Internal medicine review (Washington, D.C. : Online)最新文献

{"title":"The unrelenting pressure of the pure sciences on the field of medicine","authors":"M. Lupton","doi":"10.18103/IMR.V3I5.423","DOIUrl":"https://doi.org/10.18103/IMR.V3I5.423","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"378 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76434223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illustrating and analyzing the processes of multi-institutional collaboration: Lessons learnt at Howard University Hospital.","authors":"Mansoor Malik,&nbsp;Suneeta Kumari,&nbsp;Partam Manalai,&nbsp;Maria Hipolito","doi":"10.18103/imr.v3i5.462","DOIUrl":"https://doi.org/10.18103/imr.v3i5.462","url":null,"abstract":"<p><p>Multi-institutional collaboration offers a promising approach to the dissemination of resources for capacity building and the improvement of the training of new investigators and residents, especially in areas of novel curricular content. Physicians should keep pace with the rapid growth of curricular content in an era of restricted resources. Such collaborations, in which educational entities work together and share resources and infrastructure, have been employed in health care to improve quality of care, capacity building, disparity reduction, and resident training. This paper examines a federally funded multi-institutional collaboration for the project STRIDE (Seek, Treat, Reach to Identify Pretrial Defendants Enhancement) between Yale University, George Mason University (GMU), and Howard University, a Historically Black University. The STRIDE study collaboration focused on mental health, opioid addiction, and infectious disease/HIV among Africans Americans involved in CJS (Criminal Justice System). We discuss some of the challenges and benefits of collaborative research projects conducted at Historically Black Colleges and University (HBCUs) and highlight the educational opportunities created by such collaborations for residents and other trainees, leading to the development of independent investigators through multi-institutional, structured collaborative research. We identify some unique challenges such as substance use, race, stigma, incarceration among participants, and the cultural and power difference between participating institutions, and thereby address these issues and how it impacted the course of the multi-institutional collaborative effort.</p>","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617338/pdf/nihms905792.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35562486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-years data of the first European clinical experience with once-daily tacrolimus extended release formulation in renal transplant recipients","authors":"M. Gelens, J. Hooff, M. Mullens, M. Christiaans","doi":"10.18103/IMR.V3I5.478","DOIUrl":"https://doi.org/10.18103/IMR.V3I5.478","url":null,"abstract":"Background: Clinical data about long-term use of tacrolimus QD are lacking. Methods: Ten-years data were collected from 37 renal transplant recipients participating in a Tacrolimus BID (Prograf®) to QD (Advagraf®) conversion study. They were converted at a median of 4.1 years post-transplant (range 1.5-11.4) with a stable renal function (serum creatinine 20% had an immunological or unknown cause of renal failure. Conclusion: Patients on tacrolimus QD have excellent 10-year renal function, patient - and graft survival.","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"1 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83467926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid droplets, potential biomarker and metabolic target in glioblastoma.","authors":"Feng Geng, Deliang Guo","doi":"10.18103/imr.v3i5.443","DOIUrl":"10.18103/imr.v3i5.443","url":null,"abstract":"<p><p>Lipid droplets (LDs) are subcellular organelles that store large amounts of the neutral lipids, triglycerides (TG) and/or cholesteryl esters (CE). LDs are commonly formed in adipocytes, liver cells and macrophages, and their formation has been shown to be associated with the progression of metabolic diseases, i.e., obesity, fatty liver and atherosclerosis. Interestingly, LDs are also found in some tumor tissues. We recently showed that LDs are prevalent in glioblastoma (GBM), the most deadly brain tumor, but are not detectable in low-grade gliomas and normal brain tissues, suggesting that LDs may serve as a novel diagnostic biomarker for GBM. This short review will briefly introduce LD biology, summarize recent observations about LDs in several types of cancer tissues, and discuss LD formation in GBM. Moreover, we will highlight the role of SOAT1 (sterol-O transferase 1), a key enzyme regulating CE synthesis and LD formation in GBM, in the regulation of SREBP (sterol regulatory-element binding protein) activation. The therapeutic potential of LDs and SOAT1 will be discussed.</p>","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639724/pdf/nihms868518.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35453041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic regulation of cellular and cytomegalovirus genes during myeloid cell development.","authors":"Xue-Feng Liu,&nbsp;Mary Hummel,&nbsp;Michael Abecassis","doi":"10.18103/imr.v3i3.385","DOIUrl":"https://doi.org/10.18103/imr.v3i3.385","url":null,"abstract":"<p><p>Myeloid cells are important cell types that carry human cytomegalovirus. Latent viral DNA is present in CD34+ progenitor cells and their derived monocytes. However, differentiation of latently infected monocytes to mature macrophages or dendritic cells causes reactivation of latent viruses. During hematopoietic development, pluripotent genes are repressed, and lineage specific genes are activated in a step-wise manner. This process is governed by cell-type specific chromatin states. Enhancers in the hematopoietic system are highly dynamic and established by pioneer (first tier) transcription factors (TFs), which set the stage for second and third tier TF binding. In this review, we examine the epigenetic mechanisms that regulate myeloid cell development, cell identity, and activation with a special focus on factors that regulate viral gene expression and the status of viral infection in myeloid cells.</p>","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504688/pdf/nihms870398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35169275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncological Recurrence after Autologous Fat Grafting in Breast Reconstruction : Critical appraisal of the current literature on basic science and clinical studies","authors":"J. Groen, S. Tuinder, V. Negenborn, R. Hulst","doi":"10.18103/IMR.V3I2.359","DOIUrl":"https://doi.org/10.18103/IMR.V3I2.359","url":null,"abstract":"Background The use of Autologous Fat Grafting (AFG) in surgical procedures of the female breast has gained enormous international interest over the last decade with indications ranging from aesthetic augmentation to the treatment of postmastectomy-pain-syndromes and breast-reconstructions. One of the most important unanswered questions remains that of oncological-safety, with an almost equal sum of clinical- and basic-science-studies suggesting oncological-safety and an increased risk of oncological recurrence respectively. In this paper the authors aim to provide a comprehensive overview of the overwhelming data currently available on the subject of oncological-safety after AFG for (breast) reconstructive purposes. Method An extensive literature search was performed using the following databases; PubMed, Embase.com, Wiley/Cochrane Library and Web of Science. Original studies reporting on AFG for (breast) reconstructive purposes were included and a tabulated overview of data regarding oncological-safety from either a clinical- or basic-science point-of-view are provided. Results Thirty-five and twenty-one basic-science- and clinical-studies reported on oncological safety respectively. Thirty-one basicscience-studies described the carcinogenic effects of AFG with most reporting the effects of adipocyte-derived-stemcells in stimulating growth, migration, neo-vascularisation, self-renewal or metastatic-capabilities of different breast-cancer-cell-lines through various pathways. A meta-analysis of clinical-studies on oncological-safety after cancer treatment and breast reconstruction with AFG in a total of 2953 patients reported a locoregional-recurrence-rate of 2.5% and a distant-recurrencerate of 2.0% with no difference between mastectomy and breastconserving-therapy patients (p=0.69). However, a significant higher number of locoregional recurrences compared to a control group were found in two sub-cohorts of intra-epithelial neoplasms. Conclusion It is clear that more scientific data from both basic science studies using clinical breast cancer samples with representable ASC concentrations as well as clinicalstudies, preferably RCT’s, with a clear distinction between breast cancer types and the recurrence risk after breast-conserving therapy are needed in order to make clear assumptions about oncological safety of AFG.","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"1 1","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72503064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards Bio-active Restorative materials with Fucoindan as alternative pit and fissure sealants: in vitro","authors":"T. Perchyonok","doi":"10.18103/IMR.V3I1.336","DOIUrl":"https://doi.org/10.18103/IMR.V3I1.336","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72977224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels Of Proteasome Subunit Expression Provide Information About Host’s Immune System Status","authors":"N. Qureshi","doi":"10.18103/imr.v3i11.589","DOIUrl":"https://doi.org/10.18103/imr.v3i11.589","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73192614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Error and Disclosure: Mandate in Quality care and Patient safety","authors":"J. Kalra, E. Vantomme, Vanessa Rininsland, Ashish Kopargaonkar","doi":"10.18103/IMR.V3I6.479","DOIUrl":"https://doi.org/10.18103/IMR.V3I6.479","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"13 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72544592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient blood management in Hip and Knee surgery: A methodological approach – Part 2 Blood losses strategy and anemia tolerance","authors":"G. Oriani","doi":"10.18103/IMR.V3I3.365","DOIUrl":"https://doi.org/10.18103/IMR.V3I3.365","url":null,"abstract":"","PeriodicalId":91699,"journal":{"name":"Internal medicine review (Washington, D.C. : Online)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90834771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}