Journal of biomarkers最新文献

Corrigendum to “Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis” “生物标志物在急性胰腺炎诊断和预后评估中的作用”的勘误表

Journal of biomarkers Pub Date : 2019-12-14 DOI: 10.1155/2019/9590414

S. Meher, T. Mishra, P. Sasmal, Satyajit Rath, R. Sharma, B. Rout, M. Sahu

引用次数: 1

Body Mass Index, Haemoglobin, and Total Lymphocyte Count as a Surrogate for CD4 Count in Resource Limited Settings. 在资源有限的情况下，身体质量指数、血红蛋白和总淋巴细胞计数代替CD4计数。

Journal of biomarkers Pub Date : 2017-01-01 Epub Date: 2017-04-18 DOI: 10.1155/2017/7907352

Louis Boafo Kwantwi, Bismark Kwame Tunu, Daniel Boateng, Dan Yedu Quansah

{"title":"Body Mass Index, Haemoglobin, and Total Lymphocyte Count as a Surrogate for CD4 Count in Resource Limited Settings.","authors":"Louis Boafo Kwantwi, Bismark Kwame Tunu, Daniel Boateng, Dan Yedu Quansah","doi":"10.1155/2017/7907352","DOIUrl":"https://doi.org/10.1155/2017/7907352","url":null,"abstract":"Background. In view of the lack of evidence on the possibility of an economically viable, easy, and readily available biomarker to substitute the traditional role of CD4 counts in HIV disease progression, this study seeks to investigate the potential use of body mass index (BMI), haemoglobin (Hb), and total lymphocyte count (TLC) as surrogate biomarkers for monitoring the disease. Methods. This cross-sectional study was undertaken at the antiretroviral clinic (ART) of the Bomso Hospital, Kumasi, Ghana. We recruited 384 individuals who were 18 years or older and confirmed HIV seropositive patients. Blood samples were assayed for TLC and Hb. Weight and height were determined and BMI was calculated. Result. At a cut-off point of 12.15 g/dL, Hb had sensitivity and specificity of 73.9% and 56.8%, respectively, whereas BMI had 69.6% and 80.1% sensitivity and specificity, respectively. The sensitivity and specificity were also 100% among the studied participants at a cut-off point of 1200 mm-3 for TLC. There was a significant positive correlation between CD4 count and Hb (rho 0.262, p = 0.0001), BMI (rho 0.301, p = 0.0001), and TLC (rho 0.834, p = 0.0001). Conclusion. The study demonstrates that TLC, Hb, and BMI may provide some useful prognostic information independent of that provided by CD4 count.","PeriodicalId":91105,"journal":{"name":"Journal of biomarkers","volume":"2017 ","pages":"7907352"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7907352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34979184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Cystatin-C as a Marker for Renal Impairment in Preeclampsia. 胱氨酸抑素c作为子痫前期肾脏损害的标志物。

Journal of biomarkers Pub Date : 2017-01-01 Epub Date: 2017-07-11 DOI: 10.1155/2017/7406959

Apeksha Niraula, Madhab Lamsal, Nirmal Baral, Shankar Majhi, Seraj Ahmed Khan, Pritha Basnet, Kashyap Dahal

{"title":"Cystatin-C as a Marker for Renal Impairment in Preeclampsia.","authors":"Apeksha Niraula, Madhab Lamsal, Nirmal Baral, Shankar Majhi, Seraj Ahmed Khan, Pritha Basnet, Kashyap Dahal","doi":"10.1155/2017/7406959","DOIUrl":"https://doi.org/10.1155/2017/7406959","url":null,"abstract":"Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. This study was aimed to evaluate the diagnostic efficiency of Cystatin-C as an early marker of renal function in preeclampsia comparing it to the traditional renal markers. A hospital based comparative cross-sectional study was performed on 104 women (52 diagnosed cases of preeclampsia and 52 healthy pregnant women). Concentrations of Cystatin-C, creatinine, urea, and uric acid were measured in both the study groups. Mean serum Cystatin-C and uric acid levels were elevated in preeclampsia cases compared to controls (1.15 ± 0.37 versus 0.55 ± 0.12; 5.40 ± 1.44 versus 3.97 ± 0.68, resp.). ROC curve depicted that Cystatin-C had the highest diagnostic efficiency (sensitivity, 88.24%; specificity, 98.04%) compared to creatinine and uric acid. Serum Cystatin-C consequently seemed to closely reflect the renal functional changes, which are believed to lead to increased blood pressure levels and urinary excretion of albumin and may thus function as a marker for the stage of the transition between normal adaptive renal changes at term and preeclampsia.","PeriodicalId":91105,"journal":{"name":"Journal of biomarkers","volume":"2017 ","pages":"7406959"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7406959","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35386644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

The Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin. 精氨酸抗利尿素c末端Copeptin的昼夜节律。

Journal of biomarkers Pub Date : 2017-01-01 Epub Date: 2017-06-01 DOI: 10.1155/2017/4737082

Svetlana Beglinger, Jürgen Drewe, Mirjam Christ-Crain

{"title":"The Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin.","authors":"Svetlana Beglinger, Jürgen Drewe, Mirjam Christ-Crain","doi":"10.1155/2017/4737082","DOIUrl":"https://doi.org/10.1155/2017/4737082","url":null,"abstract":"Background: Several studies have investigated copeptin as a prognostic marker of different acute diseases and as a diagnostic marker in disorders of water and salt homeostasis. However, no data of the normal circadian rhythm of copeptin in healthy subjects are available.Aim: To investigate the circadian rhythm of copeptin in healthy subjects under standardized conditions.Methods: 19 healthy volunteers aged 18 to 53 years, male and female, were studied in a prospective observational study. In all 19 participants, blood samples for copeptin were taken in regular intervals of 30 minutes for 24 hours after a fasting period of minimum 8 hours.Results: The mean values of copeptin showed a circadian rhythm, similar to that described for AVP release, with a trend towards higher levels (5.9 ± 1 pmol/L) at night and early morning between 4 am and 6 am and lowest levels (2.3 ± 0.2 pmol/L) in the late afternoon between 5 pm and 7 pm. This finding was only observed in individuals with initial higher copeptin levels, whereas in individuals with lower basal copeptin levels no circadian rhythm was observed.Conclusion: There is evidence for a circadian rhythm in copeptin release during 24 hours, however, of minor extent. These findings suggest that copeptin levels can be determined irrespectively of the time of the day.","PeriodicalId":91105,"journal":{"name":"Journal of biomarkers","volume":"2017 ","pages":"4737082"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4737082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35123771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Determination of Urinary Neopterin/Creatinine Ratio to Distinguish Active Tuberculosis from Latent Mycobacterium tuberculosis Infection. 尿新蝶呤/肌酐比值测定鉴别活动性结核与潜伏性结核分枝杆菌感染。

Journal of biomarkers Pub Date : 2016-01-01 Epub Date: 2016-06-28 DOI: 10.1155/2016/5643853

Michael Eisenhut, Dougal S Hargreaves, Anne Scott, David Housley, Andrew Walters, Rohinton Mulla

{"title":"Determination of Urinary Neopterin/Creatinine Ratio to Distinguish Active Tuberculosis from Latent Mycobacterium tuberculosis Infection.","authors":"Michael Eisenhut, Dougal S Hargreaves, Anne Scott, David Housley, Andrew Walters, Rohinton Mulla","doi":"10.1155/2016/5643853","DOIUrl":"https://doi.org/10.1155/2016/5643853","url":null,"abstract":"Background. Biomarkers to distinguish latent from active Mycobacterium (M.) tuberculosis infection in clinical practice are lacking. The urinary neopterin/creatinine ratio can quantify the systemic interferon-gamma effect in patients with M. tuberculosis infection. Methods. In a prospective observational study, urinary neopterin levels were measured by enzyme linked immunosorbent assay in patients with active tuberculosis, in people with latent M. tuberculosis infection, and in healthy controls and the urinary neopterin/creatinine ratio was calculated. Results. We included a total of 44 patients with M. tuberculosis infection and nine controls. 12 patients had active tuberculosis (8 of them culture-confirmed). The median age was 15 years (range 4.5 to 49). Median urinary neopterin/creatinine ratio in patients with active tuberculosis was 374.1 micromol/mol (129.0 to 1072.3), in patients with latent M. tuberculosis infection it was 142.1 (28.0 to 384.1), and in controls it was 146.0 (40.3 to 200.0), with significantly higher levels in patients with active tuberculosis (p < 0.01). The receiver operating characteristics curve had an area under the curve of 0.84 (95% CI 0.70 to 0.97) (p < 0.01). Conclusions. Urinary neopterin/creatinine ratios are significantly higher in patients with active tuberculosis compared to patients with latent infection and may be a significant predictor of active tuberculosis in patients with M. tuberculosis infection. ","PeriodicalId":91105,"journal":{"name":"Journal of biomarkers","volume":"2016 ","pages":"5643853"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5643853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34683013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts. 一种灵敏的免疫组化方法监测人类肿瘤异种移植物自噬特异性标志物。

Journal of biomarkers Pub Date : 2016-01-01 Epub Date: 2016-05-10 DOI: 10.1155/2016/1274603

Helen He, Yu Yang, Zhongmin Xiang, Lunyin Yu, Jouhara Chouitar, Jie Yu, Natalie Roy D'Amore, Ping Li, Zhi Li, Douglas Bowman, Matthew Theisen, James E Brownell, Stephen Tirrell

引用次数: 7

Association Study between Promoter Polymorphism of TPH1 and Progression of Idiopathic Scoliosis. TPH1启动子多态性与特发性脊柱侧凸进展的相关性研究

Journal of biomarkers Pub Date : 2016-01-01 Epub Date: 2016-05-16 DOI: 10.1155/2016/5318239

Vasil Yablanski, Svetla Nikolova, Evgeni Vlaev, Alexey Savov, Ivo Kremensky

{"title":"Association Study between Promoter Polymorphism of TPH1 and Progression of Idiopathic Scoliosis.","authors":"Vasil Yablanski, Svetla Nikolova, Evgeni Vlaev, Alexey Savov, Ivo Kremensky","doi":"10.1155/2016/5318239","DOIUrl":"https://doi.org/10.1155/2016/5318239","url":null,"abstract":"The concept of disease-modifier genes as an element of genetic heterogeneity has been widely accepted and reported. The aim of the current study is to investigate the association between the promoter polymorphism TPH1 (rs10488682) and progression of idiopathic scoliosis (IS) in Eastern European population sample. A total of 105 patients and 210 healthy gender-matched controls were enrolled in this study. The TPH1 promoter polymorphism was genotyped by amplification followed by restriction. The statistical analysis was performed by Fisher's Exact Test. The results indicated that the genotypes and alleles of TPH1 (rs10488682) are not correlated with curve severity, curve pattern, or bracing. Therefore, the examined polymorphic variant could not be considered as a genetic factor with modifying effect of IS. In conclusion, this case-control study revealed no statistically significant association between TPH1 (rs10488682) and progression of IS in Eastern European population sample. These preliminary results should be replicated in extended population studies including larger sample sizes. The identification of molecular markers for IS could be useful for a more accurate prognosis of the risk for a rapid progression of the curve. That would permit early stage treatment of the patient with the least invasive procedures. ","PeriodicalId":91105,"journal":{"name":"Journal of biomarkers","volume":"2016 ","pages":"5318239"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/5318239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34474137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Predictive Role of Inflammatory Biomarkers in Atrial Fibrillation as Seen through Neutrophil-Lymphocyte Ratio Mirror. 通过中性粒细胞-淋巴细胞比率镜观察炎症生物标志物在房颤中的预测作用。

Journal of biomarkers Pub Date : 2016-01-01 Epub Date: 2016-07-03 DOI: 10.1155/2016/8160393

Feliciano Chanana Paquissi

引用次数: 22

The Diagnostic Value of Serum C-Reactive Protein for Identifying Pneumonia in Hospitalized Patients with Acute Respiratory Symptoms. 血清 C-反应蛋白对有急性呼吸道症状的住院病人肺炎的诊断价值。

Journal of biomarkers Pub Date : 2016-01-01 Epub Date: 2016-08-16 DOI: 10.1155/2016/2198745

Agustín Ruiz-González, Laia Utrillo, Silvia Bielsa, Miquel Falguera, José M Porcel

{"title":"The Diagnostic Value of Serum C-Reactive Protein for Identifying Pneumonia in Hospitalized Patients with Acute Respiratory Symptoms.","authors":"Agustín Ruiz-González, Laia Utrillo, Silvia Bielsa, Miquel Falguera, José M Porcel","doi":"10.1155/2016/2198745","DOIUrl":"10.1155/2016/2198745","url":null,"abstract":"Background. The clinical diagnosis of pneumonia is sometimes difficult since chest radiographs are often indeterminate. In this study, we aimed to assess whether serum C-reactive protein (CRP) could assist in identifying patients with pneumonia. Methods. For one winter, all consecutive patients with acute respiratory symptoms admitted to the emergency ward of a single center were prospectively enrolled. In addition to chest radiographs, basic laboratory tests, and microbiology, serum levels of CRP were measured at entry. Results. A total of 923 (62.3%) of 1473 patients hospitalized for acute respiratory symptoms were included. Subjects with a final diagnosis of pneumonia had higher serum CRP levels (median 187 mg/L) than those with exacerbations of chronic obstructive pulmonary disease (63 mg/L) or acute bronchitis (54 mg/L, p < 0.01). CRP was accurate in identifying pneumonia (area under the curve 0.84, 95% CI 0.82-0.87). The multilevel likelihood ratio (LR) for intervals of CRP provided useful information on the posttest probability of having pneumonia. CRP intervals above 200 mg/L were associated with LR+ > 5, for which pneumonia is likely, whereas CRP intervals below 75 mg/L were associated with LR < 0.2, for which pneumonia is unlikely. Conclusion. Serum CRP may be a useful addition for diagnosing pneumonia in hospitalized patients with acute respiratory symptoms. ","PeriodicalId":91105,"journal":{"name":"Journal of biomarkers","volume":"2016 ","pages":"2198745"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34732354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Search of Biomarkers for Idiopathic Scoliosis: Leptin and BMP4 Functional Polymorphisms. 寻找特发性脊柱侧凸的生物标志物:瘦素和BMP4功能多态性。

Journal of biomarkers Pub Date : 2015-01-01 Epub Date: 2015-08-02 DOI: 10.1155/2015/425310

Svetla Nikolova, Vasil Yablanski, Evgeni Vlaev, Gergana Getova, Ventseslav Atanasov, Luben Stokov, Alexey Slavkov Savov, Ivo Marinov Kremensky

{"title":"In Search of Biomarkers for Idiopathic Scoliosis: Leptin and BMP4 Functional Polymorphisms.","authors":"Svetla Nikolova, Vasil Yablanski, Evgeni Vlaev, Gergana Getova, Ventseslav Atanasov, Luben Stokov, Alexey Slavkov Savov, Ivo Marinov Kremensky","doi":"10.1155/2015/425310","DOIUrl":"https://doi.org/10.1155/2015/425310","url":null,"abstract":"Idiopathic scoliosis (IS) is the most common spinal disorder in children and adolescents. The current consensus on IS maintains that it has a multifactorial etiology with genetic predisposition factors. In the present study the association of two functional polymorphisms of leptin (rs7799039) and BMP4 (rs4898820) with susceptibility to IS and curve severity was investigated in a Bulgarian population sample. The molecular detection of the genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson's chi-squared test. This case-control study revealed no statistically significant association between the functional polymorphisms of leptin and BMP4 and susceptibility to IS or curve progression (p > 0.05). On the basis of these results the examined polymorphic variants of leptin and BMP4 could not be considered as genetic variants with predisposition effect or as risk factors for the progression of the curve. In addition, these results do not exclude a synergistic effect of the promoter polymorphisms of leptin and BMP4 in the etiology and pathogenesis of IS. The identification of molecular markers for IS could be useful for early detection and prognosis of the risk for a rapid progression of the curve. That would permit early stage treatment of the patient with the least invasive procedures. ","PeriodicalId":91105,"journal":{"name":"Journal of biomarkers","volume":"2015 ","pages":"425310"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/425310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34129130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5