{"title":"A Case of Unilateral Optic Neuritis in a 13 Year Old Boy","authors":"Anushree Gupta","doi":"10.24966/ocr-8887/100055","DOIUrl":"https://doi.org/10.24966/ocr-8887/100055","url":null,"abstract":"","PeriodicalId":91268,"journal":{"name":"HSOA journal of ophthalmology & clinical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44125704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seasonal Variation in Tear Secretion and Tear-Film Stability among Adults in Enugu, Nigeria: A Longitudinal Study","authors":"S. Onwubiko","doi":"10.24966/ocr-8887/100054","DOIUrl":"https://doi.org/10.24966/ocr-8887/100054","url":null,"abstract":"Aim: To investigate the variation in tear-film secretion and function between rainy and dry seasons among healthy adults in Enugu, Nigeria. Methods: This was a population-based, longitudinal study involving a cohort of 31 healthy adult Nigerians residing in Enugu in 2018. The objective tests for tear secretion (Schimer’s test) and function (tearfilm break-up time, TBUT) were conducted on the 62 eyes of the participants in January and July, the peaks of dry (D) and rainy (R) seasons, after obtaining their socio-demographic information. Their palpebral fissure height (PFH) and length, (PFL) were also obtained. Data was analysed using SPSS version 21. The level of significance was at p< 0.05. Results: The participants comprised of more females, 20 (64.5%) than males, with a mean age of 33.7 ± 9.6 SD years. They were mainly civil servants with tertiary education.The mean TBUT -R was 30.0 ±18.3 seconds and D, 15.6 ± 9.5. The mean Schirmer’s test-R was 25.2 ± 10.1 mm and D, 22.1 ± 11.2 mm. There was significant difference between these means in rainy and dry seasons. (p =0.000 TBUT, p = 0.04 Schirmer’s test). When TBUT and Schirmer’s test in both seasons were correlated with PFH and PFL, only TBUT -R and PFH showed a significantly positive correlation (r = 0.54, p= 0.002). Conclusion: A significant seasonal variation in tear-film secretion and function exists among adults in Enugu. The higher the PFH, the less the break-up of the tear-film during rainy season. These findings have great implications in the management of dry eyes. The use of therapeutic lubricant gels to prolong the TBUT time in dry seasons may therefore be preferred.","PeriodicalId":91268,"journal":{"name":"HSOA journal of ophthalmology & clinical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47620014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Outcomes of Treat and Extend Regimen of Anti-Vascular Endothelial\u0000Growth Factor in Neovascular Age-Related Macular Degeneration","authors":"M. Gill","doi":"10.24966/ocr-8887/100056","DOIUrl":"https://doi.org/10.24966/ocr-8887/100056","url":null,"abstract":"This retrospective cross-sectional cohort study describes the long-term visual and anatomic outcomes of anti-vascular\u0000endothelial growth factor (VEGF) treatment using a treat and extend (TAE) regimen. The cohort consisted of 224\u0000treatment-naïve eyes with age related macular degeneration (NV-AMD) from 202 patients that were treated with\u0000anti-VEGF agents bevacizumab, ranibizumab, and aflibercept using a TAE regimen by four physician investigators\u0000in a large urban referral center from 2008-2015. Subjects were evaluated for visual acuity, injection frequency and\u0000optical coherence tomography (OCT). Over a seven-year follow-up period (mean 3.4 years), an average 20.2 ± 14.7\u0000injections were administered per patient. Visual acuity was 0.70 logMAR (20/100 Snellen) at the first visit and 0.67\u0000logMAR (20/93 Snellen) at the final visit, with 74% of eyes maintaining or gaining more than 2 lines of vision. Longterm, 45.1% of eyes achieved 20/50 or better, while 27.1% were 20/200 or worse. 61.2% received monotherapy with\u0000no difference in visual acuity outcomes or injection frequency between the agent used. OCT analysis showed decreased\u0000fluid from initial to final follow-up visit: 70.1% to 15.6% with sub-retinal fluid (SRF) and 47.3% to 18.8% with intraretinal fluid (IRF) with no difference between the agent used. This study demonstrates that most patients (74%) improve\u0000or maintain visual acuity gains long-term using a TAE model with a significant portion (45.1%) achieving 20/50 or\u0000better with sustained treatment.","PeriodicalId":91268,"journal":{"name":"HSOA journal of ophthalmology & clinical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69144783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}