Induced Pluripotent Stem Cells—Derived Stem Cells: A Promising Tool for Disease Modeling

Abstract

Stem cells possess potential to undergo self-renewability giving rise to any cell type in the body known as pluripotency. This process, also known as differentiation, through which stem cells undergo several morphologic and genetic changes resulting in daughter cell lineages. The end point lineage depends on the growth and differentiation induction factors or proteins added to in vitro stem cell culture. These stem cells can be of embryonic source (embryonic stem cells (ESCs)) derived from the inner cell mass of embryo or induced-pluripotent stem cells (iPSCs) which are produced from reprogrammed somatic cells in the body.1 In this commentary, we will focus on iPSCs and their contribution to disease modeling in the context of reproductive disorders.