Journal of drug abuse最新文献_第2页

Differential Activation of the Left and Right Cerebral Hemispheres of Individuals Who Use or are Dependent on Drugs of Abuse. 使用或依赖滥用药物的个体左右脑半球的差异激活。

Journal of drug abuse Pub Date : 2018-01-01 Epub Date: 2018-07-25 DOI: 10.21767/2471-853X.100077

Harold W Gordon

{"title":"Differential Activation of the Left and Right Cerebral Hemispheres of Individuals Who Use or are Dependent on Drugs of Abuse.","authors":"Harold W Gordon","doi":"10.21767/2471-853X.100077","DOIUrl":"https://doi.org/10.21767/2471-853X.100077","url":null,"abstract":"Introduction: The left and right cerebral hemispheres are not equivalent in performance of cognitive functions associated with risk factors of drug abuse, nor is their development equivalently affected by drugs of abuse. The question addressed here is whether drugs of abuse affect cognitive function as assessed by brain activation, in particular related to impulsivity, and/or whether weaker brain activation associated with impulsivity increases the risk of drug abuse.Methodology: Using PubMed and key words, articles were selected that addressed brain activation in individuals who used or abused one of the psychoactive drugs. Findings are summarized.Results: For each of the drugs, hypoactivation was found. In some cases this reduced activation was reported predominantly for the right or both hemispheres. There were fewer reports for the left hemisphere.Discussion and conclusion: Rarely do authors focus on why only one or the other hemisphere is affected or why specific structures are affected. Neurobiological differences between the hemispheres and among various brain structures could provide clues to the specific effect of drugs. Increased attention to this gap in research will give additional insights into the etiology of drug abuse and provide direction for treatment.","PeriodicalId":91309,"journal":{"name":"Journal of drug abuse","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-853X.100077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36383230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dissecting the Role of Disturbed ER-Golgi Trafficking in Antivirals and Alcohol Abuse-Induced Pathogenesis of Liver Disorders. 剖析紊乱的er -高尔基体转运在抗病毒药物和酒精滥用引起的肝脏疾病发病机制中的作用。

Journal of drug abuse Pub Date : 2017-01-01 Epub Date: 2017-09-26 DOI: 10.21767/2471-853X.100054

Cheng Ji

引用次数: 8

Perceived social support and its association with amphetamine-type stimulant use among female sex workers in Guangxi, China. 广西女性性工作者的感知社会支持及其与安非他明类兴奋剂使用的关系。

Journal of drug abuse Pub Date : 2017-01-01 Epub Date: 2017-08-31 DOI: 10.21767/2471-853X.100052

Yuchen Mao, Qun Zhao, Xiaoming Li

引用次数: 0

Testing a Multidimensional Acculturation Model on Latinos who Completed Substance Abuse Treatment. 拉丁美洲人药物滥用治疗的多维文化适应模型检验。

Journal of drug abuse Pub Date : 2016-01-01 Epub Date: 2016-05-24 DOI: 10.21767/2471-853X.100023

Roberto Lopez-Tamayo, J Alvarez, L A Jason

{"title":"Testing a Multidimensional Acculturation Model on Latinos who Completed Substance Abuse Treatment.","authors":"Roberto Lopez-Tamayo, J Alvarez, L A Jason","doi":"10.21767/2471-853X.100023","DOIUrl":"https://doi.org/10.21767/2471-853X.100023","url":null,"abstract":"Disparities in substance abuse treatment (SAT) utilization and completion suggest that traditional substance abuse models may fall short of addressing the complex needs of Latinos, increasing the odds of relapsing. The need for substance use models that integrate multiple acculturation domains in relation to substance abuse is warranted. The goal of the present study is twofold: a) test a multidimensional acculturation model on Latinos who completed SAT; and b) examine the association between the proposed multidimensional acculturation and days consuming alcohol and illicit drugs in the past six months. A total of 131 participants (Mage=36.15, SD ± 10.5, 86.3% males, 48.1% non-U.S. born with a mean length of stay of 19 years in the U.S. (SD ± 13.71) were interviewed upon completion of SAT. Results from the SEM indicated adequate model fit to the population under study, supporting the use of a multidimensional acculturation approach for this population. Subsequent results from the structured regression analysis suggest that multidimensional acculturation is negatively associated with days using alcohol in the past 6 months. The implications of these findings are discussed.","PeriodicalId":91309,"journal":{"name":"Journal of drug abuse","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-853X.100023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35532546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Regional Brain Activity in Abstinent Methamphetamine Dependent Males Following Cue Exposure. 线索暴露后戒断甲基苯丙胺依赖男性脑区域活动。

Journal of drug abuse Pub Date : 2016-01-01 Epub Date: 2016-02-19 DOI: 10.21767/2471-853x.100016

Robert Malcolm, Hugh Myrick, Xingbao Li, Scott Henderson, Kathleen T Brady, Mark S George, Ronald E See

{"title":"Regional Brain Activity in Abstinent Methamphetamine Dependent Males Following Cue Exposure.","authors":"Robert Malcolm, Hugh Myrick, Xingbao Li, Scott Henderson, Kathleen T Brady, Mark S George, Ronald E See","doi":"10.21767/2471-853x.100016","DOIUrl":"https://doi.org/10.21767/2471-853x.100016","url":null,"abstract":"Background: Neuroimaging of drug-associated cue presentations has aided in understanding the neurobiological substrates of craving and relapse for cocaine, alcohol, and nicotine. However, imaging of cue-reactivity in methamphetamine addiction has been much less studied.Method: Nine caucasian male methamphetamine-dependent subjects and nine healthy controls were scanned in a Phillips 3.0T MRI scan when they viewed a randomized presentation of visual cues of methamphetamine, neutral objects, and rest conditions. Functional Imaging data were analyzed with Statistical Parametric Mapping software 5 (SPM 5).Results: Methamphetamine subjects had significant brain activation in the ventral striatum and medial frontal cortex in comparison to meth pictures and neutral pictures in healthy controls (p<0.005, threshold 15 voxels). Interestingly the ventral striatum activation significantly correlated with the days since the last use of meth (r=-0.76, p=0.017). No significant activity was found in healthy control group.Conclusion: The preliminary data suggest that methamphetamine dependent subjects, when exposed to methamphetamine-associated visual cues, have increased brain activity in ventral striatum, caudate nucleus and medial frontal cortex which subserve craving, drug-seeking, and drug use.","PeriodicalId":91309,"journal":{"name":"Journal of drug abuse","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-853x.100016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34585648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Cocaine Use and Liver Disease are Associated with All-Cause Mortality in the Miami Adult Studies in HIV (MASH) Cohort. 迈阿密成人艾滋病研究（MASH）队列中可卡因的使用和肝脏疾病与全因死亡率有关。

Journal of drug abuse Pub Date : 2016-01-01 Epub Date: 2016-11-07 DOI: 10.21767/2471-853X.100036

Adriana Campa, Sabrina Sales Martinez, Kenneth E Sherman, Joe Pedro Greer, Yinghui Li, Stephanie Garcia, Tiffanie Stewart, Boubakari Ibrahimou, O Dale Williams, Marianna K Baum

{"title":"Cocaine Use and Liver Disease are Associated with All-Cause Mortality in the Miami Adult Studies in HIV (MASH) Cohort.","authors":"Adriana Campa, Sabrina Sales Martinez, Kenneth E Sherman, Joe Pedro Greer, Yinghui Li, Stephanie Garcia, Tiffanie Stewart, Boubakari Ibrahimou, O Dale Williams, Marianna K Baum","doi":"10.21767/2471-853X.100036","DOIUrl":"10.21767/2471-853X.100036","url":null,"abstract":"Objective: Liver disease is a frequent cause of morbidity and mortality in HIV infection. We examined the relationship of cocaine use, liver disease progression and mortality in an HIV-infected cohort.Methods: Consent was obtained from 487 HIV+ participants, a subset of the Miami Adult Studies on HIV (MASH) cohort. Participants were eligible if they were followed for at least two years, completed questionnaires on demographics and illicit drug use and had complete metabolic panels, CD4 cell counts and HIV-viral loads. FIB-4 was calculated and cut-off points were used for staging liver fibrosis. Death certificates were obtained.Results: Participants were 65% men, 69% Black and 81% were on ART at recruitment. Cocaine was used by 32% of participants and 29% were HIV/HCV co-infected. Mean age was 46.9 ± 7.7 years, mean CD4 cell count was 501.9 ± 346.7 cells/μL and mean viral load was 2.75 ± 1.3 log10 copies/mL at baseline. During the follow-up, 27 patients died, with a mortality rate of 28.2/1000 person-year. Cocaine was used by 48% of those who died (specific mortality rate was 13/1000 person-year). Those who died were more likely to use cocaine (HR=3.8, P=0.006) and have more advanced liver fibrosis (HR=1.34, P<0.0001), adjusting for age, gender, CD4 cell count and HIV-viral load at baseline and over time. Among the HIV mono-infected participants, cocaine users were 5 times more likely to die (OR=5.09, P=0.006) than participants who did not use cocaine.Conclusion: Cocaine use and liver fibrosis are strong and independent predictors of mortality in HIV infected and HIV/HCV co-infected adults. Effective interventions to reduce cocaine use among people living with HIV (PHLW) are needed.","PeriodicalId":91309,"journal":{"name":"Journal of drug abuse","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35024755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ALCOHOL AND DRUG USE AT THE U.S.-MEXICO BORDER - DOES CROSS-BORDER MOBILITY MAKE A DIFFERENCE? 美墨边境的酒精和毒品使用——跨境流动有影响吗?

Journal of drug abuse Pub Date : 2016-01-01 Epub Date: 2016-01-21 DOI: 10.21767/2471-853x.100013

Cheryl J Cherpitel

引用次数: 2

Brief Interventions for Adolescents. 青少年简短干预。

Journal of drug abuse Pub Date : 2016-01-01 Epub Date: 2016-01-26

Ken C Winters

引用次数: 0

Cocaine Self-Administration Elevates GluN2B within dmPFC Mediating Heightened Cue-Elicited Operant Responding. 可卡因自我给药可提高dmPFC内GluN2B介导线索引发的高操作性反应。

Journal of drug abuse Pub Date : 2016-01-01 Epub Date: 2016-04-22 DOI: 10.21767/2471-853x.100022

Karen K Szumlinski, Melissa G Wroten, Bailey W Miller, Arianne D Sacramento, Matan Cohen, Osnat Ben-Shahar, Tod E Kippin

{"title":"Cocaine Self-Administration Elevates GluN2B within dmPFC Mediating Heightened Cue-Elicited Operant Responding.","authors":"Karen K Szumlinski, Melissa G Wroten, Bailey W Miller, Arianne D Sacramento, Matan Cohen, Osnat Ben-Shahar, Tod E Kippin","doi":"10.21767/2471-853x.100022","DOIUrl":"https://doi.org/10.21767/2471-853x.100022","url":null,"abstract":"Cue-elicited drug-craving correlates with hyperactivity within prefrontal cortex (PFC), which is theorized to result from dysregulated excitatory neurotransmission. The NMDA glutamate receptor is highly implicated in addiction-related neuroplasticity. As NMDA receptor function is regulated critically by its GluN2 subunits, herein, we assayed the relation between incubated cue-elicited cocaine-seeking following extended access to intravenous cocaine (6 h/d; 0.25 mg/infusion for 10 d) and the expression of GluN2A/B receptor subunits within PFC sub regions during early versus late withdrawal (respectively, 3 vs. 30 days). Cocaine-seeking rats exhibited elevated GluN2B expression within the dorsomedial aspect of the PFC (dmPFC); this effect was apparent at both 3 and 30 days withdrawal and occurred in cocaine-experienced rats, regardless of experiencing an extinction test or not. Thus, elevated dmPFC GluN2B expression appears to reflect a pharmacodynamic response to excessive cocaine intake that is independent of the duration of drug withdrawal or re-exposure to drug-taking context. The functional relevance of elevated dmPFC GluN2B expression for drug-seeking was assessed by the local infusion of the prototypical GluN2B-selective antagonist ifenprodil (1.0 µg/side). Ifenprodil did not alter cue-elicited responding in animals with a history of saline self-administration. In contrast, ifenprodil lowered cue-elicited cocaine-seeking, while potentiating cue-elicited sucrose-seeking. Thus, the effects of an intra-dmPFC ifenprodil infusion upon cue reactivity are reinforcer-specific, arguing in favor of targeting GluN2B-containing NMDA receptors as a pharmacological strategy for reducing behavioral reactivity to drug-associated cues with the potential benefit of heightening the reinforcing properties of cues associated with non-drug primary rewards.","PeriodicalId":91309,"journal":{"name":"Journal of drug abuse","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-853x.100022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34722376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Current Rural Drug Use in the US Midwest 当前美国中西部农村药物使用情况

Journal of drug abuse Pub Date : 2016-01-01 DOI: 10.21767/2471-853X.100030

K. Dombrowski, Devan Crawford, Bilal Khan, Kimberly A. Tyler

引用次数: 3