Neuroscience journal最新文献_第4页

Fingolimod Real World Experience: Efficacy and Safety in Clinical Practice 芬戈莫德真实世界经验:临床实践的有效性和安全性

Neuroscience journal Pub Date : 2015-11-26 DOI: 10.1155/2015/389360

J. Fonseca

{"title":"Fingolimod Real World Experience: Efficacy and Safety in Clinical Practice","authors":"J. Fonseca","doi":"10.1155/2015/389360","DOIUrl":"https://doi.org/10.1155/2015/389360","url":null,"abstract":"Fingolimod is a multiple sclerosis treatment licensed in Europe since 2011. Its efficacy has been demonstrated in three large phase III trials, used in the regulatory submissions throughout the world. As usual, in these trials the inclusion and exclusion criteria were designed to obtain a homogeneous population, with interchangeable characteristics in the different treatment arms. Although this is the best strategy to achieve a robust answer to the investigation question, it does not guaranty the treatment efficacy in the clinical practice, since in the real world there are concomitant treatments, comorbidities, adherence, and persistence challenges. But, to make informed treatment decision for a real life patient, we need to have evidence of the treatment efficacy, what has been called treatment effectiveness. This work aims to review fingolimod effectiveness, using, as source of information, abstracts, posters, and manuscripts. This unorthodox strategy was developed because more than half of the published experience with fingolimod is still on abstracts and posters. Only a small part of the studies reviewed are already published in peer reviewed journals. Fingolimod seems to be, at least, as effective and safe as it was on clinical trials, and with its long-term experience no new safety signals were observed.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/389360","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64938961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Do Three Different Passive Assessments of Quadriceps Spasticity Relate to the Functional Activity of Walking for Children Diagnosed with Cerebral Palsy? 脑性麻痹儿童四头肌痉挛的三种不同被动评估与行走功能活动有关吗?

Neuroscience journal Pub Date : 2015-10-20 DOI: 10.1155/2015/872015

H. White, T. Uhl, S. Augsburger

{"title":"Do Three Different Passive Assessments of Quadriceps Spasticity Relate to the Functional Activity of Walking for Children Diagnosed with Cerebral Palsy?","authors":"H. White, T. Uhl, S. Augsburger","doi":"10.1155/2015/872015","DOIUrl":"https://doi.org/10.1155/2015/872015","url":null,"abstract":"A stiff-knee gait pattern is frequently associated with several impairments including quadriceps spasticity in children diagnosed with cerebral palsy (CP). The relationship of clinical measures of quadriceps spasticity and the stiff-knee gait pattern in children diagnosed with CP has not been well established. Therefore, the purpose of this study was to determine the ability of clinical measures of quadriceps spasticity (modified Ashworth scale [MAS], Ely tests, and pendulum test) to categorize a stiff-knee gait pattern in children with CP. Children were categorized as having a stiff-knee gait pattern based on kinematic and EMG gait data. Results of a logistic regression model revealed that the only significant measure was A1 of the pendulum test. Discriminant analysis functions were used to predict group membership (stiff-knee, not stiff-knee gait pattern) for each measure. The A1 of the pendulum test demonstrated the highest classification accuracy and the highest sensitivity compared to the other measures. Therefore, a negative pendulum test (indicated by an A1 value of 45 degrees or more) is more useful for ruling out a stiff-knee gait pattern compared to the other clinical measures.","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/872015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65195849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Sex Differences and the Impact of Chronic Stress and Recovery on Instrumental Learning. 性别差异及慢性压力与恢复对器乐学习的影响。

Neuroscience journal Pub Date : 2015-01-01 Epub Date: 2015-04-16 DOI: 10.1155/2015/697659

Angela L McDowell, Kathryn M H Fransen, Kevin S Elliott, Alhasan Elghouche, Polina V Kostylev, Pamela K O'Dea, Preston E Garraghty

{"title":"Sex Differences and the Impact of Chronic Stress and Recovery on Instrumental Learning.","authors":"Angela L McDowell, Kathryn M H Fransen, Kevin S Elliott, Alhasan Elghouche, Polina V Kostylev, Pamela K O'Dea, Preston E Garraghty","doi":"10.1155/2015/697659","DOIUrl":"https://doi.org/10.1155/2015/697659","url":null,"abstract":"We have previously shown that 21-day chronic restraint stress impacts instrumental learning, but overall few studies have examined sex differences on the impact of stress on learning. We further examined sex differences in response to extended 42-day chronic stress on instrumental learning, as well as recovery from chronic stress. Rats were tested in aversive training tasks with or without prior appetitive experience, and daily body weight data was collected as an index of stress. Relative to control animals, reduced body weight was maintained from day 22 through day 42 across the stress period for males, but not for females. Stressed males had increased response speed and lower learning efficiency during appetitive acquisition and aversive learning. Males overall showed slower escape shaping times and more shock exposure. In contrast, stressed females showed slower appetitive response speeds and higher appetitive and aversive efficiency but overall reduced avoidance rates during acquisition and maintenance for transfer animals and during maintenance for aversive-only animals. These tasks reveal important nuances on the effect of stress on goal-directed behavior and further highlight sexually divergent effects on appetitive versus aversive motivation. Furthermore, these data underscore that systems are temporally impacted by chronic stress in a sexually divergent pattern. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2015 ","pages":"697659"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/697659","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34026371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Evaluation of Motor Neuron Excitability by CMAP Scanning with Electric Modulated Current. 调制电流CMAP扫描对运动神经元兴奋性的评价。

Neuroscience journal Pub Date : 2015-01-01 Epub Date: 2015-08-26 DOI: 10.1155/2015/360648

Tiago Araújo, Rui Candeias, Neuza Nunes, Hugo Gamboa

{"title":"Evaluation of Motor Neuron Excitability by CMAP Scanning with Electric Modulated Current.","authors":"Tiago Araújo, Rui Candeias, Neuza Nunes, Hugo Gamboa","doi":"10.1155/2015/360648","DOIUrl":"https://doi.org/10.1155/2015/360648","url":null,"abstract":"Introduction. Compound Muscle Action Potential (CMAP) scan is a noninvasive promissory technique for neurodegenerative pathologies diagnosis. In this work new CMAP scan protocols were implemented to study the influence of electrical pulse waveform on peripheral nerve excitability. Methods. A total of 13 healthy subjects were tested. Stimulation was performed with an increasing intensities range from 4 to 30 mA. The procedure was repeated 4 times per subject, using a different single pulse stimulation waveform: monophasic square and triangular and quadratic and biphasic square. Results. Different waveforms elicit different intensity-response amplitude curves. The square pulse needs less current to generate the same response amplitude regarding the other waves and this effect is gradually decreasing for the triangular, quadratic, and biphasic pulse, respectively. Conclusion. The stimulation waveform has a direct influence on the stimulus-response slope and consequently on the motoneurons excitability. This can be a new prognostic parameter for neurodegenerative disorders. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2015 ","pages":"360648"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/360648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34042800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Change in Motor and Nonmotor Symptoms Severity in a "Real-Life" Cohort of Subjects with Parkinson's Disease. 帕金森病患者“现实生活”队列中运动和非运动症状严重程度的变化

Neuroscience journal Pub Date : 2015-01-01 Epub Date: 2015-08-20 DOI: 10.1155/2015/368989

Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Rodrigo Llorens-Arenas, Humberto Calderón-Fajardo, Mayela Rodríguez-Violante

{"title":"Change in Motor and Nonmotor Symptoms Severity in a \"Real-Life\" Cohort of Subjects with Parkinson's Disease.","authors":"Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Rodrigo Llorens-Arenas, Humberto Calderón-Fajardo, Mayela Rodríguez-Violante","doi":"10.1155/2015/368989","DOIUrl":"https://doi.org/10.1155/2015/368989","url":null,"abstract":"Background. Parkinson's disease (PD) is a chronic and progressive disorder. Rates of change in motor symptoms have been more studied compared to nonmotor symptoms. The objective was to describe these changes in a real-life cohort of subjects with PD. Methods. A cohort study was carried out from 2011 to 2013. Consecutive patients with PD were recruited from a movement disorders clinic. MDS-UPDRS, PDQ-8, and NMSS were applied to all subjects at an initial evaluation and a subsequent visit (21 ± 3 months). Disease severity was categorized using a recent classification of MDS-UPDRS severity. Results. The MDS-UPDRS Part III showed a significant decrease of 7.2 ± 2.31 points (p = 0.001) between evaluations. A mean increase of 0.9 ± 0.6 points (p = 0.015) in the MDS-UPDRS Part IV was observed. An increase of 14.3 ± 11.4 points (p = 0.043) in the NMSS total score was found; when assessed individually, the difference was statistically significant only for the perceptual problems/hallucinations item. Quality of life remained unchanged. Conclusion. Motor improvement was observed accompanied by an increase in motor complications possibly as a result of treatment optimization. Nonmotor symptoms worsened as a whole. The overall effect in the quality of life was negligible. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2015 ","pages":"368989"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/368989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34170488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Neuroscience journal Pub Date : 2015-01-01 Epub Date: 2015-03-23 DOI: 10.1155/2015/696787

Mathias Ogbonna Nnanna Nnadi, Olufemi Babatola Bankole, Beleudanyo Gbalipre Fente

{"title":"Motorcycle-Related Traumatic Brain Injuries: Helmet Use and Treatment Outcome.","authors":"Mathias Ogbonna Nnanna Nnadi, Olufemi Babatola Bankole, Beleudanyo Gbalipre Fente","doi":"10.1155/2015/696787","DOIUrl":"https://doi.org/10.1155/2015/696787","url":null,"abstract":"Summary. With increasing use of motorcycle as means of transport in developing countries, traumatic brain injuries from motorcycle crashes have been increasing. The only single gadget that protects riders from traumatic brain injury is crash helmet. Objective. The objectives were to determine the treatment outcome among traumatic brain injury patients from motorcycle crashes and the rate of helmet use among them. Methods. It was a prospective, cross-sectional study of motorcycle-related traumatic brain injury patients managed in our center from 2010 to 2014. Patients were managed using our unit protocol for traumatic brain injuries. Data for the study were collected in accident and emergency, intensive care unit, wards, and outpatient clinic. The data were analyzed using Environmental Performance Index (EPI) info 7 software. Results. Ninety-six patients were studied. There were 87 males. Drivers were 65. Only one patient wore helmet. Majority of them were between 20 and 40 years. Fifty-three patients had mild head injuries. Favorable outcome among them was 84.35% while mortality was 12.5%. Severity of the injury affected the outcome significantly. Conclusion. Our study showed that the helmet use by motorcycle riders was close to zero despite the existing laws making its use compulsory in Nigeria. The outcome was related to severity of injuries. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2015 ","pages":"696787"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/696787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Age- and Sex-Dependent Changes in Androgen Receptor Expression in the Developing Mouse Cortex and Hippocampus. 发育中的小鼠皮质和海马中雄激素受体表达的年龄和性别依赖性变化。

Neuroscience journal Pub Date : 2015-01-01 Epub Date: 2015-02-03 DOI: 10.1155/2015/525369

Houng-Wei Tsai, Saori Taniguchi, Jason Samoza, Aaron Ridder

{"title":"Age- and Sex-Dependent Changes in Androgen Receptor Expression in the Developing Mouse Cortex and Hippocampus.","authors":"Houng-Wei Tsai, Saori Taniguchi, Jason Samoza, Aaron Ridder","doi":"10.1155/2015/525369","DOIUrl":"https://doi.org/10.1155/2015/525369","url":null,"abstract":"During the perinatal period, male mice are exposed to higher levels of testosterone (T) than females, which promotes sexual dimorphism in their brain structures and behaviors. In addition to acting via estrogen receptors after being locally converted into estradiol by aromatase, T also acts directly through androgen receptor (AR) in the brain. Therefore, we hypothesized that AR expression in the developing mouse cortex and hippocampus was sexually dimorphic. To test our hypothesis, we measured and determined AR mRNA and protein levels in mouse cortex/hippocampus collected on the day of birth (PN0) and 7 (PN7), 14 (PN14), and 21 (PN21) days after birth. We demonstrated that, as age advanced, AR mRNA levels increased in the cortex/hippocampus of both sexes but showed no sex difference. Two AR proteins, the full-length (110 kDa) and a smaller isoform (70 kDa), were detected in the developing mouse cortex/hippocampus with an age-dependent increase in protein levels of both AR isoforms at PN21 and a transient masculine increase in expression of the full-length AR protein on PN7. Thus, we conclude that the postnatal age and sex differences in AR protein expression in combination with the sex differences in circulating T may cause sexual differentiation of the mouse cortex/hippocampus. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2015 ","pages":"525369"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/525369","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Impact of Age and Duration of Symptoms on Surgical Outcome of Single-Level Microscopic Anterior Cervical Discectomy and Fusion in the Patients with Cervical Spondylotic Radiculopathy. 年龄和症状持续时间对神经根型颈椎病患者单节段显微前路椎间盘切除术融合手术疗效的影响

Neuroscience journal Pub Date : 2014-01-01 Epub Date: 2014-09-30 DOI: 10.1155/2014/808596

Farzad Omidi-Kashani, Ebrahim Ghayem Hasankhani, Reza Ghandehari

{"title":"Impact of Age and Duration of Symptoms on Surgical Outcome of Single-Level Microscopic Anterior Cervical Discectomy and Fusion in the Patients with Cervical Spondylotic Radiculopathy.","authors":"Farzad Omidi-Kashani, Ebrahim Ghayem Hasankhani, Reza Ghandehari","doi":"10.1155/2014/808596","DOIUrl":"https://doi.org/10.1155/2014/808596","url":null,"abstract":"We aim to evaluate the impact of age and duration of symptoms on surgical outcome of the patients with cervical spondylotic radiculopathy (CSR) who had been treated by single-level microscopic anterior cervical discectomy and fusion (ACDF). We retrospectively evaluated 68 patients (48 female and 20 male) with a mean age of 41.2 ± 4.3 (ranged from 24 to 72 years old) in our Orthopedic Department, Imam Reza Hospital. They were followed up for 31.25 ± 4.1 months (ranged from 25 to 65 months). Pain and disability were assessed by Visual Analogue Scale (VAS) and Neck Disability Index (NDI) questionnaires in preoperative and last follow-up visits. Functional outcome was eventually evaluated by Odom's criteria. Surgery could significantly improve pain and disability from preoperative 6.2 ± 1.4 and 22.2 ± 6.2 to 3.5 ± 2.0 and 8.7 ± 5.2 (1-21) at the last follow-up visit, respectively. Satisfactory outcomes were observed in 89.7%. Symptom duration of more and less than six months had no effect on surgical outcome, but the results showed a statistically significant difference in NDI improvement in favor of the patients aged more than 45 years (P = 0.032), although pain improvement was similar in the two groups. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2014 ","pages":"808596"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/808596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Language Development across the Life Span: A Neuropsychological/Neuroimaging Perspective. 终身语言发展:神经心理学/神经影像学的视角。

Neuroscience journal Pub Date : 2014-01-01 Epub Date: 2014-12-18 DOI: 10.1155/2014/585237

Mónica Rosselli, Alfredo Ardila, Esmeralda Matute, Idaly Vélez-Uribe

{"title":"Language Development across the Life Span: A Neuropsychological/Neuroimaging Perspective.","authors":"Mónica Rosselli, Alfredo Ardila, Esmeralda Matute, Idaly Vélez-Uribe","doi":"10.1155/2014/585237","DOIUrl":"https://doi.org/10.1155/2014/585237","url":null,"abstract":"Language development has been correlated with specific changes in brain development. The aim of this paper is to analyze the linguistic-brain associations that occur from birth through senescence. Findings from the neuropsychological and neuroimaging literature are reviewed, and the relationship of language changes observable in human development and the corresponding brain maturation processes across age groups are examined. Two major dimensions of language development are highlighted: naming (considered a major measure of lexical knowledge) and verbal fluency (regarded as a major measure of language production ability). Developmental changes in the brain lateralization of language are discussed, emphasizing that in early life there is an increase in functional brain asymmetry for language, but that this asymmetry changes over time, and that changes in the volume of gray and white matter are age-sensitive. The effects of certain specific variables, such as gender, level of education, and bilingualism are also analyzed. General conclusions are presented and directions for future research are suggested. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2014 ","pages":"585237"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/585237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats. 大鼠失神发作的年龄依赖性增加和睡眠纺锤波的固有频率动态。

Neuroscience journal Pub Date : 2014-01-01 Epub Date: 2014-06-23 DOI: 10.1155/2014/370764

Evgenia Sitnikova, Alexander E Hramov, Vadim Grubov, Alexey A Koronovsky

{"title":"Age-Dependent Increase of Absence Seizures and Intrinsic Frequency Dynamics of Sleep Spindles in Rats.","authors":"Evgenia Sitnikova, Alexander E Hramov, Vadim Grubov, Alexey A Koronovsky","doi":"10.1155/2014/370764","DOIUrl":"https://doi.org/10.1155/2014/370764","url":null,"abstract":"The risk of neurological diseases increases with age. In WAG/Rij rat model of absence epilepsy, the incidence of epileptic spike-wave discharges is known to be elevated with age. Considering close relationship between epileptic spike-wave discharges and physiologic sleep spindles, it was assumed that age-dependent increase of epileptic activity may affect time-frequency characteristics of sleep spindles. In order to examine this hypothesis, electroencephalograms (EEG) were recorded in WAG/Rij rats successively at the ages 5, 7, and 9 months. Spike-wave discharges and sleep spindles were detected in frontal EEG channel. Sleep spindles were identified automatically using wavelet-based algorithm. Instantaneous (localized in time) frequency of sleep spindles was determined using continuous wavelet transform of EEG signal, and intraspindle frequency dynamics were further examined. It was found that in 5-months-old rats epileptic activity has not fully developed (preclinical stage) and sleep spindles demonstrated an increase of instantaneous frequency from beginning to the end. At the age of 7 and 9 months, when animals developed matured and longer epileptic discharges (symptomatic stage), their sleep spindles did not display changes of intrinsic frequency. The present data suggest that age-dependent increase of epileptic activity in WAG/Rij rats affects intrinsic dynamics of sleep spindle frequency. ","PeriodicalId":91144,"journal":{"name":"Neuroscience journal","volume":"2014 ","pages":"370764"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/370764","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22