Bone Marrow Transplantation最新文献_第4页

Outcomes of Hematopoietic Stem Cell Transplantation in children with Sickle Cell Disease: Does donor Sickle cell trait status matter? 造血干细胞移植治疗儿童镰状细胞病的结果：供体镰状细胞特性状态是否重要？

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-18 DOI: 10.1038/s41409-025-02572-8

Mohamed Bayoumy, Enass H Raffa, Amal Alseraihy Alharbi, Ibraheem Abosoudah, Amany Orabe, Hassan Altrabolsi, Abdulatef Ahmed, Marwa Elhadidy, Lamis Alkhateeb, Wasil Jastaniah

引用次数: 0

First-line chemotherapies administered before hematopoietic cell transplantation in children with acute leukemia: effect on the spermatogonial pool. 急性白血病患儿造血细胞移植前一线化疗：对精原池的影响。

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-17 DOI: 10.1038/s41409-025-02547-9

A S Gille, L Lenez, A Vanhæsebrouck, D Rivet-Danon, C Lapoujade, L Riou, J H Dalle, K Yakouben, M Peycelon, M Fahd, A Paye-Jaouen, G Leverger, M D Tabone, H Boutroux, S Irtan, C Chenouf, M Sibony, C Chalas, C Patrat, J P Wolf, N Boissel, P Fouchet, C Poirot, V Barraud-Lange

引用次数: 0

Chimeric antigen receptor T-cell therapy for relapsed/refractory multiple myeloma: a real-world experience. 嵌合抗原受体t细胞治疗复发/难治性多发性骨髓瘤：现实世界的经验。

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-17 DOI: 10.1038/s41409-025-02607-0

Bhavesh Mohan Lal, Toshali Pandey, Marah Alzubi, Jawad Alrawabdeh, John Shaughnessy, Fenghuang Zhan, Eric R Siegel, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Samer Al Hadidi

引用次数: 0

The impact of the SARS-CoV-2 pandemic on umbilical cord blood transplantation in Japan: insights from an interrupted time series analysis. SARS-CoV-2大流行对日本脐带血移植的影响：来自中断时间序列分析的见解

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-17 DOI: 10.1038/s41409-025-02588-0

Nobuhiko Nakamura, Tetsuji Morishita, Hiromi Hayashi, Motohito Okabe, Hideki Nakasone, Naoyuki Uchida, Noriko Doki, Takahiro Fukuda, Satoshi Yoshihara, Masatsugu Tanaka, Tetsuya Nishida, Yuta Hasegawa, Ken-Ichi Matsuoka, Masashi Sawa, Tetsuya Eto, Makoto Onizuka, Yuta Katayama, Koji Kato, Fumihiko Ishimaru, Ken Tabuchi, Yoshiko Atsuta, Nobuhiro Kanemura, Takanori Teshima

{"title":"The impact of the SARS-CoV-2 pandemic on umbilical cord blood transplantation in Japan: insights from an interrupted time series analysis.","authors":"Nobuhiko Nakamura, Tetsuji Morishita, Hiromi Hayashi, Motohito Okabe, Hideki Nakasone, Naoyuki Uchida, Noriko Doki, Takahiro Fukuda, Satoshi Yoshihara, Masatsugu Tanaka, Tetsuya Nishida, Yuta Hasegawa, Ken-Ichi Matsuoka, Masashi Sawa, Tetsuya Eto, Makoto Onizuka, Yuta Katayama, Koji Kato, Fumihiko Ishimaru, Ken Tabuchi, Yoshiko Atsuta, Nobuhiro Kanemura, Takanori Teshima","doi":"10.1038/s41409-025-02588-0","DOIUrl":"https://doi.org/10.1038/s41409-025-02588-0","url":null,"abstract":"The SARS-CoV-2 pandemic disrupted healthcare systems worldwide, particularly affecting hematopoietic stem cell transplantation (HSCT) activities. Understanding the impact of the SARS-CoV-2 pandemic on transplant practices, especially in Japan, where cord blood transplantation (CBT) is prevalent, is crucial. A total of 40,444 allogeneic HSCT cases in Japan between 2011 and 2021 were examined using an interrupted time series analysis to assess the impact of COVID-19 on CBT utilization. Following the SARS-CoV-2 pandemic, CBT cases demonstrated a significant increase (11.06 [95% confidence interval (CI): 1.87 to 20.25] cases per month), whereas bone marrow transplantation cases decreased, by 10.74 cases per month (95% CI, -19.84 to -1.63 cases per month). Total HSCT cases remained stable with a level change of 5.47 cases per month (95% CI, -10.07 to 21.01 cases per month) and a trend change of -1.11 cases per month (95% CI, -2.22 to 0.004 cases per month). The interrupted time series analysis showed significantly increased CBT cases in Japan, highlighting its crucial role as an alternative transplant source during the pandemic. CBT offset the impact of the decrease in bone marrow transplantation and contributed to the maintenance of HSCT activity in Japan during the unprecedented crisis.","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of ABO compatibility on allogeneic hematopoietic cell transplantation outcomes: a contemporary and comprehensive study from the transplant complications working party of the EBMT. ABO相容性对同种异体造血细胞移植结果的影响：EBMT移植并发症工作组的当代综合研究。

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-17 DOI: 10.1038/s41409-025-02580-8

Mustafa Güven, Christophe Peczynski, William Boreland, Didier Blaise, Régis Peffault de Latour, Ibrahim Yakoub-Agha, Tobias Gedde-Dahl, Urpu Salmenniemi, Edouard Forcade, Jakob Passweg, Patrice Chevallier, Loron Sandrine, Stephan Mielke, Annoek Broers, Patrice Ceballos, Jennifer Byrne, Cristina Castilla-Llorente, Johan Maertens, Anne Huynh, Raffaella Cerretti, Claude Eric Bulabois, Gwendolyn van Gorkom, Charles Crawley, Charlotte Graham, Alberto Mussetti, Hélène Schoemans, Olaf Penack, Ivan Moiseev, Zinaida Peric

{"title":"The impact of ABO compatibility on allogeneic hematopoietic cell transplantation outcomes: a contemporary and comprehensive study from the transplant complications working party of the EBMT.","authors":"Mustafa Güven, Christophe Peczynski, William Boreland, Didier Blaise, Régis Peffault de Latour, Ibrahim Yakoub-Agha, Tobias Gedde-Dahl, Urpu Salmenniemi, Edouard Forcade, Jakob Passweg, Patrice Chevallier, Loron Sandrine, Stephan Mielke, Annoek Broers, Patrice Ceballos, Jennifer Byrne, Cristina Castilla-Llorente, Johan Maertens, Anne Huynh, Raffaella Cerretti, Claude Eric Bulabois, Gwendolyn van Gorkom, Charles Crawley, Charlotte Graham, Alberto Mussetti, Hélène Schoemans, Olaf Penack, Ivan Moiseev, Zinaida Peric","doi":"10.1038/s41409-025-02580-8","DOIUrl":"https://doi.org/10.1038/s41409-025-02580-8","url":null,"abstract":"The role of ABO blood group system mismatch on allogeneic hematopoietic cell transplantation (allo-HCT) outcomes is controversial since current publications of large datasets are lacking. We retrospectively analyzed 30,487 patients transplanted between 2010 and 2021 using the EBMT registry to assess ABO incompatibility's effect on non-relapse mortality (NRM), overall survival (OS), progression-free survival (PFS), relapse incidence (RI), acute GvHD (aGvHD), chronic GvHD (cGvHD), and neutrophil engraftment. Transplantations were classified as ABO-compatible (56.3%), major (18.1%), minor (20.1%), and bidirectional (5.5%) incompatibilities. Mainly peripheral blood stem cells (PBSC) were used as the cell source in 85.6% of cases. Multivariate analysis found no significant association between compatibility status, with the compatible group serving as the reference, and NRM, OS, PFS, RI or cGvHD. The incidence of non-engraftment was significantly higher in the major (HR 1.04, 95% CI 1.01-1.07, p = 0.021) and bidirectional (HR 1.09, 95% CI 1.03-1.15, p = 0.003) incompatibilities. At the same time, the risk of severe aGvHD grades III-IV was lower in the major incompatibility group (HR 0.85, 95% CI 0.77-0.94, p = 0.001). Our large contemporary study, showing no major impact on outcomes, suggests that the ABO blood group system should not be a primary consideration in donor selection for PBSC-based allo-HCT.","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CAR-T for multiple myeloma: practice pearls. CAR-T治疗多发性骨髓瘤：练珍珠。

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-17 DOI: 10.1038/s41409-025-02582-6

Daniel O'Leary, Veronika Bachanova

引用次数: 0

Regulatory T cell therapy for Graft-versus-Host Disease. 移植物抗宿主病的调节性T细胞治疗。

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-16 DOI: 10.1038/s41409-025-02553-x

Memnon Lysandrou, Dionysia Kefala, Janaki Manoja Vinnakota, Nikolaos Savvopoulos, Robert Zeiser, Alexandros Spyridonidis

引用次数: 0

"Learn and Know" in the era of gene addition/gene editing based approaches for sickle cell disease: The EHA-EBMT consensus paper. 在镰状细胞病的基因添加/基因编辑方法时代“学习和了解”：EHA-EBMT共识论文。

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-16 DOI: 10.1038/s41409-025-02561-x

Lucia De Franceschi, Emanuele Angelucci

引用次数: 0

Posaconazole versus fluconazole as primary antifungal prophylaxis for patients at high risk of invasive fungal infections receiving allogeneic hematopoietic stem cell transplantation. 泊沙康唑与氟康唑对接受同种异体造血干细胞移植的侵袭性真菌感染高风险患者的首选抗真菌预防

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-16 DOI: 10.1038/s41409-025-02589-z

Valentin Letailleur, Maxime Jullien, Alice Garnier, Pierre Peterlin, Sophie Vantyghem, Aude-Marie Fourmont, Thierry Guillaume, Patrice Chevallier, Amandine Le Bourgeois

{"title":"Posaconazole versus fluconazole as primary antifungal prophylaxis for patients at high risk of invasive fungal infections receiving allogeneic hematopoietic stem cell transplantation.","authors":"Valentin Letailleur, Maxime Jullien, Alice Garnier, Pierre Peterlin, Sophie Vantyghem, Aude-Marie Fourmont, Thierry Guillaume, Patrice Chevallier, Amandine Le Bourgeois","doi":"10.1038/s41409-025-02589-z","DOIUrl":"https://doi.org/10.1038/s41409-025-02589-z","url":null,"abstract":"With the aim to reduce the incidence of invasive fungal infections (IFI) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), the ECIL group recommends the use of drugs active against molds such as posaconazole instead of fluconazole in high-risk (HR) IFI patients. But data to support this recommendation are poor. The aim of this monocentric study was to compare retrospectively the use of fluconazole (n = 96) vs. posaconazole (n = 63), as primary antifungal prophylaxis within the first 90 days (D) post-transplant in a cohort of patients at HR-IFI (n = 159). HR-IFI was defined by the use of an alternative donor, post-transplant cyclophosphamide and/or sequential conditioning regimen, and/or an active disease at transplant or a previous allo-HSCT. Incidences of D90, 6-month, 1-year and 2-year CI of IFI as well as D90 primary prophylaxis failure (IFI resulting in the initiation of a curative antifungal therapy or a permanent discontinuation of the prophylaxis for toxicity) were similar between both groups. However, the number of probable/proven IFI that occurred between D0 and D90 was the double in the fluco group (9 vs. 4). Also, no proven IFI (vs. 4) or mucormycoses (vs. 1) or IFI related death (vs. 4) occurred in the posa group in the first 90 days. Posaconazole thus appears to be a good option to prevent IFI after allo-HSCT in patients at HR-IFI.","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in liver stiffness measurement: cardiovascular complications as diagnostic pitfalls in sinusoidal obstruction syndrome. 肝硬度测量的挑战：心血管并发症作为窦状静脉阻塞综合征的诊断陷阱。

IF 4.5 2区医学

Bone Marrow Transplantation Pub Date : 2025-04-16 DOI: 10.1038/s41409-025-02603-4

Lorenzo Lazzari, Antonella Capasso, Matteo Cristante, Maddalena Ponti, Maria Teresa Lupo-Stanghellini, Fabio Ciceri, Annalisa Ruggeri, Andrea Assanelli

引用次数: 0