 30 min in this group. Group II increased its PPT immediately (p  <  0.005) and afterwards (p < 0.05). Group I also changed its PPP immediately (p < 0.005). No changes in extensor muscle strength were observed. Conclusions: The results demonstrate an immediate improvement in pain variables after the application of ice massage, MFR and MFR with ice in young adults with a latent MTrP.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2017.1403526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60128326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morning Stiffness in Rheumatoid Arthritis: Investigating its Relationship with Disease Activity as Assessed by Power Doppler Ultrasonography and Composite Scores","authors":"Kazushige Seki, T. Kanchiku, A. Tokushige, H. Ogasa, T. Imagama, T. Seki, T. Taguchi","doi":"10.1080/24708593.2017.1365797","DOIUrl":"https://doi.org/10.1080/24708593.2017.1365797","url":null,"abstract":"Abstract Objective: This study investigated potential associations of morning stiffness (MS) with rheumatoid arthritis (RA) disease activity and ultrasonography (US). Methods: We conducted a cross-sectional analysis of 100 consecutive patients with RA divided into MS-positive group (n = 38) and MS-negative group (n = 62). US findings, disease activity score in 28 joints (DAS28) and Clinical Disease Activity Index (CDAI) were compared. Results: DAS28, CDAI and the number of power Doppler (PD) signal-positive joints were significantly higher in the MS-positive group (p < 0.01). The number of patients who did not achieve the DAS28 or CDAI remission criteria was significantly higher in the MS-positive group (p < 0.01). When cut-off points were applied, MS duration of ≥10 min was associated with PD signal-positive joints, with a sensitivity of 47.5% and a specificity of 92.3% (area under curve = 0.7087, chi-square test: p < 0.0001). Conclusion: This study showed that in patients with MS duration of ≥10 min, there was a high probability of PD-positive joints in the hand.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2017.1365797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60128220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Study of the Diurnal Variation and Reliability of Biomarkers Related to Physiological Damage Experienced in Work-Related Musculoskeletal Disorders","authors":"M. Christian, M. Nussbaum","doi":"10.1080/24708593.2016.1246503","DOIUrl":"https://doi.org/10.1080/24708593.2016.1246503","url":null,"abstract":"Abstract Objectives: Select biomarkers derived from such tissue damage have been proposed as a tool for predicting MSD risk. Factors beyond the exposure to biomechanical stress, although, may influence these biomarkers and thus should be quantified. The purpose of this exploratory study was to determine (1) whether diurnal variations exist for Cartilage Oligomeric Matrix Protein (COMP), Interleukin-6 (IL6), and Creatine Kinase (CK); and (2) if these diurnal variations are influenced by personal factors including age, obesity status, and gender. Methods: Twenty-seven participants were dichotomously classified by age (young = 24.7 [3.9], older = 55.2 [5.0]), body mass index (BMI) (not obese = 23.1 [2.2], obese = 34.1 [2.9]), and gender (males = 14, females = 13), and had blood samples drawn at six time points over a 24-hour period (22:00, 07:00, 10:00, 14:00, 18:00, and 22:00) during which any strenuous physical activity was restricted. Results: COMP levels were significantly higher for males, had significant diurnal variation (p < 0.01), and this diurnal variation differed between genders (p = 0.05). IL6 did not have any significant diurnal variation or differences related to age, obesity status, or gender. CK levels exhibited significant diurnal variation (p = 0.05), and levels were significantly influenced by age (p < 0.07) and an obesity status × gender interaction (p < 0.02). Reliability (between two samples at 22:00), measured by the intraclass correlation, was classified as “excellent” for all biomarker levels. Conclusions: Diurnal changes in COMP and CK may reflect differences in body composition between groups. The present results may aid in future study interpretation or design utilizing these biomarkers in the occupational environment.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2016.1246503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60128291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Extracorporeal Shock Wave Therapy on Numerical Rating Scale of Pain in Patients with Chronic Plantar Fasciitis","authors":"Amin Kordi Yoosefinejad, R. Ghalamghash","doi":"10.1080/24708593.2016.1271851","DOIUrl":"https://doi.org/10.1080/24708593.2016.1271851","url":null,"abstract":"Abstract Objectives: Heel pain secondary to plantar fasciitis [PF] is a common problem making up 11–15% of foot problems. Extracorporeal shock wave therapy [ESWT] is a relatively new approach that has evolved as a treatment option, but there are controversies about the applied parameters. The effects of ESWT have not been studied in an Iranian population, so the aim of our study was to investigate the effects of ESWT on patients with PF. Methods: A total of 168 patients [70 men and 98 women] with the mean age of 50 ± 4.55 years were treated between March 2010 and 2013. Each patient was treated four times [once a week] and received a total of 8000 pulses. The parameters were set according to patients’ perception of pain and increased gradually in accordance with patients’ tolerance. Results: We evaluated the visual analog scale [VAS] of pain, TUG test, and activities of daily living [ADLs] in patients during the first session and immediately after the completion of the sessions. We also followed up the patients for a mean of 10.5 months. Both VAS and ADLs have demonstrated improvement immediately after the completion of treatment course and during the follow up period. TUG test showed significant statistical differences among the evaluations. Conclusions: ESWT is a safe and efficient treatment method for recalcitrant plantar fasciitis, especially, if prescribed dosage would be considered individually.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2016.1271851","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60127842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalographic Changes After Application of Dry Needling [DNHS© Technique] in Two Patients With Chronic Stroke","authors":"S. Calvo, J. Navarro, P. Herrero, R. D. del Moral, Cristina de Diego, P. Marijuán","doi":"10.1080/24708593.2017.1291550","DOIUrl":"https://doi.org/10.1080/24708593.2017.1291550","url":null,"abstract":"Abstract Background: Dry needling [DNHS© technique] is a promising treatment modality for patients with spasticity. However, little is known regarding the indirect effects of dry needling on regional brain activity. This study aimed to describe the electroencephalographic changes found after the application of DNHS© in two patients with stroke. Findings: Two patients with chronic stroke and spasticity received a single session of dry needling in spastic muscles selected after clinical evaluation. An improvement in the regional brain activity was observed after the application of DNHS© based on the measurement of quantitative electroencephalographic activity and electroencephalographic cordance. Conclusions: This study shows that the DNHS© technique, which is based on a peripheral application, has a positive effect on regional brain activity.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2017.1291550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60127904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Myofascial Pain and Fibromyalgia on Pain and Disability of the Computer Users with Cumulative Trauma Disorders","authors":"H. Genç, Ö. B. Tuncer, H. Erdem, B. Nacır","doi":"10.1080/24708593.2017.1410271","DOIUrl":"https://doi.org/10.1080/24708593.2017.1410271","url":null,"abstract":"Abstract Objectives: We hypothesized that Cumulative Trauma Disorders (CTD) is common in computer workers and computer workers with CTD will have more FFS and MPS than those without. We further hypothesized that those with CTD and FS or MPS will have greater disability than those without. Methods: 170 computer users and 55 age, sex and body mass index matched healthy controls were included in the study. Pain assessment was made by visual analog scale. The presence of FS was evaluated using 2010 ACR classification criteria. The existence of MPS was evaluated using specific diagnostic criteria. In order to measure the general disability levels of the participants, Quick DASH Score (QDS) was used, besides to measure their disability levels during work, Quick DASH Work Score (QDWS) was used. Results: 114 (69%) of the computer users had CTD. The presence of MPS and FS in CTD group was significantly higher than the non-CTD group and controls (p < 0.001, p < 0.001). QDS and QDWS were significantly higher in CTD group (p < 0.01–p < 0.05). Statistically significant increases were found in pain score, QDS and QDWS in CTD group with FS and MPS (p < 0.05–p < 0.001). Conclusions: We observed that CTD is common in computer users and determined that the existence of fibromyalgia and MPS are found to be serious risk factors for disability in computer users with CTD. We believe that treatment of FS and MPS have great importance in the treatment and more importantly in the prevention of this clinic entity which can cause serious pain, disability and workforce loss.","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2017.1410271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60127866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MYOPAIN takes a break","authors":"Michael R. Sorrell","doi":"10.1080/24708593.2017.1389066","DOIUrl":"https://doi.org/10.1080/24708593.2017.1389066","url":null,"abstract":"After this, the second issue of the journal that was previously known as the Journal of Musculoskeletal Pain, MYOPAIN, a journal of myofascial pain and fibromyalgia, will, like the JMP before it, go into hiatus or slumber. To signal the intensity of our focus, the editorial board and the International Myopain Society board of directors decided, with the change of the name of the journal, to limit the publication to topics related to muscle pain to the exclusion of rheumatologic disorders. We wanted to be the place where researchers and clinicians went to discuss muscle pain, which affects almost everyone and which attracts relatively little specific scientific interest. We were unable to sustain the volume of submissions and the recruitment of reviewers for those articles to publish the journal in the frequency needed to be the forum the topic deserved. It is a wonder to those who study and treat muscle pain why the topic does not attract more clinical and research attention. We know myofascial pain is a regional pain of muscles and tendons. Most people have had it. Although myofascial pain has a specific anatomy and physiology, it needs further exploration. The clinical evaluation of the patient with it is relatively simple. Actually examining muscles, is an event becoming rare in clinical medicine, to prove the patient has primary or secondary myofascial pain leads to effective treatment and fewer expensive misdiagnoses. Fibromyalgia pervades our society. It can be considered the muscular component of a widespread syndrome we are coming to term ‘‘chronic pain.’’ It is different from myofascial pain, but the two often inhabit the same patient. Fibromyalgia has a signature on functional MRI showing where and why patients are so prone to pain. There is no easy treatment for any of the chronic pain conditions. We need controlled research to identify the biologic basis of the muscle pain of fibromyalgia. The results should lead to inventive therapy. As we wait in our ignorance, fibromyalgia patients are at risk for medication abuse, as they drop out of productive life while their care givers watch in frustration and exhaustion. I thank associate editor Scott Mist (USA), and section editors Jacob Ablin (Israel), Robert Gerwin (USA), Carmen Gota (USA), Roberta Moreira (Brazil), and Matthew Robbins (USA) for their diligence and long hours of work on the journal. They and our reviewers have helped improve the quality of the submissions. I appreciate the efforts of various editors and assistant editors at Taylor & Francis, especially those of Lucy Francis, in helping with the publication process. Like Snow White, MYOPAIN will enter sleep from a potion of circumstances beyond its control. It will be served while in repose by acolytes, in this case the believers in the entities of myofascial pain and fibromyalgia: scientists, academicians, clinicians, patients. It will await rescue from a person or organization of nobility. Once restored, it will again ser","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/24708593.2017.1389066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60128290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Joint Hypermobility is not Benign","authors":"R. Gerwin","doi":"10.3109/10582452.2016.1156289","DOIUrl":"https://doi.org/10.3109/10582452.2016.1156289","url":null,"abstract":"","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10582452.2016.1156289","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69501318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble Adenosine Deaminase Activity in Fibromyalgia Syndrome","authors":"R. V., C. E., E. B., Fais A.","doi":"10.3109/10582452.2015.1127305","DOIUrl":"https://doi.org/10.3109/10582452.2015.1127305","url":null,"abstract":"Fibromyalgia syndrome (FMS) is a widespread pain disorder of unknown etiology. It is characterized by tender points noted on physical examination and is often accompanied by a number of associated symptoms (1). Pain perception is altered in patients with FMS. For example, in genetically predisposed individuals, negative environmental influences may lead to central sensitization (CS) characterized by hyperalgesia, allodynia, an expansion of the receptive field and unpleasant poststimulus pain. CS implies that there is enhanced excitability of the dorsal horn neurons, with altered nociceptive information being provided to the brain. In the neuroanatomical circuits, the roles of a variety of substances, such as serotonin, dopamine, excitatory amino acids, cytokines, nitric oxide and purines, have been established (2). The antinociceptive effects of adenosine, which acts on A1 receptors, are well established (3). Recent studies have highlighted a reduction of circulating adenosine levels (4,5) in FMS. Moreover, a negative correlation was found between adenosine and the fibromyalgia impact questionnaire (FIQ), which was in agreement (5) with there being nociception alterations in FMS. Extracellular adenosine can pass through the cell membrane or can be deaminated to inosine by adenosine deaminase (ADA-EC 3.5.4.4.). ADA is a cytosolic enzyme, but it is also found on the surface of mononuclear cells (MCADA) in association with the CD26 glycoprotein, which exhibits dipeptidylpeptidase IV (DPPIV) activity. Moreover, a form of ADA that does not bind soluble CD26-DPPIV exists in the serum. Guieu (4) reported that there were low adenosine plasma concentrations in patients with FMS as a result of greater CD26–MCADA complex activities. In light of these findings, soluble ADA activity in patients with FMS and healthy subjects was assessed and compared in this study to evaluate the possible correlation between ADA activity and lower circulating adenosine levels that was previously reported in patients with FMS (5). The present study was approved by the ethical committee of the University Hospital of Cagliari and written informed consent was obtained from each woman for the use of her clinical information and blood samples. Twenty-two females affected by FMS (according to the 1990 and 2010 American College for Rheumatology Criteria (6,7)) and 22 controls were studied. The samples used were identical to those described in our previous study (5) and were stored at 80 C and never thawed. Total ADA activity (tADA) was estimated by the Giusti method (8). Statistical analysis was performed using the STAT VIEW5.0 software program developed by the SAS Institute Inc (Cary, NC). The tADA (mean ± SD) in patients with FMS (17.24 ± 5.95 U/l) was slightly increased compared with the controls (16.45 ± 4.58 U/l), but the difference was not statistically significant (Figure 1). The patients with FMS were divided in two groups (severe (n1⁄4 12) or mild (n1⁄4 10)) according to thei","PeriodicalId":91773,"journal":{"name":"Myopain","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10582452.2015.1127305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69500388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}