Lung cancer international最新文献_第2页

Alveolar Macrophage Polarisation in Lung Cancer. 肺泡巨噬细胞极化在肺癌中的作用。

Lung cancer international Pub Date : 2014-01-01 Epub Date: 2014-05-08 DOI: 10.1155/2014/721087

Saleh A Almatroodi, Christine F McDonald, Dodie S Pouniotis

引用次数: 28

Simple and Objective Prediction of Survival in Patients with Lung Cancer: Staging the Host Systemic Inflammatory Response. 简单客观的肺癌患者生存预测:宿主全身炎症反应分期。

Lung cancer international Pub Date : 2014-01-01 Epub Date: 2014-03-05 DOI: 10.1155/2014/731925

Derek Grose, Graham Devereux, Louise Brown, Richard Jones, Dave Sharma, Colin Selby, David S Morrison, Kirsty Docherty, David McIntosh, Penny McElhinney, Marianne Nicolson, Donald C McMillan, Robert Milroy

{"title":"Simple and Objective Prediction of Survival in Patients with Lung Cancer: Staging the Host Systemic Inflammatory Response.","authors":"Derek Grose, Graham Devereux, Louise Brown, Richard Jones, Dave Sharma, Colin Selby, David S Morrison, Kirsty Docherty, David McIntosh, Penny McElhinney, Marianne Nicolson, Donald C McMillan, Robert Milroy","doi":"10.1155/2014/731925","DOIUrl":"https://doi.org/10.1155/2014/731925","url":null,"abstract":"Background. Prediction of survival in patients diagnosed with lung cancer remains problematical. The aim of the present study was to examine the clinical utility of an established objective marker of the systemic inflammatory response, the Glasgow Prognostic Score, as the basis of risk stratification in patients with lung cancer. Methods. Between 2005 and 2008 all newly diagnosed lung cancer patients coming through the multidisciplinary meetings (MDTs) of four Scottish centres were included in the study. The details of 882 patients with a confirmed new diagnosis of any subtype or stage of lung cancer were collected prospectively. Results. The median survival was 5.6 months (IQR 4.8-6.5). Survival analysis was undertaken in three separate groups based on mGPS score. In the mGPS 0 group the most highly predictive factors were performance status, weight loss, stage of NSCLC, and palliative treatment offered. In the mGPS 1 group performance status, stage of NSCLC, and radical treatment offered were significant. In the mGPS 2 group only performance status and weight loss were statistically significant. Discussion. This present study confirms previous work supporting the use of mGPS in predicting cancer survival; however, it goes further by showing how it might be used to provide more objective risk stratification in patients diagnosed with lung cancer. ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2014 ","pages":"731925"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/731925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer. 非小细胞肺癌核仁组织区嗜银蛋白、临床形态学参数与生存之间的关系。

Lung cancer international Pub Date : 2014-01-01 Epub Date: 2014-01-02 DOI: 10.1155/2014/891917

Dmitriy Kobyakov, Vladimir Klimachev, Ashot Avdalyan, Igor Bobrov, Elena Bychkova, Natalia Kruglova, Aleksandr Lazarev, Elena Lushnikova, Lev Nepomnyashchikh

{"title":"Association between Argyrophilic Proteins of Nucleolar Organizer Regions, Clinicomorphological Parameters, and Survival in Non-Small-Cell Lung Cancer.","authors":"Dmitriy Kobyakov, Vladimir Klimachev, Ashot Avdalyan, Igor Bobrov, Elena Bychkova, Natalia Kruglova, Aleksandr Lazarev, Elena Lushnikova, Lev Nepomnyashchikh","doi":"10.1155/2014/891917","DOIUrl":"https://doi.org/10.1155/2014/891917","url":null,"abstract":"We studied argyrophilic proteins associated with nucleolar organizer regions (AgNOR) in non-small-cell cancer. We determined the area index (AI) and coefficient of variation (CV) of AgNOR. AI is associated with the key clinicomorphological parameters within the TNM system: T and N values, greatest tumor dimension up to 3 cm and more, disease stage, histogenesis, and tumor differentiation. CV is associated with T value, greatest tumor dimension up to 3 cm and more, histogenesis, and tumor differentiation. Survival of patients is longer in low AI or CV values versus high AI or CV values, longer in low AI and CV values (-AI/-CV type), shorter in high AI and CV values (+AI/+CV type), and intermediate in opposite AI and CV values (-AI/+CV and +AI/-CV types). Independent predictors in non-small-cell lung cancer include N value, greatest tumor dimension, histogenesis, and CV. Assessment of quantitative values and heterogeneity of AgNOR is important for differential diagnosis and prognosis of non-small-cell lung cancer. ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2014 ","pages":"891917"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/891917","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Analysis of Expression of Vascular Endothelial Growth Factor A and Hypoxia Inducible Factor-1alpha in Patients Operated on Stage I Non-Small-Cell Lung Cancer. 血管内皮生长因子A和缺氧诱导因子-1 α在I期非小细胞肺癌手术患者中的表达分析。

Lung cancer international Pub Date : 2014-01-01 Epub Date: 2014-02-10 DOI: 10.1155/2014/810786

Antonio Francisco Honguero Martínez, Antonio Arnau Obrer, Santiago Figueroa Almánzar, Pablo León Atance, Ricardo Guijarro Jorge

{"title":"Analysis of Expression of Vascular Endothelial Growth Factor A and Hypoxia Inducible Factor-1alpha in Patients Operated on Stage I Non-Small-Cell Lung Cancer.","authors":"Antonio Francisco Honguero Martínez, Antonio Arnau Obrer, Santiago Figueroa Almánzar, Pablo León Atance, Ricardo Guijarro Jorge","doi":"10.1155/2014/810786","DOIUrl":"https://doi.org/10.1155/2014/810786","url":null,"abstract":"Objectives. Recent studies show that expression of hypoxia inducible factor-1alpha (HIF-1α) favours expression of vascular endothelial growth factor A (VEGF-A), and these biomarkers are linked to cellular proliferation, angiogenesis, and metastasis in different cancers. We analyze expression of HIF-1α and VEGF-A to clinicopathologic features and survival of patients operated on stage I non-small-cell lung cancer. Methodology. Prospective study of 52 patients operated on with stage I. Expression of VEGF-A and HIF-1α was performed through real-time quantitative polymerase chain reaction (qRT-PCR). Results. Mean age was 64.7 and 86.5% of patients were male. Stage IA represented 23.1% and stage IB 76.9%. Histology classification was 42.3% adenocarcinoma, 34.6% squamous cell carcinoma, and 23.1% others. Median survival was 81.0 months and 5-year survival 67.2%. There was correlation between HIF-1α and VEGF-A (P = 0.016). Patients with overexpression of HIF-1α had a tendency to better survival with marginal statistical significance (P = 0.062). Patients with overexpression of VEGF-A had worse survival, but not statistically significant (P = 0.133). Conclusion. The present study revealed that VEGF-A showed correlation with HIF-1α. HIF-1α had a tendency to protective effect with a P value close to statistical significance. VEGF-A showed a contrary effect but without statistical significance. ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2014 ","pages":"810786"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/810786","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Potential Pitfall in the Assessment of Lung Cancer with FDG-PET/CT: Talc Pleurodesis Causes Intrathoracic Nodal FDG Avidity. FDG- pet /CT评估肺癌的潜在缺陷:滑石粉胸膜切除术导致胸内淋巴结FDG贪婪。

Lung cancer international Pub Date : 2013-01-01 Epub Date: 2013-05-25 DOI: 10.1155/2013/683582

Yingbing Wang, Brett W Carter, Victorine Muse, Subba Digumarthy, Jo-Anne Shepard, Amita Sharma

{"title":"Potential Pitfall in the Assessment of Lung Cancer with FDG-PET/CT: Talc Pleurodesis Causes Intrathoracic Nodal FDG Avidity.","authors":"Yingbing Wang, Brett W Carter, Victorine Muse, Subba Digumarthy, Jo-Anne Shepard, Amita Sharma","doi":"10.1155/2013/683582","DOIUrl":"https://doi.org/10.1155/2013/683582","url":null,"abstract":"Objective. Talc pleurodesis is a common procedure performed to treat complications related to lung cancer. The purpose of our study was to characterize any thoracic nodal findings on FDG PET/CT associated with prior talc pleurodesis. Materials and Methods. The electronic medical record identified 44 patients who underwent PET/CT between January 2006 and December 2010 and had a history of talc pleurodesis. For each exam, we evaluated the distribution pattern, size, and attenuation of intrathoracic lymph nodes and the associated standardized uptake value. Results. High-attenuation intrathoracic lymph nodes were noted in 11 patients (25%), and all had corresponding increased FDG uptake (range 2-9 mm). Involved nodal groups were anterior peridiaphragmatic (100%), paracardiac (45%), internal mammary (25%), and peri-IVC (18%) nodal stations. Seven of the 11 patients (63%) had involvement of multiple lymph nodal groups. Mean longitudinal PET/CT and standalone CT followups of 15 ± 11 months showed persistence of both high-attenuation and increased uptake at these sites, without increase in nodal size suggesting metastatic disease involvement. Conclusions. FDG avid, high-attenuation lymph nodes along the lymphatic drainage pathway for parietal pleura are a relatively common finding following talc pleurodesis and should not be mistaken for nodal metastases during the evaluation of patients with history of lung cancer. ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2013 ","pages":"683582"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/683582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34129114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Helicobacter pylori Infection and Risk of Lung Cancer: A Meta-Analysis. 幽门螺杆菌感染与肺癌风险:一项meta分析。

Lung cancer international Pub Date : 2013-01-01 Epub Date: 2013-02-28 DOI: 10.1155/2013/131869

Pulikonda Mounika

{"title":"Helicobacter pylori Infection and Risk of Lung Cancer: A Meta-Analysis.","authors":"Pulikonda Mounika","doi":"10.1155/2013/131869","DOIUrl":"https://doi.org/10.1155/2013/131869","url":null,"abstract":"Background. Recent evidence showed that Helicobacter pylori seropositivity is a risk factor for gastric and several other cancers. However, evidence on H. pylori infection and risk of lung cancer has been controversial, with a limited number of underpowered studies. We therefore examined the association between H. pylori infection and risk of lung cancer. Methods. A comprehensive literature search was performed using PubMed, EMBASE (until October 2012) for studies investigating an association between Helicobacter pylori (H. pylori) infection and risk of lung cancer. Pooled odds ratio (OR) was calculated using random-effects model. Subgroup and sensitivity analysis were also done. Results. A total of seven studies (6 case-control and 1 cohort study) were included for the analysis. There was a significant heterogeneity among the studies, but no publication bias was observed. We found that H. pylori infection was associated with significantly increased risk of lung cancer (pooled OR, 2.29 (95% CI, 1.34-3.91) P = 0.01). Conclusions. Our meta-analysis suggests a significant increased risk of lung cancer in patients with H. pylori infection. Further research is needed to confirm these findings and to identify the underlying biological mechanisms. ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2013 ","pages":"131869"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/131869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34129112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

National Mesothelioma Virtual Bank: A Platform for Collaborative Research and Mesothelioma Biobanking Resource to Support Translational Research. 国家间皮瘤虚拟库：合作研究平台和间皮瘤生物库资源，支持转化研究。

Lung cancer international Pub Date : 2013-01-01 Epub Date: 2013-09-18 DOI: 10.1155/2013/765748

Waqas Amin, Anil V Parwani, Jonathan Melamed, Raja Flores, Arjun Pennathur, Federico Valdivieso, Nancy B Whelan, Rodeny Landreneau, James Luketich, Michael Feldman, Harvey I Pass, Michael J Becich

{"title":"National Mesothelioma Virtual Bank: A Platform for Collaborative Research and Mesothelioma Biobanking Resource to Support Translational Research.","authors":"Waqas Amin, Anil V Parwani, Jonathan Melamed, Raja Flores, Arjun Pennathur, Federico Valdivieso, Nancy B Whelan, Rodeny Landreneau, James Luketich, Michael Feldman, Harvey I Pass, Michael J Becich","doi":"10.1155/2013/765748","DOIUrl":"10.1155/2013/765748","url":null,"abstract":"The National Mesothelioma Virtual Bank (NMVB), developed six years ago, gathers clinically annotated human mesothelioma specimens for basic and clinical science research. During this period, this resource has greatly increased its collection of specimens by expanding the number of contributing academic health centers including New York University, University of Pennsylvania, University of Pittsburgh Medical Center, and Mount Sinai School of Medicine. Marketing efforts at both national and international annual conferences increase awareness and availability of the mesothelioma specimens at no cost to approved investigators, who query the web-based NMVB database for cumulative and appropriate patient clinicopathological information on the specimens. The data disclosure and specimen distribution protocols are tightly regulated to maintain compliance with participating institutions' IRB and regulatory committee reviews. The NMVB currently has over 1120 annotated cases available for researchers, including paraffin embedded tissues, fresh frozen tissue, tissue microarrays (TMA), blood samples, and genomic DNA. In addition, the resource offers expertise and assistance for collaborative research. Furthermore, in the last six years, the resource has provided hundreds of specimens to the research community. The investigators can request specimens and/or data by submitting a Letter of Intent (LOI) that is evaluated by NMVB research evaluation panel (REP). ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2013 ","pages":"765748"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC. 胸苷酸合成酶作为非小细胞肺癌培美曲塞反应的预测性生物标志物。

Lung cancer international Pub Date : 2013-01-01 Epub Date: 2013-12-25 DOI: 10.1155/2013/436409

Ali A Bukhari, Ranjit K Goudar

引用次数: 7

Attitudes towards Lung Cancer Screening in an Australian High-Risk Population. 澳大利亚高危人群对肺癌筛查的态度

Lung cancer international Pub Date : 2013-01-01 Epub Date: 2013-07-15 DOI: 10.1155/2013/789057

Alexandra E Flynn, Matthew J Peters, Lucy C Morgan

{"title":"Attitudes towards Lung Cancer Screening in an Australian High-Risk Population.","authors":"Alexandra E Flynn, Matthew J Peters, Lucy C Morgan","doi":"10.1155/2013/789057","DOIUrl":"https://doi.org/10.1155/2013/789057","url":null,"abstract":"Objectives. To determine whether persons at high risk of lung cancer would participate in lung cancer screening test if available in Australia and to elicit general attitudes towards cancer screening and factors that might affect participation in a screening program. Methods. We developed a 20-item written questionnaire, based on two published telephone interview scripts, addressing attitudes towards cancer screening, perceived risk of lung cancer, and willingness to be screened for lung cancer and to undertake surgery if lung cancer were detected. The questionnaire was given to 102 current and former smokers attending the respiratory clinic and pulmonary rehabilitation programmes. Results. We gained 90 eligible responses (M:F, 69:21). Mean [SD] age was 63 [11] and smoking history was 32 [21] pack years. 95% of subjects would participate in a lung cancer screening test, and 91% of these would consider surgery if lung cancer was detected. 44% of subjects considered that they were at risk of lung cancer. This was lower in ex-smokers than in current smokers. Conclusions. There is high willingness for lung cancer screening and surgical treatment. There is underrecognition of risk among ex-smokers. This misperception could be a barrier to a successful screening or case-finding programme in Australia. ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2013 ","pages":"789057"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/789057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34130755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Mutated KRAS Is an Independent Negative Prognostic Factor for Survival in NSCLC Stage III Disease Treated with High-Dose Radiotherapy. KRAS突变是高剂量放疗治疗的NSCLC III期疾病生存的独立负面预后因素。

Lung cancer international Pub Date : 2012-01-01 Epub Date: 2012-09-17 DOI: 10.1155/2012/587424

A Hallqvist, F Enlund, C Andersson, H Sjögren, A Hussein, E Holmberg, J Nyman

{"title":"Mutated KRAS Is an Independent Negative Prognostic Factor for Survival in NSCLC Stage III Disease Treated with High-Dose Radiotherapy.","authors":"A Hallqvist, F Enlund, C Andersson, H Sjögren, A Hussein, E Holmberg, J Nyman","doi":"10.1155/2012/587424","DOIUrl":"https://doi.org/10.1155/2012/587424","url":null,"abstract":"Background. The main attention regarding prognostic and predictive markers in NSCLC directs towards the EGFR-targeted pathway, where the most studied genetic alterations include EGFR mutations, EGFR copy number, and KRAS mutations. We wanted to explore the prognostic impact of mutated KRAS in the stage III setting treated with high-dose radiochemotherapy. Methods. Samples were obtained from patients participating in two prospective studies of locally advanced NSCLC receiving combined radiochemotherapy: the RAKET study, a randomized phase II study where patients were treated with induction chemotherapy (carboplatin/paclitaxel) followed by concurrent radiochemotherapy, and the Satellite trial, a phase II study with induction chemotherapy (cisplatin/docetaxel) followed by radiotherapy concurrent cetuximab. The samples were analysed regarding KRAS mutations, EGFR mutations, and EGFR FISH positivity. Results. Patients with mutated KRAS had a significantly inferior survival, which maintained its significance in a multivariate analysis when other possible prognostic factors were taken into account. The prevalence of KRAS mutations, EGFR mutations, and EGFR FISH positivity were 28.8%, 7.5%, and 19.7%, respectively. Conclusion. Mutated KRAS is an independent negative prognostic factor for survival in NSCLC stage III disease treated with combined radiochemotherapy. The prevalence of KRAS mutations and EGFR mutations are as expected in this Scandinavian population. ","PeriodicalId":91139,"journal":{"name":"Lung cancer international","volume":"2012 ","pages":"587424"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/587424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34129108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13