Open medicine journal最新文献_第4页

Chronic Inflammatory Demyelinating Polyneuropathy in Systemic Lupus Erythematosus: A Rare Entity 系统性红斑狼疮的慢性炎症性脱髓鞘性多神经病变:一种罕见的实体

Open medicine journal Pub Date : 2018-09-29 DOI: 10.2174/1874220301805010056

R. Mohd, F. Nordin, Rizna Cader

{"title":"Chronic Inflammatory Demyelinating Polyneuropathy in Systemic Lupus Erythematosus: A Rare Entity","authors":"R. Mohd, F. Nordin, Rizna Cader","doi":"10.2174/1874220301805010056","DOIUrl":"https://doi.org/10.2174/1874220301805010056","url":null,"abstract":"Neurological manifestations in Systemic Lupus Erythematous (SLE) varies and commonly affects the Central Nervous System (CNS) rather than the peripheral nervous system. Neuropsychiatric or CNS manifestation can be as high as 24-54%, whereas the peripheral nervous system involvement is lower around 5-27%. Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP) is one of the three commonest peripheral nervous system involvements in SLE patients and results with severe debilitating effects. However, it is rarely reported.A retrospective review of all SLE patients that were diagnosed with CIDP between 2000 and 2015 was done under follow up at our center that were diagnosed with CIDP between 2000 and 2015. We reviewed their medical records and analyzed their clinical presentation, investigations, treatment instituted, response to therapy and any neurological sequealae.A total of 512 case notes were reviewed. Of these 4 patients presented with CIDP (3 females, 1 male) aged between 26 to 46 years old. Three presented with transverse myelitis and the other one with acute motor and sensory axonal neuropathy. All patients were treated with high dose corticosteroids, three patients received cyclophosphamide whilst the other patient was induced with mycophenolate mofetil. Complete recovery was seen in one patient, two had persistent but improving numbness and the other one had a residual weakness.Peripheral nervous system involvement in SLE can result in serious debilitating effects. Early diagnosis and treatment are crucial in limiting the neurological sequealae.","PeriodicalId":91371,"journal":{"name":"Open medicine journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45728910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Standardization of Dhatryadi Ghrita: A Herbal Ghee Based Ayurvedic Medicinal Preparation Dhatryadi Ghrita的标准化：一种以Ghee为基础的阿育吠陀草药制剂

Open medicine journal Pub Date : 2018-08-31 DOI: 10.2174/1874220301805010047

R. Pal, A. Mishra

{"title":"Standardization of Dhatryadi Ghrita: A Herbal Ghee Based Ayurvedic Medicinal Preparation","authors":"R. Pal, A. Mishra","doi":"10.2174/1874220301805010047","DOIUrl":"https://doi.org/10.2174/1874220301805010047","url":null,"abstract":"In the current time, there is a need to thoroughly examine the process of systematic research methodology and to provide genuine findings to provide the reference for further investigations of traditional herbal medicines, which are beneficial for various disorders.To standardize Dhatryadi Ghrita on various parameters, in order to assure its safety and efficacy on various grounds.The Ghrita was analyzed for its organoleptic, physico-chemical features and screened for its phyto-constituents as well as its chromatographic analysis.The physicochemical standards would serve as a preliminary test for the standardization of the formulation, which helps to lay standards for further use as reference for the quality control/quality assurance laboratory of a Pharmaceutical house.The improvement of analytical methodologies can serve as a specific basis for research in herbal drug technology, thereby, facilitating the producers and researchers to set quality standards as well as parameters, so as to fulfill the requirements of regulatory bodies for the establishment of therapeutic efficacy, safety and purity of herbal drugs. The obtained values can be adopted to lay down new pharmacopoeial standards to be followed in its preparation with batch to batch consistency.","PeriodicalId":91371,"journal":{"name":"Open medicine journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46251786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Association of Mannose-Binding Lectin Gene Polymorphisms with Liver Diseases: A Review 甘露糖结合凝集素基因多态性与肝病的关系

Open medicine journal Pub Date : 2018-08-29 DOI: 10.2174/1874220301805010039

Robert S. Lo, A. Austin, J. Freeman

引用次数: 0

The Importance of the Time that Elapses Before Spontaneous Circulation is Established Following an Out-of-Hospital Cardiac Arrest 院外心脏骤停后自发循环建立前时间的重要性

Open medicine journal Pub Date : 2018-07-24 DOI: 10.2174/1874220301805010033

A. Sakurai, K. Kinoshita, A. Utagawa, J. Yamaguchi, M. Furukawa, A. Noda

{"title":"The Importance of the Time that Elapses Before Spontaneous Circulation is Established Following an Out-of-Hospital Cardiac Arrest","authors":"A. Sakurai, K. Kinoshita, A. Utagawa, J. Yamaguchi, M. Furukawa, A. Noda","doi":"10.2174/1874220301805010033","DOIUrl":"https://doi.org/10.2174/1874220301805010033","url":null,"abstract":"\u0000 \u0000 In order to clarify indications for therapeutic hypothermia, we retrospectively examined patients resuscitated after Out-of-Hospital Cardiac Arrest (OHCA) who recorded an Auditory Brainstem Response (ABR) wave V according to the Utstein-style guidelines.\u0000 \u0000 \u0000 \u0000 Patients who recorded an ABR wave V immediately after resuscitation from OHCA were kept at 34 °C for 48 hours. The cohort was divided into two groups: A favorable neurological outcome group (F group: N=12) and an unfavorable neurological outcome group (U group: N=14). Favorable neurological outcome was defined as Pittsburgh Cerebral-Performance Scale (CPC) 1 or 2 and unfavorable as CPC 3-5. Data used to compare the groups included whether CA was witnessed, if a bystander initiated cardiopulmonary resuscitation, presence of cardiac etiology, initial cardiac rhythm and elapsed time from emergency call receipt until Return of Spontaneous Circulation (ROSC).\u0000 \u0000 \u0000 \u0000 Elapsed time from receipt of the emergency call until ROSC was significantly shorter in the F group than in the U group. ROC curve analysis indicated that the cut-off duration was 28 minutes for a favorable neurological outcome.\u0000 \u0000 \u0000 \u0000 For OHCA patients with an ABR wave V, elapsed time from receipt of emergency call until ROSC may be an important parameter within the Utstein-style guidelines to determine the usefulness of therapeutic hypothermia.\u0000","PeriodicalId":91371,"journal":{"name":"Open medicine journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48918143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiponectin and Inflammation in Health and Disease: An Update 脂联素和炎症在健康和疾病:最新进展

Open medicine journal Pub Date : 2018-05-31 DOI: 10.2174/1874220301805010020

A. Geagea, S. Mallat, C. Matar, R. Zerbe, Estelle Filfili, Maria Francis, Hanine Haidar, A. Jurjus

引用次数: 16

Frailty Characteristics in Chronic HIV Patients are Markers of White Matter Atrophy Independently of Age and Depressive Symptoms: A Pilot Study 慢性HIV患者的虚弱特征是独立于年龄和抑郁症状的白质萎缩的标志:一项初步研究

Open medicine journal Pub Date : 2016-08-29 DOI: 10.2174/1874220301603010138

K. Kallianpur, Marissa E Sakoda, L. M. Gangcuangco, L. Ndhlovu, Tracie M Umaki, D. Chow, Suwarat Wongjittraporn, C. Shikuma

{"title":"Frailty Characteristics in Chronic HIV Patients are Markers of White Matter Atrophy Independently of Age and Depressive Symptoms: A Pilot Study","authors":"K. Kallianpur, Marissa E Sakoda, L. M. Gangcuangco, L. Ndhlovu, Tracie M Umaki, D. Chow, Suwarat Wongjittraporn, C. Shikuma","doi":"10.2174/1874220301603010138","DOIUrl":"https://doi.org/10.2174/1874220301603010138","url":null,"abstract":"Background Chronic HIV disease is associated with neurocognitive impairment and age-related conditions such as frailty. Objective To determine whether regional brain volumetric changes correlate with frailty parameters in older (≥ 40 years) HIV+ patients on stable combination antiretroviral therapy. Method Thirty-five HIV-infected participants in the Hawaii Aging with HIV Cohort - Cardiovascular Disease study underwent T1-weighted brain magnetic resonance imaging, frailty assessment and neuropsychological testing. Five physical frailty traits were assessed: low physical activity; exhaustion; unintentional weight loss; weak hand grip strength; slow walking speed. Linear regression quantified cross-sectional relationships of 12 brain regions to walking times and hand grip strength. Results Participants were 50.6 ± 6.8 years old and 77% had undetectable plasma viral load. One subject was frail (possessing ≥ 3 frailty traits); 23% were pre-frail (1–2 frailty traits) and had worse composite learning and memory z-scores than did non-frail individuals (p=0.06). Pre-frail or frail subjects had reduced hand grip strength relative to the non-frail group (p=0.001). Longer walking times (slower gait) related independently to lower volumes of cerebellar white matter (p<0.001, β=−0.6) and subcortical gray matter (p<0.05, β=−0.30). Reduced thalamus volume was linked to weaker grip strength (p < 0.05, β=0.4). Caudate volume was negatively associated with grip strength (p<0.01, β=−0.5). Conclusion Volumetric changes in cerebellar white matter and subcortical gray matter, brain regions involved in motor control and cognition, may be connected to frailty development in well-controlled HIV. Gait speed is particularly sensitive to white matter alterations and should be investigated as a predictor of frailty and brain atrophy in chronically infected patients.","PeriodicalId":91371,"journal":{"name":"Open medicine journal","volume":"3 1","pages":"138 - 152"},"PeriodicalIF":0.0,"publicationDate":"2016-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68057346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Group, One-on-One, or Internet? Preferences for Mindfulness Meditation Delivery Format and their Predictors. 小组、一对一还是互联网？对正念冥想授课形式的偏好及其预测因素。

Open medicine journal Pub Date : 2014-01-01 Epub Date: 2014-11-28 DOI: 10.2174/1874220301401010066

Helané Wahbeh, Matthew N Svalina, Barry S Oken

{"title":"Group, One-on-One, or Internet? Preferences for Mindfulness Meditation Delivery Format and their Predictors.","authors":"Helané Wahbeh, Matthew N Svalina, Barry S Oken","doi":"10.2174/1874220301401010066","DOIUrl":"10.2174/1874220301401010066","url":null,"abstract":"Objectives: Group mindfulness meditation interventions have improved symptoms in many health conditions. However, many people are unwilling to receive group treatment, so alternative delivery methods such as individual and internet may be a useful option. The study objective was to examine mindfulness meditation intervention delivery format preferences and their relationship to potential predictors.Design: An online survey was conducted of adult English speakers. Data was collected on interest and preference for internet, individual, or group formats of a mindfulness meditation intervention. Age, gender, personality, and posttraumatic stress disorder score and status and depression status were also collected.Results and conclusions: 500 eligible participants completed the survey (mean age 39±15; range 18-70; 68% female). Participants were more interested in the Internet (n=356) and individual formats (n=384) than the group format (n=245). Fifty-five participants (11%) said they would refuse a group format. Internet was the first choice format for most participants (Internet 212 (43%), Individual 187 (38%), Group 97 (20%) and group was the last choice for most participants (Internet 140 (29%), Individual 70 (14%), Group 279 (57%)). Age, extraversion and emotional stability were significant in predicting first choice format. These results support the need for more research and implementation of alternative mindfulness meditation intervention delivery formats. Future research will incorporate additional predictors and include a broader range of participants.","PeriodicalId":91371,"journal":{"name":"Open medicine journal","volume":"1 1","pages":"66-74"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68057281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0