Journal of neurology and neuroscience最新文献_第5页

Comparison of Microfiber Alteration of Fornix in Idiopathic Normal Pressure Hydrocephalus Patients, Alzheimer’s Disease Patients and Healthy Volunteers via Diffusion Tensor Imaging 弥散张量成像对特发性常压脑积水患者、阿尔茨海默病患者和健康志愿者穹窿微纤维改变的比较

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.21767/2171-6625.1000283

N. C., Gonthong A, W. J., C. P., C. O, M. W., W. T.

引用次数: 0

Vertebral Artery Dissection Following Tonic Clonic Seizure 强直性阵挛性发作后椎动脉夹层

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.3.298

R. S, G. V., Hakim M

引用次数: 0

Spinal Segmental Myoclonus Masquerading as a Psychogenic Movement Disorder 伪装成心因性运动障碍的脊髓节段性肌阵挛

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.21767/2171-6625.1000282

L. Khanna, A. Batra, Ankita Sharma

引用次数: 0

Clinical Manifestations of Neurosarcoidosis in the Netherlands 荷兰神经结节病的临床表现

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.2.292

M. Voortman, D. Fritz, Oscar J.M. Vogels, Diederik van de Beek, J. Vries, Matthijs C. Brouwer, M. Drent

{"title":"Clinical Manifestations of Neurosarcoidosis in the Netherlands","authors":"M. Voortman, D. Fritz, Oscar J.M. Vogels, Diederik van de Beek, J. Vries, Matthijs C. Brouwer, M. Drent","doi":"10.36648/2171-6625.10.2.292","DOIUrl":"https://doi.org/10.36648/2171-6625.10.2.292","url":null,"abstract":"Background: Neurosarcoidosis is a rare disease. We investigated the prevalence of different manifestations of neurosarcoidosis and the influence of race or gender in the Netherlands, as well as the treatment strategies for neurosarcoidosis patients. Methods: Multicentre observational cohort study of patients with neurosarcoidosis in two tertiary referral centres; the ILD Center of Excellence of the St. Antonius Hospital, Nieuwegein and the Amsterdam University Medical Centre (UMC), the Netherlands, from 2015 till 2017, as well as participants of the Dutch Neurosarcoidosis Registry between June 2014 and December 2017. Results: A total of 194 patients were included, 27 of whom were in the Dutch Neurosarcoidosis Registry, 70 treated at the ILD Center of Excellence and 97 treated at the Amsterdam UMC. Of the 194 patients included, 54% were female. The most common neurosarcoidosis manifestations were chronic meningitis (41%), cranial nerve dysfunction (39%), myelopathy (28%) and cerebral parenchymal disease (26%). Age, gender and race did not differ for the various manifestations, except for peripheral polyneuropathy, which was more prevalent in men than in women (21% versus 10%). Most neurosarcoidosis patients were treated with prednisone (89%), methotrexate (46%) or infliximab (21%). A total of 102 patients (53%) received second- or third-line treatment. Conclusion: In a large cohort of neurosarcoidosis patients, chronic meningitis, cranial nerve dysfunction, spinal cord involvement and cerebral parenchymal disease were the most common manifestations. Age, race and gender did not influence the clinical presentation, except for peripheral polyneuropathy (men>women). Over half of the patients required multiple immunosuppressive treatments.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69697962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Relationship between Cytochrome P450 G1347A Gene Polymorphism and Risk of Ischemic Stroke in North Indian Population: A Case-Control Study 北印度人群细胞色素P450 G1347A基因多态性与缺血性卒中风险的关系:一项病例对照研究

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.2.297

Ram Sagar, Amit Kumar, S. Misra, Pradeep Kumar, R. Raj, A. Gulati, K. Prasad

{"title":"Relationship between Cytochrome P450 G1347A Gene Polymorphism and Risk of Ischemic Stroke in North Indian Population: A Case-Control Study","authors":"Ram Sagar, Amit Kumar, S. Misra, Pradeep Kumar, R. Raj, A. Gulati, K. Prasad","doi":"10.36648/2171-6625.10.2.297","DOIUrl":"https://doi.org/10.36648/2171-6625.10.2.297","url":null,"abstract":"Objective: Present study was taken up to establish the association between CYP4F2 G1347A polymorphism and risk of ischemic stroke (IS) in a North Indian population. Methods: In a hospital-based case-control study, 250 cases and 250 age and sex matched control subjects were recruited from Outpatient Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. Polymerase chain reaction – Restriction fragment length polymorphism (PCR-RFLP) was used for genotyping. Data were analyzed using STATA software, Version 13. Results: The mean age of IS patients were 52.83 ± 12.59 years and in control group were 50.97 ± 12.70 years. Genotypic frequency distributions were in accordance with Hardy Weinberg Equilibrium (HWE) in both cases and controls. Conditional logistic regression analysis showed an independent association between CYP450 G1347A gene polymorphism with the risk of IS under dominant model (OR 2.05; 95% CI 1.18 to 3.56). Analysis based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification discerned a significant association with Large Vessel Disease (LVD) subtype of IS in both the unadjusted (OR, 2.5; 95% CI 1.49 to 4.20) and adjusted (OR, 3.32; 95% CI 1.72 to 6.43) analysis and a significant association with Small Vessel Disease (SVD) subtype of IS after the adjusted analysis (OR, 2.43; 95% CI 1.14 to 5.16) under recessive model. Conclusion: Present study suggests that CYP4F2 G1347A polymorphism may be an important risk factor for IS mainly for LVD subtype of IS. Prospective studies with large sample size are needed to confirm the present findings.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.36648/2171-6625.10.2.297","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69698374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association between Early Hyperoxia and Neurologic Outcome in Patient with High Grade Aneurysmal Subarachnoid Hemorrhage 高度动脉瘤性蛛网膜下腔出血患者早期高氧与神经系统预后的关系

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.3.299

Camille Beaudeux, L. Kanagaratnam, M. Bard, H. Habchi, B. Marlier, J. Kleiber, V. Legros

{"title":"Association between Early Hyperoxia and Neurologic Outcome in Patient with High Grade Aneurysmal Subarachnoid Hemorrhage","authors":"Camille Beaudeux, L. Kanagaratnam, M. Bard, H. Habchi, B. Marlier, J. Kleiber, V. Legros","doi":"10.36648/2171-6625.10.3.299","DOIUrl":"https://doi.org/10.36648/2171-6625.10.3.299","url":null,"abstract":"Background: Oxygenation support is a common practice in patients with aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to analyze the association between early hyperoxia and the neurological outcome in patients presenting a High Grade SAH, using the modified Rankin Scale (mRS) at 6 months. Methods: We retrospectively analyzed data of SAH in a single center, retrospective, observational study. The inclusion criteria were patients’ ≥ 18 years-old, under mechanical ventilation upon admission to the intensive care unit (ICU) and presenting an aneurysmal SAH with a WFNS score ≥3. Hyperoxia was defined as PaO2 > 120 mmHg and classified into 3 subgroups: mild (121-200 mmHg), moderate (201-300 mmHg) and severe (> 300 mmHg). Patients with a 6 months-mRS >3 were considered as having a poor outcome. Results: One hundred and thirty-nine patients with aneurysmal SAH were included. 82% of patients were exposed to hyperoxia with predominance of mild hyperoxia (42.8%). A higher yet non-statistical, poor neurologic outcome was identified in the hyperoxic compared to normoxic group (72% vs. 87.7% OR 2.8 [1.02-7.71], p 0.12). Following a multivariate analysis, a statistical trend was identified between the hyperoxic group and a 6-month poor neurological outcome (OR 2.84, 95% CI, 0.99-8.19; p=0.052), but no statistical association was found with delayed cerebral ischemia (OR 1.68, 95% CI, 0.5-5.71, p=0.39) nor with 28-day mortality (OR 2.17, 95% CI, 0.82-5.75, p=0.11). Conclusions: Our findings suggest a statistical trend between early hyperoxia and a poor neurological outcome at 6 months, in patients with a high grade aneurysmal SAH admitted to the ICU. Further, large-scale studies are required to fully evaluate the effects of hyperoxia.","PeriodicalId":91329,"journal":{"name":"Journal of neurology and neuroscience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.36648/2171-6625.10.3.299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69698468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficacy of Bisphosphonate to Increase the Skull Density Ratio of MRI-guided Focused Ultrasound Candidates with Brain Disorders 双膦酸盐提高mri引导的脑疾病聚焦超声候选人颅骨密度比的疗效

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.2.293

Hisashi Ito, J. Rumià, Shigeru Fukutake, Kazuaki Yamamoto, Toshio Yamaguchi, T. Taira, T. Kamei

引用次数: 5

Specifying Ontologies in a Social Networking ImagesÃ¢Â€Â™ Sample Obtained with a Multiagent System 在社交网络中指定本体ImagesÃ¢Â€Â™用多代理系统获得的示例

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.21767/2171-6625.1000285

M. Cisneros, Nemesio Castillo, A. Ochoa, Luis Cisneros, Rosa Saucedo

引用次数: 0

Physiological Correlates of Arousal: A Metaanalytic Review 唤醒的生理关联:荟萃分析回顾

Journal of neurology and neuroscience Pub Date : 2019-01-01 DOI: 10.36648/2171-6625.10.4.302

Dhruv Beri, Jayasankara Reddy K

引用次数: 8

An old and new challenge for treatment of Alzheimers disease 阿尔茨海默病治疗的新旧挑战

Journal of neurology and neuroscience Pub Date : 2018-11-01 DOI: 10.21767/2171-6625-C3-013

M. Tsolaki

引用次数: 0