Biochemistry & molecular biology journal最新文献

筛选
英文 中文
Carbonic Anhydrases: Nature's Way to Balance CO2 Concentration. 碳酸酐酶:大自然平衡二氧化碳浓度的方法。
Biochemistry & molecular biology journal Pub Date : 2015-01-01 Epub Date: 2015-12-16 DOI: 10.21767/2471-8084.100008
Mayank Aggarwal, Robert McKenna
{"title":"Carbonic Anhydrases: Nature's Way to Balance CO<sub>2</sub> Concentration.","authors":"Mayank Aggarwal, Robert McKenna","doi":"10.21767/2471-8084.100008","DOIUrl":"10.21767/2471-8084.100008","url":null,"abstract":"","PeriodicalId":91454,"journal":{"name":"Biochemistry & molecular biology journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34833409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onco-Golgi: Is Fragmentation a Gate to Cancer Progression? 肿瘤-高尔基:分裂是癌症进展的大门吗?
Biochemistry & molecular biology journal Pub Date : 2015-01-01 Epub Date: 2015-11-07 DOI: 10.21767/2471-8084.100006
Armen Petrosyan
{"title":"Onco-Golgi: Is Fragmentation a Gate to Cancer Progression?","authors":"Armen Petrosyan","doi":"10.21767/2471-8084.100006","DOIUrl":"https://doi.org/10.21767/2471-8084.100006","url":null,"abstract":"<p><p>The Golgi apparatus-complex is a highly dynamic organelle which is considered the \"heart\" of intracellular transportation. Since its discovery by Camillo Golgi in 1873, who described it as the \"black reaction,\" and despite the enormous volume of publications about Golgi, this apparatus remains one of the most enigmatic of the cytoplasmic organelles. A typical mammalian Golgi consists of a parallel series of flattened, disk-shaped cisternae which align into stacks. The tremendous volume of Golgi-related incoming and outgoing traffic is mediated by different motor proteins, including members of the dynein, kinesin, and myosin families. Yet in spite of the strenuous work it performs, Golgi contrives to maintain its monolithic morphology and orchestration of matrix and residential proteins. However, in response to stress, alcohol, and treatment with many pharmacological drugs over time, Golgi undergoes a kind of disorganization which ranges from mild enlargement to critical scattering. While fragmentation of the Golgi was confirmed in cancer by electron microscopy almost fifty years ago, it is only in recent years that we have begun to understand the significance of Golgi fragmentation in the biology of tumors. Below author would like to focus on how Golgi fragmentation opens the doors for cascades of fatal pathways which may facilitate cancer progression and metastasis. Among the issues addressed will be the most important cancer-specific hallmarks of Golgi fragmentation, including aberrant glycosylation, abnormal expression of the Ras GTPases, dysregulation of kinases, and hyperactivity of myosin motor proteins.</p>","PeriodicalId":91454,"journal":{"name":"Biochemistry & molecular biology journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-8084.100006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34449193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 88
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信