Bone Marrow Transplantation最新文献

{"title":"Analytical variability in chimerism testing may influence longitudinal clinical interpretation after allogeneic hematopoietic cell transplantation.","authors":"Reut Hod Dvorai, Alan M Sanfilippo, Anna L Greenshields, Ahmed Mostafa, William Hoffman, Rajesh Parmar, Neng Yu, Ketevan Gendzekhadze, Lee Ann Baxter-Lowe, Olga A Timofeeva","doi":"10.1038/s41409-026-03048-z","DOIUrl":"https://doi.org/10.1038/s41409-026-03048-z","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Secondary autoimmune and inflammatory diseases after allogeneic hematopoietic stem cell transplantation: a retrospective study from the EBMT transplant complications and autoimmune diseases working parties.","authors":"Arsene Mekinian, Artem Oganesyan, Zinaida Perić, Myriam Labopin, Urpu Salmenniemi, José Antonio Pérez Simón, Anke Verlinden, Ioanna Sakellari, Mohsen Alzahrani, Massimo Martino, Frédéric Baron, John A Snowden, Hakan Ozdogu, Alexander Kulagin, Edgar Jost, Anna Torrent, Fabio Benedetti, Anna De Becker, Sylvie François, Montserrat Rovira, Hans Christian Reinhardt, Alessandra Biffi, Mark Ringhoffer, Pascal Ambron, Jose Luis López Lorenzo, Nabil Yafour, Alexandre Galvagni, Manuela Badoglio, Ivan Moiseev, Tobias Alexander, Mohamad Mohty, Olivier Fain, Raffaella Greco, Olaf Penack","doi":"10.1038/s41409-026-03047-0","DOIUrl":"https://doi.org/10.1038/s41409-026-03047-0","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Use of Rabbit ATG and poSt-tranSplant Immunosuppression with Cyclophosphamide, without any other graft-versus-host disease prophylaxis, for HLA-matched peripheral blood hematopoietic cell transplantation - The JURASSIC phase I trial.","authors":"Leonardo Javier Arcuri, Simone Maradei, Elias Hallack Atta, Decio Lerner, Mariana de Andrade Roque Assumpcao, Simone Pereira Lermontov, Carla de Oliveira Ribeiro","doi":"10.1038/s41409-026-03053-2","DOIUrl":"https://doi.org/10.1038/s41409-026-03053-2","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial complications after post-transplant cyclophosphamide in pediatric HSCT for non-malignant disorders: infants at highest risk.","authors":"Alice Corsia, Benjamin Fournier, Martin Castelle, Jean-Sébastien Diana, Roman Klifa, Charles de Marcellus, Maryline Lévy, Bénédicte Neven, Despina Moshous","doi":"10.1038/s41409-026-03039-0","DOIUrl":"https://doi.org/10.1038/s41409-026-03039-0","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HHV-6B encephalitis after allogeneic stem cell transplantation: a single center cohort study.","authors":"Franziska Marquard, Luise Brakert, Sofia Oechsler, Johanna Richter, Kristin Rathje, Nico Gagelmann, Radwan Massoud, Mathias Schäfersküpper, Jette Lüdersen, Benno Lickefett, Maraike Harfmann, Max Wichmann, Claudia Langebrake, Adrin Dadkhah, Evgeny Klyuchnikov, Silke Heidenreich, Ina Rudolph, Jochim Reinert, Catherina Lück, Felix Stahl, Nicolaus Kröger, Francis Ayuk","doi":"10.1038/s41409-026-03050-5","DOIUrl":"https://doi.org/10.1038/s41409-026-03050-5","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective single center assessment of the new EBMT weighed score to predict SOS/VOD in pediatric HSCT.","authors":"Viola Carzaniga, Emanuele Lanino, Sonia Bonanomi, Adriana Cristina Balduzzi, Maria Grazia Valsecchi, Elena Tassistro, Alessandro Cattoni, Marta Verna","doi":"10.1038/s41409-026-03041-6","DOIUrl":"https://doi.org/10.1038/s41409-026-03041-6","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decentralized CAR-T production: clinical, economic, and regulatory perspectives. Worldwide Network for Blood & Marrow Transplantation (WBMT) special article.","authors":"Abdulrahman Nasiri, Riad El Fakih, Christian Chabannon, Laurent Garderet, Jurgen Kuball, Ali Bazarbachi, Anna Sureda, Marcos De Lima, Muhammad Bilal Abid, Farhatullah Syed, Ibrahim N Muhsen, Daniel Weisdorf, Hildegard T Greinix, Anna Ossami Saidy, Mohammad Alhomoud, Abdulwahab Albabtain, Helen Baldomero, Shahrukh Hashmi, Lorenz Thurner, Nina Worel, Adrian Seber, Sebastian Galeano, Usama Gergis, Raheel Iftikhar, Yoshihisa Kodera, Marcelo Pasquini, Yoshiko Atsuta, Syed Osman Ahmed, Damiano Rondelli, Mohamad Mohty, John A Snowden, Ibrahim Yakoub Agha, Mohamed Kharfan-Dabaja, Dietger Niederwieser, Mickey Koh, Mahmoud Aljurf","doi":"10.1038/s41409-026-03044-3","DOIUrl":"https://doi.org/10.1038/s41409-026-03044-3","url":null,"abstract":"<p><p>Chimeric antigen receptor T-cell therapy transformed the treatment of hematologic malignancies and is rapidly expanding into solid tumors and autoimmune diseases. However, its full clinical potential remains constrained by centralized manufacturing, production costs, logistical complexity, prolonged vein-to-vein times, limited global accessibility, and regulatory frameworks that hinder rapid implementation of manufacturing innovations. Decentralized point-of-care manufacturing, pioneered by academic and clinical centers, offers a promising alternative to address these limitations and broaden patient access. This review summarizes the current landscape of POC CAR T-cell manufacturing, emphasizing clinical outcomes, economic sustainability, and regulatory considerations. Program experience across North America, Europe, Asia, and other regions demonstrates manufacturing innovations that reduce production times from several weeks to as few as 6-8 days. Early clinical studies report safety and efficacy comparable to commercially manufactured products while substantially lowering costs, with some models targeting production expenses of approximately USD 40,000 per treatment (excluding building and maintaining the production facility). We also examine supportive policy initiatives and regulatory pathways, including hospital exemption models, together with implementation challenges such as manufacturing heterogeneity, quality assurance, and workforce development. Finally, we discuss emerging technologies, including allogeneic CAR T-cell platforms, artificial intelligence-driven manufacturing, and in vivo gene editing, that may democratize global access.</p>","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced-intensity T-replete allogeneic stem cell transplantation provides long-term survival in relapsed angioimmunoblastic T-cell lymphoma post-autologous transplant in patients over the age of 50.","authors":"Ioannis Arvanitis, Cristina Maschio, Dimitrios Panaretos, Julieta Osorio Zuluaga, Faraz Khan, Mariam Alamin, Charmaine Campbell, Nabeel Bader, Alexandros Kanellopoulos, Emmanouil Nikolousis","doi":"10.1038/s41409-026-03037-2","DOIUrl":"https://doi.org/10.1038/s41409-026-03037-2","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149029740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplant-associated thrombotic microangiopathy in children treated with allogeneic hematopoietic stem cell transplantation.","authors":"Tomasz Jarmoliński, Monika Rosa, Iwona Bil-Lula, Joanna Korlaga, Krzysztof Kujawa, Marek Ussowicz, Krzysztof Kałwak","doi":"10.1038/s41409-026-03042-5","DOIUrl":"https://doi.org/10.1038/s41409-026-03042-5","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FLT3 inhibitor maintenance after allogeneic transplantation is associated with improved survival in FLT3-mutated AML: MRD-stratified evidence from an updated meta-analysis.","authors":"Abdulrahim Mohammed Basendwah, Akihiro Miyashita, Henri Fero, Mohammed Alasmari, Fahad Alabbas","doi":"10.1038/s41409-026-03049-y","DOIUrl":"https://doi.org/10.1038/s41409-026-03049-y","url":null,"abstract":"","PeriodicalId":9126,"journal":{"name":"Bone Marrow Transplantation","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}