Borneo Journal of Pharmacy最新文献_第8页

Determination of the Active Chemical Compounds and the Antibacterial Activity of Various Fractions of Lawsonia inermis L. 刺槐不同部位活性成分及抑菌活性的测定。

Borneo Journal of Pharmacy Pub Date : 2022-08-31 DOI: 10.33084/bjop.v5i3.3221

S. Mulyaningsih, Febriyati Adji Rachmadani

{"title":"Determination of the Active Chemical Compounds and the Antibacterial Activity of Various Fractions of Lawsonia inermis L.","authors":"S. Mulyaningsih, Febriyati Adji Rachmadani","doi":"10.33084/bjop.v5i3.3221","DOIUrl":"https://doi.org/10.33084/bjop.v5i3.3221","url":null,"abstract":"Lawsonia inermis L., or henna leaves, are usually used to treat wounds on the skin. Lawsonia inermis contain naphthoquinones, flavonoids, tannins, and saponins. The antibacterial activity of L. inermis leaf extract in various solvents has been extensively studied. However, which component is responsible for the antibacterial activity is still unknown. This study was intended to investigate the antibacterial effect of L. inermis fractions against Staphylococcus aureus and to discover the antibacterial chemical class in the most active fraction. The methanol extract was fractionated with n-hexane and ethyl acetate subsequently. The antibacterial activity of various fractions was tested using the well diffusion method. TLC-bioautography was used to identify the class of active chemicals as antibacterial agents. Antibacterial activity against S. aureus was highest in the ethyl acetate fraction. TLC-bioautography of the ethyl acetate fraction showed inhibition areas at Rf values of 0.25 and 0.53, respectively, indicating the naphthoquinones and phenolic compounds groups. In conclusion, naphthoquinones and phenolic compounds are suggested to contribute to the antibacterial effect of the ethyl acetate fraction of L. inermis leaves.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76906079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Tyrosinase Inhibition Activity and Phytochemical Screening of Melaleuca leucadendron L. Leaves 白千层树叶片酪氨酸酶抑制活性及植物化学筛选

Borneo Journal of Pharmacy Pub Date : 2022-08-31 DOI: 10.33084/bjop.v5i3.3694

Munawarohthus Sholikha, Ainun Wulandari

{"title":"Tyrosinase Inhibition Activity and Phytochemical Screening of Melaleuca leucadendron L. Leaves","authors":"Munawarohthus Sholikha, Ainun Wulandari","doi":"10.33084/bjop.v5i3.3694","DOIUrl":"https://doi.org/10.33084/bjop.v5i3.3694","url":null,"abstract":"Melaleuca leucadendron L. is a plant whose almost all parts (bark, leaves, twigs, and fruit) can be used as medicine, such as antioxidants, antifungals, sedative effects, and anti-hyaluronidase. This research was conducted to determine tyrosinase inhibition activity and compound content of M. leucadendron leaves. Maceration of M. leucadendron leaves was done in methanol, then carried out liquid-liquid fractionation with n-butanol, chloroform, and water. Methanol extract, butanol fraction, chloroform fraction, and water fraction were tested for phytochemical screening and tyrosinase inhibition using L-DOPA substrate with an ELISA plate well reader. The results of the tyrosinase inhibition activity test at concentrations of 100, 1000 and 10000 μg/mL respectively showed that methanol extract 29.532%, 55.227%, 89.583%; butanol fraction 29.313%, 59.174%, 94.737%, chloroform fraction 21.820%, 24.671%; 53.765%; water fraction 24,086%, 47.661%, 91.118%. Inhibition of the tyrosinase enzyme is shown through the IC50 value from methanol extract, butanol fraction and water fraction, and kojic acid as a positive control, respectively 645.438 μg/mL, 517.935 μg/mL, 669.403 μg/mL, 50.064 μg/mL. Phytochemical screening showed that the extract and fraction contained tannins, flavonoids, saponins, terpenes, and steroids. These results indicate that the butanol fraction is more potent as an anti-tyrosinase agent than the others.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"170 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77989434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Antibiotics Susceptibility Profile of Gram-Positive Bacteria from Primary Health Centers in Jega, Kebbi State Kebbi州Jega初级卫生中心革兰氏阳性菌抗生素敏感性分析

Borneo Journal of Pharmacy Pub Date : 2022-08-31 DOI: 10.33084/bjop.v5i3.3293

B. Jega, Isa Musa Maishanu, B. Aliyu, M. Kasim

{"title":"Antibiotics Susceptibility Profile of Gram-Positive Bacteria from Primary Health Centers in Jega, Kebbi State","authors":"B. Jega, Isa Musa Maishanu, B. Aliyu, M. Kasim","doi":"10.33084/bjop.v5i3.3293","DOIUrl":"https://doi.org/10.33084/bjop.v5i3.3293","url":null,"abstract":"Nosocomial or healthcare-associated infection (HCAI) is an infection acquired during receiving health care that was not present during admission. The research aimed to determine the antibiotic susceptibility pattern of gram-positive bacteria isolated from Primary Health Centers in Jega Town. A total of fifty (50) swab samples were collected from 10 different health centers and analyzed using the streak plate technique. Pure bacterial isolates were maintained and characterized using biochemical tests; their percentage of occurrence show; Staphylococcus aureus 18 (43.9%), Enterococcus feacalis 8 (19.5%), Streptococcus spp 8 (19.5%), Bacillus cereus 4 (9.8%), and Staphylococcus epidermidis 3 (7.3%). McFarland standard solution was prepared and used to control inoculants, after which the antibiotic susceptibility pattern of the isolates was determined using the disc diffusion method. Staphylococcus epidermidis was resistant to Gentamycin, and other isolates were multi-drug resistant. In light of this research, there is a need for thorough disinfection and conscientious contact control procedures to minimize the spread of these pathogens in health centers where interaction between patients, HCWs, and caregivers is widespread and frequent.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77997837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Bibliometric Analysis of the Utilisation of FINDRISC in Patients with Diabetes: 2005-2021 糖尿病患者使用FINDRISC的文献计量学分析:2005-2021

Borneo Journal of Pharmacy Pub Date : 2022-08-31 DOI: 10.33084/bjop.v5i3.3267

M. Rokhman, Bustanul Arifin, Z. Zulkarnain, Saidah Rauf, D. Perwitasari

{"title":"Bibliometric Analysis of the Utilisation of FINDRISC in Patients with Diabetes: 2005-2021","authors":"M. Rokhman, Bustanul Arifin, Z. Zulkarnain, Saidah Rauf, D. Perwitasari","doi":"10.33084/bjop.v5i3.3267","DOIUrl":"https://doi.org/10.33084/bjop.v5i3.3267","url":null,"abstract":"Research on risk factors for diabetes (DM) is growing. Identification of these risk factors aims to prevent DM as early as possible. This study intends to identify the utilization of the Finnish diabetes risk score (FINDRISC) and its development using bibliometric analysis. The keywords “FINDRISC AND Diabetes” were used to search for articles published in 2005-2021 in PubMed. A total of 249 articles were analyzed based on the number of publications per year, journals that publish the papers, number of publications by author and year of publication, number of publications by affiliation and year of publication, number of publications by country of origin of authors and year of publication, number of keywords, number of citations, types of articles, specific topics, and theme mapping. The data visualization was obtained from the Scopus database and the VOSviewer and Biblioshiny applications. Despite the increase in publications, the number of publications on FINDRISC in DM patients is still very few per year, with 92.8% being the primary study. Based on clusters of the country of origin, publications are still dominated by researchers from countries in the European region, and the researchers intensely relate to each other through citations. Research themes related to FINDRISC are not limited to DM risk factors. This study is the first study of a bibliometric analysis of the utilization of FINRISC in DM patients. The analysis results can be used to evaluate existing research gaps and identify future research opportunities.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80032106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Fraksinasi dan identifikasi senyawa tanin dari ekstrak pandan hutan (Freycinetia sessiliflora Rizki)

Borneo Journal of Pharmacy Pub Date : 2022-08-18 DOI: 10.57174/jborn.v2i2.48

Ade Ferdinan, Fitri Sri Rizki, Erwan Kurnianto, Kurniawan Kurniawan

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Analısıs karakterıstık organoleptıs dan kimia tepung ıkan sepat rawa (Trıchopodus trıchopterus) 肛门性格ısısı圣ık organoleptısı面粉和化学吧口感清爽沼泽(Trıchopodus Trıchopterus)

Borneo Journal of Pharmacy Pub Date : 2022-08-18 DOI: 10.57174/jborn.v2i2.47

Bella Rosalina Endah, Fitri Yanti, Karunita Ika Astuti, Vebruati Vebruati

{"title":"Analısıs karakterıstık organoleptıs dan kimia tepung ıkan sepat rawa (Trıchopodus trıchopterus)","authors":"Bella Rosalina Endah, Fitri Yanti, Karunita Ika Astuti, Vebruati Vebruati","doi":"10.57174/jborn.v2i2.47","DOIUrl":"https://doi.org/10.57174/jborn.v2i2.47","url":null,"abstract":"Ikan sepat rawa (Trıchopodus trıchopterus) merupakan hewan yang banyak ditemukan di Kalimantan Selatan. Ikan sepat rawa muncul musiman namun belum dimanfaatkan secara maksimal. Penelitian ini bertujuan untuk mengatahui karakteristik oraganoleptis dan kimia berupa kadar air, kadar abu, kadar serat, kadar lemak dan kadar protein tepung ikan sepat rawa. Pembuatan tepung ikan sepat rawa dengan menggunakan metode pengukusan pada suhu 90˚C selama 20 menit dan pemanasan oven dengan suhu 70˚C selama 80 menit. Hasil penelitian ikan sepat rawa menunjukkan karakteristik organoleptis berupa warna cokelat muda, aroma harum/khas, rasa hambar kemanisan, dan tekstur kering sedangkan hasil analisis kimia didapatkan kadar protein sebesar 44,84%, kadar serat 1,88%, kadar lemak 4,12%, kadar abu 14,63%, dan kadar air 5,98%. Berdasarkan Standar Nasional Indonesi (SNI), dari kelima pengujian karakteristik kimia didapatkan hasil uji kadar protein termasuk dalam standar mutu III, serat termasuk dalam standar mutu II, kadar lemak termasuk dalam standar mutu I, kadar abu termasuk standar mutu I, kadar air temasuk standar mutu I.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82052636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Pola peresepan obat pada pasıen gastrıtıs dı apotek “X” kota Tarakan tahun 2021 药物peresepan图案适合ıen gastrıt dısı药店“X”城市塔拉坎2021年

Borneo Journal of Pharmacy Pub Date : 2022-07-31 DOI: 10.57174/jborn.v2i2.46

Didin Sampurno Aji, Benazir Evita Rukaya, Syuhada

引用次数: 0

Uji aktivitas fraksi n-hexan dan etil asetat ekstrak etanol daun pepaya (Carica papaya L.) terhadap Propionibacterium acnes 测试木瓜叶乙醇(Carica papaya L)的n-hexan和乙醇乙酸提取物对丙烯活性的活性

Borneo Journal of Pharmacy Pub Date : 2022-07-31 DOI: 10.57174/jborn.v2i2.36

Syarifah Fauziah, Benazir Evita Rukaya, Syuhada

{"title":"Uji aktivitas fraksi n-hexan dan etil asetat ekstrak etanol daun pepaya (Carica papaya L.) terhadap Propionibacterium acnes","authors":"Syarifah Fauziah, Benazir Evita Rukaya, Syuhada","doi":"10.57174/jborn.v2i2.36","DOIUrl":"https://doi.org/10.57174/jborn.v2i2.36","url":null,"abstract":"Pepaya (Carica papaya L.) merupakan salah satu buah dengan banyak manfaat, termasuk dalam pemanfaatannya sebagai obat tradisional. Secara tradisional daun pepaya digunakan dalam pengobatan jerawat. Penelitian ini bertujuan untuk mengetahui aktivitas fraksi n-hexan dan etil asetat ekstrak etanol daun pepaya terhadap pertumbuhan Propionibacterium acnes. Fraksi n-hexan dan etil asetat diperoleh dengan melakukan ekstraksi bertingkat menggunakan metode maserasi. Fraksi yang diperoleh kemudian diuji menggunakan metode difusi agar (sumuran) untuk melihat efektivitasnya dalam menghambat pertumbuhan bakteri Propionibacterium acnes. Hasil uji yang diperoleh dari fraksi n-hexan dan etil asetat konsentrasi 10%, 15% dan 20% dengan kontrol positif erythromicin 0,375%, dan kontrol negatif pelarut (n-hexan dan etil asetat) berupa diameter zona hambat. Fraksi etil asetat dengan konsentrasi 10%, 15% dan 20% merupakan fraksi yang paling efektif dengan diameter rata-rata sebesar 14,7±6,33; 16,4±1,55; dan 18,7±4,14. Kesimpulan yang diperoleh dari penelitian ini adalah fraksi etil asetat daun pepaya konsentrasi 15% adalah fraksi yang paling optimal dalam menghambat pertumbuhan bakteri Propionibacterium acnes.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83095835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Uji stabilitas fisik serum anti-aging ekstrak etil asetat daun cempedak (Arthocarpus champeden Spreng.) 测试抗aging葡萄提取物(Arthocarpus champeden Spreng)的生理稳定性。

Borneo Journal of Pharmacy Pub Date : 2022-07-31 DOI: 10.57174/jborn.v2i2.37

Salsabyla Asky, Benazir evita rukaya, Faizal Mustamin

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Ujı aktıvıtas sedıaan granul darı ekstrak etanol daun komba-komba (Chromolaena odorata L.) sebagaı larvasıda

Borneo Journal of Pharmacy Pub Date : 2022-07-31 DOI: 10.57174/jborn.v2i2.45

Fery Indradewi Armadany, Dian Munasari Solo, Ari Putra Utama, Andi Nafisah Tendri Adjeng

{"title":"Ujı aktıvıtas sedıaan granul darı ekstrak etanol daun komba-komba (Chromolaena odorata L.) sebagaı larvasıda","authors":"Fery Indradewi Armadany, Dian Munasari Solo, Ari Putra Utama, Andi Nafisah Tendri Adjeng","doi":"10.57174/jborn.v2i2.45","DOIUrl":"https://doi.org/10.57174/jborn.v2i2.45","url":null,"abstract":"Komba-komba (Chromolaena odorata L.) merupakan salah satu tumbuhan yang dapat digunakan sebagai larvasida alami. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun komba-komba berbunga kuning dan bentuk sediaan granulnya sebagai larvasida. Daun komba-komba diekstraksi secara maserasi menggunakan etanol 96% kemudian didelipidasi menggunakan n-heksan. Ekstrak diidentifikasi metabolit sekundernya melalui skrining fitokimia secara kualitatif mengikuti metode Harborne. Pengujian aktivitas larvasida dilakukan pada ekstrak etanol dan ekstrak etanol terdelipidasi pada konsentrasi 250 ppm, 500 ppm, 1000 ppm dan 2000 ppm untuk mengetahui nilai Lethal Concentration/LC50. Ekstrak diformulasi menjadi sediaan granul menggunakan metode granulasi basah. Hasil skrining fitokimia menunjukkan metabolit sekunder ekstrak etanol daun komba-komba yaitu alkaloid, flavonoid, saponin dan tannin. Uji aktivitas larvasida menunjukkan bahwa ekstrak etanol terdelipidasi memiliki aktivitas lebih baik dibandingkan ekstrak etanol dengan nilai LC50 ekstrak etanol terdelipidasi sebesar 261,6 ppm dan ekstrak etanol sebesar 317,1 ppm. Ekstrak tanol terdelipidasi dengan konsentrasi 1000 ppm ke atas berpotensi untuk dikembangkan dalam bentuk sediaan granul karena memiliki aktivitas larvasida setara dengan kontrol positif (temefos 1000 ppm). Ekstrak etanol terdelipidasi daun komba-komba diformulasikan dalam bentuk sediaan granul menggunakan kombinasi eksipien amilum, PVP dan laktosa. Uji aktivitas larvasida pada granul menunjukkan nilai LC50 sebesar 225,8 ppm.","PeriodicalId":9118,"journal":{"name":"Borneo Journal of Pharmacy","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91311116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0