Bosnian journal of basic medical sciences最新文献_第6页

Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention 代谢综合征对子宫内膜癌风险的影响及生活方式在预防中的作用

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-27 DOI: 10.17305/bjbms.2021.6963

Alejandra Rocío Pérez-Martín, D. Castro-Eguiluz, L. Cetina-Pérez, Yadira Velasco-Torres, Antonio Bahena-González, E. Montes-Servín, E. González-Ibarra, Raquel Espinoza-Romero, D. Gallardo-Rincón

{"title":"Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention","authors":"Alejandra Rocío Pérez-Martín, D. Castro-Eguiluz, L. Cetina-Pérez, Yadira Velasco-Torres, Antonio Bahena-González, E. Montes-Servín, E. González-Ibarra, Raquel Espinoza-Romero, D. Gallardo-Rincón","doi":"10.17305/bjbms.2021.6963","DOIUrl":"https://doi.org/10.17305/bjbms.2021.6963","url":null,"abstract":"Endometrial cancer (EC) is the second gynecological cancer with the highest global incidence. Among many associated risk factors, metabolic syndrome (MetS) is an important and preventable one. It comprises a group of conditions that often occur together: central adiposity, hyperglycemia, arterial hypertension, and atherogenic dyslipidemia. This review aimed to describe the epidemiological and biological relationship between MetS and EC, focusing on the role of lifestyle in prevention. A literature search was carried out in the PubMed database. 4824 publications were screened, and 123 were included for this review. The association between MetS and EC has been described. Chronic adipose tissue inflammation and insulin resistance are involved in the development of obesity, particularly visceral adiposity. These changes promote the ideal environment for the development of EC. Strategies based on lifestyle modifications may be effective for the prevention of MetS and consequently EC. Some of these modifications include adopting a diet rich in fruits, vegetables, whole grains, and legumes, depending to the accessibility of these foods for each region. Avoiding ultra-processed foods and increasing daily physical activity were also some suggested modifications. We propose that women be screened for MetS to establish early treatment and to possibly prevent EC. Clinical trials designed to prove the effect of lifestyle modifications on the prevention of EC are needed.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"499 - 510"},"PeriodicalIF":3.4,"publicationDate":"2022-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46434325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Audiological and vestibular evaluations in vitiligo patients. 白癜风患者的听力学和前庭功能评估。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.5703

Alessandra Manno, Annalisa Pace, Giannicola Iannella, Valeria Rossetti, Roberta Polimeni, Alessandro Milani, Salvatore Cocuzza, Antonino Maniaci, Giuseppe Magliulo

{"title":"Audiological and vestibular evaluations in vitiligo patients.","authors":"Alessandra Manno, Annalisa Pace, Giannicola Iannella, Valeria Rossetti, Roberta Polimeni, Alessandro Milani, Salvatore Cocuzza, Antonino Maniaci, Giuseppe Magliulo","doi":"10.17305/bjbms.2021.5703","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5703","url":null,"abstract":"The aim of this paper was to investigate audiological abnormalities and potential vestibular injury in a sample of vitiligo subjects. Thirty-five patients with non-segmental vitiligo (NSV) were enrolled in the study. They underwent pure tonal audiometry (PTA), vestibular Fitzgerald-Hallpike caloric test, C-VEM, and O-VEMP testing. The χ2 test and multiple regression analysis were performed. At PTA, 69% of patients presented with bilateral hearing loss, 8% monaural hearing loss, and 23% normal values. Bilateral caloric stimulations were performed and demonstrated that 14% of patients had a monolateral and 9% had a bilateral pathological response. VEMPs analysis showed that 20% of patients had no O-VEMPs response and 3% had no C-VEMPs response. Comparison between the normal values of healthy subjects and NSV patients showed an alteration of VEMPs in 44%. Multiple regression showed no statistical differences. We propose a specific diagnostic protocol employing PTA, bithermal caloric tests, C-VEMP, and O-VEMP testing to evaluate audio-vestibular damage. Our data were concordant with the anatomic-physiological melanocytic distribution and their possible degeneration linked with NSV.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"140-146"},"PeriodicalIF":3.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39297086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Long noncoding RNA RP11-70C1.3 confers chemoresistance of breast cancer cells through miR-6736-3p/NRP-1 axis. 长链非编码RNA RP11-70C1.3通过miR-6736-3p/NRP-1轴赋予乳腺癌细胞化疗耐药。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.5803

Lansheng Zhang, Xia Zheng, Anqi Shen, Daojin Hua, Panrong Zhu, Caihong Li, Zhengxiang Han

{"title":"Long noncoding RNA RP11-70C1.3 confers chemoresistance of breast cancer cells through miR-6736-3p/NRP-1 axis.","authors":"Lansheng Zhang, Xia Zheng, Anqi Shen, Daojin Hua, Panrong Zhu, Caihong Li, Zhengxiang Han","doi":"10.17305/bjbms.2021.5803","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5803","url":null,"abstract":"Chemoresistance remains a major obstacle for improving the clinical outcome of patients with breast cancer. Recently, long noncoding RNAs (lncRNAs) have been implicated in breast cancer chemoresistance. However, the function and underlying mechanism are still largely unknown. Using lncRNA microarray, we identified 122 upregulated and 475 downregulated lncRNAs that might be related to the breast cancer chemoresistance. Among them, RP11-70C1.3 was one of the most highly expressed lncRNAs. In breast cancer patients, high RP11-70C1.3 expression predicted poor prognosis. Knockdown of RP11-70C1.3 inhibited the multidrug resistance of breast cancer cells in vitro and in vivo. Further investigations revealed that RP11-70C1.3 functioned as a competing endogenous RNA (ceRNA) for miR-6736-3p to increase NRP-1 expression. Notably, the rescue experiments showed that both miR-6736-3p inhibitor and NRP-1 overexpression could partly reverse the suppressive influence of RP11-70C1.3 knockdown on breast cancer chemoresistance. In conclusion, our study indicated that lncRNA RP11-70C1.3 regulated NRP-1 expression by sponging miR-6736-3p to confer chemoresistance of breast cancer cells. RP11-70C1.3 might be a potential therapeutic target in enhancing the clinical efficacy of chemotherapy in breast cancer.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"87-99"},"PeriodicalIF":3.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39297085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Multidimensional study of cell division cycle-associated proteins with prognostic value in gastric carcinoma. 胃癌细胞分裂周期相关蛋白与预后价值的多维研究。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.5783

Peixin Lu, Wen Cheng, Kexin Fang, Bin Yu

{"title":"Multidimensional study of cell division cycle-associated proteins with prognostic value in gastric carcinoma.","authors":"Peixin Lu, Wen Cheng, Kexin Fang, Bin Yu","doi":"10.17305/bjbms.2021.5783","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5783","url":null,"abstract":"Gastric cancer (GC) represents a widespread malignancy with a poor prognosis. Hence, discovering reliable biomarkers is necessary. The cell division cycle-associated protein (CDCA) family, comprising CDCA1-8, plays a key role in tumor progression. However, whether CDCA expression has prognostic value in GC, especially stomach adenocarcinoma (STAD), has not been elucidated yet. Consequently, we conducted a multifaceted study using bioinformatic tools aimed at exploring CDCA expression levels and appraising their potential prognostic values in patients with STAD. All eight CDCAs were significantly upregulated in STAD tissues compared with healthy tissues. Elevated CDCA4/7/8 mRNA expression predicted a short overall survival, and increased CDCA7 transcriptional levels predicted a short disease-free survival. The most frequent alteration in patients with STAD was low mRNA expression. The functional enrichment analysis incorporating the gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathways showed that the cell cycle, foxO signaling pathway, and Epstein-Barr virus were relevant to the main functions of CDCAs. Finally, the immune infiltration analysis revealed a significant correlation between CDCA expression and the infiltration extent of six immunocytes. Therefore, differentially expressed CDCAs may represent potential biomarkers for the prognosis of patients with STAD that can improve survival. Furthermore, this study might offer new ideas for the design and development of immunotherapeutic drugs.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"64-76"},"PeriodicalIF":3.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38989776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The prognostic significance of different proportion of signet-ring cells of colorectal carcinoma. 结直肠癌印戒细胞不同比例的预后意义。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.5856

Wei Chen, Huajun Cai, Kui Chen, Xing Liu, Weizhong Jiang, Shoufeng Li, Yiyi Zhang, Zhifen Chen, Guoxian Guan

{"title":"The prognostic significance of different proportion of signet-ring cells of colorectal carcinoma.","authors":"Wei Chen, Huajun Cai, Kui Chen, Xing Liu, Weizhong Jiang, Shoufeng Li, Yiyi Zhang, Zhifen Chen, Guoxian Guan","doi":"10.17305/bjbms.2021.5856","DOIUrl":"https://doi.org/10.17305/bjbms.2021.5856","url":null,"abstract":"While the prognosis of patients with partial SRCC (PSRCC) has been rarely reported, colorectal signet-ring cell carcinoma (SRCC) has been associated with poor prognosis. The aim of this study was to analyze the prognosis of patients with different SRCC composition and establish a prediction model. A total of 91 patients with SRC component were included in the study. These patients were divided into two groups: SRCC group (SRC composition > 50%; n=41) and partial SRCC (PSRCC) group (SRC composition ≤ 50%; n=50). COX regression model was used to identify independent prognostic factors for overall survival (OS). A predictive nomogram was established and compared with the 7th AJCC staging system. After a median follow-up of 16 months, no significant difference in OS was observed in either group. Preoperative carcinoembryonic antigen (CEA) level, pN stage, M stage, preoperative ileus, and adjuvant chemotherapy were independent prognostic risk factors for OS (p<0.05). A nomogram for predicting the overall survival of colorectal SRCC was established with a C-index of 0.800, and it showed better performance than that of the 7th AJCC staging system (p<0.001). In summary, the ratio of SRC component was not an independent prognostic factor of the OS. Those patients with less than 50% of SRC component should be given the same clinical attention. A predictive nomogram for survival based on five independent prognostic factors was developed and showed better performance than the 7th AJCC staging system. This resulted to be helpful for individualized prognosis prediction and risk assessment.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"124-130"},"PeriodicalIF":3.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39172585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates. 血清胶质原纤维酸性蛋白作为早产儿脑损伤的生物标志物。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.6205

Dimitra Metallinou, Grigorios Karampas, Georgia Nyktari, Nicoletta Iacovidou, Katerina Lykeridou, Demetrios Rizos

{"title":"Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates.","authors":"Dimitra Metallinou, Grigorios Karampas, Georgia Nyktari, Nicoletta Iacovidou, Katerina Lykeridou, Demetrios Rizos","doi":"10.17305/bjbms.2021.6205","DOIUrl":"https://doi.org/10.17305/bjbms.2021.6205","url":null,"abstract":"Neonatal brain injury is a serious adverse outcome of prematurity. Early detection of high risk premature neonates to develop neonatal brain injury is not currently feasible. The predictive value of many biomarkers has been tested, but none is used currently in clinical practice. The purpose of this study was to determine the levels and predictive value of serum glial fibrillary acidic protein (GFAP) in a prospective longitudinal case-control study during the first three days of life in premature neonates (<34 weeks of gestation) that later developed either intraventricular hemorrhage or periventricular leukomalacia. Each case (n=29) was matched according to birth weight and gestational age to one neonate with normal head ultrasound scans. No significant difference on GFAP levels was observed between the groups. Nevertheless, neonates with brain injury presented more frequently GFAP levels above the lowest detection limit (0.056 ng/ml) and this trend was significantly different during all days. The effectiveness of GFAP as an early biomarker of neonatal brain injury in premature neonates seems to be limited.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"46-53"},"PeriodicalIF":3.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39197615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Sustained seroprevalence of SARS-CoV-2 antibodies one year after infection: one of the first COVID-19 cluster cases in Bosnia and Herzegovina. 感染 SARS-CoV-2 抗体一年后的持续血清阳性反应：波斯尼亚和黑塞哥维那首例 COVID-19 群集病例之一。

IF 3.1 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.6340

Božo Šušak, Vinka Mikulić, Armina Lazarević, Ivanka Mikulić, Jurica Arapovic

{"title":"Sustained seroprevalence of SARS-CoV-2 antibodies one year after infection: one of the first COVID-19 cluster cases in Bosnia and Herzegovina.","authors":"Božo Šušak, Vinka Mikulić, Armina Lazarević, Ivanka Mikulić, Jurica Arapovic","doi":"10.17305/bjbms.2021.6340","DOIUrl":"10.17305/bjbms.2021.6340","url":null,"abstract":"SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) is a novel virus that has been identified as a causal agent of COVID-19, an emergent infectious disease which brought about a new pandemic in the twenty-first century. The immune responses and clinical features of individuals infected with SARS-CoV-2 have not yet been fully described. Thus, in this study, we compare the seroprevalence and define the correlation between symptoms and serological results in the first COVID-19 cluster in the city of Konjic, Bosnia and Herzegovina. Of the total number, 93% of RT-PCR positive participants had positive IgG serology and 75% of them developed symptoms of COVID-19. We found that there was no significant alteration in specific IgG (p = 0.504) antibody levels during the 1-year period after COVID-19. Our results indicate that symptomatic COVID-19 patients have a higher rate of seroconversion (p < 0.01). The IgG seroconversion was correlated with high fever (p = 0.002) and headache (p = 0.007), suggesting that these symptoms could be considered as indicators of a better immune response. This study has demonstrated persistence of sustained levels of specific SARS-CoV-2 antibodies after recovering from COVID-19 infection. However, in order to gain a better insight into the immune response to SARS-CoV-2, further systematic studies should be focused on quality and longevity analyses.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"147-152"},"PeriodicalIF":3.1,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39311506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trop-2 protein as a therapeutic target: A focused review on Trop-2-based antibody-drug conjugates and their predictive biomarkers. Trop-2蛋白作为治疗靶点:基于Trop-2的抗体-药物偶联物及其预测性生物标志物的重点综述

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.6100

Semir Vranic, Zoran Gatalica

引用次数: 16

Perineural spread in head and neck malignancies: imaging findings - an updated literature review. 头颈部恶性肿瘤的神经周围扩散:影像学发现-最新文献综述。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.5897

Olga Medvedev, Mihaela Hedesiu, Anca Ciurea, Manuela Lenghel, Horatiu Rotar, Cristian Dinu, Rares Roman, Dragos Termure, Csaba Csutak

引用次数: 8

Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-кB/cyclooxygenase-2/prostaglandin E2 axis. 肿瘤蛋白P63调节1通过调节NF-κB/环氧合酶-2/前列腺素E2轴促进腺性膀胱炎的炎症和细胞增殖。

IF 3.4 4区医学

Bosnian journal of basic medical sciences Pub Date : 2022-02-01 DOI: 10.17305/bjbms.2021.6763

Tao Hong, Songzhe Piao, Liangxue Sun, Yiran Tao, Mang Ke

{"title":"Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-кB/cyclooxygenase-2/prostaglandin E2 axis.","authors":"Tao Hong, Songzhe Piao, Liangxue Sun, Yiran Tao, Mang Ke","doi":"10.17305/bjbms.2021.6763","DOIUrl":"https://doi.org/10.17305/bjbms.2021.6763","url":null,"abstract":"Cystitis glandularis is characterized by chronic inflammation and hyperproliferation of bladder mucosa, and contributes to progression of bladder adenocarcinoma. TPRG1 (Tumor Protein P63 Regulated 1) is related to cellular inﬂammatory response, and dysregulation of TPRG1 in tumor tissues is associated with tumor early recurrence. The effect of TPRG1 on cystitis glandularis was investigated in this study. Firstly, bladder specimen were isolated from patients with cystitis glandularis and E. coli-induced cystitis rat. Expression of TPRG1 was found to be up-regulated in the bladder specimen. Moreover, adeno-associated virus (AAV)-mediated silence of TPRG1 was delivered into rat, and data from hematoxylin and eosin (H and E) staining showed that injection with AAV-shTPRG1 ameliorated E. coli-induced histological changes in bladder tissues of rats, and suppressed the inflammatory response. Secondly, TPRG1 was also increased in primary cystitis glandularis cells. Knockdown of TPRG1 decreased cell proliferation of primary cystitis glandularis cells, and suppressed the migration. Thirdly, cyclooxygenase-2 (COX-2) was up-regulated in the bladder specimen isolated from patients with cystitis glandularis and E. coli-induced cystitis rat. Injection with AAV-shTPRG1 reduced protein expression of COX-2, p65 and prostaglandin E2 (PGE2) in the bladder specimen. Lastly, interference of COX-2 attenuated TPRG1 over-expression-induced increase of cell proliferation and migration in the primary cystitis glandularis cells. In conclusion, TPRG1 promoted inflammation and cell proliferation of cystitis glandularis through activation of NF-кB/COX2/PGE2 axis.","PeriodicalId":9147,"journal":{"name":"Bosnian journal of basic medical sciences","volume":"22 1","pages":"100-109"},"PeriodicalIF":3.4,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39795929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0