International journal of pediatrics and child health最新文献

{"title":"Primary Amenorrhea in Pallister Killian Syndrome: Clinical Manifestation or Complication?","authors":"L. Abbattista, P. Baldassarre, Roberta Grazi, V. Calcaterra, P. Carlucci, V. Fabiano, P. Erba, E. Verduci, G. Zuccotti","doi":"10.12974/2311-8687.2021.09.4","DOIUrl":"https://doi.org/10.12974/2311-8687.2021.09.4","url":null,"abstract":"Introduction: Pallister-Killian syndrome (PKS) is a rare genetic disorder caused by a mosaic tetrasomy of the short arm of chromosome 12 (12p). PKS has a wide spectrum of clinical manifestations which vary in different age groups. However, in the up to date literature there are no reported cases of puberty disorder associated with this syndrome. We describe a caucasian 17- year-old girl with PKS with primary amenorrhea as failure of appropriate pubertal progression.\u0000Patient: at first general examination, the patient shows a phenotype compatible with the PKS of adulthood was noted. Auxological data revealed undernutrition (BMI ?3 z-score), with pubertal Tanner stage 3. A retarded bone age was detected. At pelvic ultrasound prepubertal uterus and microfollicular ovaries were noted. The laboratory data was compatible with hypogonadotropic hypogonadism.\u0000Conclusion: this is the first case of primary amenorrhea in PKS. It would be interesting to reassess this novel finding in other patients affected by the same condition in order to establish whether hypogonadotropic hypogonadism is a typical clinical manifestation of the syndrome or it’s secondary to nutritional and stressful status. ","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47918406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoestrogens in Soybean and Precocious Pubertal Development: Causality or Casuality?","authors":"V. Calcaterra, C. Regalbuto, G. Mercurio, E. Tenuta, E. Verduci, G. Zuccotti, V. Fabiano","doi":"10.12974/2311-8687.2021.09.6","DOIUrl":"https://doi.org/10.12974/2311-8687.2021.09.6","url":null,"abstract":"Introduction: Data on the effects of phytoestrogens soy exposure on pubertal timing have been equivocal. We reported a case of a girl who had eaten only soy and derivatives for her first 9 years of life and presented clinical manifestation of precocious pubertal development.\u0000Case presentation: A caucasian female infant, after 40 days of exclusive breastfeeding, was introduced to soy formula due to suspected milk protein allergy. Since then, the patient ate soy beverage and soy-based foods exclusively. At the age of 7 years and 9 months, the girl showed premature thelarche and pubarche. Advanced skeletal age was detected. Peak of LH after GnRH stimulation test was <5 mU/ml. At the age of 9 years, Tanner pubertal stage was 3, with a further advanced bone age; initial pubertal growth spurt and estrogenization of the external genitalia were also revealed. GnRH stimulation test produced a peak of LH 3.7 mU/ml. Other hormonal parameters resulted within normality ranges. Suspension of the intake of soy-based Fozods was adopted. After 6- 12 months of follow-up, the physical examination and lab results were unchanged compared to the previous investigation, without progression of bone age. A slow progression of puberty was recorded. The patient had menarche at the age of 11 years and 1 month.\u0000Conclusion: This case suggests that soybean compounds may play a key role, as an environmental factor, in the precocious pubertal development. Special attention to diet is mandatory in pediatric age in order to preserve a physiological development and future health. ","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47158831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis Intoxication, a Neglected Cause of Altered Level of Consciousness in Children: A Case Series","authors":"A. Mari, L. Gianolio, L. Abbattista, Francesca Ripoli, V. Calcaterra, V. Fabiano","doi":"10.12974/2311-8687.2021.09.5","DOIUrl":"https://doi.org/10.12974/2311-8687.2021.09.5","url":null,"abstract":"Altered level of consciousness (ALC) represents a neurological emergency, which demands a methodical approach to evaluation and treatment. Emergency departments’ Paediatricians dealing with children with ALC need a rapid and reliable diagnostic process to rule out life-threatening conditions. ALC can be caused by structural and non-structural conditions, and, among non-structural conditions, intoxications must always be investigated. Toddlers and young children exposed to cannabis may present ALC due to explorative ingestion of the substance.\u0000We report three cases of toddlers who were admitted to our emergency department over a 12-month period with ALC due to cannabis intoxication. The three cases highlight how clinical presentation of cannabis intoxication can be variegated.\u0000Therefore, in case of afebrile children presenting with ALC Cannabis intoxication must be suspected and a urine drug test should be performed. ","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49470597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Gastrointestinal Manifestations in Children Presenting with COVID-19","authors":"S. Salvatore, M. Agosti, S. Arrigo, M. Stracuzzi, D. Dilillo, L. Folgori, R. Giacchero, V. Giacomet, E. Longoni, A. Meini, G. Marseglia, A. Plebani, A. Ruffolo, L. Barcellini, G. Zuccotti","doi":"10.12974/2311-8687.2021.09.1","DOIUrl":"https://doi.org/10.12974/2311-8687.2021.09.1","url":null,"abstract":"SARS-CoV-2 infection commonly presents with mild to severe respiratory symptoms and possibly other organs involvement. Gastrointestinal manifestations have been frequently documented in adult patients whilst their occurrence in children is uncertain. This study aimed to perform a Systematic Review of gastrointestinal symptoms in children with Coronavirus disease (COVID-19) and to compare these clinical findings with those reported in a cohort of Italian children in the early phase of pandemic.\u0000Methods: Literature search was conducted using the Cochrane Library and MEDLINE (via Pubmed) databases from 1st December 2019 to 28th April 2020, according to the PRISMA guidelines. The following search terms were inserted: “Coronavirus” OR “COVID-19” OR “SARS-CoV-2” AND “gastrointestinal” or “diarrhea”. Only papers including children (0-18 years) and gastrointestinal symptoms were considered as eligible. Data records of children living in Lombardy, Italy, with infection of SARS-CoV-2 diagnosed by rRT-PCR on pharyngeal swabs, from 1st March to 28th April were also collected, analyzed and compared.\u0000Results: The Systematic Review showed that only a minority of studies assessed gastrointestinal symptoms in children. However, diarrhea accounted for 0-50%, vomit 5-67% and abdominal pain 5.8-33.3% of infected children and gastrointestinal symptoms may represent the sole feature of COVID-19. Gastrointestinal symptoms were reported in 51/116 (44%) Italian children with SARS-CoV-2 infection. Poor feeding was present in 23.3% of children, diarrhea (median duration 2.3 days, range 1-5 days) in 22.4%, vomit in 10.4% and abdominal pain in 6.9% of cases. Respiratory symptoms were reported in 35.3% of children with gastrointestinal symptoms that represented the first clinical manifestation of COVID-19 in 25% of all patients.\u0000Conclusions: We found that gastrointestinal symptoms are common in children with COVID-19 and, in some cases, they may represent the first and the sole clinical manifestation of SARS-CoV-2 infection. Health care professionals must be aware of the frequent gastrointestinal involvement in children to assure an accurate diagnosis and therapeutic management. The correct identification of children with COVID-19 is also crucial to adopt preventive measures and to limit the transmission of the virus. ","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42855261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Response and Susceptibility to SARS-CoV2 Virus in Children","authors":"M. Merchán, Rosa Silva, D. Velandia","doi":"10.12974/2311-8687.2021.09.2","DOIUrl":"https://doi.org/10.12974/2311-8687.2021.09.2","url":null,"abstract":": The COVID-19 disease that was first discovered in Wuhan-China province, also called severe acute respiratory syndrome, is a serious public health concern in the 21st century. This disease affects the respiratory system and its causal agent is the SARS-CoV2 virus, which is part of the family of beta-corona viruses that many associate with the bat. This virus not only affects the population that is considered vulnerable but also affects young adults and children. The objective of the present review is to describe the characteristics of the immune response and susceptibility in children with SARS-COV2. We examined articles in the Elsevier, Google Scholar, PubMed and Scielo databases regarding the immune systems of children with the disease of COVID-19 and the physio-pathological mechanisms of SARS-CoV2 that contribute to illness in this population. Although the capacity of infection of SARS-CoV2 in children is very high, the mechanism of the virus against pathogenicity in this population group is not clear. The objective of the present review is to describe the characteristics of the immune response and susceptibility in children with SARS-COV2","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44247594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choreic Movements as Manifestation of Hyperthyroidism in an Adolescent at the Onset of Graves’ Disease","authors":"V. Calcaterra, M. Burrone, D. Dilillo, G. Zuccotti","doi":"10.12974/2311-8687.2020.08.5","DOIUrl":"https://doi.org/10.12974/2311-8687.2020.08.5","url":null,"abstract":"","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47129682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Precocious Puberty in Girls","authors":"E. Bozzola, R. Gaudino, V. Calcaterra, G. Farello, Manuela Gasparri, C. Monti, A. Villani, M. Bozzola","doi":"10.12974/2311-8687.2020.08.1","DOIUrl":"https://doi.org/10.12974/2311-8687.2020.08.1","url":null,"abstract":"Puberty is one of the most astonishing periods of human life, when significant physical alterations occur along with psychosocial maturation. Precocious Puberty (PP) is defined as the appearance and progressive development of secondary sexual characteristics at a younger age than the general population, i.e. for Caucasian girls before 8 years of age. Untreated precocious puberty usually leads to short stature and can also cause significant emotional and behavioral issues. In recent years, an increased incidence of PP has been found in many countries although several studies now suggest that this trend has slowed down over the last decade in most industrialized countries, while persisting in other countries. Some girls with idiopathic precocious puberty may also have slowly progressive pubertal development without deterioration of their predicted height over a 2-year follow-up period. It is important to determine which girls to treat and the role of the clinician remains crucial. The clinician also needs to be familiar with the terminology of pubertal progression. The aim of this review was to examine the diagnosis of central precocious puberty (CPP) taking in account clinical practice and international literature.","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47907737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teenage Obese Pregnancy: The \"Double Burden\" of Age and Excessive Weight on the Mother-Offspring Pair’s Health","authors":"C. Berti, Z. Bhutta, P. Catalano, S. Elahi, M. W. Hanson, M. Krawinkel, V. Savasi, I. Cetin","doi":"10.12974/2311-8687.2019.07.1","DOIUrl":"https://doi.org/10.12974/2311-8687.2019.07.1","url":null,"abstract":"Obesity and pregnancy are a combination that may create unique interconnected challenges for the health of the next generation. Although pregnant obese adolescents are of concern worldwide, yet it is an issue that is currently unattended to. Here, we provide an overview of the implications for the mother-offspring pair’s health associated to teenage-pregnancy, with a focus on obesity and ‘what works’ to prevent the obesity-risk during pregnancy. Interrelated health-issues are highlighted, which include: increased negative consequences related to childbearing at young age; associations of maternal pre-gravid excessive-weight with maternal and fetal complications; and limited evidence addressing obese pregnancy in adolescents. Targeting adolescents appears the most effective approach to reduce the obesity-risk trajectory of the prospective parents early-in-life, thus breaking the intergenerational cycle of non-communicable diseases. Specifically-focused educational programs with clear and motivational messages about nutrition, physical activity and sexual health, are perceived as key-components of preventive campaigns with digital web-based technology and specialized health-services being the most promising platforms to deliver knowledge. Successful education has a double advantage: to establish healthy behaviors among adolescents at an early-stage of life, thereby preventing both obesity and early pregnancy. Lastly, realistic solutions require also political understanding and commitment. ","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43181833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Religion and Spirituality in Early Childhood Education: A Phenomenological Interpretative Analysis","authors":"Cassandra Chaney, Jennifer A. Baumgartner","doi":"10.12974/2311-8687.2019.07.2","DOIUrl":"https://doi.org/10.12974/2311-8687.2019.07.2","url":null,"abstract":"Religiosity and spirituality are distinct constructs that can inform the thoughts, emotions, and behaviours of humans; however, few studies have examined the role of these constructs as a frame for early education pedagogy. Given the current void in the literature, this exploratory study will examine the extent these constructs inform early education. By using Interpretive Phenomenological Analysis (IPA) as our foundation, this qualitative, pilot study involves examining the responses of six African American females related to eight questions regarding the role of religiosity and/or spirituality in their educational pedagogy. The authors will provide recommendations regarding how early child educators can use religiosity and/or spirituality to heighten the learning experience for themselves and the children in their care. ","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43221327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Vitamin C Deficiency or Fractures Due to Non-Accidental Injury?","authors":"C. Paterson","doi":"10.12974/2311-8687.2018.06.3","DOIUrl":"https://doi.org/10.12974/2311-8687.2018.06.3","url":null,"abstract":"","PeriodicalId":91713,"journal":{"name":"International journal of pediatrics and child health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45693922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}