International journal of biotechnology最新文献

{"title":"The CHO cell line as a potentially safer host for cetuximab therapeutic antibody production than the Sp2/0 cell line","authors":"Sławomir Jaros, Julita Balcerek, T. Pietrucha, Olga H. Grzyb, Piotr Miłek, Paulina E. Toboła, Karolina M. Lonkwic, Bartłomiej Czubek, Edyta E. Bartusik Czubek","doi":"10.1504/ijbt.2023.10056057","DOIUrl":"https://doi.org/10.1504/ijbt.2023.10056057","url":null,"abstract":"","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66714586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The endothelin receptor antagonist macitentan ameliorates endothelin-mediated vasoconstriction and promotes the survival of retinal ganglion cells in rats.","authors":"Bindu Kodati, Wei Zhang, Shaoqing He, Jennifer H Pham, Kallen J Beall, Zoe E Swanger, Vignesh R Krishnamoorthy, Payton E Harris, Trent Hall, Ashley V Tran, Renuka M Chaphalkar, Sai H Chavala, Dorota L Stankowska, Raghu R Krishnamoorthy","doi":"10.3389/fopht.2023.1185755","DOIUrl":"10.3389/fopht.2023.1185755","url":null,"abstract":"<p><p>Glaucoma is a chronic and progressive eye disease, commonly associated with elevated intraocular pressure (IOP) and characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells (RGCs). The pathological changes in glaucoma are triggered by multiple mechanisms and both mechanical effects and vascular factors are thought to contribute to the etiology of glaucoma. Various studies have shown that endothelin-1 (ET-1), a vasoactive peptide, acting through its G protein coupled receptors, ET_A and ET_B, plays a pathophysiologic role in glaucoma. However, the mechanisms by which ET-1 contribute to neurodegeneration remain to be completely understood. Our laboratory and others demonstrated that macitentan (MAC), a pan endothelin receptor antagonist, has neuroprotective effects in rodent models of IOP elevation. The current study aimed to determine if oral administration of a dual endothelin antagonist, macitentan, could promote neuroprotection in an acute model of intravitreal administration of ET-1. We demonstrate that vasoconstriction following the intravitreal administration of ET-1 was attenuated by dietary administration of the ET_A/ET_B dual receptor antagonist, macitentan (5 mg/kg body weight) in retired breeder Brown Norway rats. ET-1 intravitreal injection produced a 40% loss of RGCs, which was significantly lower in macitentan-treated rats. We also evaluated the expression levels of glial fibrillary acidic protein (GFAP) at 24 h and 7 days post intravitreal administration of ET-1 in Brown Norway rats as well as following ET-1 treatment in cultured human optic nerve head astrocytes. We observed that at the 24 h time point the expression levels of GFAP was upregulated (indicative of glial activation) following intravitreal ET-1 administration in both retina and optic nerve head regions. However, following macitentan administration for 7 days after intravitreal ET-1 administration, we observed an upregulation of GFAP expression, compared to untreated rats injected intravitreally with ET-1 alone. Macitentan treatment in ET-1 administered rats showed protection of RGC somas but was not able to preserve axonal integrity and functionality. The endothelin receptor antagonist, macitentan, has neuroprotective effects in the retinas of Brown Norway rats acting through different mechanisms, including enhancement of RGC survival and reduction of ET-1 mediated vasoconstriction.</p>","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88805749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The yield and price effects of growing genetically modified corn: evidence from the US corn belt","authors":"Prince Fosu","doi":"10.1504/ijbt.2022.10049247","DOIUrl":"https://doi.org/10.1504/ijbt.2022.10049247","url":null,"abstract":"","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66714527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of types, influences, and how select Central European entrepreneurship ecosystems developed in the biopharmaceutical sector","authors":"David Williams","doi":"10.1504/ijbt.2022.10051121","DOIUrl":"https://doi.org/10.1504/ijbt.2022.10051121","url":null,"abstract":"","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66714570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance Development in Multi-Drug Resistant Bacteria to Antimicrobials from Methanolic Extract of The Stem Bark of Artocarpus altilis","authors":"E. AdetayoTemidayo, O. NnoliChidinma, A. OgunjobiAdeniyi","doi":"10.18488/JOURNAL.57.2021.101.31.38","DOIUrl":"https://doi.org/10.18488/JOURNAL.57.2021.101.31.38","url":null,"abstract":"","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"10 1","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67988433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Organic Substrates for Outdoor Cultivation of Pleurotus Tuber-Regium","authors":"O. Adedokun, Juliet N. Friday","doi":"10.18488/journal.57.2020.91.8.13","DOIUrl":"https://doi.org/10.18488/journal.57.2020.91.8.13","url":null,"abstract":"","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"9 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67987475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Fermentation on the Proximate and Antinutrient Composition of Banana Peels","authors":"Ozabor P.T, Ojokoh A.O, Wahab A.A., A. O.O","doi":"10.18488/journal.57.2020.92.105.117","DOIUrl":"https://doi.org/10.18488/journal.57.2020.92.105.117","url":null,"abstract":"","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"9 1","pages":"105-117"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67988509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Genetically Modified (GM) Maize Adoption in Small Scale Farms on Cropping Systems of the Eastern Cape Province, South Africa","authors":"Tendayi Lovemore Kadango, Y. Assefa, S. Mnkeni","doi":"10.18488/journal.57.2020.92.67.80","DOIUrl":"https://doi.org/10.18488/journal.57.2020.92.67.80","url":null,"abstract":"Article History Received: 17 April 2020 Revised: 20 May 2020 Accepted: 25 June 2020 Published: 13 July 2020","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"9 1","pages":"67-80"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67988593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactivity studies of an endangered medicinal plant Celastrus paniculatus willd.: an overview","authors":"B. Biswal, B. Jena, A. Giri, L. Acharya","doi":"10.1504/ijbt.2020.10031442","DOIUrl":"https://doi.org/10.1504/ijbt.2020.10031442","url":null,"abstract":"Celastrus paniculatus willd., an extremely versatile medicinal plant, is commonly used as memory sharpener, anti-depressant, rejuvenant, nervine tonic, free radical scavenger, anti-oxidant etc. The present review is made to enlighten the information based upon scientific evidence regarding morphological description, pharmacological actions and phytoconstituents of this plant. The leaves of the plant show significant anti-fungal and anti-microbial activity. The root bark exhibited antimalarial activity while seed shows sedative, antidepressant, antifertility and wound healing activity. These plants are naturally used for treatment of blood purification after delivery, menstruation cycle and abortion. Due to the wide range of medicinal properties, the plant is being harvested erratically from wild coupled with cultivars; the species is listed as endangered and a vulnerable medicinal plant. Hence, realising the importance of the plant and the current threat to its existence, more scientific effort is required for conservation and efficient propagation for this plant to meet the growing demand.","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66714474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attractiveness of Arthropodal Hexapod Orders to Light-Emitting Diode and Incandescent Bulb Light Colours","authors":"Okrikata Emmanuel, Yakubu Stephen, O. J. Itohan, C. Timothy, Mai-Bukar Sani","doi":"10.18488/journal.57.2020.91.1.7","DOIUrl":"https://doi.org/10.18488/journal.57.2020.91.1.7","url":null,"abstract":"Article History Received: 7 November 2019 Revised: 11 December 2019 Accepted: 15 January 2020 Published: 3 February 2020","PeriodicalId":91506,"journal":{"name":"International journal of biotechnology","volume":"9 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67987657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}