Gynecology and obstetrics research : open journal最新文献

Induced Pluripotent Stem Cells—Derived Stem Cells: A Promising Tool for Disease Modeling 诱导多能干细胞衍生干细胞:一种有前途的疾病建模工具

Gynecology and obstetrics research : open journal Pub Date : 2022-12-30 DOI: 10.17140/goroj-8-158

P. Parasar

引用次数: 0

A Rare Case of Vulvar Dermatofibrosarcoma Protuberans: A Case Report 外阴隆突性皮肤纤维肉瘤1例

Gynecology and obstetrics research : open journal Pub Date : 2022-12-30 DOI: 10.17140/goroj-8-157

Tewodros Deneke, Abel Tefera, Woubshet Girma, F. Assefa, Demsew Alemu, Bahiru Gossaye

引用次数: 0

Systemic Lupus Erythematosus as a Risk Factor for Cervical Cancer and its Precursor Conditions: Assessment Using Pap Smear and Histopathology 系统性红斑狼疮是宫颈癌及其前体疾病的危险因素:使用巴氏涂片和组织病理学进行评估

Gynecology and obstetrics research : open journal Pub Date : 2022-12-30 DOI: 10.17140/goroj-8-155

M. Gobran, Soheir El-Ghoneimey, S. Ibrahim, Sabah Mohamedhanafy

引用次数: 0

Association of Gestational Hypertension and Eclampsia to Maternal Smoking by Pre-Pregnancy Body Mass Index Status Among Aged 20-29-Years in the United States 美国20-29岁孕妇孕前体重指数状况与妊娠期高血压和子痫的关系

Gynecology and obstetrics research : open journal Pub Date : 2022-12-30 DOI: 10.17140/goroj-8-156

Holly Bihun, J. Liu

{"title":"Association of Gestational Hypertension and Eclampsia to Maternal Smoking by Pre-Pregnancy Body Mass Index Status Among Aged 20-29-Years in the United States","authors":"Holly Bihun, J. Liu","doi":"10.17140/goroj-8-156","DOIUrl":"https://doi.org/10.17140/goroj-8-156","url":null,"abstract":"Objective To investigate whether gestational hypertension (GH) and/or eclampsia was associated with the timing of maternal smoking when stratified by pre-pregnancy body mass index (pBMI) status. Study Design and Methods 1,376,271 US-born mothers aged 20-29 from the 2019 infant natality data who had a singleton birth (20+ weeks of gestation) were analyzed in this study. Maternal smoking status was defined into five groups, i.e., non-smokers, quitted smoking before pregnancy, quitted smoking before the 2nd trimester, quitted smoking before the 3rd trimester, and smoked whole-time. Odds ratios (ORs) of GH or eclampsia were estimated separately using multiple logistic regression for maternal smoking by pBMI status (kg/m2): underweight (<18.5), normal (18.5≤25.0), overweight (25.0≤30.0), and obese (≥30.0). Results Compared to non-smokers, the adjusted ORs (95% CIs) of GH for mothers who quit before pregnancy with pBMI underweight, normal, overweight, and obese were 1.17 (0.92-1.49), 1.11 (1.03-1.19), 1.13 (1.05-1.22), 1.13 (1.08-1.19), respectively. While the ORs (95% CIs) of GH for mothers who smoked for the entirety of their pregnancy were 0.71 (0.60-0.84), 0.80 (0.75-0.84), 0.79 (0.74-0.84), and 0.82 (0.78-0.85), respectively. The adjusted ORs for eclampsia showed a different pattern, only that for mothers who smoked for their whole pregnancy with normal and obese showed significantly (0.69 (0.53-0.91) for normal weight, 0.73 (0.58-0.92) for obese). Conclusion In comparison to non-smokers, an increase in the odds of GH were observed amongst normal, overweight, and obese mothers quitting before pregnancy meanwhile a decreased odds were observed amongst mothers smoking throughout pregnancy in all pBMI classes.","PeriodicalId":91488,"journal":{"name":"Gynecology and obstetrics research : open journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74819216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pitfalls of Sexual and Reproductive Healthcare of Women in India 印度妇女性健康和生殖健康的陷阱

Gynecology and obstetrics research : open journal Pub Date : 2022-12-30 DOI: 10.17140/goroj-8-e007

Srivarsha Ala

引用次数: 0

How does Antimullerian Hormone Explain the impairment of folliculogenesis in PCOS, its effects on the dysfunctional gonadotropin control, besides its implication in transgenerational transfer of PCOS-A Systematic Review 抗苗勒管激素如何解释多囊卵巢综合征的卵泡发育障碍，它对功能失调的促性腺激素控制的影响，以及它在多囊卵巢综合征的跨代转移中的含义- a系统评价

Gynecology and obstetrics research : open journal Pub Date : 2022-01-23 DOI: 10.52803/22123stmg

K. Kaur

引用次数: 0

Cesarean Section Rate at Lumbini Zonal Hospital, Nepal: An Analysis Using the Robson Ten Group Classification System 尼泊尔蓝毗尼地区医院剖宫产率:使用罗布森十组分类系统的分析

Gynecology and obstetrics research : open journal Pub Date : 2020-12-31 DOI: 10.17140/GOROJ-7-154

B. Gautam, Shree Acharya, V. P. Sapkota, Raut B. Batsal, L. Bhattarai, M. José, K. Paudel

{"title":"Cesarean Section Rate at Lumbini Zonal Hospital, Nepal: An Analysis Using the Robson Ten Group Classification System","authors":"B. Gautam, Shree Acharya, V. P. Sapkota, Raut B. Batsal, L. Bhattarai, M. José, K. Paudel","doi":"10.17140/GOROJ-7-154","DOIUrl":"https://doi.org/10.17140/GOROJ-7-154","url":null,"abstract":"Background Caesarean section (CS) rates have increased globally. The World Health Organization (WHO) recommends the use of the TenGroup Robson classification as the global standard for assessing appropriateness of CS. Nepal has higher-than-global average rates of CS requiring further investigation into appropriateness. Aim This study aims to investigate the caesarean section rates at tertiary care center in Nepal and make analysis based on the group-10 classification. Methods A retrospective cross-sectional study was carried out from 2016 April -2017 March in Lumbini Zonal Hospital, Butwal, Rupendehi, Nepal. 3,817 women who birth over a 12-month period were analyzed using this classification. The caesarean rate, its indications were calculated and categorized into groups according to Robson’s 10-group classification. Results Women with previous CS (Group 5) comprise the largest proportion (9.4%) of the overall 26.41% CS rate. The second largest contributor was a singleton nulliparous woman with cephalic presentation at term (6.6% of total 26.41%). Caesarean section rates in single breech pregnancies were very high (>65%). Robson’s Group 5 was the highest contributors to overall CS rate contributing 35% of all C-sections, followed by Group 2 (24%), and Group 1 (13%). Conclusion The ten-group classification helped to identify the main groups of the subjects who contribute the most to the overall caesarean section rate. This study results suggest that women with previous CS are at risk for having another CS delivery in subsequent pregnancies and therefore there is an urgent need for a dedicated vaginal birth after caesarean section (VBAC) clinic to support this such women to ensure CS are only done when indicated. Furthermore, reducing the CS rate for nulliparous i.e. Group 1 and 2 would, in the long-term, also reduce the size of Group 5 in the future.","PeriodicalId":91488,"journal":{"name":"Gynecology and obstetrics research : open journal","volume":"228 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80187762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Unusual Case of Nausea and Vomiting in Pregnancy: A Case Report 妊娠期恶心呕吐1例报告

Gynecology and obstetrics research : open journal Pub Date : 2020-12-31 DOI: 10.17140/GOROJ-7-152

B. Karavadra, M. Sule, C. Portelli

引用次数: 0

Clinical and Ultrasonographic Evaluation of the Pelvic Floor in Primiparous Women after Normal Vaginal Delivery with Episiotomy and without Episiotomy 阴道正常分娩的初产妇经外阴切开术和不经外阴切开术后盆底的临床和超声评价

Gynecology and obstetrics research : open journal Pub Date : 2020-12-31 DOI: 10.17140/GOROJ-7-153

Nora H. K. Elabady, A. Awara, Amr El-badry, Nareman M. El-Hamamy

{"title":"Clinical and Ultrasonographic Evaluation of the Pelvic Floor in Primiparous Women after Normal Vaginal Delivery with Episiotomy and without Episiotomy","authors":"Nora H. K. Elabady, A. Awara, Amr El-badry, Nareman M. El-Hamamy","doi":"10.17140/GOROJ-7-153","DOIUrl":"https://doi.org/10.17140/GOROJ-7-153","url":null,"abstract":"Objective The aim of this prospective study is clinical and ultrasonographic evaluation of the pelvic floor in primiparous women after normal vaginal delivery with episiotomy and without episiotomy. Methods This is a cross-section study of primiparous women with a history of delivery at Tanta University Hospital from August 2018 to August 2019. The sample power was calculated based on avulsion (major and minor) in two groups (vaginal delivery with episiotomy and without episiotomy) of total forty-primiparous women with an interval after delivery (20 cases after normal vaginal delivery with episiotomy and 20 cases after normal vaginal delivery without episiotomy). Results Twenty-four hours of delivery there was a highly significant difference between group A (with episiotomy) and group B (without episiotomy) regarding to ultrasound abnormalities, degree of tear, blood loss, hemoglobin concentration and clinical findings, while no difference regarding levator ani weakness. Two months later from delivery there was no significant difference between group A and group B regarding to ultrasound abnormalities and levator ani weakness while there was a difference between the two groups in regarding with clinical findings. Conclusion Normal vaginal delivery without episiotomy in primiparous women is better than normal vaginal delivery with episiotomy as there is no perineal tenderness, no dyspareunia. Low incidence of urinary, rectal incontinence, tear and perineal infection.","PeriodicalId":91488,"journal":{"name":"Gynecology and obstetrics research : open journal","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75602753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecularly-Targeted Therapies in Gynecologic Cancer 妇科肿瘤的分子靶向治疗

Gynecology and obstetrics research : open journal Pub Date : 2018-12-30 DOI: 10.17140/goroj-5-145

K. Kennedy, W. Robinson

{"title":"Molecularly-Targeted Therapies in Gynecologic Cancer","authors":"K. Kennedy, W. Robinson","doi":"10.17140/goroj-5-145","DOIUrl":"https://doi.org/10.17140/goroj-5-145","url":null,"abstract":"Copyright 2018 by Robinson W. This is an open-access article distributed under Creative Commons Attribution 4.0 International License (CC BY 4.0), which allows to copy, redistribute, remix, transform, and reproduce in any medium or format, even commercially, provided the original work is properly cited. cc The development of chemotherapy agents that precisely target specific molecular structures in cancer cells have become a priority in oncology research. In principle, this method halts cancer cell proliferation while allowing normal function of healthy cells. These molecular-based chemotherapy agents target many types of molecules involved in the growth, spread, and survival of malignant cells. Several of these target molecules have been identified in female genital tract malignancies, and multiple agents targeted at those molecules have been developed as a treatment. This review outlines three major types of targeted agents that have clinical relevance in the treatment of gynecologic cancer. The first group of drugs inhibits vascular endothelial growth factor (VEGF), which normally facilitates angiogenesis. The second group inhibits poly (ADP-ribose) polymerase (PARP), a base-excision enzyme that repairs single-strand DNA breaks. The final category is a set of drugs that inhibit programmed-cell death protein 1, an immune checkpoint that normally prevents autoimmunity. Therapeutic benefit has been demonstrated for each of these drug types in gynecologic, and particularly ovarian, cancers. New agents, and applications for these agents have been developing at a rapid pace in each of these categories. Food and Drug Administration (FDA) approval has been accelerated for several of these agents in recent years, suggesting a significant change in the process by which new drugs enter the clinical armamentarium. In short, the development of molecularly-targeted drugs for the treatment of cancer is a promising and rapidly-moving field.","PeriodicalId":91488,"journal":{"name":"Gynecology and obstetrics research : open journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45679851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1